GREMLIN Database
T0905_30-353_1_324 - T0905_30-353 1-324
ID: 90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 324 (279)
Sequences: 437 (383)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_T251_I7.4641.00
244_F251_I5.1151.00
244_F247_T4.9461.00
121_L126_E4.7481.00
182_Q186_D4.3291.00
291_T302_H4.1261.00
24_W154_I3.8931.00
279_G315_I3.3861.00
132_F153_V2.6790.99
35_S202_I2.5090.98
21_D151_L2.4550.98
161_D225_R2.3260.97
21_D149_A2.3010.97
226_L233_T2.2770.97
305_S308_A2.2670.97
155_I199_V2.2080.96
201_T230_A2.1960.96
153_V191_Y2.1840.96
230_A233_T2.0990.95
244_F248_L2.0660.95
247_T254_S2.0380.94
305_S309_A2.0340.94
128_A155_I2.0280.94
39_L154_I1.9940.93
208_A220_R1.9930.93
39_L156_V1.9410.92
101_M104_N1.9300.92
157_S226_L1.8950.92
245_G248_L1.8780.91
313_I317_F1.8760.91
247_T250_L1.8300.90
126_E159_E1.8080.89
24_W63_T1.8060.89
27_D31_S1.8050.89
9_Y317_F1.7480.88
223_S226_L1.7310.87
248_L264_L1.7300.87
22_I288_N1.7170.87
286_A291_T1.7140.87
268_P275_I1.7050.86
21_D146_R1.6510.85
32_M158_D1.6490.84
43_F47_I1.6350.84
63_T111_V1.6000.83
36_Q64_T1.5860.82
28_N64_T1.5710.81
184_Y187_F1.5660.81
284_N291_T1.5570.81
23_L153_V1.5260.79
305_S319_P1.5060.79
59_M64_T1.5050.78
26_I39_L1.4720.77
247_T252_S1.4650.77
129_F161_D1.4520.76
230_A234_A1.4510.76
228_E232_L1.4440.75
293_D300_T1.4430.75
52_Q154_I1.4430.75
230_A235_G1.4390.75
265_N278_N1.4280.75
127_R260_S1.4080.74
66_A131_S1.4070.74
146_R149_A1.3940.73
194_S251_I1.3760.72
45_S153_V1.3640.71
315_I318_Y1.3630.71
60_A153_V1.3520.70
19_Q148_E1.3480.70
234_A289_G1.3340.69
6_A305_S1.3300.69
30_G228_E1.3240.69
166_S296_N1.2910.67
264_L317_F1.2850.66
64_T128_A1.2560.65
28_N36_Q1.2500.64
65_E161_D1.2500.64
128_A226_L1.2480.64
248_L251_I1.2250.63
25_V135_A1.2220.62
84_A273_I1.2210.62
20_I57_F1.2190.62
314_T318_Y1.2180.62
284_N302_H1.2170.62
61_V304_S1.2080.62
203_T317_F1.2070.61
268_P301_F1.2050.61
209_C241_C1.1910.60
131_S184_Y1.1790.60
29_S157_S1.1750.59
25_V146_R1.1730.59
128_A159_E1.1650.59
6_A9_Y1.1580.58
127_R159_E1.1570.58
299_I302_H1.1530.58
56_D146_R1.1520.58
264_L268_P1.1490.58
260_S319_P1.1420.57
34_T255_I1.1360.57
120_T126_E1.1320.56
60_A197_Y1.1320.56
84_A100_I1.1290.56
42_N146_R1.1250.56
184_Y296_N1.1240.56
191_Y277_V1.1170.55
101_M108_L1.1170.55
288_N302_H1.1070.55
43_F46_F1.1070.55
180_T269_Q1.1070.55
251_I254_S1.1050.55
301_F317_F1.0820.53
227_P230_A1.0820.53
16_I186_D1.0780.53
46_F59_M1.0780.53
235_G239_S1.0770.53
22_I152_A1.0740.52
148_E252_S1.0730.52
29_S204_V1.0660.52
58_H141_N1.0650.52
129_F225_R1.0650.52
25_V28_N1.0630.52
21_D301_F1.0500.51
152_A197_Y1.0460.51
285_D288_N1.0360.50
24_W59_M1.0310.49
198_S202_I1.0290.49
208_A289_G1.0170.48
37_D106_A1.0110.48
25_V62_T1.0060.48
244_F252_S1.0060.48
274_V281_S1.0050.48
238_G249_E1.0020.47
15_F254_S0.9990.47
26_I160_E0.9980.47
23_L151_L0.9920.47
84_A134_E0.9790.46
50_F62_T0.9790.46
135_A153_V0.9770.46
247_T253_D0.9760.46
153_V254_S0.9700.45
291_T303_G0.9680.45
60_A142_A0.9650.45
132_F188_L0.9650.45
110_D114_T0.9560.44
280_V316_D0.9520.44
299_I303_G0.9480.44
58_H227_P0.9470.44
247_T257_Q0.9440.43
28_N162_F0.9420.43
53_Y253_D0.9400.43
103_K280_V0.9340.43
29_S125_D0.9340.43
297_L315_I0.9320.43
53_Y200_S0.9280.42
186_D242_S0.9270.42
60_A303_G0.9240.42
225_R229_L0.9220.42
194_S199_V0.9210.42
36_Q63_T0.9160.42
131_S160_E0.9140.41
31_S158_D0.9130.41
127_R161_D0.9120.41
149_A301_F0.9110.41
260_S305_S0.9080.41
259_S292_Y0.9070.41
226_L230_A0.9070.41
81_K154_I0.9060.41
23_L63_T0.9040.41
60_A231_T0.9010.41
231_T267_E0.8980.40
43_F112_F0.8940.40
51_Q246_S0.8930.40
204_V244_F0.8930.40
280_V285_D0.8890.40
157_S201_T0.8800.39
186_D195_R0.8790.39
33_K117_K0.8790.39
288_N315_I0.8740.39
273_I283_P0.8690.38
159_E260_S0.8650.38
49_R52_Q0.8640.38
135_A204_V0.8630.38
132_F239_S0.8590.38
41_A313_I0.8590.38
112_F116_A0.8590.38
59_M303_G0.8430.37
202_I238_G0.8310.36
268_P315_I0.8300.36
16_I22_I0.8280.36
147_S229_L0.8270.36
17_P299_I0.8250.36
109_G263_K0.8250.36
149_A307_P0.8240.36
150_F299_I0.8230.35
227_P233_T0.8230.35
201_T246_S0.8110.35
68_E312_N0.8100.35
129_F149_A0.8090.35
128_A161_D0.8090.35
134_E302_H0.8070.34
64_T159_E0.8060.34
72_N75_S0.8050.34
25_V47_I0.8050.34
164_S180_T0.8020.34
291_T296_N0.8000.34
265_N311_A0.8000.34
128_A157_S0.7980.34
102_D106_A0.7960.34
157_S313_I0.7900.33
58_H82_D0.7900.33
280_V310_D0.7880.33
25_V161_D0.7880.33
251_I269_Q0.7840.33
18_K196_N0.7830.33
26_I235_G0.7820.33
201_T232_L0.7780.33
129_F184_Y0.7770.33
149_A292_Y0.7770.33
200_S205_P0.7770.33
276_T281_S0.7690.32
23_L135_A0.7690.32
204_V319_P0.7660.32
159_E202_I0.7660.32
64_T292_Y0.7640.32
137_L196_N0.7640.32
119_G240_L0.7630.32
121_L124_G0.7630.32
22_I163_S0.7600.32
63_T240_L0.7600.32
136_L187_F0.7560.31
63_T301_F0.7550.31
130_S162_F0.7550.31
243_N252_S0.7540.31
30_G162_F0.7530.31
22_I246_S0.7500.31
200_S233_T0.7460.31
67_W296_N0.7430.31
27_D157_S0.7430.31
107_N229_L0.7410.30
235_G272_T0.7400.30
42_N179_H0.7390.30
269_Q272_T0.7370.30
299_I311_A0.7370.30
185_V193_G0.7320.30
51_Q300_T0.7290.30
121_L125_D0.7270.30
36_Q159_E0.7250.30
29_S158_D0.7240.29
132_F270_E0.7240.29
29_S233_T0.7190.29
27_D158_D0.7170.29
25_V131_S0.7120.29
151_L229_L0.7110.29
226_L235_G0.7110.29
164_S225_R0.7100.29
110_D179_H0.7100.29
312_N315_I0.7070.28
292_Y299_I0.7060.28
167_A278_N0.7050.28
156_V161_D0.7030.28
65_E159_E0.7000.28
26_I131_S0.6970.28
23_L146_R0.6970.28
153_V271_D0.6950.28
198_S305_S0.6940.28
45_S116_A0.6920.28
49_R249_E0.6850.27
203_T314_T0.6840.27
306_V309_A0.6830.27
206_D299_I0.6810.27
253_D311_A0.6800.27
18_K131_S0.6790.27
112_F272_T0.6790.27
154_I197_Y0.6780.27
251_I255_I0.6770.27
263_K298_T0.6770.27
30_G63_T0.6760.27
148_E165_S0.6740.27
156_V291_T0.6730.27
46_F151_L0.6710.26
269_Q320_K0.6710.26
45_S119_G0.6700.26
39_L205_P0.6680.26
83_G110_D0.6670.26
152_A229_L0.6660.26
19_Q39_L0.6660.26
193_G315_I0.6650.26
159_E226_L0.6620.26
24_W107_N0.6590.26
69_K112_F0.6560.26
200_S319_P0.6550.26
280_V298_T0.6540.26
25_V245_G0.6540.26
247_T256_I0.6530.26
66_A261_V0.6530.26
78_A285_D0.6500.25
24_W48_S0.6480.25
282_V309_A0.6470.25
28_N72_N0.6460.25
116_A206_D0.6450.25
53_Y201_T0.6440.25
25_V264_L0.6440.25
293_D296_N0.6440.25
23_L64_T0.6420.25
255_I262_F0.6400.25
14_V255_I0.6390.25
76_E235_G0.6380.25
232_L246_S0.6380.25
155_I260_S0.6370.25
106_A249_E0.6370.25
28_N308_A0.6360.25
57_F196_N0.6360.25
104_N282_V0.6360.25
15_F238_G0.6350.25
155_I159_E0.6320.24
14_V263_K0.6320.24
18_K22_I0.6320.24
61_V141_N0.6300.24
103_K256_I0.6300.24
157_S204_V0.6270.24
23_L144_F0.6260.24
13_A105_T0.6260.24
84_A118_Q0.6250.24
104_N108_L0.6230.24
47_I65_E0.6220.24
22_I310_D0.6210.24
263_K295_S0.6200.24
28_N151_L0.6190.24
261_V298_T0.6180.24
27_D126_E0.6170.24
245_G252_S0.6170.24
111_V131_S0.6120.23
188_L202_I0.6100.23
25_V148_E0.6090.23
139_P252_S0.6080.23
203_T276_T0.6070.23
37_D207_D0.6070.23
152_A293_D0.6060.23
235_G241_C0.6040.23
8_D12_Q0.6030.23
64_T248_L0.6010.23
110_D182_Q0.5990.23
50_F136_L0.5990.23
300_T303_G0.5990.23
159_E233_T0.5980.23
101_M264_L0.5960.23
50_F239_S0.5950.23
24_W66_A0.5950.23
184_Y191_Y0.5940.23
36_Q240_L0.5940.23
43_F108_L0.5930.22
26_I240_L0.5920.22
204_V248_L0.5910.22
109_G113_S0.5840.22
61_V154_I0.5810.22
101_M285_D0.5800.22
40_A113_S0.5800.22
53_Y127_R0.5800.22
200_S203_T0.5800.22
233_T260_S0.5800.22
116_A145_R0.5770.22
199_V204_V0.5760.22
72_N76_E0.5760.22
285_D289_G0.5760.22
142_A187_F0.5750.22
127_R155_I0.5750.22
15_F293_D0.5720.21
32_M36_Q0.5710.21
84_A280_V0.5690.21
48_S281_S0.5690.21
184_Y209_C0.5650.21
245_G299_I0.5640.21
68_E250_L0.5640.21
151_L301_F0.5630.21
131_S134_E0.5630.21
19_Q292_Y0.5610.21
14_V52_Q0.5590.21
133_K300_T0.5570.21
248_L254_S0.5560.21
182_Q245_G0.5550.21
307_P317_F0.5550.21
147_S294_A0.5540.21
206_D227_P0.5540.21
12_Q246_S0.5530.21
155_I319_P0.5480.20
316_D319_P0.5470.20
42_N247_T0.5440.20
25_V188_L0.5440.20
26_I75_S0.5410.20
21_D223_S0.5380.20
20_I129_F0.5360.20
307_P310_D0.5360.20
312_N316_D0.5350.20
273_I287_V0.5340.20
14_V312_N0.5330.20
25_V63_T0.5330.20
27_D32_M0.5320.20
41_A57_F0.5300.20
135_A267_E0.5290.20
35_S157_S0.5290.20
37_D221_K0.5280.20
186_D297_L0.5270.19
104_N253_D0.5240.19
192_V301_F0.5240.19
112_F229_L0.5240.19
196_N199_V0.5200.19
44_Q269_Q0.5180.19
50_F285_D0.5170.19
74_A233_T0.5150.19
245_G254_S0.5150.19
115_N280_V0.5150.19
76_E277_V0.5140.19
153_V228_E0.5060.19
45_S157_S0.5060.19
19_Q35_S0.5050.19
68_E308_A0.5040.18
156_V303_G0.5020.18
220_R261_V0.5010.18
20_I46_F0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fcs_B 1 0.9043 99.7 0.748 Contact Map
4um9_B 1 0.8858 99.7 0.754 Contact Map
4neh_B 1 0.9136 99.7 0.755 Contact Map
4wk0_B 1 0.9012 99.7 0.759 Contact Map
4um8_B 1 0.8951 99.7 0.759 Contact Map
3t3p_B 1 0.9012 99.6 0.762 Contact Map
2b2x_A 1 0.571 99.6 0.764 Contact Map
5bv8_A 1 0.6142 99.6 0.765 Contact Map
1q0p_A 1 0.5432 99.6 0.767 Contact Map
1v7p_C 1 0.5648 99.6 0.767 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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