GREMLIN Database
T0869_1_120 - T0869 1-120
ID: 9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (105)
Sequences: 28 (24)
Seq/√Len: 2.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_V105_L3.1850.43
8_I18_T2.3540.27
28_I57_T2.3460.26
65_L102_D2.3420.26
65_L104_R2.3420.26
60_L92_W2.2740.25
64_G107_V2.1350.23
9_S32_F1.9550.20
86_P98_K1.8980.19
46_P73_M1.8570.19
70_A73_M1.8460.19
8_I95_L1.7830.18
7_V26_S1.7760.18
19_S101_Q1.7260.17
17_S86_P1.7080.17
62_S106_G1.7020.17
28_I51_G1.5900.16
23_Y40_K1.5740.15
8_I63_S1.5640.15
38_W84_S1.5220.15
92_W104_R1.5080.15
92_W102_D1.5080.15
95_L100_R1.4360.14
32_F95_L1.4300.14
24_L55_I1.4140.14
2_M94_Q1.3920.13
27_R37_M1.3620.13
65_L69_L1.3500.13
24_L33_H1.3410.13
6_I36_D1.3280.13
2_M8_I1.3260.13
5_S78_A1.3110.13
31_Q75_A1.2820.12
9_S42_E1.2680.12
46_P85_F1.2670.12
32_F102_D1.2590.12
32_F104_R1.2590.12
63_S94_Q1.2580.12
11_E63_S1.2290.12
86_P106_G1.2280.12
66_S105_L1.2260.12
32_F66_S1.2090.12
39_I73_M1.1990.12
4_G85_F1.1840.11
40_K82_E1.1600.11
14_V63_S1.1510.11
40_K66_S1.1470.11
5_S15_P1.1450.11
43_V65_L1.1420.11
30_D81_A1.1410.11
73_M97_E1.1220.11
43_V66_S1.0980.11
47_M87_L1.0910.11
4_G70_A1.0860.11
94_Q107_V1.0770.11
8_I102_D1.0620.10
8_I104_R1.0620.10
57_T60_L1.0390.10
13_R62_S1.0250.10
15_P95_L1.0160.10
64_G106_G0.9920.10
29_G44_Y0.9870.10
5_S19_S0.9840.10
2_M92_W0.9830.10
10_K62_S0.9610.10
2_M9_S0.9580.10
8_I94_Q0.9460.09
15_P32_F0.9430.09
26_S72_V0.9380.09
30_D76_R0.9220.09
41_D65_L0.9130.09
39_I96_V0.9070.09
8_I62_S0.9050.09
61_N93_N0.9030.09
75_A98_K0.8870.09
92_W105_L0.8790.09
17_S105_L0.8750.09
73_M85_F0.8630.09
9_S12_V0.8600.09
16_V95_L0.8570.09
57_T99_L0.8480.09
63_S78_A0.8350.09
24_L73_M0.8330.09
32_F39_I0.8280.09
17_S77_A0.8270.09
52_M104_R0.8210.09
52_M102_D0.8210.09
16_V32_F0.8060.08
25_V53_S0.7990.08
33_H37_M0.7960.08
68_F99_L0.7880.08
21_F54_F0.7860.08
22_D46_P0.7740.08
68_F78_A0.7680.08
77_A100_R0.7670.08
28_I75_A0.7590.08
63_S77_A0.7550.08
85_F97_E0.7540.08
10_K74_R0.7440.08
22_D94_Q0.7440.08
6_I54_F0.7420.08
55_I64_G0.7400.08
17_S46_P0.7220.08
33_H40_K0.7100.08
23_Y83_E0.7060.08
31_Q76_R0.7030.08
47_M81_A0.7020.08
17_S69_L0.7010.08
37_M72_V0.6980.08
97_E102_D0.6930.08
97_E104_R0.6930.08
39_I60_L0.6920.08
38_W82_E0.6880.08
36_D84_S0.6820.08
19_S80_Q0.6760.08
43_V57_T0.6680.08
59_S75_A0.6620.08
26_S106_G0.6540.07
12_V56_S0.6530.07
5_S12_V0.6510.07
32_F54_F0.6190.07
24_L81_A0.6150.07
43_V71_T0.6140.07
33_H71_T0.6100.07
15_P77_A0.6060.07
101_Q106_G0.6040.07
75_A99_L0.6020.07
63_S68_F0.5970.07
26_S78_A0.5930.07
8_I97_E0.5860.07
51_G88_Y0.5860.07
64_G86_P0.5810.07
29_G52_M0.5810.07
51_G57_T0.5730.07
20_Q55_I0.5690.07
3_A85_F0.5640.07
3_A84_S0.5560.07
62_S95_L0.5550.07
8_I108_S0.5550.07
4_G51_G0.5550.07
9_S14_V0.5530.07
19_S78_A0.5460.07
68_F80_Q0.5430.07
19_S68_F0.5400.07
6_I13_R0.5380.07
6_I10_K0.5370.07
2_M6_I0.5350.07
61_N106_G0.5340.07
26_S41_D0.5330.07
51_G54_F0.5310.07
92_W97_E0.5260.07
17_S61_N0.5240.07
32_F48_E0.5230.07
10_K13_R0.5190.07
68_F83_E0.5140.07
21_F53_S0.5090.07
3_A83_E0.5070.07
3_A101_Q0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fqg_A 1 0.4583 15.1 0.926 Contact Map
2b7e_A 1 0.4333 15 0.926 Contact Map
3hfh_A 1 0.0583 13.3 0.928 Contact Map
2p7n_A 1 0.825 11.4 0.93 Contact Map
2ck3_A 1 0.5833 11.2 0.93 Contact Map
3nft_A 1 0.8083 9.8 0.932 Contact Map
5cdf_A 1 0.575 8.4 0.934 Contact Map
1wch_A 1 0.65 8.3 0.934 Contact Map
4yzz_A 1 0.925 8 0.935 Contact Map
2juc_A 1 0.425 8 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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