GREMLIN Database
T0924_1_89 - T0924 1-89
ID: 89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (74)
Sequences: 229 (163)
Seq/√Len: 19.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_Y53_N3.1950.99
40_L75_L2.5850.97
47_E85_Y2.5430.97
24_L27_N2.2390.94
77_D81_K2.0880.92
78_I88_C2.0000.90
29_A32_L1.9670.89
23_E26_Q1.8850.87
43_L75_L1.8080.84
29_A36_A1.6990.80
29_A67_L1.6780.79
29_A64_L1.6500.78
18_A40_L1.6480.78
81_K84_V1.6460.78
71_V74_L1.6190.77
21_K29_A1.6120.76
43_L50_Y1.5340.73
78_I85_Y1.5060.71
19_R40_L1.4540.69
33_L36_A1.3430.62
76_K81_K1.3400.62
17_D55_K1.3370.62
25_L43_L1.3280.61
28_E60_K1.3120.60
42_L60_K1.3070.60
17_D58_E1.2940.59
85_Y88_C1.2730.58
25_L32_L1.1420.50
39_K47_E1.1350.49
61_A70_E1.0980.47
58_E81_K1.0980.47
52_D56_Y1.0940.47
60_K74_L1.0710.45
64_L67_L1.0520.44
30_K34_A1.0220.42
69_G83_A1.0210.42
37_N55_K1.0160.42
52_D59_D1.0000.41
71_V78_I1.0000.41
27_N31_T0.9990.41
86_S89_L0.9890.40
68_E85_Y0.9750.39
26_Q50_Y0.9720.39
26_Q79_S0.9560.38
63_E78_I0.9510.38
64_L71_V0.9450.38
22_A30_K0.9350.37
20_R39_K0.9140.36
63_E72_R0.9120.36
41_Q55_K0.9040.35
64_L81_K0.8960.35
62_Q87_T0.8860.34
27_N38_S0.8730.33
39_K50_Y0.8670.33
27_N37_N0.8660.33
22_A82_V0.8560.32
27_N42_L0.8470.32
70_E79_S0.8460.32
46_L82_V0.8430.32
22_A25_L0.8360.31
44_E80_E0.7990.29
58_E65_V0.7950.29
79_S86_S0.7680.28
20_R34_A0.7620.27
68_E87_T0.7550.27
55_K73_S0.7480.27
32_L46_L0.7300.26
52_D73_S0.7290.26
26_Q86_S0.7280.26
53_N57_L0.7210.25
18_A76_K0.7190.25
62_Q66_R0.7180.25
32_L67_L0.7180.25
36_A57_L0.7160.25
59_D62_Q0.7140.25
38_S42_L0.7120.25
37_N44_E0.7100.25
83_A86_S0.7090.25
33_L86_S0.6830.24
68_E86_S0.6820.24
63_E77_D0.6690.23
67_L85_Y0.6630.23
75_L82_V0.6480.22
38_S66_R0.6420.22
25_L29_A0.6380.22
33_L46_L0.6360.22
48_R62_Q0.6350.22
82_V86_S0.6100.20
25_L67_L0.6030.20
68_E74_L0.5940.20
28_E68_E0.5920.20
53_N60_K0.5810.19
17_D66_R0.5790.19
50_Y56_Y0.5750.19
31_T58_E0.5700.19
70_E74_L0.5630.19
31_T41_Q0.5500.18
16_A44_E0.5490.18
24_L31_T0.5470.18
46_L60_K0.5420.18
65_V81_K0.5380.18
20_R24_L0.5300.17
24_L76_K0.5280.17
39_K75_L0.5270.17
62_Q70_E0.5170.17
62_Q69_G0.5140.17
62_Q80_E0.5100.17
26_Q29_A0.5100.17
41_Q45_D0.5090.17
34_A38_S0.5030.16
27_N40_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c9i_A 1 1 83 0.735 Contact Map
4lin_A 1 1 74.9 0.754 Contact Map
5bu8_A 1 0.1573 74.8 0.755 Contact Map
4cgk_A 1 0.8315 73.5 0.757 Contact Map
1deq_A 1 0.9888 68.8 0.765 Contact Map
4q4g_X 1 0 67.7 0.766 Contact Map
1i84_S 1 0.0674 64.1 0.772 Contact Map
2dfs_A 1 0.8876 61.6 0.775 Contact Map
3ghg_A 1 0.9663 60.7 0.777 Contact Map
1lwu_C 1 0.764 56.9 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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