GREMLIN Database
T0922_21_93 - T0922 21-93
ID: 88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (64)
Sequences: 1140 (1028)
Seq/√Len: 128.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_V60_Q3.3971.00
19_I56_V3.0131.00
26_M63_Q2.8421.00
48_T51_S2.6231.00
30_A67_L2.5571.00
20_S57_L2.4621.00
25_I62_I2.2231.00
31_N68_G1.8001.00
12_N18_D1.7701.00
27_Q64_S1.7131.00
35_Y41_G1.7131.00
16_I53_G1.6501.00
32_P69_L1.5601.00
38_T41_G1.5301.00
29_M66_C1.5041.00
17_V65_Y1.4541.00
18_D55_T1.4501.00
6_K44_N1.4141.00
64_S69_L1.3951.00
22_A66_C1.3741.00
29_M59_A1.2271.00
8_P49_G1.1830.99
40_K44_N1.1800.99
11_A25_I1.1510.99
19_I23_V1.1360.99
59_A63_Q1.0490.98
30_A63_Q1.0190.98
47_V65_Y1.0190.98
48_T55_T1.0160.98
48_T52_D1.0150.98
39_D42_R0.9860.98
35_Y38_T0.9770.98
13_C41_G0.9430.97
11_A24_L0.9190.96
35_Y40_K0.9140.96
11_A45_A0.9140.96
29_M63_Q0.8920.96
26_M59_A0.8900.96
12_N20_S0.8890.96
63_Q67_L0.8750.95
45_A54_V0.8740.95
28_T34_K0.8720.95
46_D51_S0.8720.95
10_D14_D0.8380.94
22_A59_A0.8360.94
28_T42_R0.8340.94
48_T61_F0.8260.94
17_V62_I0.8230.94
24_L61_F0.7920.92
47_V62_I0.7600.91
65_Y70_V0.7590.90
8_P43_I0.7560.90
19_I60_Q0.7540.90
40_K43_I0.7420.89
51_S55_T0.7310.89
46_D52_D0.6950.86
10_D21_D0.6890.86
42_R54_V0.6850.85
8_P47_V0.6810.85
33_S41_G0.6710.84
26_M56_V0.6700.84
57_L61_F0.6650.84
23_V27_Q0.6610.83
11_A44_N0.6440.82
28_T35_Y0.6400.81
8_P65_Y0.6360.81
7_F15_G0.6340.81
14_D18_D0.6280.80
20_S66_C0.6210.79
15_G21_D0.6130.78
13_C44_N0.6020.77
17_V44_N0.6000.77
5_Q69_L0.6000.77
22_A63_Q0.5930.76
22_A26_M0.5920.76
20_S27_Q0.5870.75
21_D58_D0.5860.75
17_V47_V0.5800.75
28_T39_D0.5800.75
40_K47_V0.5800.75
7_F13_C0.5740.74
62_I66_C0.5730.74
26_M30_A0.5580.72
5_Q13_C0.5560.71
49_G52_D0.5480.70
35_Y54_V0.5450.70
64_S70_V0.5390.69
11_A62_I0.5370.69
24_L33_S0.5300.68
34_K71_E0.5240.67
41_G44_N0.5230.67
15_G71_E0.5230.67
8_P13_C0.5100.65
31_N64_S0.5090.65
52_D55_T0.5090.65
47_V70_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yik_A 1 0 99.5 -0.033 Contact Map
4fl4_A 1 0.9041 99.4 -0.013 Contact Map
4cj0_A 1 0 99.4 -0.012 Contact Map
4uyp_B 1 0.9315 99.4 -0.006 Contact Map
4dh2_B 1 0.9178 99.4 0.027 Contact Map
2ccl_B 1 0.8493 99.3 0.066 Contact Map
1daq_A 1 0.9041 99.3 0.073 Contact Map
2y3n_B 1 0.8219 99.3 0.081 Contact Map
2vn6_B 1 0.863 99.2 0.089 Contact Map
3ul4_B 1 0.863 99.2 0.101 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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