GREMLIN Database
T0921_1_149 - T0921 1-149
ID: 86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 149 (134)
Sequences: 1656 (1459)
Seq/√Len: 126.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_A101_V3.7911.00
50_T102_P3.7041.00
50_T100_N3.2401.00
51_I97_L3.0691.00
52_E100_N3.0411.00
48_P110_Y2.9591.00
24_T98_Y2.8581.00
45_V99_V2.7171.00
45_V69_M2.6211.00
26_D96_T2.4641.00
123_S127_S2.3511.00
51_I99_V2.2881.00
23_V101_V2.2761.00
24_T96_T2.1951.00
28_L93_A2.1301.00
12_F136_G2.0801.00
17_A23_V1.9221.00
41_V76_F1.8891.00
110_Y140_V1.8791.00
22_E98_Y1.8561.00
18_K21_D1.8451.00
49_L99_V1.8081.00
51_I74_A1.7551.00
109_T137_A1.6561.00
60_A92_A1.6311.00
10_F43_F1.6031.00
22_E100_N1.5301.00
39_M94_V1.5201.00
19_A103_A1.4701.00
44_K115_N1.4541.00
38_A122_K1.4481.00
101_V140_V1.4291.00
43_F97_L1.4261.00
27_V95_F1.4101.00
51_I54_I1.4011.00
46_D110_Y1.3971.00
17_A138_I1.3661.00
36_I129_F1.3581.00
27_V97_L1.3081.00
25_V112_V1.2921.00
16_T139_T1.2621.00
31_S90_D1.2601.00
9_V30_D1.2531.00
69_M72_L1.2341.00
53_E98_Y1.2330.99
13_Q26_D1.2150.99
20_G101_V1.2000.99
57_E61_F1.1780.99
49_L112_V1.1470.99
52_E98_Y1.1330.99
30_D91_G1.1260.99
19_A102_P1.1140.99
48_P140_V1.1100.99
124_N127_S1.1100.99
25_V99_V1.1010.99
40_D122_K1.1010.99
68_N71_I1.1010.99
27_V41_V1.0900.99
45_V72_L1.0830.99
121_H131_V1.0570.98
60_A63_T1.0550.98
23_V138_I1.0540.98
114_F117_K1.0260.98
12_F15_Y1.0200.98
42_K116_G0.9890.98
49_L110_Y0.9830.97
68_N72_L0.9730.97
38_A120_V0.9580.97
128_Q131_V0.9470.97
109_T139_T0.9390.97
55_D84_E0.9340.97
123_S129_F0.9320.97
87_V90_D0.9170.96
37_S79_L0.9150.96
76_F95_F0.9140.96
117_K133_S0.9090.96
46_D58_S0.9040.96
19_A140_V0.9030.96
44_K73_G0.9020.96
7_D132_A0.8990.96
10_F27_V0.8980.96
32_K36_I0.8970.96
15_Y138_I0.8940.96
90_D94_V0.8900.96
93_A96_T0.8890.95
42_K75_N0.8700.95
26_D93_A0.8660.95
22_E52_E0.8620.95
27_V117_K0.8450.94
29_V94_V0.8390.94
43_F119_E0.8280.93
117_K131_V0.8260.93
10_F112_V0.8170.93
27_V114_F0.8020.92
40_D116_G0.7900.92
36_I39_M0.7620.90
28_L46_D0.7610.90
40_D77_K0.7570.90
54_I74_A0.7530.90
49_L72_L0.7500.90
19_A101_V0.7430.89
102_P110_Y0.7380.89
13_Q27_V0.7380.89
37_S80_D0.7250.88
8_V12_F0.7170.87
55_D98_Y0.7160.87
133_S138_I0.7080.87
122_K126_G0.7040.86
48_P103_A0.7000.86
77_K83_G0.6980.86
74_A94_V0.6980.86
69_M74_A0.6930.85
120_V128_Q0.6890.85
47_S102_P0.6890.85
38_A86_L0.6880.85
15_Y25_V0.6830.85
111_Y137_A0.6820.85
33_N97_L0.6760.84
111_Y135_N0.6760.84
48_P108_G0.6720.84
113_G135_N0.6640.83
39_M56_K0.6620.83
33_N36_I0.6570.82
44_K113_G0.6560.82
28_L92_A0.6560.82
107_D141_G0.6520.82
51_I69_M0.6500.82
114_F133_S0.6470.81
58_S92_A0.6470.81
26_D91_G0.6460.81
56_K112_V0.6420.81
12_F138_I0.6390.81
51_I67_T0.6360.80
59_L97_L0.6330.80
57_E92_A0.6300.80
74_A99_V0.6300.80
8_V42_K0.6290.80
43_F74_A0.6270.79
16_T117_K0.6250.79
103_A140_V0.6220.79
22_E27_V0.6200.79
42_K73_G0.6180.78
54_I95_F0.6140.78
18_K129_F0.6120.78
64_T67_T0.6120.78
9_V28_L0.6100.77
44_K139_T0.6070.77
47_S115_N0.6070.77
114_F138_I0.6060.77
5_N32_K0.6010.76
109_T132_A0.5840.74
15_Y136_G0.5830.74
36_I121_H0.5830.74
29_V36_I0.5820.74
55_D96_T0.5810.74
43_F66_M0.5810.74
70_A113_G0.5790.74
46_D49_L0.5770.73
34_K115_N0.5760.73
10_F135_N0.5720.73
13_Q28_L0.5700.73
65_V78_S0.5690.72
25_V58_S0.5680.72
39_M42_K0.5680.72
31_S91_G0.5650.72
32_K91_G0.5640.72
39_M127_S0.5600.71
10_F32_K0.5600.71
26_D136_G0.5590.71
50_T93_A0.5590.71
108_G140_V0.5570.71
14_N70_A0.5560.71
58_S61_F0.5550.71
55_D64_T0.5540.70
32_K89_K0.5480.70
78_S94_V0.5480.70
87_V124_N0.5460.69
113_G142_T0.5460.69
65_V122_K0.5450.69
67_T71_I0.5340.68
28_L49_L0.5320.67
39_M78_S0.5280.67
10_F29_V0.5270.67
20_G23_V0.5270.67
22_E109_T0.5260.66
83_G86_L0.5260.66
77_K120_V0.5260.66
27_V74_A0.5260.66
29_V39_M0.5220.66
37_S59_L0.5210.66
37_S124_N0.5180.65
43_F142_T0.5160.65
67_T70_A0.5140.65
110_Y141_G0.5110.64
82_K122_K0.5110.64
115_N131_V0.5100.64
102_P138_I0.5080.64
35_P89_K0.5080.64
5_N141_G0.5070.64
97_L113_G0.5030.63
16_T134_K0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vn6_A 1 0.9463 99.6 0.313 Contact Map
3ul4_A 1 0.906 99.6 0.318 Contact Map
4ums_A 1 0.953 99.6 0.338 Contact Map
2ccl_A 1 0.9329 99.6 0.345 Contact Map
1aoh_A 1 0.8993 99.5 0.347 Contact Map
4dh2_A 1 0.953 99.5 0.353 Contact Map
3kcp_A 1 0.953 99.4 0.386 Contact Map
2xdh_A 1 0.8926 99.4 0.392 Contact Map
4uyp_A 1 0.9195 99.1 0.475 Contact Map
2vo8_A 1 0.8658 98.8 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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