GREMLIN Database
T0919_1_306 - T0919 1-306
ID: 85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 306 (265)
Sequences: 101 (98)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_G115_F6.2571.00
299_F303_K4.1520.95
50_Q184_M3.7890.92
117_R121_G3.6270.90
197_I220_N3.2980.84
244_F275_P3.1970.82
220_N239_D3.0600.79
65_I117_R2.9660.77
170_N274_H2.9020.75
89_C152_R2.6880.69
252_Y266_R2.6410.68
199_P262_G2.6210.67
97_G244_F2.5850.66
275_P292_N2.3970.60
258_D269_R2.3740.59
73_L92_F2.3050.57
258_D266_R2.2760.56
216_L300_I2.2370.54
41_S183_T2.2310.54
266_R269_R2.1100.50
275_P288_G2.0770.49
171_S180_E2.0720.49
66_P117_R2.0670.48
45_V48_M2.0280.47
276_S288_G2.0240.47
97_G116_T1.9780.45
7_V52_A1.9460.44
249_N252_Y1.9450.44
182_H226_D1.9150.43
254_G266_R1.8960.42
32_I225_A1.7670.38
36_A48_M1.7640.38
101_T113_L1.7580.38
169_R185_V1.7480.37
182_H227_F1.7340.37
92_F97_G1.6790.35
99_F165_V1.6590.34
193_R256_V1.6140.33
7_V42_D1.6010.33
39_G255_D1.5890.32
185_V227_F1.5860.32
92_F115_F1.5490.31
8_G168_G1.5380.31
185_V195_F1.5350.31
202_P241_L1.5310.30
166_W220_N1.5280.30
248_Y252_Y1.5140.30
238_V273_L1.5120.30
227_F292_N1.5030.30
297_A300_I1.5010.30
65_I115_F1.4920.29
243_N249_N1.4920.29
255_D267_S1.4800.29
45_V289_A1.4800.29
6_V21_S1.4780.29
24_L36_A1.4720.29
199_P303_K1.4440.28
27_L183_T1.4380.28
194_R287_I1.4380.28
14_T216_L1.4330.28
39_G170_N1.4240.27
170_N255_D1.4200.27
196_V299_F1.4190.27
71_V115_F1.4180.27
46_A52_A1.4030.27
168_G268_L1.3900.26
207_T210_T1.3900.26
201_F264_T1.3880.26
198_C303_K1.3860.26
6_V36_A1.3820.26
197_I239_D1.3810.26
39_G267_S1.3810.26
116_T197_I1.3700.26
276_S289_A1.3610.26
47_M121_G1.3590.26
27_L293_A1.3470.25
224_K231_Y1.3340.25
169_R223_L1.3330.25
228_P303_K1.3240.25
9_H181_L1.3240.25
238_V296_I1.3150.24
68_S71_V1.3120.24
9_H200_E1.2990.24
39_G274_H1.2870.24
39_G293_A1.2820.24
198_C296_I1.2600.23
40_A92_F1.2580.23
7_V124_V1.2530.23
7_V36_A1.2510.23
199_P228_P1.2460.23
181_L200_E1.2460.23
185_V188_M1.2440.23
6_V12_F1.2400.22
42_D288_G1.2350.22
168_G271_D1.2270.22
126_S231_Y1.2230.22
269_R293_A1.2220.22
73_L227_F1.2200.22
30_T162_I1.2180.22
42_D183_T1.2130.22
66_P71_V1.2130.22
36_A45_V1.2010.22
67_A121_G1.1920.21
46_A169_R1.1890.21
46_A183_T1.1840.21
88_K269_R1.1700.21
188_M220_N1.1440.20
120_A287_I1.1420.20
89_C204_D1.1370.20
7_V94_G1.1180.20
57_Y99_F1.1110.19
169_R200_E1.1060.19
271_D274_H1.1020.19
9_H39_G1.1000.19
223_L231_Y1.0970.19
12_F150_R1.0930.19
53_I248_Y1.0850.19
39_G52_A1.0800.19
146_I150_R1.0610.18
200_E220_N1.0530.18
216_L220_N1.0510.18
165_V296_I1.0470.18
228_P299_F1.0390.18
165_V184_M1.0370.18
165_V196_V1.0300.18
188_M262_G1.0260.18
227_F262_G1.0080.17
102_T112_Q1.0060.17
5_T216_L1.0050.17
9_H169_R1.0020.17
102_T210_T0.9980.17
11_S52_A0.9830.17
9_H12_F0.9720.17
195_F230_N0.9700.16
33_Y296_I0.9690.16
71_V124_V0.9680.16
224_K261_N0.9620.16
171_S239_D0.9590.16
79_G149_G0.9560.16
228_P275_P0.9540.16
165_V227_F0.9500.16
184_M227_F0.9490.16
165_V231_Y0.9430.16
47_M65_I0.9420.16
46_A184_M0.9410.16
262_G273_L0.9360.16
207_T226_D0.9320.16
59_P62_G0.9320.16
12_F99_F0.9220.16
46_A304_G0.9170.15
97_G121_G0.9170.15
166_W169_R0.9110.15
40_A44_E0.9080.15
181_L220_N0.9080.15
242_Q262_G0.9040.15
165_V224_K0.9030.15
11_S62_G0.9020.15
113_L201_F0.8930.15
213_A252_Y0.8890.15
264_T269_R0.8820.15
29_G255_D0.8820.15
254_G262_G0.8770.15
169_R206_E0.8740.15
7_V304_G0.8640.15
224_K275_P0.8630.14
47_M164_I0.8590.14
115_F197_I0.8580.14
36_A163_Y0.8550.14
89_C221_N0.8500.14
202_P264_T0.8480.14
9_H52_A0.8470.14
57_Y73_L0.8420.14
2_R48_M0.8390.14
179_S227_F0.8330.14
5_T88_K0.8310.14
171_S178_V0.8310.14
251_A259_I0.8290.14
9_H219_L0.8280.14
21_S36_A0.8280.14
220_N271_D0.8280.14
35_F73_L0.8270.14
117_R267_S0.8260.14
39_G44_E0.8250.14
160_D244_F0.8240.14
164_I178_V0.8180.14
95_I224_K0.8170.14
171_S216_L0.8160.14
65_I97_G0.8150.14
45_V170_N0.8140.14
220_N241_L0.8130.14
20_S246_S0.8120.14
5_T14_T0.8010.13
161_D241_L0.8010.13
243_N293_A0.8000.13
46_A50_Q0.7990.13
166_W292_N0.7980.13
71_V108_T0.7960.13
224_K299_F0.7940.13
231_Y293_A0.7940.13
47_M70_S0.7930.13
182_H186_A0.7920.13
95_I117_R0.7910.13
46_A269_R0.7880.13
5_T184_M0.7870.13
166_W246_S0.7840.13
99_F305_W0.7820.13
12_F200_E0.7820.13
69_G230_N0.7770.13
10_S168_G0.7740.13
70_S116_T0.7720.13
11_S158_H0.7700.13
71_V97_G0.7680.13
73_L244_F0.7670.13
165_V229_D0.7660.13
113_L269_R0.7660.13
169_R181_L0.7610.13
146_I244_F0.7580.13
74_T218_A0.7540.13
170_N271_D0.7510.13
243_N251_A0.7470.13
61_G305_W0.7450.13
175_T197_I0.7440.13
126_S223_L0.7410.12
45_V262_G0.7400.12
41_S174_Y0.7360.12
257_T261_N0.7340.12
88_K238_V0.7340.12
13_C293_A0.7320.12
181_L185_V0.7290.12
65_I225_A0.7290.12
93_G243_N0.7290.12
197_I225_A0.7270.12
96_D305_W0.7250.12
89_C197_I0.7240.12
241_L245_K0.7220.12
9_H305_W0.7220.12
6_V73_L0.7190.12
24_L275_P0.7160.12
113_L231_Y0.7140.12
54_T152_R0.7140.12
80_I259_I0.7130.12
68_S221_N0.7070.12
47_M117_R0.7040.12
76_T183_T0.7040.12
4_V93_G0.7020.12
240_L245_K0.6990.12
65_I126_S0.6990.12
47_M54_T0.6990.12
97_G184_M0.6970.12
169_R220_N0.6950.12
245_K259_I0.6920.12
97_G197_I0.6910.12
255_D274_H0.6910.12
248_Y256_V0.6880.12
41_S164_I0.6870.12
244_F268_L0.6840.12
97_G268_L0.6830.12
200_E219_L0.6820.12
64_S71_V0.6820.12
197_I271_D0.6810.12
7_V112_Q0.6790.12
3_S161_D0.6790.12
200_E203_Y0.6780.12
21_S24_L0.6770.12
9_H270_E0.6770.12
264_T268_L0.6740.11
166_W197_I0.6720.11
276_S286_Y0.6720.11
13_C46_A0.6710.11
58_A69_G0.6700.11
24_L51_E0.6690.11
29_G170_N0.6680.11
238_V286_Y0.6680.11
155_S196_V0.6660.11
12_F21_S0.6660.11
274_H288_G0.6630.11
56_Q276_S0.6610.11
168_G274_H0.6600.11
189_H195_F0.6600.11
222_N226_D0.6580.11
263_I293_A0.6530.11
9_H223_L0.6530.11
28_L297_A0.6510.11
178_V188_M0.6510.11
300_I306_G0.6500.11
51_E198_C0.6500.11
36_A231_Y0.6460.11
45_V250_P0.6450.11
94_G297_A0.6400.11
175_T204_D0.6390.11
102_T221_N0.6380.11
83_N270_E0.6340.11
28_L42_D0.6340.11
10_S274_H0.6340.11
167_G297_A0.6340.11
167_G200_E0.6330.11
94_G124_V0.6330.11
9_H226_D0.6320.11
251_A266_R0.6310.11
74_T225_A0.6300.11
248_Y259_I0.6300.11
40_A249_N0.6290.11
7_V288_G0.6270.11
169_R259_I0.6250.11
74_T260_A0.6240.11
298_Q303_K0.6180.11
89_C166_W0.6180.11
178_V300_I0.6180.11
240_L291_V0.6150.11
192_R198_C0.6130.11
165_V298_Q0.6110.11
59_P115_F0.6080.11
218_A248_Y0.6080.11
175_T231_Y0.6070.11
27_L39_G0.6070.11
14_T34_N0.5970.10
23_E289_A0.5960.10
58_A305_W0.5930.10
17_V31_D0.5910.10
54_T251_A0.5880.10
163_Y189_H0.5840.10
146_I198_C0.5830.10
83_N100_S0.5820.10
147_P259_I0.5790.10
239_D264_T0.5790.10
92_F95_I0.5780.10
98_T121_G0.5780.10
253_A305_W0.5770.10
160_D249_N0.5760.10
110_E231_Y0.5760.10
42_D168_G0.5750.10
210_T268_L0.5750.10
38_G178_V0.5740.10
71_V93_G0.5730.10
89_C242_Q0.5720.10
47_M253_A0.5700.10
61_G123_A0.5700.10
116_T196_V0.5690.10
95_I238_V0.5690.10
97_G231_Y0.5660.10
12_F32_I0.5650.10
25_N94_G0.5650.10
195_F206_E0.5640.10
171_S220_N0.5630.10
9_H18_V0.5630.10
62_G305_W0.5590.10
213_A293_A0.5580.10
188_M241_L0.5570.10
241_L249_N0.5570.10
299_F305_W0.5570.10
84_G228_P0.5560.10
33_Y291_V0.5560.10
166_W181_L0.5550.10
213_A227_F0.5540.10
178_V190_T0.5530.10
165_V228_P0.5530.10
220_N246_S0.5530.10
14_T161_D0.5520.10
170_N288_G0.5510.10
203_Y276_S0.5510.10
164_I208_T0.5500.10
221_N226_D0.5500.10
46_A223_L0.5480.10
28_L165_V0.5460.10
98_T294_D0.5420.10
25_N207_T0.5410.10
11_S200_E0.5400.10
123_A226_D0.5380.10
100_S207_T0.5380.10
230_N303_K0.5380.10
10_S271_D0.5280.10
101_T155_S0.5280.10
24_L99_F0.5270.10
185_V200_E0.5260.10
116_T271_D0.5250.09
121_G302_S0.5250.09
50_Q296_I0.5250.09
184_M268_L0.5240.09
39_G46_A0.5240.09
165_V201_F0.5230.09
16_D207_T0.5230.09
148_A267_S0.5210.09
94_G100_S0.5200.09
6_V198_C0.5190.09
24_L244_F0.5190.09
89_C206_E0.5180.09
45_V227_F0.5140.09
66_P124_V0.5130.09
73_L89_C0.5110.09
108_T275_P0.5090.09
27_L117_R0.5080.09
36_A239_D0.5070.09
44_E275_P0.5030.09
90_I220_N0.5030.09
275_P293_A0.5020.09
36_A95_I0.5020.09
85_A203_Y0.5010.09
199_P231_Y0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9a_A 1 0.5654 99.4 0.842 Contact Map
1k7c_A 1 0.6797 99.4 0.843 Contact Map
4jhl_A 1 0.5719 99.4 0.844 Contact Map
1fxw_F 1 0.5556 99.3 0.846 Contact Map
3rjt_A 1 0.5621 99.3 0.847 Contact Map
1es9_A 1 0.5556 99.3 0.85 Contact Map
3skv_A 1 0.5588 99.3 0.85 Contact Map
1esc_A 1 0.634 99.3 0.85 Contact Map
4c1b_A 1 0.5261 99.3 0.851 Contact Map
2hsj_A 1 0.5359 99.3 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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