GREMLIN Database
T0918_1-420_1_420 - T0918_1-420 1-420
ID: 84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 420 (398)
Sequences: 2099 (1375)
Seq/√Len: 68.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L88_A9.5111.00
62_I88_A7.0571.00
290_M339_I6.1061.00
273_D276_S4.7601.00
290_M409_T4.7341.00
73_E89_R4.6171.00
176_V202_L4.4321.00
183_V250_F4.3581.00
61_T68_D4.3341.00
72_V86_I4.2041.00
36_Y40_H3.7901.00
100_K137_S3.6071.00
305_V339_I3.5881.00
55_I75_A3.5661.00
185_S205_N3.1201.00
100_K139_M3.0861.00
35_F39_S2.9451.00
78_A83_H2.9441.00
291_F334_R2.9231.00
186_V202_L2.8481.00
288_Y339_I2.7551.00
49_T144_L2.6801.00
373_K385_D2.6351.00
103_V131_Q2.6251.00
44_E89_R2.5901.00
226_V235_V2.5401.00
176_V204_I2.5111.00
192_D199_S2.4351.00
90_L98_L2.3641.00
43_P90_L2.3631.00
101_D133_G2.3621.00
47_L62_I2.3451.00
167_A189_S2.2111.00
112_G115_G2.1431.00
176_V248_V2.1201.00
262_V268_F2.1121.00
48_I83_H2.0851.00
237_M243_L2.0851.00
62_I90_L2.0811.00
101_D134_A2.0281.00
77_L97_L2.0221.00
160_V202_L1.9331.00
99_H133_G1.9301.00
47_L144_L1.9081.00
159_R187_E1.9081.00
49_T86_I1.8551.00
48_I85_E1.8161.00
314_T340_R1.7801.00
206_A209_D1.7781.00
212_V216_V1.7781.00
221_D249_S1.7771.00
155_A205_N1.7681.00
46_T141_K1.7661.00
102_T130_L1.7571.00
213_T252_V1.7571.00
274_Q278_Q1.7361.00
90_L94_M1.7041.00
311_R314_T1.6931.00
316_S338_L1.6811.00
289_L336_P1.6610.99
228_L233_M1.6600.99
161_I201_Q1.6600.99
361_G365_K1.6450.99
202_L248_V1.6030.99
159_R201_Q1.5430.99
170_L248_V1.5390.99
291_F336_P1.5260.99
399_R404_Y1.5110.99
221_D238_G1.4820.99
272_D276_S1.4820.99
53_E120_G1.4760.99
98_L130_L1.4740.99
287_D340_R1.4700.99
61_T71_V1.4690.99
45_V88_A1.4620.99
296_V335_I1.4600.99
76_T87_K1.4580.99
373_K383_Y1.4550.99
158_I209_D1.4530.99
103_V145_L1.4490.99
385_D389_Y1.4490.99
86_I144_L1.4470.98
227_D234_R1.4390.98
305_V315_V1.4360.98
106_V144_L1.4350.98
48_I143_D1.4300.98
373_K389_Y1.4270.98
361_G400_E1.4240.98
297_R375_G1.4190.98
215_N256_L1.4110.98
192_D197_N1.4020.98
229_T234_R1.3930.98
375_G383_Y1.3890.98
57_G75_A1.3880.98
214_N262_V1.3660.98
262_V266_T1.3610.98
383_Y417_I1.3610.98
339_I407_I1.3410.98
371_S385_D1.3310.97
317_K338_L1.3240.97
72_V88_A1.3190.97
166_K180_G1.3110.97
56_E59_K1.3090.97
32_W36_Y1.3080.97
263_A266_T1.3000.97
101_D135_K1.2980.97
13_V16_W1.2890.97
251_D274_Q1.2870.97
342_E345_R1.2840.97
164_S198_I1.2820.97
163_D267_A1.2810.97
302_G314_T1.2770.97
301_P318_V1.2630.96
101_D136_G1.2530.96
190_T201_Q1.2520.96
110_Q148_P1.2420.96
52_A75_A1.2420.96
208_Y211_L1.2410.96
225_A236_E1.2350.96
74_S87_K1.2350.96
86_I128_I1.2330.96
55_I72_V1.2230.96
389_Y392_T1.2220.96
186_V248_V1.2210.96
95_E140_D1.2180.96
20_W23_P1.2050.95
306_E311_R1.2040.95
160_V212_V1.2020.95
399_R402_N1.1820.95
12_K25_V1.1800.95
240_L244_L1.1660.94
57_G74_S1.1640.94
50_A146_D1.1590.94
46_T85_E1.1550.94
183_V208_Y1.1540.94
316_S340_R1.1510.94
27_A82_T1.1430.94
289_L338_L1.1370.94
44_E87_K1.1340.94
163_D197_N1.1220.93
67_V186_V1.1160.93
69_V97_L1.1130.93
81_L97_L1.1060.93
25_V28_L1.0990.92
130_L154_D1.0940.92
22_F34_L1.0930.92
392_T395_I1.0900.92
49_T72_V1.0840.92
118_G121_T1.0830.92
72_V144_L1.0830.92
219_W250_F1.0800.92
28_L31_A1.0740.92
45_V62_I1.0710.91
104_F128_I1.0650.91
46_T87_K1.0640.91
99_H130_L1.0640.91
78_A85_E1.0580.91
71_V310_I1.0570.91
315_V337_V1.0560.91
290_M384_V1.0510.91
297_R306_E1.0490.91
312_L341_I1.0470.90
164_S200_Y1.0430.90
370_G384_V1.0400.90
88_A98_L1.0330.90
72_V75_A1.0290.90
99_H139_M1.0240.89
188_T200_Y1.0230.89
400_E405_Q1.0220.89
188_T201_Q1.0210.89
292_F337_V1.0140.89
81_L86_I1.0100.89
219_W251_D1.0080.89
307_F363_L1.0080.89
398_I407_I1.0040.89
92_S95_E1.0030.88
357_V361_G1.0020.88
64_S129_E1.0010.88
22_F27_A1.0000.88
124_S207_P0.9990.88
224_I243_L0.9890.88
297_R303_A0.9850.88
220_K223_G0.9840.88
108_K144_L0.9830.87
369_R392_T0.9800.87
102_T116_I0.9780.87
31_A35_F0.9780.87
107_V127_Y0.9760.87
139_M142_Y0.9730.87
180_G238_G0.9720.87
287_D316_S0.9680.87
99_H135_K0.9640.86
214_N266_T0.9610.86
21_I25_V0.9580.86
57_G132_P0.9570.86
97_L130_L0.9540.86
32_W98_L0.9500.86
48_I141_K0.9440.85
11_Q16_W0.9370.85
45_V90_L0.9360.85
190_T199_S0.9340.85
195_K211_L0.9300.84
36_Y39_S0.9300.84
92_S293_K0.9230.84
165_K376_N0.9180.84
167_A200_Y0.9170.84
392_T396_T0.9120.83
16_W284_D0.9120.83
339_I384_V0.9090.83
83_H176_V0.9090.83
231_A300_Q0.9080.83
207_P345_R0.9070.83
290_M370_G0.8940.82
31_A36_Y0.8930.82
33_V93_G0.8870.81
178_F211_L0.8870.81
234_R273_D0.8840.81
362_E365_K0.8800.81
150_L240_L0.8730.80
201_Q228_L0.8710.80
83_H96_K0.8700.80
308_R387_D0.8700.80
44_E73_E0.8690.80
371_S389_Y0.8680.80
99_H102_T0.8670.80
57_G106_V0.8630.80
176_V250_F0.8610.80
63_K66_S0.8520.79
182_R205_N0.8490.79
291_F321_F0.8460.78
372_L384_V0.8460.78
33_V40_H0.8450.78
81_L96_K0.8430.78
307_F346_L0.8420.78
372_L376_N0.8400.78
226_V398_I0.8400.78
55_I126_V0.8400.78
21_I45_V0.8350.77
216_V350_L0.8330.77
293_K334_R0.8310.77
186_V200_Y0.8230.76
122_L213_T0.8230.76
291_F406_I0.8230.76
315_V339_I0.8230.76
53_E108_K0.8190.76
303_A375_G0.8170.76
308_R335_I0.8160.76
160_V204_I0.8110.75
175_P298_G0.8100.75
69_V130_L0.8080.75
300_Q381_A0.8080.75
375_G379_T0.8060.75
221_D239_S0.8050.75
33_V36_Y0.8030.75
282_Y342_E0.8020.74
230_S304_P0.8010.74
168_G222_S0.7990.74
389_Y410_V0.7980.74
399_R406_I0.7980.74
259_G414_L0.7950.74
214_N263_A0.7880.73
23_P26_T0.7870.73
212_V250_F0.7870.73
286_I341_I0.7860.73
51_N106_V0.7840.73
358_E362_E0.7800.72
175_P247_G0.7790.72
19_V33_V0.7770.72
134_A154_D0.7770.72
34_L37_H0.7770.72
105_W149_P0.7740.72
62_I98_L0.7740.72
194_Q199_S0.7740.72
248_V332_D0.7730.72
300_Q303_A0.7730.72
399_R403_G0.7720.72
183_V249_S0.7700.71
112_G245_S0.7680.71
55_I86_I0.7640.71
294_D415_A0.7610.71
181_Y198_I0.7590.70
176_V338_L0.7590.70
157_G203_F0.7580.70
216_V252_V0.7580.70
269_V272_D0.7560.70
66_S97_L0.7560.70
19_V39_S0.7500.69
242_T245_S0.7440.69
240_L243_L0.7430.69
76_T93_G0.7410.69
108_K146_D0.7400.68
170_L174_D0.7400.68
325_M330_N0.7390.68
360_L363_L0.7390.68
102_T370_G0.7350.68
301_P317_K0.7350.68
200_Y368_L0.7340.68
299_L303_A0.7320.68
190_T341_I0.7320.68
32_W132_P0.7300.67
293_K332_D0.7300.67
297_R383_Y0.7290.67
68_D91_N0.7250.67
281_L340_R0.7230.67
22_F374_T0.7220.67
109_P115_G0.7220.67
164_S197_N0.7200.66
158_I212_V0.7200.66
45_V148_P0.7190.66
358_E361_G0.7190.66
221_D225_A0.7130.66
24_I27_A0.7130.66
110_Q117_S0.7100.65
236_E274_Q0.7100.65
258_L312_L0.7090.65
32_W102_T0.7090.65
175_P182_R0.7090.65
271_Y311_R0.7050.65
8_A24_I0.7040.65
303_A384_V0.7020.64
236_E273_D0.7020.64
320_F335_I0.7010.64
142_Y176_V0.7000.64
158_I264_P0.6990.64
355_D358_E0.6990.64
222_S239_S0.6990.64
357_V400_E0.6990.64
212_V217_R0.6980.64
225_A228_L0.6970.64
29_I113_R0.6960.64
376_N381_A0.6940.63
87_K101_D0.6930.63
77_L245_S0.6920.63
248_V312_L0.6920.63
73_E116_I0.6910.63
203_F207_P0.6880.63
57_G178_F0.6880.63
16_W259_G0.6860.63
11_Q15_N0.6860.63
94_M97_L0.6820.62
285_H342_E0.6820.62
41_Q376_N0.6810.62
292_F384_V0.6790.62
98_L132_P0.6760.61
85_E242_T0.6750.61
69_V81_L0.6730.61
296_V384_V0.6710.61
301_P316_S0.6690.61
63_K127_Y0.6680.61
10_I15_N0.6670.60
292_F372_L0.6670.60
296_V392_T0.6660.60
83_H365_K0.6660.60
378_V410_V0.6650.60
7_E11_Q0.6650.60
332_D366_R0.6650.60
170_L200_Y0.6650.60
65_R307_F0.6650.60
204_I265_K0.6650.60
73_E87_K0.6640.60
287_D341_I0.6630.60
222_S247_G0.6600.60
312_L324_N0.6600.60
369_R408_P0.6580.59
63_K156_K0.6580.59
69_V383_Y0.6580.59
58_G332_D0.6560.59
135_K211_L0.6550.59
298_G369_R0.6540.59
8_A12_K0.6530.59
72_V128_I0.6520.59
204_I335_I0.6510.59
223_G250_F0.6500.58
341_I358_E0.6500.58
109_P124_S0.6490.58
152_P187_E0.6470.58
166_K238_G0.6460.58
201_Q265_K0.6460.58
35_F47_L0.6440.58
277_I292_F0.6440.58
231_A391_N0.6410.57
341_I351_G0.6400.57
303_A342_E0.6370.57
376_N379_T0.6360.57
132_P180_G0.6350.57
164_S192_D0.6350.57
41_Q44_E0.6330.56
66_S241_T0.6330.56
207_P298_G0.6330.56
170_L301_P0.6320.56
299_L318_V0.6300.56
158_I204_I0.6290.56
227_D396_T0.6260.56
253_P259_G0.6250.55
229_T268_F0.6250.55
97_L132_P0.6240.55
323_P330_N0.6240.55
21_I286_I0.6230.55
368_L388_F0.6230.55
107_V121_T0.6220.55
65_R131_Q0.6210.55
154_D361_G0.6200.55
98_L335_I0.6200.55
208_Y290_M0.6170.55
123_L211_L0.6150.54
139_M202_L0.6150.54
11_Q87_K0.6150.54
310_I335_I0.6150.54
233_M323_P0.6150.54
26_T230_S0.6140.54
109_P112_G0.6130.54
230_S375_G0.6130.54
33_V38_Y0.6130.54
273_D331_D0.6120.54
333_Y384_V0.6120.54
336_P339_I0.6100.54
30_G59_K0.6100.54
119_L222_S0.6090.54
122_L277_I0.6080.53
292_F387_D0.6080.53
98_L102_T0.6070.53
20_W26_T0.6060.53
123_L247_G0.6060.53
180_G211_L0.6050.53
130_L376_N0.6030.53
323_P333_Y0.6030.53
203_F206_A0.6020.53
176_V265_K0.6010.53
51_N108_K0.6010.53
127_Y223_G0.6000.52
322_A333_Y0.6000.52
11_Q22_F0.5970.52
31_A41_Q0.5960.52
109_P174_D0.5960.52
103_V235_V0.5960.52
41_Q280_S0.5950.52
22_F26_T0.5950.52
52_A60_T0.5950.52
18_P41_Q0.5920.52
74_S91_N0.5920.52
51_N126_V0.5900.51
213_T335_I0.5900.51
21_I335_I0.5890.51
224_I256_L0.5890.51
16_W25_V0.5880.51
34_L274_Q0.5880.51
157_G367_G0.5880.51
109_P118_G0.5880.51
109_P129_E0.5860.51
298_G345_R0.5850.51
47_L128_I0.5850.51
133_G211_L0.5840.51
290_M341_I0.5830.50
282_Y345_R0.5820.50
290_M388_F0.5820.50
401_F406_I0.5820.50
30_G192_D0.5800.50
94_M130_L0.5800.50
52_A222_S0.5790.50
7_E10_I0.5780.50
16_W375_G0.5740.49
83_H273_D0.5740.49
138_K312_L0.5730.49
74_S95_E0.5730.49
96_K233_M0.5730.49
56_E61_T0.5720.49
32_W38_Y0.5700.49
51_N361_G0.5690.49
273_D317_K0.5690.49
189_S200_Y0.5690.49
398_I410_V0.5690.49
88_A142_Y0.5680.49
85_E224_I0.5680.49
100_K135_K0.5680.49
229_T239_S0.5680.49
13_V36_Y0.5670.49
105_W157_G0.5670.49
308_R388_F0.5660.48
10_I14_K0.5660.48
182_R321_F0.5660.48
92_S140_D0.5650.48
273_D343_P0.5640.48
210_R332_D0.5630.48
229_T232_G0.5630.48
37_H71_V0.5630.48
331_D362_E0.5630.48
22_F362_E0.5620.48
188_T335_I0.5620.48
109_P191_F0.5610.48
288_Y341_I0.5600.48
66_S164_S0.5600.48
177_L249_S0.5580.47
30_G34_L0.5580.47
68_D71_V0.5570.47
172_P307_F0.5560.47
52_A84_V0.5560.47
117_S167_A0.5560.47
296_V318_V0.5550.47
124_S312_L0.5550.47
117_S270_L0.5540.47
216_V338_L0.5540.47
112_G305_V0.5530.47
99_H132_P0.5530.47
304_P311_R0.5530.47
256_L316_S0.5530.47
275_K279_D0.5530.47
101_D137_S0.5530.47
137_S194_Q0.5530.47
45_V61_T0.5520.47
266_T269_V0.5510.47
12_K39_S0.5510.47
192_D337_V0.5500.46
239_S242_T0.5490.46
8_A11_Q0.5490.46
223_G232_G0.5480.46
69_V350_L0.5470.46
374_T383_Y0.5470.46
121_T247_G0.5460.46
8_A97_L0.5460.46
268_F384_V0.5460.46
29_I45_V0.5460.46
166_K218_F0.5450.46
102_T312_L0.5450.46
189_S212_V0.5440.46
167_A238_G0.5420.46
60_T211_L0.5420.46
27_A33_V0.5410.45
150_L187_E0.5400.45
110_Q146_D0.5400.45
37_H41_Q0.5390.45
52_A56_E0.5370.45
99_H138_K0.5370.45
31_A257_D0.5370.45
114_E134_A0.5370.45
240_L294_D0.5370.45
158_I261_P0.5340.45
321_F334_R0.5340.45
217_R243_L0.5330.44
8_A283_T0.5320.44
161_I199_S0.5320.44
56_E120_G0.5320.44
414_L417_I0.5320.44
11_Q14_K0.5320.44
123_L170_L0.5310.44
250_F298_G0.5310.44
269_V273_D0.5300.44
243_L249_S0.5280.44
212_V392_T0.5280.44
54_G60_T0.5280.44
265_K275_K0.5270.44
224_I266_T0.5270.44
50_A252_V0.5260.44
306_E385_D0.5250.43
311_R342_E0.5250.43
35_F41_Q0.5250.43
159_R209_D0.5250.43
150_L161_I0.5250.43
140_D229_T0.5240.43
230_S247_G0.5240.43
115_G241_T0.5230.43
275_K382_L0.5220.43
398_I414_L0.5210.43
24_I28_L0.5210.43
69_V319_P0.5210.43
89_R414_L0.5200.43
109_P294_D0.5200.43
336_P341_I0.5200.43
80_D83_H0.5190.43
186_V221_D0.5190.43
166_K225_A0.5180.43
124_S248_V0.5180.43
155_A243_L0.5170.43
339_I409_T0.5170.43
385_D388_F0.5160.42
100_K289_L0.5140.42
65_R172_P0.5130.42
131_Q151_A0.5130.42
21_I28_L0.5120.42
34_L41_Q0.5120.42
238_G242_T0.5120.42
172_P188_T0.5110.42
21_I141_K0.5100.42
69_V172_P0.5100.42
19_V393_P0.5090.42
193_T235_V0.5090.42
128_I151_A0.5090.42
301_P304_P0.5090.42
51_N144_L0.5090.42
40_H355_D0.5080.41
147_S188_T0.5070.41
149_P157_G0.5070.41
295_S298_G0.5050.41
161_I267_A0.5030.41
8_A14_K0.5020.41
36_Y147_S0.5010.41
37_H40_H0.5000.41
84_V292_F0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5u_A 1 0.4429 17.3 0.977 Contact Map
2zz9_A 1 0.0905 12.3 0.979 Contact Map
2jd3_A 1 0.1786 10 0.98 Contact Map
2na6_A 1 0.0667 9 0.98 Contact Map
3iyz_A 1 0.0905 8.5 0.98 Contact Map
1v7w_A 1 0.2024 7.3 0.981 Contact Map
2m8r_A 1 0.1 7.3 0.981 Contact Map
4fvy_A 1 0.1381 6.9 0.981 Contact Map
4b96_A 1 0.2976 5.1 0.982 Contact Map
1rl2_A 1 0.2524 4.1 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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