GREMLIN Database
T0917_1_409 - T0917 1-409
ID: 82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 409 (376)
Sequences: 4145 (2494)
Seq/√Len: 128.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_R255_D4.8751.00
247_L357_S4.4101.00
379_E398_K4.1001.00
89_G116_I3.8231.00
245_Y261_K3.6771.00
375_P402_K3.5301.00
252_D255_D3.3641.00
237_R240_E3.2811.00
218_V238_A3.2811.00
310_E352_K3.2381.00
194_V263_A3.0981.00
284_M405_F2.8201.00
207_T259_R2.7591.00
310_E407_K2.6021.00
232_D323_R2.5921.00
215_F239_I2.5191.00
58_A62_D2.4971.00
76_E88_E2.4711.00
312_N392_N2.4631.00
402_K406_R2.3611.00
42_A100_V2.3531.00
214_V242_V2.3431.00
84_T174_P2.2821.00
307_P408_S2.2621.00
93_V150_L2.2421.00
374_I402_K2.1971.00
52_K75_G2.1821.00
378_T402_K2.1471.00
209_I299_Q2.1411.00
232_D235_A2.1151.00
200_K256_I2.1141.00
26_G197_D2.0361.00
41_K70_E2.0311.00
110_M154_A2.0261.00
397_S400_D2.0231.00
239_I327_I1.9981.00
30_K33_E1.9461.00
61_I65_E1.9371.00
199_L263_A1.9211.00
353_N357_S1.8681.00
48_K75_G1.8571.00
398_K402_K1.8521.00
78_E85_V1.8391.00
243_T331_L1.8131.00
363_P366_E1.7711.00
284_M304_I1.7511.00
378_T398_K1.7441.00
86_V171_I1.7431.00
42_A102_V1.7311.00
377_M405_F1.7241.00
350_G353_N1.7111.00
236_I330_A1.7081.00
78_E82_T1.7051.00
371_E406_R1.6601.00
21_I267_T1.6571.00
25_S197_D1.6561.00
303_S367_L1.6541.00
25_S260_E1.6531.00
25_S256_I1.6531.00
117_A149_T1.6311.00
199_L259_R1.6301.00
49_S54_L1.6171.00
295_I300_A1.6141.00
207_T249_A1.5971.00
238_A269_A1.5841.00
310_E345_S1.5821.00
221_N232_D1.5741.00
62_D66_S1.5711.00
403_E407_K1.5631.00
280_L396_V1.5621.00
309_M351_L1.5511.00
257_K261_K1.5411.00
45_V116_I1.5331.00
46_T75_G1.5291.00
103_A113_A1.5261.00
236_I326_R1.5221.00
244_E261_K1.5181.00
117_A150_L1.5141.00
247_L251_E1.5101.00
242_V265_A1.5051.00
215_F242_V1.4981.00
255_D258_A1.4951.00
251_E357_S1.4761.00
91_E95_E1.4761.00
329_V343_A1.4631.00
313_I344_A1.4541.00
281_R301_L1.4421.00
281_R305_S1.4341.00
103_A152_V1.4281.00
365_S409_L1.4211.00
80_N294_D1.4171.00
35_T100_V1.4071.00
322_E340_T1.3901.00
32_G63_Y1.3901.00
199_L207_T1.3841.00
218_V269_A1.3751.00
304_I404_I1.3701.00
240_E244_E1.3621.00
82_T85_V1.3551.00
51_M54_L1.3551.00
58_A61_I1.3541.00
248_R257_K1.3461.00
400_D403_E1.3441.00
222_L326_R1.3381.00
291_Y376_E1.3381.00
349_D353_N1.3361.00
241_Y261_K1.3251.00
202_M206_L1.3221.00
248_R252_D1.3161.00
370_E406_R1.3151.00
101_V117_A1.3131.00
339_N342_Q1.3031.00
86_V112_A1.2901.00
88_E91_E1.2831.00
221_N235_A1.2831.00
83_T174_P1.2781.00
403_E406_R1.2771.00
292_Y373_K1.2681.00
197_D256_I1.2681.00
85_V88_E1.2641.00
35_T153_I1.2601.00
165_V267_T1.2571.00
284_M401_V1.2471.00
211_G262_M1.2421.00
285_A300_A1.2401.00
48_K76_E1.2381.00
242_V262_M1.2281.00
204_P250_V1.2281.00
311_H400_D1.2261.00
93_V120_A1.2231.00
313_I345_S1.2211.00
345_S349_D1.2180.99
101_V113_A1.2120.99
250_V359_D1.1970.99
287_P405_F1.1900.99
72_V96_E1.1890.99
27_T193_I1.1880.99
240_E326_R1.1860.99
250_V358_L1.1860.99
154_A189_P1.1830.99
44_L61_I1.1800.99
27_T30_K1.1790.99
280_L308_I1.1780.99
399_E402_K1.1780.99
291_Y380_G1.1770.99
221_N272_S1.1740.99
43_I92_I1.1670.99
356_R362_K1.1640.99
43_I98_C1.1570.99
249_A253_G1.1460.99
219_S239_I1.1420.99
307_P407_K1.1390.99
211_G246_L1.1380.99
245_Y248_R1.1370.99
212_Y355_L1.1350.99
286_H386_G1.1310.99
130_S133_D1.1300.99
204_P251_E1.1160.99
212_Y360_L1.1120.99
204_P208_A1.1110.99
170_V181_G1.1070.99
168_Y183_G1.1050.99
219_S327_I1.1040.99
48_K53_K1.1010.99
72_V98_C1.0930.99
113_A152_V1.0880.99
93_V116_I1.0800.99
74_Y88_E1.0750.99
375_P398_K1.0730.99
41_K96_E1.0720.99
278_T286_H1.0630.99
44_L57_L1.0610.99
311_H394_V1.0600.99
165_V271_L1.0590.99
51_M57_L1.0560.99
223_T309_M1.0560.99
87_D130_S1.0550.99
288_I295_I1.0550.99
25_S200_K1.0530.99
42_A69_V1.0500.98
103_A154_A1.0490.98
156_T194_V1.0460.98
41_K97_G1.0440.98
245_Y257_K1.0400.98
34_E191_V1.0350.98
314_E394_V1.0350.98
264_V268_Y1.0300.98
288_I300_A1.0250.98
31_I155_A1.0240.98
59_D197_D1.0230.98
225_K395_D1.0230.98
374_I406_R1.0220.98
60_A104_L1.0220.98
216_S301_L1.0130.98
87_D91_E1.0120.98
376_E380_G1.0110.98
29_E59_D1.0080.98
173_N176_T1.0070.98
118_M187_S1.0030.98
207_T253_G1.0020.98
72_V92_I0.9960.98
110_M163_S0.9900.98
92_I98_C0.9860.98
215_F219_S0.9810.98
311_H396_V0.9800.98
326_R330_A0.9770.98
44_L71_T0.9740.98
17_P271_L0.9740.98
170_V183_G0.9720.97
22_I30_K0.9720.97
46_T73_H0.9700.97
90_A119_V0.9690.97
159_S199_L0.9560.97
104_L155_A0.9530.97
65_E71_T0.9510.97
159_S263_A0.9510.97
78_E88_E0.9500.97
216_S281_R0.9430.97
41_K72_V0.9400.97
285_A289_S0.9400.97
237_R241_Y0.9350.97
20_D34_E0.9320.97
234_L268_Y0.9310.97
61_I71_T0.9290.97
219_S305_S0.9270.97
91_E94_L0.9260.97
77_I112_A0.9250.97
103_A110_M0.9250.97
177_K294_D0.9210.97
213_D297_H0.9200.96
234_L271_L0.9200.96
328_A347_A0.9200.96
249_A259_R0.9140.96
286_H384_Y0.9140.96
249_A258_A0.9070.96
196_I260_E0.9050.96
115_G171_I0.9050.96
307_P310_E0.9040.96
40_D99_D0.8960.96
115_G182_F0.8950.96
23_F260_E0.8940.96
205_R209_I0.8850.96
373_K376_E0.8810.96
202_M210_T0.8810.96
325_S344_A0.8720.95
93_V98_C0.8670.95
285_A301_L0.8650.95
244_E247_L0.8640.95
382_F398_K0.8630.95
26_G29_E0.8600.95
221_N276_S0.8580.95
159_S207_T0.8550.95
233_P237_R0.8500.95
217_H269_A0.8490.95
152_V190_K0.8400.94
80_N289_S0.8360.94
321_W341_R0.8300.94
223_T324_Y0.8300.94
396_V400_D0.8290.94
223_T277_G0.8290.94
226_G277_G0.8280.94
52_K58_A0.8270.94
374_I409_L0.8230.94
92_I96_E0.8210.93
375_P378_T0.8190.93
59_D63_Y0.8190.93
23_F196_I0.8170.93
56_F104_L0.8170.93
310_E349_D0.8120.93
41_K98_C0.8070.93
57_L104_L0.8070.93
283_A387_G0.8060.93
197_D200_K0.8010.93
84_T88_E0.8000.93
155_A193_I0.8000.93
58_A65_E0.7970.92
216_S305_S0.7960.92
247_L350_G0.7920.92
42_A71_T0.7910.92
280_L283_A0.7890.92
333_A346_K0.7860.92
236_I327_I0.7850.92
288_I405_F0.7830.92
168_Y273_N0.7820.92
312_N394_V0.7800.92
55_G58_A0.7760.91
33_E67_A0.7740.91
28_L59_D0.7730.91
222_L323_R0.7720.91
257_K260_E0.7700.91
289_S300_A0.7690.91
306_V355_L0.7670.91
120_A150_L0.7650.91
227_D232_D0.7650.91
200_K207_T0.7640.91
282_H297_H0.7630.91
65_E70_E0.7610.91
244_E265_A0.7590.91
312_N324_Y0.7580.90
29_E197_D0.7550.90
238_A242_V0.7530.90
279_T286_H0.7510.90
278_T386_G0.7500.90
153_I193_I0.7500.90
346_K349_D0.7500.90
280_L401_V0.7500.90
24_G27_T0.7450.90
51_M104_L0.7450.90
51_M56_F0.7440.90
47_G51_M0.7430.90
123_S134_F0.7420.90
239_I331_L0.7420.90
40_D70_E0.7400.89
325_S343_A0.7400.89
243_T247_L0.7380.89
248_R258_A0.7380.89
236_I240_E0.7330.89
243_T350_G0.7330.89
213_D282_H0.7320.89
86_V116_I0.7320.89
205_R299_Q0.7300.89
228_H231_A0.7290.89
299_Q360_L0.7240.88
222_L236_I0.7230.88
214_V266_D0.7220.88
240_E330_A0.7220.88
287_P380_G0.7220.88
90_A94_L0.7220.88
149_T190_K0.7200.88
194_V267_T0.7180.88
36_K67_A0.7170.88
74_Y89_G0.7170.88
309_M324_Y0.7150.88
43_I93_V0.7110.87
245_Y249_A0.7100.87
307_P404_I0.7100.87
253_G258_A0.7100.87
361_D366_E0.7100.87
325_S340_T0.7090.87
381_A405_F0.7080.87
62_D65_E0.7050.87
122_H129_I0.7040.87
49_S55_G0.7010.87
206_L210_T0.7000.87
28_L63_Y0.6990.87
313_I348_V0.6970.86
354_L358_L0.6960.86
78_E294_D0.6950.86
83_T87_D0.6940.86
42_A99_D0.6930.86
166_T270_G0.6920.86
54_L57_L0.6910.86
208_A250_V0.6900.86
87_D90_A0.6890.86
112_A116_I0.6880.86
326_R329_V0.6870.86
239_I242_V0.6870.86
164_H192_S0.6860.86
309_M348_V0.6860.86
309_M347_A0.6850.85
327_I347_A0.6840.85
52_K57_L0.6800.85
313_I324_Y0.6790.85
28_L60_A0.6780.85
115_G169_A0.6750.85
24_G30_K0.6740.84
159_S259_R0.6720.84
199_L249_A0.6700.84
235_A272_S0.6680.84
211_G250_V0.6680.84
43_I96_E0.6680.84
288_I364_L0.6650.84
311_H397_S0.6650.84
122_H147_E0.6640.84
306_V352_K0.6640.84
374_I405_F0.6630.84
299_Q361_D0.6620.83
284_M287_P0.6600.83
376_E379_E0.6590.83
123_S130_S0.6580.83
295_I367_L0.6560.83
167_P274_T0.6550.83
34_E37_K0.6540.83
31_I60_A0.6530.83
308_I404_I0.6520.83
379_E383_I0.6510.82
32_G35_T0.6500.82
253_G259_R0.6500.82
102_V155_A0.6490.82
158_T161_T0.6490.82
148_K190_K0.6490.82
217_H297_H0.6480.82
168_Y277_G0.6480.82
287_P381_A0.6460.82
90_A120_A0.6450.82
333_A350_G0.6440.82
152_V189_P0.6430.82
212_Y302_A0.6430.82
349_D352_K0.6430.82
213_D298_G0.6430.82
103_A109_S0.6420.82
273_N278_T0.6380.81
30_K34_E0.6380.81
117_A152_V0.6370.81
100_V153_I0.6370.81
231_A275_I0.6340.81
22_I34_E0.6330.81
45_V89_G0.6330.81
396_V404_I0.6330.81
209_I296_S0.6320.81
29_E63_Y0.6300.80
80_N286_H0.6290.80
237_R268_Y0.6290.80
36_K40_D0.6250.80
121_G150_L0.6250.80
333_A347_A0.6230.80
304_I408_S0.6220.79
284_M381_A0.6220.79
245_Y258_A0.6210.79
26_G195_D0.6200.79
65_E69_V0.6200.79
35_T69_V0.6200.79
246_L358_L0.6190.79
28_L198_I0.6170.79
23_F194_V0.6170.79
341_R345_S0.6170.79
90_A116_I0.6150.79
214_V265_A0.6150.79
59_D198_I0.6130.78
230_T233_P0.6130.78
239_I330_A0.6110.78
317_D322_E0.6090.78
82_T174_P0.6090.78
203_P206_L0.6080.78
208_A211_G0.6080.78
281_R304_I0.6070.78
234_L269_A0.6060.78
32_G66_S0.6050.78
281_R285_A0.6040.77
222_L327_I0.6040.77
101_V150_L0.6030.77
344_A347_A0.6020.77
219_S347_A0.6000.77
86_V90_A0.5990.77
216_S279_T0.5980.77
41_K99_D0.5980.77
81_P108_S0.5970.77
227_D323_R0.5970.77
370_E409_L0.5960.77
65_E68_G0.5960.77
60_A155_A0.5930.76
131_V134_F0.5930.76
322_E326_R0.5930.76
19_S188_F0.5920.76
39_G99_D0.5900.76
343_A346_K0.5900.76
279_T312_N0.5880.76
48_K109_S0.5870.75
181_G277_G0.5850.75
328_A333_A0.5840.75
168_Y181_G0.5840.75
352_K356_R0.5840.75
375_P379_E0.5840.75
200_K254_E0.5830.75
156_T266_D0.5820.75
121_G149_T0.5810.75
382_F401_V0.5780.74
110_M156_T0.5770.74
213_D217_H0.5760.74
149_T152_V0.5740.74
241_Y268_Y0.5730.74
52_K55_G0.5720.74
219_S281_R0.5720.74
352_K362_K0.5700.73
118_M186_H0.5690.73
310_E348_V0.5670.73
154_A192_S0.5670.73
291_Y373_K0.5670.73
171_I286_H0.5670.73
215_F351_L0.5670.73
281_R289_S0.5660.73
331_L350_G0.5650.73
224_A276_S0.5650.73
314_E341_R0.5650.73
286_H289_S0.5620.72
212_Y404_I0.5610.72
321_W340_T0.5600.72
47_G203_P0.5560.71
102_V153_I0.5540.71
36_K61_I0.5540.71
208_A360_L0.5530.71
61_I73_H0.5530.71
248_R251_E0.5530.71
204_P253_G0.5520.71
86_V115_G0.5520.71
122_H149_T0.5510.71
361_D367_L0.5500.71
47_G54_L0.5500.71
85_V112_A0.5480.70
168_Y269_A0.5470.70
108_S217_H0.5470.70
218_V235_A0.5440.70
52_K61_I0.5430.70
277_G286_H0.5400.69
93_V101_V0.5400.69
31_I63_Y0.5390.69
223_T279_T0.5390.69
36_K62_D0.5380.69
181_G386_G0.5380.69
260_E264_V0.5360.69
382_F396_V0.5350.69
78_E174_P0.5340.68
233_P268_Y0.5330.68
23_F264_V0.5330.68
325_S329_V0.5330.68
47_G53_K0.5330.68
216_S306_V0.5320.68
199_L253_G0.5310.68
32_G42_A0.5310.68
63_Y66_S0.5300.68
302_A355_L0.5290.68
179_K213_D0.5280.68
121_G148_K0.5270.67
350_G357_S0.5260.67
129_I134_F0.5260.67
338_D346_K0.5260.67
284_M377_M0.5250.67
369_V377_M0.5250.67
45_V109_S0.5240.67
135_A180_P0.5220.67
244_E248_R0.5220.67
362_K366_E0.5210.67
59_D62_D0.5210.67
49_S53_K0.5210.67
324_Y347_A0.5210.67
401_V405_F0.5200.66
291_Y377_M0.5200.66
80_N135_A0.5190.66
17_P21_I0.5190.66
335_K343_A0.5180.66
279_T392_N0.5170.66
208_A249_A0.5170.66
52_K73_H0.5160.66
94_L97_G0.5160.66
192_S260_E0.5160.66
219_S309_M0.5150.66
79_P217_H0.5150.66
275_I278_T0.5150.66
231_A276_S0.5130.65
283_A287_P0.5130.65
289_S301_L0.5130.65
282_H298_G0.5130.65
224_A279_T0.5100.65
35_T39_G0.5100.65
69_V100_V0.5080.65
181_G286_H0.5080.65
329_V340_T0.5070.65
336_P342_Q0.5070.65
169_A183_G0.5060.64
302_A360_L0.5040.64
283_A286_H0.5040.64
44_L73_H0.5030.64
48_K73_H0.5030.64
220_E297_H0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bfj_A 1 0.9267 100 0.185 Contact Map
3ox4_A 1 0.9315 100 0.187 Contact Map
4fr2_A 1 0.9291 100 0.19 Contact Map
1vlj_A 1 0.9364 100 0.19 Contact Map
5br4_A 1 0.9315 100 0.201 Contact Map
4qgs_A 1 0.912 100 0.21 Contact Map
1o2d_A 1 0.8729 100 0.223 Contact Map
3zdr_A 1 0.9413 100 0.232 Contact Map
3w5s_A 1 0.8386 100 0.29 Contact Map
3iv7_A 1 0.8411 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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