GREMLIN Database
T0916_1_166 - T0916 1-166
ID: 81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (157)
Sequences: 101 (71)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_L157_L3.0870.78
147_L157_L3.0070.76
117_V154_L2.6260.65
119_S122_E2.5680.63
148_Y151_V2.5210.62
101_V116_Q2.3120.55
35_G103_E2.2960.54
27_L96_E2.2930.54
147_L154_L2.2310.52
18_L96_E2.2230.52
95_S102_A2.0770.47
90_A110_L2.0280.45
8_L73_A1.9760.43
44_E76_L1.9530.43
104_A113_L1.9260.42
117_V146_A1.8780.40
65_L73_A1.8460.39
89_D98_Q1.8440.39
20_E103_E1.8440.39
137_Y151_V1.8070.38
100_F113_L1.7720.37
7_K86_D1.7610.36
19_T23_R1.6470.33
43_L88_L1.6350.32
84_I100_F1.6090.31
136_D148_Y1.6020.31
93_E96_E1.5740.30
148_Y157_L1.5720.30
106_E116_Q1.5230.29
5_K9_E1.5210.29
90_A146_A1.5150.29
94_L116_Q1.5060.28
44_E89_D1.4620.27
66_L80_R1.4460.27
146_A154_L1.4310.26
72_A108_G1.4250.26
59_E129_A1.4220.26
95_S100_F1.4160.26
113_L116_Q1.3780.25
60_D93_E1.3770.25
146_A157_L1.3670.25
104_A109_T1.3570.24
44_E139_P1.3480.24
150_V155_L1.3380.24
71_N74_G1.3330.24
96_E123_Q1.3320.24
34_L110_L1.3270.24
54_R62_D1.3160.23
117_V147_L1.3090.23
38_D109_T1.3050.23
40_R43_L1.3020.23
148_Y154_L1.2910.23
65_L99_Q1.2880.23
42_D79_A1.2860.23
9_E118_K1.2700.22
137_Y145_C1.2630.22
117_V157_L1.2590.22
107_K144_L1.2470.22
18_L93_E1.2370.22
100_F110_L1.2040.21
86_D116_Q1.2040.21
39_I45_Q1.1970.21
80_R84_I1.1950.21
13_S66_L1.1910.20
35_G64_P1.1840.20
147_L151_V1.1800.20
111_P129_A1.1640.20
67_S107_K1.1450.19
75_V103_E1.1260.19
60_D129_A1.1230.19
66_L118_K1.1120.19
69_L81_A1.0950.18
41_Q45_Q1.0840.18
45_Q66_L1.0810.18
65_L118_K1.0760.18
36_K158_A1.0690.18
73_A149_V1.0690.18
29_S33_C1.0620.18
26_V76_L1.0510.18
36_K120_V1.0470.17
127_E141_A1.0430.17
78_E114_K1.0360.17
61_S69_L1.0310.17
1_S15_L1.0300.17
137_Y146_A1.0140.17
20_E59_E0.9930.16
109_T112_L0.9900.16
97_E105_L0.9840.16
65_L145_C0.9840.16
26_V142_R0.9830.16
77_V139_P0.9830.16
1_S4_M0.9820.16
8_L40_R0.9770.16
1_S7_K0.9640.16
95_S122_E0.9590.16
34_L137_Y0.9570.16
121_M157_L0.9500.16
102_A110_L0.9500.16
49_E54_R0.9480.16
23_R59_E0.9390.15
109_T113_L0.9380.15
80_R86_D0.9360.15
47_V151_V0.9350.15
63_K117_V0.9200.15
1_S43_L0.9130.15
8_L43_L0.9010.15
28_N39_I0.8970.15
23_R27_L0.8920.15
4_M151_V0.8910.15
42_D92_L0.8900.15
115_D145_C0.8880.14
117_V137_Y0.8860.14
8_L87_F0.8850.14
41_Q129_A0.8820.14
15_L69_L0.8700.14
14_V45_Q0.8630.14
91_L150_V0.8620.14
96_E109_T0.8580.14
30_L139_P0.8580.14
132_P156_E0.8530.14
64_P83_A0.8400.14
4_M7_K0.8300.14
119_S138_D0.8260.13
99_Q115_D0.8160.13
93_E113_L0.8140.13
26_V89_D0.8130.13
67_S112_L0.7990.13
69_L85_L0.7970.13
12_E38_D0.7960.13
104_A160_G0.7950.13
75_V82_K0.7910.13
36_K115_D0.7830.13
83_A131_S0.7780.13
5_K32_K0.7740.13
6_E107_K0.7700.13
146_A151_V0.7670.13
127_E134_D0.7590.12
85_L109_T0.7560.12
80_R83_A0.7550.12
19_T104_A0.7540.12
137_Y154_L0.7420.12
22_K80_R0.7400.12
30_L77_V0.7380.12
133_P150_V0.7330.12
1_S106_E0.7320.12
136_D144_L0.7250.12
23_R84_I0.7200.12
87_F121_M0.7200.12
114_K156_E0.7200.12
84_I118_K0.7170.12
151_V157_L0.7170.12
25_D85_L0.7100.12
5_K46_R0.7050.12
4_M87_F0.7030.12
19_T89_D0.7000.12
74_G115_D0.6960.11
42_D160_G0.6950.11
33_C80_R0.6940.11
1_S8_L0.6870.11
136_D151_V0.6840.11
77_V150_V0.6830.11
76_L122_E0.6800.11
151_V154_L0.6780.11
100_F115_D0.6770.11
18_L72_A0.6740.11
40_R98_Q0.6740.11
93_E150_V0.6680.11
19_T67_S0.6650.11
76_L139_P0.6630.11
145_C158_A0.6600.11
23_R98_Q0.6590.11
13_S39_I0.6590.11
27_L30_L0.6580.11
34_L60_D0.6580.11
85_L91_L0.6560.11
84_I124_N0.6530.11
30_L91_L0.6520.11
93_E119_S0.6520.11
62_D65_L0.6510.11
11_M71_N0.6470.11
4_M133_P0.6440.11
52_I98_Q0.6390.11
94_L100_F0.6280.11
144_L151_V0.6280.11
94_L102_A0.6200.10
133_P143_I0.6190.10
18_L140_E0.6160.10
119_S123_Q0.6080.10
90_A117_V0.6070.10
88_L144_L0.6020.10
123_Q136_D0.6010.10
134_D137_Y0.6000.10
72_A130_S0.6000.10
124_N152_S0.5970.10
39_I66_L0.5930.10
27_L49_E0.5890.10
11_M155_L0.5870.10
45_Q98_Q0.5870.10
84_I102_A0.5860.10
13_S21_E0.5850.10
30_L150_V0.5850.10
65_L149_V0.5840.10
88_L112_L0.5780.10
145_C151_V0.5770.10
98_Q122_E0.5750.10
24_K29_S0.5740.10
1_S58_M0.5740.10
38_D130_S0.5700.10
30_L44_E0.5680.10
138_D145_C0.5630.10
14_V58_M0.5610.10
44_E61_S0.5590.10
5_K36_K0.5590.10
60_D69_L0.5540.10
24_K80_R0.5540.10
118_K144_L0.5520.10
28_N156_E0.5510.10
8_L83_A0.5490.10
18_L106_E0.5490.10
26_V49_E0.5470.10
141_A159_E0.5410.09
35_G152_S0.5400.09
122_E158_A0.5370.09
65_L110_L0.5320.09
49_E91_L0.5320.09
23_R138_D0.5300.09
50_V143_I0.5240.09
13_S120_V0.5220.09
14_V150_V0.5220.09
2_R22_K0.5210.09
94_L101_V0.5160.09
54_R152_S0.5140.09
84_I93_E0.5060.09
137_Y147_L0.5030.09
7_K47_V0.5000.09
41_Q92_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5cwv_A 1 0.8373 28.5 0.945 Contact Map
2nvn_A 1 0.2651 11.7 0.954 Contact Map
2it9_A 1 0.259 11.7 0.954 Contact Map
4dhx_B 1 0.2169 7.6 0.958 Contact Map
4i1o_B 1 0.4337 7.2 0.958 Contact Map
4fq0_C 1 0.3012 6.3 0.959 Contact Map
1xi4_A 1 0.8494 5.3 0.96 Contact Map
1vcs_A 1 0.506 4.5 0.962 Contact Map
2qyw_A 1 0.4398 4.3 0.962 Contact Map
4jvs_A 1 0.4458 4.2 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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