GREMLIN Database
T0868_1_161 - T0868 1-161
ID: 8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (141)
Sequences: 36 (27)
Seq/√Len: 2.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_F117_L3.4270.48
102_I106_F3.0320.40
56_L146_I2.9700.38
138_N156_K2.7830.35
139_K161_K2.7700.34
151_Q155_A2.4330.28
29_L146_I2.3280.26
105_F109_N2.2600.25
102_I144_K2.2430.25
65_Q126_F2.1660.23
27_V30_N2.1110.23
46_R145_A2.0780.22
116_T126_F2.0580.22
45_F64_L2.0200.21
58_N89_F1.8510.19
55_E132_R1.8450.19
144_K154_Q1.8090.18
43_G81_P1.8080.18
39_D66_R1.8060.18
80_G84_G1.8040.18
94_D132_R1.7730.18
120_H124_A1.7660.18
66_R75_F1.7520.18
36_N47_P1.6560.16
73_V132_R1.6470.16
120_H127_V1.6340.16
55_E73_V1.6150.16
123_A130_A1.6150.16
31_A57_E1.5920.16
57_E135_S1.5620.15
48_G93_P1.5370.15
63_T154_Q1.4230.14
47_P98_Q1.3690.13
34_R128_P1.3600.13
91_L110_L1.3380.13
60_L154_Q1.3290.13
78_S152_K1.2900.12
57_E141_L1.2560.12
49_E74_D1.2540.12
61_G74_D1.2540.12
49_E61_G1.2540.12
108_K121_A1.2440.12
41_A132_R1.2360.12
93_P99_A1.2230.12
119_D154_Q1.2210.12
79_S138_N1.2160.12
45_F102_I1.2020.12
73_V160_I1.1990.12
51_G101_K1.1970.12
52_A89_F1.1950.12
56_L80_G1.1950.12
60_L158_I1.1940.12
112_N119_D1.1910.11
79_S156_K1.1830.11
23_A37_V1.1750.11
102_I154_Q1.1680.11
46_R132_R1.1640.11
48_G99_A1.1540.11
79_S128_P1.1470.11
96_V142_L1.1430.11
75_F86_T1.1200.11
25_N76_V1.1130.11
133_F159_L1.1080.11
31_A42_V1.1060.11
124_A127_V1.1020.11
90_M120_H1.0930.11
46_R94_D1.0860.11
86_T124_A1.0850.11
46_R83_N1.0850.11
64_L125_D1.0650.10
126_F158_I1.0430.10
93_P131_S1.0390.10
49_E134_L1.0380.10
74_D134_L1.0380.10
61_G134_L1.0380.10
48_G101_K1.0370.10
111_N118_S1.0370.10
54_A150_P1.0350.10
29_L56_L1.0310.10
60_L102_I1.0000.10
86_T109_N0.9990.10
105_F156_K0.9940.10
117_L154_Q0.9690.10
32_F68_P0.9670.10
118_S145_A0.9620.10
106_F142_L0.9500.10
88_D103_N0.9350.09
64_L106_F0.9190.09
53_A79_S0.8990.09
53_A128_P0.8950.09
54_A108_K0.8890.09
73_V145_A0.8890.09
78_S144_K0.8860.09
50_A54_A0.8850.09
39_D84_G0.8820.09
35_L74_D0.8790.09
35_L61_G0.8790.09
35_L49_E0.8790.09
77_F151_Q0.8740.09
84_G88_D0.8620.09
83_N114_M0.8600.09
99_A157_I0.8540.09
22_V146_I0.8490.09
21_I133_F0.8460.09
25_N89_F0.8390.09
93_P101_K0.8380.09
23_A67_A0.8230.09
43_G87_V0.8190.09
55_E62_G0.8170.09
88_D127_V0.8160.09
105_F157_I0.8150.09
91_L113_F0.8080.08
22_V33_D0.8050.08
76_V146_I0.7990.08
154_Q158_I0.7980.08
77_F145_A0.7940.08
52_A152_K0.7910.08
77_F129_L0.7870.08
29_L82_N0.7840.08
38_V135_S0.7840.08
61_G149_L0.7810.08
74_D149_L0.7810.08
49_E149_L0.7810.08
103_N134_L0.7490.08
117_L145_A0.7450.08
67_A73_V0.7370.08
102_I158_I0.7300.08
127_V153_L0.7230.08
101_K121_A0.7190.08
54_A113_F0.7090.08
55_E142_L0.7090.08
95_T139_K0.6990.08
131_S161_K0.6990.08
88_D128_P0.6980.08
122_A143_V0.6970.08
72_S76_V0.6970.08
25_N160_I0.6880.08
115_N145_A0.6870.08
45_F55_E0.6780.08
72_S155_A0.6780.08
46_R118_S0.6750.08
115_N137_A0.6730.08
126_F136_E0.6650.08
73_V126_F0.6630.08
65_Q68_P0.6590.08
40_P58_N0.6520.07
102_I119_D0.6510.07
122_A137_A0.6500.07
130_A134_L0.6490.07
58_N132_R0.6490.07
53_A66_R0.6460.07
65_Q136_E0.6460.07
131_S139_K0.6430.07
47_P150_P0.6430.07
35_L134_L0.6410.07
24_S73_V0.6400.07
74_D103_N0.6360.07
61_G103_N0.6360.07
49_E103_N0.6360.07
32_F60_L0.6290.07
23_A38_V0.6250.07
34_R149_L0.6240.07
131_S159_L0.6220.07
40_P76_V0.6210.07
57_E110_L0.6180.07
83_N89_F0.6160.07
53_A89_F0.6150.07
121_A130_A0.6150.07
82_N146_I0.6120.07
83_N126_F0.6100.07
80_G158_I0.6090.07
97_A107_D0.6050.07
78_S156_K0.5910.07
32_F126_F0.5870.07
113_F154_Q0.5860.07
134_L149_L0.5840.07
33_D81_P0.5830.07
50_A53_A0.5770.07
64_L69_Q0.5750.07
99_A105_F0.5730.07
65_Q73_V0.5720.07
44_K139_K0.5720.07
89_F106_F0.5670.07
52_A73_V0.5670.07
94_D145_A0.5650.07
28_D150_P0.5640.07
139_K160_I0.5610.07
120_H159_L0.5610.07
112_N137_A0.5570.07
52_A128_P0.5570.07
53_A68_P0.5560.07
146_I159_L0.5500.07
92_T125_D0.5430.07
90_M124_A0.5410.07
22_V82_N0.5360.07
44_K87_V0.5330.07
143_V158_I0.5310.07
37_V113_F0.5260.07
68_P136_E0.5250.07
64_L129_L0.5230.07
46_R110_L0.5220.07
99_A106_F0.5210.07
67_A89_F0.5200.07
69_Q147_G0.5160.07
64_L102_I0.5130.07
28_D110_L0.5120.07
76_V135_S0.5090.07
73_V86_T0.5090.07
51_G142_L0.5040.07
44_K81_P0.5020.07
22_V29_L0.5020.07
46_R160_I0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j8p_A 1 0.1988 52.8 0.947 Contact Map
4p1l_A 1 0.7391 20 0.958 Contact Map
2ayu_A 1 0.1491 17 0.959 Contact Map
3k93_A 1 0.9379 15.7 0.96 Contact Map
3zih_A 1 0.3851 14.2 0.961 Contact Map
4ovq_A 1 0.7453 12.4 0.962 Contact Map
3zie_A 1 0.3789 11.4 0.962 Contact Map
3zig_A 1 0.3913 11.1 0.963 Contact Map
4fzv_A 1 0.9503 10.8 0.963 Contact Map
3p04_A 1 0.3975 10.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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