GREMLIN Database
T0915_1_161 - T0915 1-161
ID: 79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (160)
Sequences: 19 (16)
Seq/√Len: 1.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_D73_L2.5680.19
107_Y111_A2.4500.18
46_D88_Y2.2690.16
73_L150_Y2.2490.16
58_L135_L2.2260.16
85_A150_Y2.1830.15
113_N155_K2.1570.15
35_A76_L2.1450.15
123_G151_N2.0440.14
139_P161_N2.0280.14
39_L42_L2.0190.14
39_L57_I2.0190.14
42_L57_I2.0190.14
9_K24_E1.9940.14
34_D105_L1.9920.14
27_S31_P1.9310.13
55_K104_A1.9190.13
17_Y84_Y1.8230.13
22_Y60_S1.7840.12
107_Y120_V1.7570.12
78_L110_C1.7140.12
14_L22_Y1.6840.12
101_L157_Y1.6810.12
69_K89_L1.6800.12
35_A104_A1.6700.12
56_K132_Y1.6630.11
14_L21_G1.6540.11
49_G97_T1.6170.11
106_F128_L1.5950.11
26_D32_E1.5950.11
111_A120_V1.5820.11
38_C65_G1.5720.11
46_D150_Y1.5600.11
14_L17_Y1.5250.11
54_C68_I1.5170.11
31_P54_C1.5050.10
130_K135_L1.5000.10
38_C112_K1.4960.10
20_N143_F1.4790.10
27_S54_C1.4790.10
10_D35_A1.4730.10
10_D76_L1.4480.10
59_K137_N1.4270.10
105_L131_R1.4190.10
17_Y131_R1.4070.10
25_A28_F1.4010.10
88_Y124_L1.3910.10
112_K121_P1.3830.10
43_L137_N1.3770.10
26_D47_S1.3570.10
33_D98_L1.3490.10
34_D125_F1.3400.09
106_F112_K1.3310.09
5_N70_G1.3150.09
17_Y60_S1.3080.09
86_F117_P1.3040.09
55_K124_L1.2920.09
18_L108_F1.2860.09
65_G112_K1.2840.09
39_L76_L1.2820.09
42_L76_L1.2820.09
57_I76_L1.2820.09
39_L101_L1.2810.09
57_I101_L1.2810.09
42_L101_L1.2810.09
139_P160_N1.2790.09
11_I26_D1.2550.09
132_Y150_Y1.2540.09
46_D101_L1.2360.09
141_A157_Y1.2270.09
42_L153_F1.2010.09
57_I153_F1.2010.09
39_L153_F1.2010.09
8_A24_E1.1690.09
47_S91_S1.1560.08
92_N113_N1.1470.08
27_S30_D1.1430.08
120_V148_E1.1390.08
53_F127_K1.1370.08
79_S112_K1.0820.08
32_E41_N1.0670.08
35_A101_L1.0590.08
53_F141_A1.0560.08
51_L82_W1.0480.08
73_L124_L1.0440.08
105_L108_F1.0440.08
16_S27_S1.0280.08
67_F92_N1.0260.08
26_D41_N1.0170.08
104_A124_L1.0110.08
67_F134_E1.0100.08
67_F135_L1.0080.08
10_D14_L1.0050.08
38_C64_D1.0020.08
87_E95_N1.0000.08
20_N27_S0.9980.08
85_A141_A0.9930.08
21_G78_L0.9760.08
36_L67_F0.9730.08
7_T45_K0.9710.08
9_K32_E0.9580.08
28_F33_D0.9540.08
33_D50_G0.9530.08
35_A153_F0.9460.07
69_K111_A0.9380.07
77_L111_A0.9220.07
18_L25_A0.9160.07
9_K26_D0.9160.07
33_D81_Q0.9010.07
69_K112_K0.8980.07
89_L112_K0.8900.07
18_L22_Y0.8890.07
11_I32_E0.8860.07
77_L112_K0.8820.07
108_F157_Y0.8820.07
7_T11_I0.8740.07
124_L146_L0.8690.07
93_A100_E0.8670.07
22_Y56_K0.8660.07
27_S50_G0.8590.07
89_L111_A0.8570.07
60_S131_R0.8480.07
38_C96_I0.8400.07
73_L146_L0.8370.07
10_D38_C0.8350.07
8_A87_E0.8270.07
125_F146_L0.8230.07
25_A30_D0.8210.07
28_F98_L0.8210.07
72_A142_K0.8180.07
21_G24_E0.8160.07
6_S158_P0.8080.07
69_K77_L0.8060.07
69_K88_Y0.8040.07
131_R150_Y0.8040.07
21_G80_E0.7930.07
34_D131_R0.7790.07
37_E48_R0.7650.07
30_D54_C0.7620.07
14_L132_Y0.7610.07
77_L89_L0.7570.07
81_Q143_F0.7490.07
2_I144_Y0.7470.07
18_L98_L0.7320.07
17_Y22_Y0.7300.07
13_G18_L0.7290.07
19_A143_F0.7270.07
13_G106_F0.7250.07
5_N105_L0.7190.06
12_E41_N0.7160.06
134_E138_D0.7140.06
148_E152_D0.7100.06
10_D24_E0.7090.06
24_E103_K0.7050.06
50_G54_C0.7020.06
121_P128_L0.6940.06
17_Y21_G0.6840.06
85_A160_N0.6820.06
55_K142_K0.6800.06
38_C76_L0.6790.06
115_T126_K0.6740.06
9_K44_V0.6660.06
28_F31_P0.6640.06
111_A148_E0.6600.06
122_E127_K0.6590.06
39_L132_Y0.6560.06
42_L132_Y0.6560.06
57_I132_Y0.6560.06
46_D70_G0.6510.06
128_L136_K0.6510.06
43_L49_G0.6450.06
29_N80_E0.6420.06
89_L96_I0.6420.06
96_I128_L0.6390.06
35_A124_L0.6380.06
4_V161_N0.6360.06
35_A57_I0.6260.06
35_A42_L0.6260.06
35_A39_L0.6260.06
112_K128_L0.6220.06
106_F110_C0.6190.06
31_P50_G0.6180.06
7_T71_S0.6110.06
55_K88_Y0.6050.06
67_F149_T0.6040.06
26_D66_V0.6010.06
49_G85_A0.6000.06
51_L81_Q0.6000.06
125_F142_K0.5960.06
11_I47_S0.5950.06
25_A56_K0.5920.06
96_I101_L0.5920.06
86_F108_F0.5910.06
72_A84_Y0.5900.06
14_L18_L0.5900.06
34_D115_T0.5860.06
83_S92_N0.5860.06
76_L104_A0.5830.06
13_G128_L0.5770.06
149_T158_P0.5740.06
3_N26_D0.5700.06
101_L124_L0.5690.06
54_C132_Y0.5680.06
79_S121_P0.5680.06
106_F121_P0.5660.06
126_K140_D0.5650.06
5_N125_F0.5610.06
65_G156_A0.5610.06
6_S87_E0.5590.06
26_D60_S0.5590.06
116_D120_V0.5580.06
11_I45_K0.5580.06
37_E130_K0.5570.06
31_P99_A0.5540.06
110_C113_N0.5540.06
58_L152_D0.5500.06
67_F113_N0.5490.06
11_I85_A0.5480.06
18_L38_C0.5410.06
18_L23_V0.5390.06
107_Y112_K0.5350.06
122_E155_K0.5340.06
53_F124_L0.5280.06
32_E74_N0.5270.06
56_K156_A0.5240.06
53_F121_P0.5220.06
126_K144_Y0.5200.06
34_D82_W0.5200.06
6_S19_A0.5180.06
54_C150_Y0.5160.06
69_K114_E0.5140.06
14_L84_Y0.5140.06
80_E92_N0.5130.06
109_Y140_D0.5110.06
106_F136_K0.5100.06
34_D142_K0.5080.06
5_N158_P0.5060.06
91_S141_A0.5050.06
134_E139_P0.5050.06
89_L107_Y0.5000.06
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a1u_G 1 0.9441 18.3 0.955 Contact Map
5byh_M 1 0.913 11.4 0.959 Contact Map
2nn6_G 1 0.3416 10.7 0.96 Contact Map
2m7l_A 1 0.7888 9.3 0.961 Contact Map
4rku_N 1 0.2298 8.3 0.962 Contact Map
2v7s_A 1 0.2609 8.1 0.962 Contact Map
4gkp_A 1 0.3851 4.9 0.965 Contact Map
1t35_A 1 0.2609 4.6 0.966 Contact Map
1xzp_A 1 0.4658 4.3 0.966 Contact Map
3u0k_A 1 0.0745 4.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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