GREMLIN Database
T0913_1_386 - T0913 1-386
ID: 77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 386 (297)
Sequences: 682 (355)
Seq/√Len: 20.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_E243_E7.0141.00
71_T372_E6.4191.00
75_L122_A5.2811.00
326_K348_I4.6021.00
123_T127_N4.5301.00
341_R349_E4.3941.00
338_Q342_D3.7351.00
77_M119_E3.6231.00
124_A350_V3.4651.00
301_E343_A3.3911.00
72_E191_N3.3521.00
320_L366_V3.2981.00
74_A369_I3.2721.00
99_G146_G3.1080.99
326_K346_E2.9660.99
218_T232_L2.7910.99
113_A116_R2.7680.99
72_E133_H2.7610.99
279_K301_E2.7480.99
63_G373_P2.6320.98
352_G356_R2.6060.98
212_A215_V2.5860.98
124_A348_I2.5640.98
165_V208_C2.5420.98
123_T126_E2.3860.97
128_N346_E2.3490.96
216_L245_F2.3370.96
62_F159_I2.3190.96
275_I303_I2.1860.95
160_W208_C2.1460.94
276_D279_K2.1040.93
220_L247_N2.0730.93
165_V232_L2.0700.93
279_K345_V1.9180.90
338_Q341_R1.9040.89
72_E131_K1.8780.89
287_L304_E1.8780.89
279_K325_G1.8610.88
216_L236_I1.8410.88
163_G195_L1.8340.87
282_V287_L1.7740.86
246_H294_W1.7670.85
68_G374_G1.7660.85
354_E357_K1.6790.82
176_V179_S1.6720.82
75_L366_V1.6620.82
71_T370_N1.6600.81
125_F322_L1.6330.80
128_N322_L1.5930.79
157_G183_A1.5620.77
115_Q119_E1.5590.77
215_V244_E1.5150.75
201_G228_G1.5120.75
329_A347_V1.5080.75
120_E123_T1.4910.74
282_V302_L1.4900.74
164_S187_W1.4730.73
319_V329_A1.4610.72
158_S208_C1.4210.70
213_D373_P1.3920.68
209_N363_K1.3920.68
303_I343_A1.3870.68
157_G187_W1.3850.68
69_R323_E1.3770.68
213_D374_G1.3740.67
244_E297_D1.3580.66
250_L319_V1.3510.66
331_A351_T1.3500.66
339_K343_A1.3350.65
76_H81_Y1.3350.65
331_A349_E1.3260.65
112_A116_R1.3200.64
133_H191_N1.3120.64
253_A265_C1.3040.63
75_L125_F1.2980.63
156_W176_V1.2840.62
210_M242_T1.2800.62
133_H369_I1.2630.61
182_L195_L1.2630.61
157_G175_M1.2390.59
125_F130_I1.2290.58
153_F169_F1.2280.58
102_G266_A1.2280.58
163_G193_P1.2220.58
160_W165_V1.2200.58
112_A334_H1.2150.58
122_A186_A1.2090.57
338_Q349_E1.1920.56
128_N326_K1.1910.56
113_A351_T1.1840.56
184_K188_N1.1820.55
291_A295_L1.1740.55
122_A126_E1.1720.55
69_R374_G1.1720.55
116_R120_E1.1630.54
66_G155_S1.1570.54
107_G312_E1.1560.54
87_S96_F1.1530.54
276_D301_E1.1440.53
327_V345_V1.1230.52
157_G164_S1.1170.51
159_I367_M1.1140.51
320_L363_K1.1100.51
305_A316_P1.1100.51
75_L134_W1.1070.51
156_W179_S1.0990.50
162_G193_P1.0980.50
279_K303_I1.0970.50
193_P239_T1.0710.48
341_R372_E1.0700.48
200_E231_Q1.0660.48
164_S183_A1.0660.48
131_K191_N1.0610.48
166_I194_P1.0590.47
184_K196_V1.0560.47
158_S349_E1.0540.47
122_A366_V1.0540.47
122_A134_W1.0500.47
270_I315_A1.0420.46
76_H117_E1.0410.46
127_N293_T1.0280.45
120_E124_A1.0280.45
128_N323_E1.0270.45
107_G237_S1.0210.45
169_F309_E1.0140.44
303_I339_K1.0010.44
166_I184_K0.9990.43
144_P164_S0.9960.43
326_K331_A0.9830.42
111_L115_Q0.9820.42
69_R372_E0.9640.41
76_H248_L0.9620.41
141_P283_S0.9610.41
326_K342_D0.9580.41
341_R346_E0.9570.41
168_R177_G0.9510.40
120_E351_T0.9500.40
86_Q263_G0.9490.40
213_D241_G0.9490.40
341_R347_V0.9480.40
135_V186_A0.9470.40
270_I359_C0.9440.40
327_V341_R0.9430.40
137_Y348_I0.9360.39
162_G231_Q0.9350.39
68_G163_G0.9310.39
282_V288_D0.9310.39
214_E299_N0.9290.39
71_T229_T0.9210.39
137_Y293_T0.9200.38
135_V183_A0.9200.38
63_G162_G0.9180.38
290_D293_T0.9170.38
226_Q230_D0.9160.38
156_W205_P0.9140.38
77_M211_I0.9110.38
156_W360_G0.9090.38
345_V369_I0.9090.38
63_G234_A0.9040.37
207_A224_Y0.8950.37
101_M150_G0.8860.36
183_A187_W0.8830.36
82_T265_C0.8810.36
106_R263_G0.8770.36
144_P351_T0.8770.36
228_G289_W0.8710.35
157_G367_M0.8680.35
320_L362_I0.8660.35
305_A317_C0.8610.35
153_F315_A0.8590.35
116_R296_Y0.8550.34
188_N194_P0.8540.34
235_A239_T0.8540.34
157_G221_S0.8540.34
250_L363_K0.8500.34
219_C268_P0.8490.34
282_V300_F0.8480.34
80_K83_L0.8460.34
135_V283_S0.8450.34
137_Y307_P0.8410.34
171_F222_A0.8410.34
252_P263_G0.8370.33
311_R361_G0.8360.33
76_H82_T0.8340.33
311_R357_K0.8320.33
124_A328_I0.8300.33
100_L106_R0.8240.33
123_T277_V0.8230.33
57_V218_T0.8190.32
228_G245_F0.8170.32
177_G187_W0.8170.32
166_I203_M0.8110.32
181_Y184_K0.8100.32
244_E264_A0.8090.32
82_T99_G0.8010.31
271_N310_Q0.7990.31
228_G231_Q0.7970.31
219_C223_S0.7970.31
277_V301_E0.7950.31
213_D228_G0.7930.31
64_F242_T0.7890.31
246_H297_D0.7860.31
252_P265_C0.7830.30
175_M329_A0.7710.30
83_L334_H0.7690.30
206_G368_Q0.7670.29
265_C283_S0.7660.29
77_M115_Q0.7620.29
154_L288_D0.7570.29
176_V205_P0.7570.29
107_G357_K0.7570.29
65_N333_C0.7560.29
322_L366_V0.7540.29
159_I369_I0.7530.29
112_A228_G0.7480.28
216_L222_A0.7470.28
327_V350_V0.7440.28
99_G277_V0.7440.28
229_T247_N0.7440.28
319_V362_I0.7420.28
109_V211_I0.7420.28
271_N281_V0.7410.28
144_P168_R0.7410.28
141_P307_P0.7350.28
143_N239_T0.7320.28
74_A183_A0.7310.28
77_M134_W0.7300.27
166_I235_A0.7290.27
158_S167_S0.7270.27
228_G242_T0.7240.27
232_L346_E0.7220.27
145_Y341_R0.7200.27
154_L186_A0.7190.27
210_M274_A0.7170.27
149_M266_A0.7160.27
119_E134_W0.7130.27
114_F282_V0.7090.26
221_S317_C0.7070.26
270_I310_Q0.7050.26
112_A124_A0.7040.26
167_S208_C0.7010.26
203_M232_L0.6990.26
69_R130_I0.6950.26
212_A298_N0.6940.26
101_M365_R0.6940.26
165_V194_P0.6930.26
187_W367_M0.6920.26
144_P349_E0.6910.25
274_A280_L0.6880.25
221_S229_T0.6870.25
66_G156_W0.6850.25
109_V134_W0.6820.25
266_A270_I0.6790.25
165_V369_I0.6780.25
226_Q247_N0.6780.25
60_R162_G0.6770.25
268_P340_I0.6760.25
284_P288_D0.6750.25
236_I344_G0.6750.25
101_M207_A0.6730.25
181_Y277_V0.6710.24
155_S269_D0.6710.24
59_G369_I0.6700.24
65_N68_G0.6700.24
84_H110_D0.6700.24
101_M330_H0.6680.24
311_R354_E0.6680.24
187_W194_P0.6670.24
282_V304_E0.6650.24
151_H182_L0.6630.24
113_A353_T0.6630.24
234_A238_K0.6620.24
157_G171_F0.6620.24
128_N348_I0.6610.24
72_E369_I0.6610.24
266_A359_C0.6610.24
130_I338_Q0.6580.24
331_A341_R0.6570.24
65_N128_N0.6560.24
83_L366_V0.6550.24
148_L186_A0.6540.24
217_V279_K0.6520.24
167_S237_S0.6510.24
76_H336_T0.6500.23
220_L249_Q0.6500.23
125_F320_L0.6500.23
149_M270_I0.6490.23
205_P223_S0.6450.23
203_M228_G0.6450.23
191_N231_Q0.6440.23
220_L229_T0.6430.23
188_N231_Q0.6390.23
306_D339_K0.6380.23
213_D243_E0.6370.23
193_P265_C0.6370.23
195_L201_G0.6360.23
315_A359_C0.6340.23
61_T239_T0.6330.23
225_D338_Q0.6330.23
290_D294_W0.6310.23
150_G153_F0.6300.23
66_G207_A0.6300.23
102_G315_A0.6280.22
195_L239_T0.6270.22
212_A363_K0.6260.22
251_R264_A0.6260.22
159_I181_Y0.6240.22
125_F275_I0.6230.22
248_L281_V0.6230.22
277_V374_G0.6220.22
178_V309_E0.6210.22
295_L302_L0.6200.22
75_L209_N0.6200.22
157_G297_D0.6190.22
207_A266_A0.6160.22
287_L292_R0.6150.22
338_Q346_E0.6140.22
130_I341_R0.6130.22
298_N365_R0.6130.22
84_H198_I0.6110.22
116_R331_A0.6110.22
119_E211_I0.6110.22
168_R184_K0.6110.22
60_R299_N0.6100.22
157_G247_N0.6080.22
202_A225_D0.6080.22
318_N364_C0.6070.22
83_L158_S0.6060.21
211_I217_V0.6060.21
107_G353_T0.6010.21
72_E192_I0.6000.21
133_H307_P0.5980.21
175_M183_A0.5980.21
102_G270_I0.5980.21
139_E192_I0.5960.21
275_I347_V0.5950.21
305_A367_M0.5950.21
150_G355_I0.5920.21
162_G199_T0.5920.21
69_R193_P0.5910.21
63_G71_T0.5910.21
280_L300_F0.5910.21
355_I365_R0.5900.21
297_D369_I0.5900.21
203_M296_Y0.5890.21
212_A323_E0.5890.21
205_P360_G0.5890.21
301_E345_V0.5880.21
200_E239_T0.5860.21
221_S253_A0.5840.21
145_Y226_Q0.5830.20
179_S205_P0.5830.20
82_T331_A0.5810.20
243_E338_Q0.5810.20
61_T374_G0.5800.20
63_G148_L0.5780.20
221_S275_I0.5770.20
169_F358_A0.5770.20
222_A266_A0.5760.20
68_G195_L0.5760.20
114_F159_I0.5750.20
188_N339_K0.5740.20
149_M222_A0.5730.20
155_S268_P0.5710.20
113_A331_A0.5690.20
244_E296_Y0.5680.20
322_L339_K0.5660.20
66_G224_Y0.5650.20
171_F305_A0.5650.20
249_Q252_P0.5640.20
249_Q294_W0.5630.20
213_D238_K0.5630.20
75_L322_L0.5630.20
280_L302_L0.5620.20
186_A243_E0.5610.20
143_N342_D0.5600.19
317_C334_H0.5600.19
203_M206_G0.5580.19
284_P351_T0.5580.19
116_R234_A0.5530.19
161_R242_T0.5510.19
308_D332_D0.5480.19
229_T284_P0.5470.19
274_A321_L0.5470.19
135_V178_V0.5460.19
69_R322_L0.5440.19
146_G373_P0.5400.19
68_G372_E0.5390.19
156_W207_A0.5390.19
175_M187_W0.5380.19
331_A339_K0.5370.19
165_V225_D0.5370.19
121_L337_N0.5360.19
183_A367_M0.5360.19
69_R127_N0.5360.19
334_H352_G0.5360.19
266_A330_H0.5350.18
328_I338_Q0.5350.18
243_E249_Q0.5350.18
185_W300_F0.5350.18
284_P291_A0.5310.18
300_F328_I0.5300.18
61_T194_P0.5290.18
127_N346_E0.5290.18
160_W193_P0.5280.18
100_L175_M0.5270.18
151_H183_A0.5260.18
168_R227_R0.5250.18
158_S163_G0.5250.18
278_G288_D0.5250.18
311_R359_C0.5250.18
69_R213_D0.5230.18
132_V340_I0.5230.18
59_G238_K0.5230.18
248_L291_A0.5220.18
155_S176_V0.5220.18
325_G353_T0.5220.18
342_D346_E0.5220.18
81_Y153_F0.5220.18
238_K374_G0.5210.18
129_G275_I0.5210.18
94_P150_G0.5200.18
95_S307_P0.5200.18
207_A311_R0.5190.18
301_E326_K0.5160.18
130_I322_L0.5160.18
120_E137_Y0.5150.18
114_F157_G0.5150.18
245_F338_Q0.5120.18
250_L366_V0.5110.18
342_D349_E0.5110.18
146_G277_V0.5110.18
282_V305_A0.5070.17
69_R177_G0.5070.17
234_A372_E0.5060.17
193_P201_G0.5060.17
79_T95_S0.5050.17
159_I213_D0.5050.17
129_G344_G0.5040.17
83_L298_N0.5040.17
83_L115_Q0.5030.17
86_Q283_S0.5030.17
185_W217_V0.5020.17
116_R245_F0.5010.17
74_A192_I0.5000.17
364_C371_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bof_A 1 0.7617 100 0.454 Contact Map
2a9g_A 1 0.7591 100 0.454 Contact Map
4e4j_A 1 0.7591 100 0.461 Contact Map
1s9r_A 1 0.7824 100 0.464 Contact Map
1jdw_A 1 0.7772 100 0.514 Contact Map
1bwd_A 1 0.7876 100 0.526 Contact Map
3i4a_A 1 0.6788 100 0.568 Contact Map
1h70_A 1 0.6528 100 0.573 Contact Map
2ci1_A 1 0.2254 100 0.581 Contact Map
2ewo_A 1 0.7642 100 0.735 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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