T0912_100-310_1_211 - CASP12 - GREMLIN Contacts

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T0912_100-310_1_211 - T0912_100-310 1-211

ID:	76	Sequences: VIRPVADEKVVLSGGIRIGGWKKQGKLWVADVPMFNGRPLDFRQLWVNGKKAVRARDVEDFEKMNRICSVDEKNEILYVPAVAIRRLVDGKGALKAKYAEMVLHQMWCVANLRIRSVELAGDSAAIRFHQPESRIQFEHPWPRPMVTTDGHNSAFYLTNARELLDVAGEWYHDIDARKVYYYPREGEKLQDAGTEVIVPAIETLIQVKGTF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	211 (192)
Sequences:	2106 (1774)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_V	178_K	5.579	1.00
59_E	165_D	5.081	1.00
5_V	8_E	3.818	1.00
165_D	169_E	3.748	1.00
173_D	176_A	3.461	1.00
4_P	10_V	3.408	1.00
15_G	197_I	2.961	1.00
52_A	181_Y	2.546	1.00
18_I	30_A	2.533	1.00
31_D	178_K	2.528	1.00
203_T	206_Q	2.485	1.00
98_Y	174_I	2.402	1.00
22_K	29_V	2.328	1.00
42_F	172_H	2.196	1.00
161_R	180_Y	2.183	1.00
56_R	156_Y	2.171	1.00
160_A	163_L	2.107	1.00
99_A	114_I	2.049	1.00
17_R	195_E	2.045	1.00
188_K	191_D	1.959	1.00
54_R	158_T	1.950	1.00
48_N	194_T	1.947	1.00
54_R	159_N	1.908	1.00
59_E	169_E	1.888	1.00
24_Q	29_V	1.873	1.00
16_I	200_A	1.859	1.00
172_H	177_R	1.854	1.00
47_V	181_Y	1.812	1.00
47_V	52_A	1.778	1.00
23_K	28_W	1.767	1.00
189_L	194_T	1.685	1.00
43_R	100_E	1.657	1.00
99_A	160_A	1.650	1.00
50_K	184_R	1.635	1.00
184_R	187_E	1.624	1.00
24_Q	27_L	1.606	1.00
41_D	174_I	1.597	1.00
61_F	64_M	1.585	1.00
24_Q	161_R	1.568	1.00
29_V	180_Y	1.512	1.00
81_A	155_F	1.480	1.00
44_Q	51_K	1.426	1.00
96_A	99_A	1.411	1.00
45_L	179_V	1.388	1.00
188_K	194_T	1.383	1.00
40_L	198_V	1.372	1.00
102_V	111_N	1.336	1.00
52_A	187_E	1.335	1.00
114_I	157_L	1.328	1.00
31_D	176_A	1.318	1.00
27_L	161_R	1.307	1.00
128_F	132_E	1.272	1.00
13_S	197_I	1.265	1.00
96_A	162_E	1.260	1.00
55_A	164_L	1.251	1.00
27_L	182_Y	1.240	1.00
52_A	184_R	1.214	0.99
42_F	198_V	1.214	0.99
157_L	163_L	1.200	0.99
168_G	183_P	1.200	0.99
167_A	182_Y	1.193	0.99
116_S	127_R	1.176	0.99
44_Q	199_P	1.173	0.99
32_V	172_H	1.161	0.99
32_V	179_V	1.151	0.99
159_N	171_Y	1.150	0.99
118_E	124_A	1.139	0.99
54_R	100_E	1.121	0.99
7_D	10_V	1.118	0.99
93_A	163_L	1.106	0.99
183_P	189_L	1.105	0.99
121_G	124_A	1.095	0.99
191_D	194_T	1.088	0.99
64_M	67_I	1.072	0.99
27_L	180_Y	1.047	0.98
14_G	204_L	1.047	0.98
45_L	196_V	1.045	0.98
47_V	196_V	1.043	0.98
26_K	182_Y	1.041	0.98
22_K	31_D	1.040	0.98
12_L	204_L	1.038	0.98
181_Y	187_E	1.034	0.98
3_R	6_A	1.027	0.98
181_Y	184_R	1.018	0.98
100_E	111_N	1.015	0.98
111_N	158_T	1.013	0.98
47_V	184_R	0.999	0.98
25_G	182_Y	0.993	0.98
69_S	72_E	0.992	0.98
161_R	171_Y	0.992	0.98
93_A	96_A	0.992	0.98
32_V	40_L	0.983	0.98
57_D	163_L	0.982	0.98
102_V	158_T	0.977	0.98
18_I	198_V	0.967	0.97
102_V	156_Y	0.955	0.97
42_F	199_P	0.950	0.97
161_R	182_Y	0.950	0.97
128_F	131_P	0.950	0.97
129_H	132_E	0.947	0.97
168_G	187_E	0.931	0.97
31_D	177_R	0.928	0.97
79_V	82_V	0.926	0.97
201_I	204_L	0.920	0.96
28_W	189_L	0.920	0.96
99_A	103_L	0.918	0.96
53_V	169_E	0.912	0.96
53_V	56_R	0.911	0.96
68_C	71_D	0.909	0.96
20_G	30_A	0.908	0.96
35_F	177_R	0.907	0.96
59_E	166_V	0.906	0.96
121_G	125_A	0.898	0.96
30_A	179_V	0.896	0.96
4_P	8_E	0.895	0.96
49_G	195_E	0.894	0.96
55_A	165_D	0.884	0.96
189_L	196_V	0.882	0.95
95_K	98_Y	0.873	0.95
35_F	39_P	0.872	0.95
81_A	84_I	0.869	0.95
47_V	194_T	0.865	0.95
54_R	199_P	0.865	0.95
119_L	124_A	0.864	0.95
171_Y	174_I	0.861	0.95
95_K	162_E	0.854	0.95
32_V	177_R	0.853	0.95
45_L	181_Y	0.851	0.95
45_L	198_V	0.849	0.94
21_W	179_V	0.845	0.94
48_N	195_E	0.843	0.94
95_K	99_A	0.842	0.94
53_V	165_D	0.840	0.94
102_V	109_V	0.833	0.94
115_R	129_H	0.821	0.93
75_E	78_Y	0.818	0.93
53_V	166_V	0.817	0.93
76_I	80_P	0.812	0.93
170_W	184_R	0.812	0.93
101_M	157_L	0.811	0.93
157_L	160_A	0.806	0.93
55_A	169_E	0.801	0.93
100_E	113_R	0.796	0.92
56_R	59_E	0.787	0.92
24_Q	180_Y	0.786	0.92
77_L	80_P	0.784	0.92
79_V	83_A	0.781	0.92
159_N	204_L	0.781	0.92
187_E	194_T	0.780	0.92
168_G	184_R	0.774	0.91
81_A	86_R	0.773	0.91
73_K	76_I	0.773	0.91
110_A	133_S	0.771	0.91
56_R	165_D	0.768	0.91
162_E	171_Y	0.765	0.91
112_L	132_E	0.755	0.90
55_A	163_L	0.754	0.90
117_V	124_A	0.750	0.90
24_Q	28_W	0.749	0.90
42_F	179_V	0.748	0.90
77_L	81_A	0.748	0.90
156_Y	169_E	0.748	0.90
93_A	162_E	0.742	0.89
56_R	169_E	0.738	0.89
26_K	183_P	0.738	0.89
90_G	93_A	0.733	0.89
201_I	205_I	0.731	0.89
4_P	9_K	0.728	0.88
100_E	103_L	0.727	0.88
104_H	154_A	0.724	0.88
73_K	77_L	0.717	0.88
106_M	153_S	0.716	0.88
44_Q	54_R	0.714	0.88
12_L	205_I	0.713	0.87
22_K	176_A	0.712	0.87
50_K	176_A	0.710	0.87
46_W	199_P	0.710	0.87
44_Q	170_W	0.709	0.87
40_L	177_R	0.708	0.87
94_L	173_D	0.701	0.87
190_Q	194_T	0.697	0.86
58_V	61_F	0.696	0.86
1_V	17_R	0.688	0.86
57_D	165_D	0.687	0.85
34_M	176_A	0.685	0.85
118_E	121_G	0.681	0.85
32_V	35_F	0.676	0.85
112_L	128_F	0.675	0.84
43_R	199_P	0.669	0.84
98_Y	104_H	0.662	0.83
22_K	33_P	0.660	0.83
13_S	204_L	0.657	0.83
32_V	42_F	0.656	0.83
21_W	28_W	0.655	0.83
84_I	157_L	0.650	0.82
27_L	164_L	0.643	0.81
106_M	154_A	0.643	0.81
167_A	183_P	0.642	0.81
175_D	190_Q	0.641	0.81
96_A	163_L	0.641	0.81
159_N	199_P	0.639	0.81
73_K	78_Y	0.638	0.81
42_F	54_R	0.638	0.81
72_E	75_E	0.638	0.81
99_A	157_L	0.636	0.81
113_R	129_H	0.622	0.79
77_L	83_A	0.621	0.79
51_K	199_P	0.620	0.79
55_A	59_E	0.618	0.79
66_R	69_S	0.617	0.79
104_H	152_N	0.616	0.79
43_R	54_R	0.615	0.79
18_I	179_V	0.614	0.78
21_W	30_A	0.613	0.78
166_V	182_Y	0.612	0.78
97_K	101_M	0.608	0.78
107_W	110_A	0.608	0.78
14_G	70_V	0.602	0.77
23_K	26_K	0.602	0.77
23_K	189_L	0.601	0.77
86_R	90_G	0.599	0.77
33_P	177_R	0.599	0.77
81_A	85_R	0.597	0.76
34_M	40_L	0.596	0.76
149_D	153_S	0.594	0.76
77_L	126_I	0.594	0.76
99_A	102_V	0.591	0.76
57_D	169_E	0.590	0.76
149_D	152_N	0.590	0.76
15_G	199_P	0.583	0.75
79_V	125_A	0.583	0.75
48_N	187_E	0.582	0.75
5_V	10_V	0.581	0.75
128_F	133_S	0.581	0.75
71_D	74_N	0.579	0.74
143_R	149_D	0.578	0.74
61_F	65_N	0.578	0.74
199_P	204_L	0.578	0.74
90_G	94_L	0.569	0.73
15_G	54_R	0.565	0.73
155_F	170_W	0.565	0.73
46_W	51_K	0.558	0.72
99_A	104_H	0.556	0.71
100_E	159_N	0.556	0.71
105_Q	110_A	0.553	0.71
58_V	156_Y	0.552	0.71
15_G	51_K	0.550	0.71
93_A	160_A	0.550	0.71
166_V	169_E	0.550	0.71
183_P	186_G	0.548	0.70
104_H	156_Y	0.546	0.70
18_I	42_F	0.546	0.70
23_K	29_V	0.545	0.70
14_G	44_Q	0.544	0.70
118_E	125_A	0.542	0.69
74_N	77_L	0.542	0.69
185_E	191_D	0.541	0.69
74_N	80_P	0.540	0.69
56_R	60_D	0.539	0.69
117_V	126_I	0.538	0.69
12_L	206_Q	0.536	0.69
35_F	41_D	0.535	0.68
33_P	178_K	0.529	0.68
164_L	171_Y	0.522	0.67
166_V	175_D	0.522	0.67
109_V	156_Y	0.521	0.66
55_A	157_L	0.521	0.66
43_R	113_R	0.520	0.66
8_E	196_V	0.517	0.66
100_E	104_H	0.516	0.66
70_V	73_K	0.514	0.65
120_A	125_A	0.513	0.65
113_R	172_H	0.513	0.65
107_W	205_I	0.511	0.65
16_I	40_L	0.510	0.65
68_C	153_S	0.510	0.65
22_K	40_L	0.509	0.65
26_K	91_K	0.507	0.64
114_I	126_I	0.507	0.64
79_V	126_I	0.506	0.64
77_L	86_R	0.505	0.64
132_E	135_I	0.504	0.64
65_N	207_V	0.504	0.64
28_W	180_Y	0.503	0.64
76_I	81_A	0.502	0.64
7_D	28_W	0.501	0.63
76_I	79_V	0.500	0.63
95_K	175_D	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vsv_A	1	0.7062	99.8	0.584	Contact Map
1oq1_A	1	0.4265	7.6	0.947	Contact Map
3fil_A	1	0.2607	6.4	0.949	Contact Map
4kmq_A	1	0.4502	3.4	0.955	Contact Map
2vyc_A	1	0.2986	2.7	0.957	Contact Map
4mtz_A	1	0.218	2.1	0.96	Contact Map
4m5s_A	1	0.1801	2.1	0.96	Contact Map
3vwc_A	1	0.2607	2	0.96	Contact Map
4fc9_B	1	0.3175	1.9	0.961	Contact Map
3rjp_A	1	0.1943	1.9	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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