GREMLIN Database
T0912_100-310_1_211 - T0912_100-310 1-211
ID: 76 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 211 (192)
Sequences: 2106 (1774)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_V178_K5.5791.00
59_E165_D5.0811.00
5_V8_E3.8181.00
165_D169_E3.7481.00
173_D176_A3.4611.00
4_P10_V3.4081.00
15_G197_I2.9611.00
52_A181_Y2.5461.00
18_I30_A2.5331.00
31_D178_K2.5281.00
203_T206_Q2.4851.00
98_Y174_I2.4021.00
22_K29_V2.3281.00
42_F172_H2.1961.00
161_R180_Y2.1831.00
56_R156_Y2.1711.00
160_A163_L2.1071.00
99_A114_I2.0491.00
17_R195_E2.0451.00
188_K191_D1.9591.00
54_R158_T1.9501.00
48_N194_T1.9471.00
54_R159_N1.9081.00
59_E169_E1.8881.00
24_Q29_V1.8731.00
16_I200_A1.8591.00
172_H177_R1.8541.00
47_V181_Y1.8121.00
47_V52_A1.7781.00
23_K28_W1.7671.00
189_L194_T1.6851.00
43_R100_E1.6571.00
99_A160_A1.6501.00
50_K184_R1.6351.00
184_R187_E1.6241.00
24_Q27_L1.6061.00
41_D174_I1.5971.00
61_F64_M1.5851.00
24_Q161_R1.5681.00
29_V180_Y1.5121.00
81_A155_F1.4801.00
44_Q51_K1.4261.00
96_A99_A1.4111.00
45_L179_V1.3881.00
188_K194_T1.3831.00
40_L198_V1.3721.00
102_V111_N1.3361.00
52_A187_E1.3351.00
114_I157_L1.3281.00
31_D176_A1.3181.00
27_L161_R1.3071.00
128_F132_E1.2721.00
13_S197_I1.2651.00
96_A162_E1.2601.00
55_A164_L1.2511.00
27_L182_Y1.2401.00
52_A184_R1.2140.99
42_F198_V1.2140.99
157_L163_L1.2000.99
168_G183_P1.2000.99
167_A182_Y1.1930.99
116_S127_R1.1760.99
44_Q199_P1.1730.99
32_V172_H1.1610.99
32_V179_V1.1510.99
159_N171_Y1.1500.99
118_E124_A1.1390.99
54_R100_E1.1210.99
7_D10_V1.1180.99
93_A163_L1.1060.99
183_P189_L1.1050.99
121_G124_A1.0950.99
191_D194_T1.0880.99
64_M67_I1.0720.99
27_L180_Y1.0470.98
14_G204_L1.0470.98
45_L196_V1.0450.98
47_V196_V1.0430.98
26_K182_Y1.0410.98
22_K31_D1.0400.98
12_L204_L1.0380.98
181_Y187_E1.0340.98
3_R6_A1.0270.98
181_Y184_R1.0180.98
100_E111_N1.0150.98
111_N158_T1.0130.98
47_V184_R0.9990.98
25_G182_Y0.9930.98
69_S72_E0.9920.98
161_R171_Y0.9920.98
93_A96_A0.9920.98
32_V40_L0.9830.98
57_D163_L0.9820.98
102_V158_T0.9770.98
18_I198_V0.9670.97
102_V156_Y0.9550.97
42_F199_P0.9500.97
161_R182_Y0.9500.97
128_F131_P0.9500.97
129_H132_E0.9470.97
168_G187_E0.9310.97
31_D177_R0.9280.97
79_V82_V0.9260.97
201_I204_L0.9200.96
28_W189_L0.9200.96
99_A103_L0.9180.96
53_V169_E0.9120.96
53_V56_R0.9110.96
68_C71_D0.9090.96
20_G30_A0.9080.96
35_F177_R0.9070.96
59_E166_V0.9060.96
121_G125_A0.8980.96
30_A179_V0.8960.96
4_P8_E0.8950.96
49_G195_E0.8940.96
55_A165_D0.8840.96
189_L196_V0.8820.95
95_K98_Y0.8730.95
35_F39_P0.8720.95
81_A84_I0.8690.95
47_V194_T0.8650.95
54_R199_P0.8650.95
119_L124_A0.8640.95
171_Y174_I0.8610.95
95_K162_E0.8540.95
32_V177_R0.8530.95
45_L181_Y0.8510.95
45_L198_V0.8490.94
21_W179_V0.8450.94
48_N195_E0.8430.94
95_K99_A0.8420.94
53_V165_D0.8400.94
102_V109_V0.8330.94
115_R129_H0.8210.93
75_E78_Y0.8180.93
53_V166_V0.8170.93
76_I80_P0.8120.93
170_W184_R0.8120.93
101_M157_L0.8110.93
157_L160_A0.8060.93
55_A169_E0.8010.93
100_E113_R0.7960.92
56_R59_E0.7870.92
24_Q180_Y0.7860.92
77_L80_P0.7840.92
79_V83_A0.7810.92
159_N204_L0.7810.92
187_E194_T0.7800.92
168_G184_R0.7740.91
81_A86_R0.7730.91
73_K76_I0.7730.91
110_A133_S0.7710.91
56_R165_D0.7680.91
162_E171_Y0.7650.91
112_L132_E0.7550.90
55_A163_L0.7540.90
117_V124_A0.7500.90
24_Q28_W0.7490.90
42_F179_V0.7480.90
77_L81_A0.7480.90
156_Y169_E0.7480.90
93_A162_E0.7420.89
56_R169_E0.7380.89
26_K183_P0.7380.89
90_G93_A0.7330.89
201_I205_I0.7310.89
4_P9_K0.7280.88
100_E103_L0.7270.88
104_H154_A0.7240.88
73_K77_L0.7170.88
106_M153_S0.7160.88
44_Q54_R0.7140.88
12_L205_I0.7130.87
22_K176_A0.7120.87
50_K176_A0.7100.87
46_W199_P0.7100.87
44_Q170_W0.7090.87
40_L177_R0.7080.87
94_L173_D0.7010.87
190_Q194_T0.6970.86
58_V61_F0.6960.86
1_V17_R0.6880.86
57_D165_D0.6870.85
34_M176_A0.6850.85
118_E121_G0.6810.85
32_V35_F0.6760.85
112_L128_F0.6750.84
43_R199_P0.6690.84
98_Y104_H0.6620.83
22_K33_P0.6600.83
13_S204_L0.6570.83
32_V42_F0.6560.83
21_W28_W0.6550.83
84_I157_L0.6500.82
27_L164_L0.6430.81
106_M154_A0.6430.81
167_A183_P0.6420.81
175_D190_Q0.6410.81
96_A163_L0.6410.81
159_N199_P0.6390.81
73_K78_Y0.6380.81
42_F54_R0.6380.81
72_E75_E0.6380.81
99_A157_L0.6360.81
113_R129_H0.6220.79
77_L83_A0.6210.79
51_K199_P0.6200.79
55_A59_E0.6180.79
66_R69_S0.6170.79
104_H152_N0.6160.79
43_R54_R0.6150.79
18_I179_V0.6140.78
21_W30_A0.6130.78
166_V182_Y0.6120.78
97_K101_M0.6080.78
107_W110_A0.6080.78
14_G70_V0.6020.77
23_K26_K0.6020.77
23_K189_L0.6010.77
86_R90_G0.5990.77
33_P177_R0.5990.77
81_A85_R0.5970.76
34_M40_L0.5960.76
149_D153_S0.5940.76
77_L126_I0.5940.76
99_A102_V0.5910.76
57_D169_E0.5900.76
149_D152_N0.5900.76
15_G199_P0.5830.75
79_V125_A0.5830.75
48_N187_E0.5820.75
5_V10_V0.5810.75
128_F133_S0.5810.75
71_D74_N0.5790.74
143_R149_D0.5780.74
61_F65_N0.5780.74
199_P204_L0.5780.74
90_G94_L0.5690.73
15_G54_R0.5650.73
155_F170_W0.5650.73
46_W51_K0.5580.72
99_A104_H0.5560.71
100_E159_N0.5560.71
105_Q110_A0.5530.71
58_V156_Y0.5520.71
15_G51_K0.5500.71
93_A160_A0.5500.71
166_V169_E0.5500.71
183_P186_G0.5480.70
104_H156_Y0.5460.70
18_I42_F0.5460.70
23_K29_V0.5450.70
14_G44_Q0.5440.70
118_E125_A0.5420.69
74_N77_L0.5420.69
185_E191_D0.5410.69
74_N80_P0.5400.69
56_R60_D0.5390.69
117_V126_I0.5380.69
12_L206_Q0.5360.69
35_F41_D0.5350.68
33_P178_K0.5290.68
164_L171_Y0.5220.67
166_V175_D0.5220.67
109_V156_Y0.5210.66
55_A157_L0.5210.66
43_R113_R0.5200.66
8_E196_V0.5170.66
100_E104_H0.5160.66
70_V73_K0.5140.65
120_A125_A0.5130.65
113_R172_H0.5130.65
107_W205_I0.5110.65
16_I40_L0.5100.65
68_C153_S0.5100.65
22_K40_L0.5090.65
26_K91_K0.5070.64
114_I126_I0.5070.64
79_V126_I0.5060.64
77_L86_R0.5050.64
132_E135_I0.5040.64
65_N207_V0.5040.64
28_W180_Y0.5030.64
76_I81_A0.5020.64
7_D28_W0.5010.63
76_I79_V0.5000.63
95_K175_D0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vsv_A 1 0.7062 99.8 0.584 Contact Map
1oq1_A 1 0.4265 7.6 0.947 Contact Map
3fil_A 1 0.2607 6.4 0.949 Contact Map
4kmq_A 1 0.4502 3.4 0.955 Contact Map
2vyc_A 1 0.2986 2.7 0.957 Contact Map
4mtz_A 1 0.218 2.1 0.96 Contact Map
4m5s_A 1 0.1801 2.1 0.96 Contact Map
3vwc_A 1 0.2607 2 0.96 Contact Map
4fc9_B 1 0.3175 1.9 0.961 Contact Map
3rjp_A 1 0.1943 1.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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