GREMLIN Database
T0911_1_445 - T0911 1-445
ID: 73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 445 (404)
Sequences: 4158 (2579)
Seq/√Len: 128.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_S195_G4.7901.00
118_G121_S4.1961.00
210_R224_R3.9341.00
178_I186_W3.6181.00
78_L127_A3.5921.00
307_G363_F3.3191.00
89_F93_V3.2531.00
105_G132_F3.2361.00
111_L192_G2.8891.00
104_F199_S2.8521.00
217_K221_D2.8381.00
270_T427_A2.8261.00
120_M124_G2.8151.00
289_T292_K2.7911.00
100_F203_F2.6961.00
201_I205_V2.6581.00
142_R146_S2.5971.00
64_T67_E2.5711.00
207_Q213_K2.5681.00
299_V360_A2.4851.00
96_R207_Q2.4481.00
86_G134_A2.4161.00
42_I195_G2.3311.00
66_A412_Q2.2501.00
114_G189_I2.2311.00
353_M357_C2.1501.00
221_D225_D2.1401.00
303_A360_A2.1081.00
266_A430_G2.0801.00
46_D133_E2.0791.00
109_A132_F2.0791.00
33_L156_A2.0711.00
82_C134_A2.0571.00
37_F166_V2.0541.00
169_A302_L2.0271.00
65_K412_Q2.0221.00
42_I198_W1.9881.00
196_I200_L1.9741.00
71_V122_L1.9431.00
217_K220_L1.9171.00
248_D251_L1.9131.00
77_W401_I1.8991.00
265_F399_G1.8831.00
70_Y405_L1.8741.00
73_S401_I1.8611.00
112_F115_F1.8441.00
342_C364_F1.8291.00
75_F79_Y1.8211.00
208_P211_L1.8011.00
200_L204_K1.8011.00
220_L224_R1.7931.00
315_A322_G1.7691.00
297_T300_P1.7691.00
380_A388_T1.7661.00
197_I201_I1.7421.00
84_I394_F1.7251.00
60_E185_H1.7171.00
35_M205_V1.7111.00
278_F346_A1.7111.00
37_F163_G1.7071.00
27_R219_E1.7051.00
106_W133_E1.7031.00
178_I190_V1.7011.00
54_S58_Q1.7001.00
147_W209_P1.6801.00
102_A135_P1.6801.00
54_S68_M1.6671.00
312_G316_D1.6321.00
109_A128_I1.6291.00
321_K325_L1.6271.00
196_I199_S1.6241.00
266_A426_V1.6161.00
108_V112_F1.6151.00
322_G378_S1.6131.00
29_R152_E1.6051.00
148_F156_A1.5911.00
54_S280_N1.5901.00
261_Y395_A1.5871.00
433_S437_L1.5851.00
63_I67_E1.5761.00
273_F423_I1.5721.00
199_S203_F1.5661.00
407_V419_A1.5501.00
342_C358_L1.5471.00
215_I220_L1.5411.00
27_R30_Y1.5181.00
262_L433_S1.5111.00
68_M72_F1.5081.00
80_T397_G1.5021.00
111_L115_F1.4991.00
272_W400_G1.4961.00
64_T412_Q1.4941.00
75_F133_E1.4831.00
49_N191_T1.4741.00
46_D106_W1.4731.00
207_Q212_T1.4681.00
100_F199_S1.4521.00
81_L127_A1.4421.00
334_I364_F1.4371.00
349_T358_L1.4221.00
269_S403_V1.4191.00
86_G135_P1.4181.00
222_Y226_G1.4031.00
83_Q393_N1.3941.00
113_Q122_L1.3881.00
82_C131_I1.3871.00
314_V325_L1.3841.00
345_G358_L1.3841.00
410_L418_P1.3821.00
109_A125_L1.3761.00
178_I182_L1.3571.00
219_E223_I1.3511.00
74_A123_I1.3501.00
154_A315_A1.3481.00
173_P176_I1.3481.00
83_Q101_I1.3431.00
37_F41_V1.3401.00
91_D142_R1.3391.00
96_R203_F1.3361.00
90_L139_T1.3291.00
175_L187_V1.3251.00
163_G167_G1.3211.00
76_A400_G1.3191.00
215_I219_E1.3131.00
162_S309_L1.3111.00
218_A221_D1.3071.00
28_R212_T1.3031.00
421_V425_A1.2971.00
158_G312_G1.2881.00
411_A419_A1.2851.00
69_G408_G1.2821.00
198_W202_W1.2811.00
103_I198_W1.2751.00
182_L186_W1.2751.00
93_V98_T1.2741.00
264_Q268_A1.2731.00
268_A396_G1.2641.00
288_I352_P1.2641.00
311_S367_G1.2611.00
314_V318_L1.2611.00
269_S423_I1.2571.00
94_G98_T1.2511.00
375_L379_L1.2441.00
127_A131_I1.2441.00
107_S196_I1.2421.00
264_Q396_G1.2411.00
278_F359_M1.2361.00
310_L314_V1.2331.00
342_C361_L1.2281.00
300_P360_A1.2140.99
269_S407_V1.2090.99
183_S186_W1.2060.99
320_R324_S1.2010.99
63_I122_L1.1980.99
340_S428_L1.1880.99
80_T398_L1.1750.99
154_A316_D1.1740.99
141_N389_G1.1730.99
249_W387_L1.1710.99
40_V137_F1.1690.99
82_C86_G1.1560.99
223_I226_G1.1540.99
85_P134_A1.1510.99
117_T121_S1.1510.99
216_S219_E1.1450.99
178_I187_V1.1420.99
53_A187_V1.1380.99
154_A379_L1.1370.99
172_T176_I1.1340.99
50_L71_V1.1330.99
53_A179_Q1.1320.99
162_S165_F1.1280.99
221_D224_R1.1210.99
104_F196_I1.1180.99
91_D387_L1.1180.99
172_T297_T1.1170.99
69_G73_S1.1120.99
123_I127_A1.1110.99
257_L388_T1.1110.99
143_M206_Y1.1070.99
95_S143_M1.1010.99
70_Y74_A1.1000.99
110_T129_T1.0990.99
28_R223_I1.0940.99
24_K28_R1.0860.99
113_Q125_L1.0820.99
310_L313_W1.0700.99
111_L193_G1.0700.99
282_L356_M1.0650.99
189_I193_G1.0630.99
224_R228_G1.0620.99
112_F125_L1.0580.99
45_V191_T1.0500.98
296_M300_P1.0500.98
257_L261_Y1.0480.98
345_G348_Y1.0460.98
212_T215_I1.0450.98
39_T136_A1.0430.98
106_W129_T1.0360.98
66_A409_Y1.0330.98
303_A363_F1.0300.98
53_A188_F1.0290.98
81_L85_P1.0280.98
344_M424_S1.0190.98
114_G185_H1.0170.98
43_C136_A1.0120.98
117_T185_H1.0040.98
306_V310_L1.0030.98
315_A321_K1.0020.98
264_Q392_F1.0020.98
113_Q129_T1.0010.98
348_Y421_V0.9950.98
155_S313_W0.9940.98
53_A57_I0.9920.98
71_V119_L0.9900.98
268_A399_G0.9890.98
35_M202_W0.9850.98
209_P219_E0.9790.98
426_V430_G0.9770.98
259_G437_L0.9760.98
311_S314_V0.9750.98
169_A305_F0.9750.98
149_P223_I0.9740.97
155_S316_D0.9710.97
282_L296_M0.9680.97
70_Y409_Y0.9670.97
33_L159_F0.9620.97
186_W190_V0.9610.97
376_V388_T0.9590.97
29_R148_F0.9550.97
176_I290_A0.9550.97
284_Q416_F0.9520.97
409_Y413_G0.9490.97
40_V136_A0.9460.97
157_V161_T0.9440.97
60_E182_L0.9430.97
422_Y426_V0.9400.97
313_W317_L0.9380.97
327_F435_I0.9370.97
273_F407_V0.9360.97
49_N187_V0.9350.97
344_M348_Y0.9300.97
280_N416_F0.9300.97
83_Q102_A0.9300.97
67_E119_L0.9290.97
357_C361_L0.9170.96
39_T198_W0.9150.96
28_R31_L0.9150.96
45_V171_L0.9100.96
212_T219_E0.9080.96
340_S424_S0.9040.96
332_P430_G0.8940.96
80_T394_F0.8930.96
303_A307_G0.8920.96
207_Q211_L0.8910.96
333_I431_A0.8840.96
265_F400_G0.8830.96
316_D322_G0.8820.96
89_F98_T0.8780.95
315_A371_I0.8710.95
261_Y391_V0.8680.95
24_K222_Y0.8660.95
315_A325_L0.8650.95
215_I223_I0.8650.95
28_R214_G0.8600.95
179_Q187_V0.8590.95
335_C427_A0.8590.95
32_T36_I0.8570.95
141_N157_V0.8550.95
142_R386_G0.8520.95
410_L415_G0.8460.94
407_V423_I0.8440.94
73_S76_A0.8440.94
225_D229_L0.8430.94
79_Y393_N0.8410.94
279_P408_G0.8400.94
31_L34_V0.8380.94
202_W206_Y0.8380.94
49_N175_L0.8350.94
111_L189_I0.8300.94
35_M198_W0.8290.94
97_V101_I0.8280.94
49_N133_E0.8270.94
265_F426_V0.8260.94
209_P212_T0.8230.94
103_I195_G0.8230.94
219_E222_Y0.8220.93
26_G218_A0.8200.93
155_S158_G0.8200.93
44_Y79_Y0.8180.93
44_Y47_R0.8160.93
406_V422_Y0.8160.93
70_Y123_I0.8150.93
149_P152_E0.8130.93
147_W152_E0.8130.93
410_L419_A0.8120.93
46_D129_T0.8090.93
78_L82_C0.8090.93
73_S404_P0.8060.93
425_A429_I0.8030.93
163_G166_V0.8020.93
252_V391_V0.7990.92
121_S125_L0.7990.92
402_T406_V0.7980.92
417_A421_V0.7930.92
376_V392_F0.7890.92
252_V257_L0.7860.92
135_P138_P0.7850.92
373_W389_G0.7830.92
175_L191_T0.7820.92
108_V196_I0.7820.92
406_V409_Y0.7810.92
258_I261_Y0.7810.92
262_L429_I0.7790.92
407_V411_A0.7790.92
76_A83_Q0.7780.91
88_W92_R0.7770.91
59_E197_I0.7760.91
349_T354_M0.7730.91
54_S57_I0.7720.91
58_Q280_N0.7700.91
178_I191_T0.7700.91
281_Y285_E0.7690.91
109_A129_T0.7680.91
266_A429_I0.7670.91
393_N400_G0.7650.91
78_L131_I0.7640.91
43_C153_R0.7620.91
399_G403_V0.7600.91
26_G216_S0.7580.90
304_A363_F0.7570.90
173_P177_W0.7570.90
116_A121_S0.7550.90
281_Y286_K0.7540.90
121_S124_G0.7480.90
39_T103_I0.7470.90
304_A366_N0.7470.90
103_I107_S0.7460.90
411_A416_F0.7460.90
115_F189_I0.7450.90
24_K27_R0.7410.89
263_G434_Y0.7400.89
119_L123_I0.7400.89
394_F397_G0.7380.89
260_V375_L0.7360.89
289_T294_G0.7330.89
253_F391_V0.7330.89
408_G412_Q0.7330.89
124_G128_I0.7320.89
248_D252_V0.7290.89
260_V379_L0.7260.88
43_C106_W0.7230.88
125_L128_I0.7230.88
65_K284_Q0.7210.88
397_G400_G0.7200.88
31_L205_V0.7200.88
166_V169_A0.7130.88
39_T99_Y0.7130.88
137_F396_G0.7120.87
334_I361_L0.7110.87
26_G30_Y0.7100.87
416_F419_A0.7070.87
147_W219_E0.7060.87
162_S305_F0.7030.87
58_Q65_K0.7030.87
166_V301_F0.7020.87
410_L414_Y0.7020.87
166_V377_S0.7000.87
240_A245_T0.7000.87
87_G91_D0.7000.87
111_L196_I0.6970.86
354_M357_C0.6960.86
48_A51_A0.6950.86
32_T212_T0.6950.86
414_Y418_P0.6940.86
264_Q393_N0.6940.86
356_M360_A0.6940.86
332_P427_A0.6930.86
152_E222_Y0.6930.86
264_Q372_T0.6920.86
56_H59_E0.6920.86
375_L378_S0.6920.86
277_W407_V0.6910.86
71_V113_Q0.6890.86
68_M71_V0.6890.86
50_L57_I0.6890.86
197_I238_K0.6860.85
58_Q68_M0.6830.85
101_I105_G0.6820.85
68_M276_T0.6820.85
224_R227_G0.6790.85
88_W387_L0.6780.85
167_G198_W0.6770.85
55_A283_T0.6740.84
225_D228_G0.6730.84
108_V111_L0.6730.84
314_V321_K0.6720.84
50_L54_S0.6720.84
418_P422_Y0.6720.84
55_A280_N0.6710.84
105_G109_A0.6690.84
294_G298_T0.6680.84
182_L185_H0.6680.84
116_A182_L0.6660.84
110_T136_A0.6650.84
54_S72_F0.6630.83
163_G198_W0.6590.83
373_W376_V0.6560.83
272_W276_T0.6530.83
167_G171_L0.6510.82
66_A70_Y0.6510.82
221_D229_L0.6500.82
415_G418_P0.6500.82
374_S378_S0.6490.82
158_G162_S0.6490.82
165_F308_V0.6480.82
110_T187_V0.6470.82
57_I63_I0.6460.82
129_T133_E0.6450.82
194_I197_I0.6440.82
291_L295_F0.6440.82
152_E155_S0.6430.82
29_R33_L0.6420.81
358_L361_L0.6390.81
100_F202_W0.6390.81
209_P223_I0.6370.81
144_V160_Y0.6360.81
51_A272_W0.6360.81
44_Y167_G0.6360.81
55_A293_A0.6350.81
47_R79_Y0.6330.81
25_P222_Y0.6330.81
69_G405_L0.6330.81
292_K296_M0.6300.80
355_I359_M0.6300.80
432_L436_L0.6270.80
76_A272_W0.6260.80
204_K213_K0.6250.80
306_V429_I0.6250.80
70_Y81_L0.6250.80
56_H179_Q0.6240.80
197_I200_L0.6240.80
78_L90_L0.6230.79
35_M39_T0.6230.79
106_W277_W0.6220.79
187_V191_T0.6220.79
265_F396_G0.6200.79
44_Y275_L0.6200.79
44_Y301_F0.6190.79
58_Q415_G0.6190.79
153_R415_G0.6180.79
98_T105_G0.6180.79
250_K255_R0.6160.79
371_I374_S0.6160.79
282_L286_K0.6150.79
283_T289_T0.6150.79
95_S98_T0.6140.79
288_I292_K0.6130.78
126_R130_G0.6120.78
87_G90_L0.6060.78
136_A391_V0.6060.78
152_E219_E0.6050.78
390_G394_F0.6040.77
35_M201_I0.6020.77
57_I189_I0.6020.77
134_A138_P0.6010.77
264_Q301_F0.6010.77
98_T135_P0.6000.77
201_I204_K0.5990.77
88_W91_D0.5970.77
222_Y227_G0.5970.77
404_P419_A0.5930.76
264_Q399_G0.5930.76
401_I405_L0.5900.76
189_I391_V0.5900.76
107_S199_S0.5890.76
324_S328_A0.5890.76
160_Y164_Q0.5860.75
193_G217_K0.5850.75
63_I68_M0.5840.75
342_C345_G0.5830.75
61_F116_A0.5820.75
44_Y272_W0.5810.75
43_C46_D0.5800.75
59_E351_D0.5800.75
276_T404_P0.5800.75
34_V38_I0.5770.74
29_R156_A0.5760.74
52_V172_T0.5750.74
155_S159_F0.5740.74
98_T101_I0.5730.74
69_G404_P0.5720.74
145_T399_G0.5700.73
141_N376_V0.5690.73
148_F160_Y0.5690.73
346_A359_M0.5680.73
141_N400_G0.5680.73
400_G404_P0.5680.73
344_M347_N0.5680.73
83_Q87_G0.5660.73
296_M299_V0.5660.73
80_T401_I0.5650.73
120_M123_I0.5630.72
141_N161_T0.5630.72
351_D354_M0.5630.72
61_F114_G0.5620.72
335_C365_G0.5600.72
94_G137_F0.5600.72
97_V433_S0.5580.72
334_I342_C0.5580.72
176_I291_L0.5570.72
158_G308_V0.5570.72
326_G371_I0.5570.72
247_K251_L0.5550.71
156_A159_F0.5550.71
231_D429_I0.5550.71
389_G393_N0.5550.71
286_K352_P0.5540.71
165_F366_N0.5530.71
87_G139_T0.5510.71
426_V429_I0.5510.71
431_A435_I0.5490.70
266_A403_V0.5490.70
256_K379_L0.5480.70
309_L313_W0.5480.70
116_A287_G0.5470.70
71_V123_I0.5470.70
264_Q369_A0.5450.70
268_A397_G0.5440.70
208_P429_I0.5440.70
138_P393_N0.5430.70
269_S426_V0.5420.69
150_E378_S0.5420.69
229_L262_L0.5410.69
30_Y34_V0.5390.69
398_L401_I0.5390.69
72_F276_T0.5390.69
126_R133_E0.5390.69
222_Y225_D0.5380.69
110_T191_T0.5370.69
195_G375_L0.5370.69
226_G229_L0.5340.68
29_R223_I0.5340.68
69_G407_V0.5310.68
116_A125_L0.5310.68
257_L391_V0.5310.68
288_I296_M0.5310.68
170_F253_F0.5290.68
45_V50_L0.5290.68
333_I341_T0.5290.68
83_Q139_T0.5280.68
73_S405_L0.5280.68
373_W393_N0.5270.67
308_V370_S0.5260.67
209_P215_I0.5250.67
268_A272_W0.5250.67
393_N397_G0.5240.67
299_V303_A0.5240.67
168_L267_V0.5240.67
282_L290_A0.5230.67
51_A54_S0.5230.67
345_G351_D0.5220.67
144_V156_A0.5210.66
69_G75_F0.5200.66
238_K429_I0.5200.66
281_Y428_L0.5190.66
41_V166_V0.5190.66
75_F83_Q0.5180.66
165_F304_A0.5170.66
271_L275_L0.5170.66
381_P384_L0.5160.66
286_K349_T0.5160.66
86_G98_T0.5150.66
246_A249_W0.5150.66
325_L329_R0.5150.66
312_G411_A0.5150.66
398_L402_T0.5130.65
46_D75_F0.5130.65
44_Y164_Q0.5130.65
166_V305_F0.5130.65
404_P408_G0.5120.65
408_G411_A0.5120.65
167_G256_K0.5110.65
70_Y77_W0.5110.65
66_A81_L0.5100.65
262_L266_A0.5100.65
157_V377_S0.5090.65
216_S223_I0.5090.65
139_T146_S0.5080.65
194_I198_W0.5070.64
24_K96_R0.5070.64
132_F387_L0.5060.64
158_G173_P0.5060.64
29_R32_T0.5050.64
428_L432_L0.5050.64
213_K219_E0.5040.64
193_G333_I0.5040.64
46_D277_W0.5030.64
161_T264_Q0.5030.64
365_G427_A0.5020.64
225_D402_T0.5020.64
168_L272_W0.5010.64
261_Y266_A0.5010.64
69_G106_W0.5000.63
220_L226_G0.5000.63
220_L223_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4_A 1 0.9169 100 0.531 Contact Map
4j05_A 1 0.8225 100 0.566 Contact Map
4yb9_D 1 0.8899 100 0.577 Contact Map
4zw9_A 1 0.9191 100 0.587 Contact Map
4gc0_A 1 0.9191 100 0.602 Contact Map
3o7q_A 1 0.8584 100 0.606 Contact Map
4lds_A 1 0.9124 100 0.607 Contact Map
4zp0_A 1 0.8697 100 0.613 Contact Map
2cfq_A 1 0.8809 100 0.616 Contact Map
4xnj_A 1 0.8989 100 0.621 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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