GREMLIN Database
T0866_1_183 - T0866 1-183
ID: 7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 183 (158)
Sequences: 2983 (1609)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_S114_L3.7591.00
43_Y81_R3.3641.00
45_T81_R3.1711.00
70_D83_T2.9291.00
72_T83_T2.7581.00
46_F101_I2.7321.00
129_K132_D2.6791.00
41_T83_T2.6061.00
43_Y133_T2.5821.00
44_A84_L2.5321.00
43_Y83_T2.5261.00
84_L112_L2.4901.00
74_D81_R2.4321.00
72_T81_R2.2161.00
69_A85_E2.1521.00
99_L114_L2.1311.00
38_P88_Q2.1011.00
41_T130_D2.0951.00
45_T133_T2.0791.00
128_L132_D2.0181.00
60_I65_V2.0061.00
54_A71_I1.9811.00
42_L84_L1.9331.00
57_P64_V1.9011.00
52_L82_V1.8081.00
50_G140_A1.7991.00
95_D119_E1.7491.00
64_V67_R1.7251.00
49_I52_L1.7021.00
164_D167_A1.6911.00
100_S115_N1.6661.00
54_A70_D1.6641.00
102_R113_A1.6351.00
39_T85_E1.5971.00
150_F154_S1.5921.00
49_I71_I1.5781.00
92_H127_I1.5651.00
56_S109_E1.5571.00
42_L130_D1.5391.00
161_N164_D1.5241.00
158_D161_N1.5191.00
93_I97_S1.5101.00
47_D139_S1.4701.00
99_L134_I1.4681.00
105_G109_E1.4661.00
98_S115_N1.4631.00
39_T88_Q1.3771.00
45_T79_L1.3631.00
160_K164_D1.3391.00
52_L71_I1.3121.00
142_V145_D1.3041.00
56_S68_V1.3041.00
96_T117_G1.2991.00
98_S138_K1.2711.00
94_P97_S1.2661.00
41_T69_A1.2321.00
46_F82_V1.2251.00
40_Y130_D1.2160.99
104_S109_E1.1890.99
44_A137_T1.1790.99
86_I90_Y1.1500.99
84_L99_L1.1360.99
13_F24_V1.1350.99
22_L26_L1.1320.99
8_I12_I1.1100.99
96_T119_E1.0920.99
59_S64_V1.0910.99
50_G110_Q1.0800.99
34_I37_E1.0710.99
101_I140_A1.0580.99
128_L134_I1.0570.99
46_F137_T1.0500.98
60_I93_I1.0440.98
162_S165_A1.0340.98
95_D132_D1.0260.98
42_L132_D1.0210.98
69_A83_T1.0180.98
134_I137_T0.9990.98
5_K9_W0.9940.98
100_S138_K0.9780.98
59_S111_Y0.9770.98
151_L155_K0.9670.97
110_Q144_E0.9600.97
150_F153_G0.9560.97
122_E127_I0.9500.97
65_V86_I0.9490.97
42_L128_L0.9390.97
93_I128_L0.9180.96
4_K8_I0.9020.96
63_V150_F0.8920.96
63_V111_Y0.8880.96
69_A84_L0.8870.96
95_D122_E0.8860.96
59_S104_S0.8830.96
7_E10_V0.8700.95
96_T118_F0.8620.95
148_G152_Y0.8510.95
121_P127_I0.8510.95
28_A31_V0.8500.94
65_V93_I0.8440.94
47_D135_Q0.8410.94
71_I80_P0.8240.94
57_P104_S0.8240.94
71_I82_V0.8190.93
14_L18_L0.8190.93
99_L112_L0.8140.93
162_S166_P0.8130.93
40_Y86_I0.8110.93
16_A20_A0.8110.93
52_L56_S0.8050.93
137_T147_I0.7880.92
42_L86_I0.7880.92
78_Y127_I0.7830.92
49_I82_V0.7760.91
19_L22_L0.7720.91
25_C30_N0.7670.91
23_F28_A0.7610.91
10_V13_F0.7530.90
21_A107_L0.7480.90
103_T106_L0.7470.90
47_D137_T0.7380.89
101_I112_L0.7370.89
98_S117_G0.7290.89
52_L148_G0.7240.88
93_I102_R0.7200.88
55_R67_R0.7180.88
94_P107_L0.7160.88
161_N167_A0.7140.88
141_M149_Q0.7110.87
49_I112_L0.7090.87
82_V137_T0.7080.87
90_Y93_I0.7040.87
45_T74_D0.6950.86
7_E11_G0.6950.86
163_G166_P0.6910.86
25_C29_A0.6890.86
94_P116_V0.6880.86
26_L32_T0.6870.85
60_I116_V0.6870.85
44_A136_D0.6820.85
108_G111_Y0.6780.85
159_N162_S0.6780.85
114_L134_I0.6770.85
19_L92_H0.6700.84
94_P127_I0.6690.84
93_I127_I0.6660.84
17_A107_L0.6640.83
17_A28_A0.6620.83
93_I117_G0.6500.82
118_F138_K0.6440.82
47_D79_L0.6440.82
159_N163_G0.6420.81
51_G62_G0.6410.81
56_S103_T0.6390.81
92_H129_K0.6380.81
50_G112_L0.6300.80
161_N165_A0.6300.80
13_F16_A0.6250.80
49_I80_P0.6230.79
30_N33_S0.6210.79
16_A45_T0.6210.79
24_V102_R0.6180.79
15_L145_D0.6180.79
144_E165_A0.6110.78
113_A149_Q0.6100.78
4_K76_K0.6080.78
11_G15_L0.6050.77
20_A24_V0.6040.77
140_A150_F0.6040.77
99_L137_T0.5980.77
71_I104_S0.5980.77
19_L75_P0.5960.76
154_S157_D0.5920.76
111_Y144_E0.5870.75
139_S148_G0.5870.75
26_L37_E0.5860.75
42_L112_L0.5850.75
70_D166_P0.5850.75
97_S116_V0.5820.75
37_E87_E0.5770.74
34_I133_T0.5740.74
56_S110_Q0.5700.73
12_I74_D0.5690.73
49_I110_Q0.5650.73
33_S76_K0.5630.72
106_L144_E0.5580.72
106_L163_G0.5570.71
52_L70_D0.5570.71
12_I16_A0.5560.71
17_A113_A0.5540.71
110_Q134_I0.5520.71
62_G66_G0.5510.71
12_I67_R0.5500.71
73_L107_L0.5490.70
159_N165_A0.5490.70
41_T76_K0.5470.70
104_S111_Y0.5460.70
42_L134_I0.5450.70
51_G71_I0.5440.70
67_R114_L0.5420.69
65_V90_Y0.5420.69
56_S143_L0.5400.69
104_S147_I0.5400.69
42_L129_K0.5370.69
98_S136_D0.5350.68
157_D162_S0.5330.68
73_L108_G0.5330.68
30_N145_D0.5320.68
56_S105_G0.5300.68
41_T85_E0.5290.68
17_A57_P0.5290.68
6_N99_L0.5270.67
85_E130_D0.5250.67
145_D149_Q0.5240.67
107_L143_L0.5240.67
42_L133_T0.5230.67
9_W12_I0.5230.67
132_D136_D0.5210.66
74_D77_T0.5210.66
25_C106_L0.5200.66
155_K164_D0.5180.66
149_Q154_S0.5180.66
5_K18_L0.5170.66
50_G113_A0.5170.66
23_F27_K0.5140.65
23_F33_S0.5120.65
18_L109_E0.5120.65
93_I108_G0.5090.65
94_P141_M0.5090.65
49_I100_S0.5090.65
51_G110_Q0.5030.64
25_C28_A0.5030.64
4_K37_E0.5030.64
81_R135_Q0.5010.63
127_I133_T0.5010.63
95_D136_D0.5010.63
60_I80_P0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lpl_A 1 0.4973 17.8 0.934 Contact Map
1yew_A 1 0.9126 9.1 0.942 Contact Map
2lt1_A 1 0.3825 8.4 0.943 Contact Map
3hd7_A 1 0.1694 7.4 0.944 Contact Map
4phz_A 1 0.9454 7.3 0.944 Contact Map
2mc7_A 1 0.1639 5.4 0.948 Contact Map
1eg1_A 1 0.3716 5.3 0.948 Contact Map
3rdv_A 1 0.3825 5.1 0.948 Contact Map
2lx0_A 1 0.1749 3.9 0.951 Contact Map
2gs0_B 1 0.0765 3.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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