GREMLIN Database
PF12673_1_171 - PF12673 1-171
ID: 68 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (146)
Sequences: 1799 (1547)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_N153_M3.6701.00
72_G102_F3.2201.00
128_A131_K3.1021.00
74_L140_A2.8521.00
128_A132_D2.7051.00
66_G110_G2.6151.00
45_D134_R2.5061.00
15_R155_E2.3251.00
19_R153_M2.3091.00
54_G126_I2.3041.00
34_K139_E2.1831.00
64_L67_K2.1511.00
121_V144_I2.1171.00
17_N155_E2.1111.00
67_K105_F1.9971.00
115_M148_V1.9641.00
121_V142_L1.9591.00
111_A148_V1.9591.00
124_E143_D1.8881.00
70_V144_I1.8721.00
28_R143_D1.8071.00
123_V140_A1.8071.00
60_E71_E1.7871.00
39_V96_M1.6951.00
36_D135_T1.6721.00
22_N150_E1.6421.00
22_N152_K1.5501.00
44_P82_A1.5491.00
77_S97_E1.5401.00
19_R151_P1.5271.00
13_V157_V1.5221.00
14_L159_D1.5191.00
78_V136_L1.4741.00
54_G74_L1.4721.00
23_V147_R1.4691.00
56_A121_V1.4661.00
29_T104_Q1.4591.00
16_E158_Q1.4501.00
18_I156_V1.4401.00
73_V99_E1.4381.00
72_G101_P1.4361.00
78_V98_A1.3841.00
24_V115_M1.3831.00
73_V101_P1.3701.00
36_D137_T1.3571.00
64_L69_I1.3451.00
68_I146_A1.3281.00
47_L83_D1.2701.00
126_I140_A1.2611.00
63_L111_A1.2511.00
106_I146_A1.2291.00
116_S151_P1.2241.00
31_A104_Q1.2170.99
49_I78_V1.2150.99
129_R132_D1.1720.99
43_K94_H1.1560.99
68_I111_A1.1470.99
63_L148_V1.1460.99
103_T107_E1.1380.99
76_I100_V1.1320.99
30_Q141_V1.1280.99
61_T117_K1.1070.99
75_E99_E1.1050.99
39_V134_R1.0950.99
46_I129_R1.0940.99
84_V90_E1.0850.99
104_Q107_E1.0630.99
69_I103_T1.0550.99
26_E145_K1.0520.98
112_R115_M1.0490.98
56_A123_V1.0400.98
23_V149_F1.0400.98
71_E103_T1.0390.98
75_E97_E1.0290.98
44_P94_H1.0270.98
25_G148_V1.0240.98
82_A94_H1.0230.98
27_A106_I1.0000.98
76_I138_V0.9990.98
111_A115_M0.9810.98
24_V150_E0.9800.98
26_E147_R0.9750.97
110_G115_M0.9650.97
67_K107_E0.9650.97
77_S95_F0.9450.97
41_E135_T0.9390.97
25_G108_V0.9330.97
65_D113_E0.9180.96
39_V46_I0.9150.96
38_S135_T0.8990.96
154_I158_Q0.8790.95
68_I108_V0.8730.95
115_M150_E0.8680.95
44_P83_D0.8510.95
96_M136_L0.8500.94
20_V154_I0.8480.94
25_G110_G0.8430.94
66_G109_E0.8430.94
41_E45_D0.8420.94
50_I93_V0.8370.94
64_L105_F0.8330.94
59_N73_V0.8310.94
44_P80_Y0.8280.94
56_A102_F0.8270.94
28_R145_K0.8260.94
110_G148_V0.8240.94
18_I40_P0.8160.93
12_Q79_L0.8140.93
39_V43_K0.8090.93
33_V102_F0.8030.93
139_E161_F0.7980.92
117_K121_V0.7870.92
60_E100_V0.7850.92
44_P134_R0.7850.92
40_P43_K0.7800.92
31_A35_S0.7760.91
120_K145_K0.7750.91
25_G68_I0.7700.91
35_S100_V0.7630.91
25_G111_A0.7570.90
37_V98_A0.7500.90
58_I73_V0.7440.90
108_V111_A0.7420.89
56_A59_N0.7400.89
30_Q125_H0.7380.89
12_Q162_S0.7310.89
119_V146_A0.7250.88
70_V106_I0.7110.87
33_V74_L0.7100.87
65_D112_R0.7080.87
122_Q143_D0.7040.87
36_D103_T0.6990.86
31_A144_I0.6950.86
14_L158_Q0.6880.86
30_Q143_D0.6870.85
57_R75_E0.6830.85
66_G111_A0.6820.85
84_V92_P0.6800.85
63_L114_D0.6770.85
116_S120_K0.6680.84
112_R145_K0.6630.83
44_P93_V0.6600.83
26_E125_H0.6580.83
24_V148_V0.6560.83
14_L161_F0.6540.83
68_I154_I0.6480.82
52_V56_A0.6420.81
40_P134_R0.6410.81
34_K104_Q0.6400.81
62_K82_A0.6360.81
11_L75_E0.6320.80
21_D151_P0.6300.80
123_V157_V0.6280.80
124_E141_V0.6280.80
74_L102_F0.6270.80
60_E90_E0.6270.80
76_I107_E0.6270.80
38_S131_K0.6210.79
128_A134_R0.6210.79
30_Q104_Q0.6160.79
131_K135_T0.6150.79
123_V126_I0.6140.78
63_L115_M0.6090.78
52_V57_R0.6080.78
125_H141_V0.6070.78
35_S137_T0.6050.77
25_G146_A0.6050.77
62_K67_K0.6050.77
56_A75_E0.6020.77
39_V42_K0.6000.77
127_R137_T0.5990.77
64_L71_E0.5970.76
63_L68_I0.5960.76
21_D116_S0.5960.76
49_I84_V0.5960.76
34_K37_V0.5930.76
40_P96_M0.5880.75
48_E81_V0.5870.75
19_R113_E0.5870.75
50_I58_I0.5810.75
84_V99_E0.5790.74
102_F144_I0.5790.74
48_E137_T0.5770.74
60_E159_D0.5760.74
47_L107_E0.5700.73
13_V160_L0.5670.73
114_D150_E0.5670.73
43_K96_M0.5630.72
59_N82_A0.5570.71
56_A142_L0.5510.71
78_V96_M0.5510.71
27_A111_A0.5500.71
112_R156_V0.5490.70
20_V99_E0.5460.70
52_V141_V0.5430.70
79_L97_E0.5390.69
15_R157_V0.5380.69
13_V16_E0.5370.69
30_Q124_E0.5360.69
37_V102_F0.5350.68
142_L156_V0.5310.68
72_G110_G0.5290.68
19_R69_I0.5230.67
47_L81_V0.5230.67
25_G32_I0.5210.66
20_V35_S0.5170.66
130_K138_V0.5160.66
16_E101_P0.5140.65
32_I141_V0.5110.65
58_I70_V0.5110.65
54_G76_I0.5110.65
42_K45_D0.5090.65
23_V70_V0.5070.64
139_E159_D0.5050.64
29_T144_I0.5050.64
33_V140_A0.5030.64
48_E92_P0.5020.64
67_K127_R0.5020.64
70_V109_E0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yww_A 1 0.4854 1.2 0.942 Contact Map
5gae_H 1 0.3977 0.8 0.947 Contact Map
2m83_A 1 0.7544 0.8 0.948 Contact Map
3q9p_A 1 0.4386 0.7 0.949 Contact Map
2mnu_B 1 0.152 0.7 0.95 Contact Map
1rf8_B 1 0.2924 0.7 0.95 Contact Map
4fei_A 1 0.5965 0.7 0.951 Contact Map
4fyy_B 1 0.5029 0.6 0.952 Contact Map
2hql_A 1 0.3684 0.6 0.952 Contact Map
2b1y_A 1 0.4152 0.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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