GREMLIN Database
T0910_1_345 - T0910 1-345
ID: 65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 345 (306)
Sequences: 4219 (2239)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_C171_Y7.0031.00
132_D258_A5.1191.00
51_V63_M4.5481.00
263_N267_K4.4861.00
139_T222_M4.1801.00
300_G305_T3.9601.00
226_L261_A3.8861.00
147_A288_Q3.8531.00
297_N300_G3.6121.00
263_N290_H3.5391.00
227_T257_I3.3361.00
222_M264_L3.3121.00
35_N52_Q3.0351.00
63_M111_L2.8991.00
135_T222_M2.5761.00
99_Y113_E2.5761.00
270_R275_E2.5701.00
143_V218_L2.5151.00
104_D109_Y2.3091.00
136_R295_G2.3051.00
139_T218_L2.2991.00
113_E173_K2.2201.00
51_V61_F2.1401.00
137_F309_P2.1321.00
39_T47_R2.1161.00
49_E65_I2.0961.00
272_N275_E2.0911.00
43_G46_G2.0421.00
139_T293_F1.9691.00
140_A301_L1.9641.00
35_N54_K1.9351.00
145_A174_L1.9251.00
167_D304_G1.8741.00
285_K288_Q1.8721.00
264_L268_L1.8631.00
278_G283_G1.7711.00
98_L110_M1.7411.00
147_A284_V1.7091.00
132_D292_W1.7021.00
169_R304_G1.6931.00
156_Y159_L1.6921.00
133_S136_R1.6741.00
215_Y284_V1.6681.00
131_E134_T1.6651.00
285_K289_K1.6391.00
234_G239_K1.6271.00
282_N286_D1.6211.00
190_W208_G1.6031.00
216_W232_F1.6011.00
119_E162_E1.5981.00
247_G271_D1.5891.00
212_S279_N1.5871.00
196_P241_Y1.5531.00
143_V215_Y1.5431.00
91_H97_R1.4971.00
158_D163_N1.4751.00
50_L60_T1.4721.00
143_V287_I1.4661.00
301_L306_L1.4621.00
300_G303_K1.4611.00
116_L168_H1.4571.00
34_F100_R1.4521.00
131_E135_T1.4471.00
253_F262_A1.4251.00
147_A151_S1.3951.00
284_V287_I1.3921.00
200_A213_A1.3811.00
165_I175_V1.3711.00
257_I265_I1.3571.00
72_V77_Q1.3561.00
314_V322_N1.3521.00
308_P312_P1.3461.00
260_N294_E1.3401.00
243_I247_G1.3271.00
144_E147_A1.2981.00
68_K103_K1.2981.00
41_G46_G1.2801.00
140_A296_F1.2781.00
39_T42_V1.2711.00
127_R134_T1.2651.00
171_Y308_P1.2621.00
307_T311_I1.2621.00
209_H213_A1.2511.00
48_V62_A1.2501.00
43_G48_V1.2441.00
142_V164_L1.2431.00
160_K163_N1.2411.00
64_K68_K1.2381.00
224_E228_G1.2321.00
29_L53_L1.2241.00
237_P241_Y1.2230.99
40_L50_L1.2230.99
30_K33_D1.2200.99
143_V147_A1.2190.99
310_I322_N1.2140.99
264_L293_F1.2120.99
96_V175_V1.2090.99
144_E302_R1.2050.99
130_F134_T1.2040.99
267_K277_L1.2010.99
67_K70_H1.1830.99
268_L276_R1.1800.99
280_L286_D1.1710.99
147_A285_K1.1690.99
218_L222_M1.1670.99
181_K189_T1.1590.99
319_D323_F1.1430.99
138_Y308_P1.1420.99
197_E240_T1.1420.99
36_I39_T1.1290.99
234_G240_T1.1240.99
314_V319_D1.1190.99
309_P312_P1.1130.99
282_N289_K1.1050.99
158_D176_D1.0980.99
251_I271_D1.0970.99
121_W162_E1.0930.99
149_L154_I1.0910.99
267_K270_R1.0880.99
164_L221_L1.0870.99
142_V221_L1.0800.99
316_S319_D1.0720.99
319_D322_N1.0690.99
76_Q79_H1.0680.99
92_S148_Y1.0630.99
296_F301_L1.0530.98
123_I130_F1.0520.98
62_A68_K1.0490.98
288_Q298_W1.0370.98
53_L57_E1.0340.98
100_R111_L1.0320.98
220_I230_P1.0300.98
50_L114_A1.0260.98
240_T244_I1.0180.98
227_T256_K1.0170.98
232_F244_I1.0170.98
139_T264_L1.0140.98
176_D195_T1.0120.98
52_Q58_S1.0100.98
315_A321_S1.0050.98
216_W219_G1.0040.98
262_A266_K1.0040.98
139_T225_L0.9990.98
192_F199_V0.9970.98
83_E87_M0.9930.98
278_G286_D0.9900.98
120_L225_L0.9880.98
159_L221_L0.9860.98
153_G211_I0.9850.98
48_V64_K0.9800.98
104_D107_Y0.9800.98
135_T226_L0.9730.97
89_G182_K0.9700.97
84_K88_Q0.9680.97
96_V112_M0.9650.97
83_E86_I0.9590.97
84_K101_T0.9560.97
195_T202_E0.9500.97
65_I107_Y0.9500.97
222_M226_L0.9500.97
31_L63_M0.9470.97
36_I63_M0.9470.97
29_L100_R0.9420.97
284_V288_Q0.9410.97
299_E302_R0.9380.97
36_I49_E0.9360.97
29_L34_F0.9280.97
158_D178_G0.9260.97
85_Q88_Q0.9250.97
92_S302_R0.9240.97
160_K176_D0.9230.97
234_G243_I0.9230.97
293_F298_W0.9230.97
214_D219_G0.9200.96
61_F100_R0.9200.96
53_L100_R0.9190.96
195_T198_Y0.9160.96
203_I209_H0.9140.96
176_D194_G0.9120.96
85_Q182_K0.9110.96
51_V111_L0.9090.96
162_E197_E0.9070.96
194_G202_E0.9050.96
203_I213_A0.9050.96
97_R113_E0.9050.96
261_A292_W0.8950.96
242_N246_R0.8950.96
203_I217_S0.8880.96
143_V298_W0.8840.96
247_G250_M0.8830.96
117_G170_G0.8770.95
181_K191_T0.8720.95
39_T49_E0.8670.95
145_A150_H0.8620.95
92_S95_I0.8580.95
92_S145_A0.8540.95
227_T230_P0.8450.94
115_C173_K0.8410.94
258_A261_A0.8390.94
36_I51_V0.8380.94
213_A217_S0.8290.94
253_F265_I0.8280.94
226_L257_I0.8280.94
222_M265_I0.8280.94
146_F218_L0.8260.94
269_C276_R0.8240.94
197_E230_P0.8190.93
60_T318_T0.8190.93
261_A264_L0.8160.93
80_I108_L0.8150.93
37_I50_L0.8140.93
71_I80_I0.8130.93
226_L265_I0.8130.93
259_K262_A0.8120.93
230_P243_I0.8100.93
265_I269_C0.8040.93
239_K242_N0.8010.93
31_L36_I0.8000.92
199_V240_T0.7990.92
324_D328_E0.7990.92
66_L80_I0.7970.92
223_Y227_T0.7970.92
323_F328_E0.7920.92
324_D327_P0.7920.92
143_V284_V0.7920.92
137_F171_Y0.7910.92
268_L277_L0.7900.92
223_Y254_P0.7870.92
313_S322_N0.7830.92
178_G196_P0.7760.91
200_A203_I0.7750.91
42_V47_R0.7740.91
247_G251_I0.7730.91
278_G287_I0.7710.91
214_D224_E0.7700.91
274_S279_N0.7690.91
267_K286_D0.7650.91
196_P199_V0.7650.91
205_L245_L0.7570.90
327_P330_N0.7560.90
45_F48_V0.7550.90
253_F257_I0.7540.90
165_I187_K0.7530.90
198_Y201_P0.7510.90
198_Y202_E0.7490.90
196_P237_P0.7490.90
257_I261_A0.7480.90
299_E303_K0.7470.90
120_L164_L0.7470.90
231_P244_I0.7460.90
268_L278_G0.7420.89
101_T110_M0.7420.89
148_Y152_K0.7420.89
23_A26_F0.7410.89
160_K165_I0.7390.89
287_I290_H0.7380.89
221_L230_P0.7370.89
164_L172_A0.7370.89
37_I52_Q0.7350.89
66_L71_I0.7320.89
55_S58_S0.7310.89
242_N245_L0.7290.89
291_K294_E0.7290.89
135_T292_W0.7290.89
123_I310_I0.7280.88
277_L290_H0.7250.88
138_Y225_L0.7150.88
113_E117_G0.7150.88
68_K102_F0.7110.87
298_W301_L0.7080.87
98_L101_T0.7050.87
146_F149_L0.7030.87
87_M112_M0.7010.87
194_G200_A0.6960.86
64_K83_E0.6950.86
164_L174_L0.6930.86
82_S86_I0.6910.86
229_S233_S0.6890.86
40_L43_G0.6880.86
194_G201_P0.6870.85
115_C165_I0.6850.85
146_F156_Y0.6840.85
180_A220_I0.6820.85
286_D289_K0.6810.85
48_V51_V0.6800.85
209_H224_E0.6790.85
52_Q318_T0.6780.85
70_H74_T0.6770.85
159_L218_L0.6770.85
120_L130_F0.6760.85
308_P311_I0.6760.85
300_G306_L0.6740.84
188_K208_G0.6740.84
233_S240_T0.6720.84
140_A143_V0.6720.84
199_V224_E0.6710.84
132_D261_A0.6710.84
283_G286_D0.6710.84
222_M292_W0.6700.84
144_E306_L0.6700.84
102_F111_L0.6660.84
100_R103_K0.6640.83
30_K34_F0.6620.83
137_F150_H0.6610.83
116_L314_V0.6600.83
40_L46_G0.6590.83
79_H191_T0.6520.82
149_L174_L0.6510.82
198_Y228_G0.6480.82
90_A149_L0.6480.82
194_G198_Y0.6460.82
236_D239_K0.6440.82
192_F241_Y0.6430.81
76_Q125_R0.6430.81
120_L217_S0.6420.81
321_S329_D0.6420.81
220_I224_E0.6410.81
199_V241_Y0.6410.81
296_F300_G0.6400.81
119_E197_E0.6400.81
109_Y167_D0.6390.81
230_P233_S0.6370.81
298_W309_P0.6370.81
155_I183_I0.6360.81
260_N291_K0.6330.80
253_F266_K0.6330.80
141_C172_A0.6320.80
188_K210_D0.6310.80
158_D161_P0.6310.80
41_G48_V0.6310.80
166_L322_N0.6280.80
52_Q60_T0.6280.80
150_H153_G0.6270.80
96_V115_C0.6250.80
163_N178_G0.6220.79
34_F41_G0.6220.79
195_T201_P0.6210.79
223_Y229_S0.6190.79
130_F137_F0.6180.79
278_G293_F0.6180.79
63_M100_R0.6150.79
293_F296_F0.6140.78
297_N303_K0.6140.78
276_R290_H0.6100.78
122_T126_D0.6090.78
273_P276_R0.6090.78
77_Q80_I0.6070.78
153_G183_I0.6060.78
257_I262_A0.6050.77
160_K166_L0.6050.77
293_F297_N0.6050.77
34_F63_M0.6050.77
193_C199_V0.6040.77
215_Y287_I0.6030.77
227_T265_I0.6020.77
280_L283_G0.6020.77
324_D330_N0.6000.77
276_R293_F0.5990.77
168_H203_I0.5990.77
45_F178_G0.5990.77
227_T254_P0.5990.77
123_I127_R0.5970.76
121_W230_P0.5970.76
34_F61_F0.5960.76
189_T193_C0.5960.76
94_F137_F0.5940.76
250_M266_K0.5920.76
215_Y268_L0.5920.76
41_G62_A0.5920.76
53_L61_F0.5920.76
222_M225_L0.5900.76
173_K178_G0.5890.76
98_L108_L0.5840.75
146_F159_L0.5820.75
66_L70_H0.5810.75
259_K291_K0.5810.75
43_G47_R0.5790.74
34_F53_L0.5790.74
134_T310_I0.5780.74
190_W210_D0.5770.74
33_D187_K0.5770.74
43_G64_K0.5750.74
34_F102_F0.5740.74
325_S329_D0.5690.73
205_L236_D0.5680.73
120_L145_A0.5660.73
202_E214_D0.5660.73
140_A292_W0.5650.73
148_Y151_S0.5650.73
61_F99_Y0.5640.72
214_D225_L0.5630.72
265_I295_G0.5590.72
163_N176_D0.5550.71
65_I108_L0.5550.71
264_L277_L0.5550.71
84_K87_M0.5510.71
42_V330_N0.5510.71
214_D228_G0.5510.71
325_S328_E0.5500.71
316_S324_D0.5500.71
146_F217_S0.5500.71
64_K176_D0.5480.70
132_D136_R0.5470.70
36_I67_K0.5470.70
290_H293_F0.5470.70
167_D178_G0.5470.70
107_Y292_W0.5460.70
214_D223_Y0.5460.70
34_F43_G0.5430.70
228_G231_P0.5430.70
202_E219_G0.5430.70
44_G199_V0.5410.69
264_L290_H0.5400.69
81_R108_L0.5400.69
32_S54_K0.5400.69
219_G224_E0.5390.69
166_L172_A0.5380.69
44_G70_H0.5360.69
68_K83_E0.5340.68
60_T66_L0.5330.68
41_G45_F0.5330.68
59_K99_Y0.5320.68
42_V213_A0.5320.68
159_L189_T0.5320.68
322_N326_F0.5310.68
115_C119_E0.5290.68
130_F224_E0.5280.67
160_K178_G0.5270.67
313_S321_S0.5270.67
40_L74_T0.5270.67
209_H215_Y0.5270.67
217_S234_G0.5260.67
173_K196_P0.5250.67
218_L268_L0.5210.66
138_Y312_P0.5200.66
76_Q180_A0.5190.66
268_L284_V0.5160.66
87_M90_A0.5150.66
119_E125_R0.5130.65
250_M270_R0.5130.65
189_T192_F0.5130.65
297_N305_T0.5130.65
290_H298_W0.5120.65
236_D295_G0.5120.65
76_Q95_I0.5120.65
316_S321_S0.5110.65
94_F104_D0.5110.65
292_W298_W0.5100.65
239_K243_I0.5100.65
85_Q126_D0.5100.65
157_R160_K0.5090.65
320_T323_F0.5090.65
103_K108_L0.5070.64
178_G195_T0.5060.64
86_I180_A0.5040.64
121_W197_E0.5020.64
159_L181_K0.5010.63
310_I320_T0.5010.63
135_T225_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfq_A 1 0.8957 100 0.259 Contact Map
4lqs_A 1 0.9362 100 0.261 Contact Map
2i0e_A 1 0.8899 100 0.262 Contact Map
4gv1_A 1 0.913 100 0.276 Contact Map
2vd5_A 1 0.9594 100 0.281 Contact Map
3c4z_A 1 0.9594 100 0.282 Contact Map
3v5w_A 1 0.9565 100 0.286 Contact Map
2r5t_A 1 0.8174 100 0.287 Contact Map
4dc2_A 1 0.8986 100 0.288 Contact Map
4aw2_A 1 0.9507 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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