T0910_1_345 - CASP12 - GREMLIN Contacts

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T0910_1_345 - T0910 1-345

ID:	65	Sequences: GLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	345 (306)
Sequences:	4219 (2239)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_C	171_Y	7.003	1.00
132_D	258_A	5.119	1.00
51_V	63_M	4.548	1.00
263_N	267_K	4.486	1.00
139_T	222_M	4.180	1.00
300_G	305_T	3.960	1.00
226_L	261_A	3.886	1.00
147_A	288_Q	3.853	1.00
297_N	300_G	3.612	1.00
263_N	290_H	3.539	1.00
227_T	257_I	3.336	1.00
222_M	264_L	3.312	1.00
35_N	52_Q	3.035	1.00
63_M	111_L	2.899	1.00
135_T	222_M	2.576	1.00
99_Y	113_E	2.576	1.00
270_R	275_E	2.570	1.00
143_V	218_L	2.515	1.00
104_D	109_Y	2.309	1.00
136_R	295_G	2.305	1.00
139_T	218_L	2.299	1.00
113_E	173_K	2.220	1.00
51_V	61_F	2.140	1.00
137_F	309_P	2.132	1.00
39_T	47_R	2.116	1.00
49_E	65_I	2.096	1.00
272_N	275_E	2.091	1.00
43_G	46_G	2.042	1.00
139_T	293_F	1.969	1.00
140_A	301_L	1.964	1.00
35_N	54_K	1.935	1.00
145_A	174_L	1.925	1.00
167_D	304_G	1.874	1.00
285_K	288_Q	1.872	1.00
264_L	268_L	1.863	1.00
278_G	283_G	1.771	1.00
98_L	110_M	1.741	1.00
147_A	284_V	1.709	1.00
132_D	292_W	1.702	1.00
169_R	304_G	1.693	1.00
156_Y	159_L	1.692	1.00
133_S	136_R	1.674	1.00
215_Y	284_V	1.668	1.00
131_E	134_T	1.665	1.00
285_K	289_K	1.639	1.00
234_G	239_K	1.627	1.00
282_N	286_D	1.621	1.00
190_W	208_G	1.603	1.00
216_W	232_F	1.601	1.00
119_E	162_E	1.598	1.00
247_G	271_D	1.589	1.00
212_S	279_N	1.587	1.00
196_P	241_Y	1.553	1.00
143_V	215_Y	1.543	1.00
91_H	97_R	1.497	1.00
158_D	163_N	1.475	1.00
50_L	60_T	1.472	1.00
143_V	287_I	1.466	1.00
301_L	306_L	1.462	1.00
300_G	303_K	1.461	1.00
116_L	168_H	1.457	1.00
34_F	100_R	1.452	1.00
131_E	135_T	1.447	1.00
253_F	262_A	1.425	1.00
147_A	151_S	1.395	1.00
284_V	287_I	1.392	1.00
200_A	213_A	1.381	1.00
165_I	175_V	1.371	1.00
257_I	265_I	1.357	1.00
72_V	77_Q	1.356	1.00
314_V	322_N	1.352	1.00
308_P	312_P	1.346	1.00
260_N	294_E	1.340	1.00
243_I	247_G	1.327	1.00
144_E	147_A	1.298	1.00
68_K	103_K	1.298	1.00
41_G	46_G	1.280	1.00
140_A	296_F	1.278	1.00
39_T	42_V	1.271	1.00
127_R	134_T	1.265	1.00
171_Y	308_P	1.262	1.00
307_T	311_I	1.262	1.00
209_H	213_A	1.251	1.00
48_V	62_A	1.250	1.00
43_G	48_V	1.244	1.00
142_V	164_L	1.243	1.00
160_K	163_N	1.241	1.00
64_K	68_K	1.238	1.00
224_E	228_G	1.232	1.00
29_L	53_L	1.224	1.00
237_P	241_Y	1.223	0.99
40_L	50_L	1.223	0.99
30_K	33_D	1.220	0.99
143_V	147_A	1.219	0.99
310_I	322_N	1.214	0.99
264_L	293_F	1.212	0.99
96_V	175_V	1.209	0.99
144_E	302_R	1.205	0.99
130_F	134_T	1.204	0.99
267_K	277_L	1.201	0.99
67_K	70_H	1.183	0.99
268_L	276_R	1.180	0.99
280_L	286_D	1.171	0.99
147_A	285_K	1.169	0.99
218_L	222_M	1.167	0.99
181_K	189_T	1.159	0.99
319_D	323_F	1.143	0.99
138_Y	308_P	1.142	0.99
197_E	240_T	1.142	0.99
36_I	39_T	1.129	0.99
234_G	240_T	1.124	0.99
314_V	319_D	1.119	0.99
309_P	312_P	1.113	0.99
282_N	289_K	1.105	0.99
158_D	176_D	1.098	0.99
251_I	271_D	1.097	0.99
121_W	162_E	1.093	0.99
149_L	154_I	1.091	0.99
267_K	270_R	1.088	0.99
164_L	221_L	1.087	0.99
142_V	221_L	1.080	0.99
316_S	319_D	1.072	0.99
319_D	322_N	1.069	0.99
76_Q	79_H	1.068	0.99
92_S	148_Y	1.063	0.99
296_F	301_L	1.053	0.98
123_I	130_F	1.052	0.98
62_A	68_K	1.049	0.98
288_Q	298_W	1.037	0.98
53_L	57_E	1.034	0.98
100_R	111_L	1.032	0.98
220_I	230_P	1.030	0.98
50_L	114_A	1.026	0.98
240_T	244_I	1.018	0.98
227_T	256_K	1.017	0.98
232_F	244_I	1.017	0.98
139_T	264_L	1.014	0.98
176_D	195_T	1.012	0.98
52_Q	58_S	1.010	0.98
315_A	321_S	1.005	0.98
216_W	219_G	1.004	0.98
262_A	266_K	1.004	0.98
139_T	225_L	0.999	0.98
192_F	199_V	0.997	0.98
83_E	87_M	0.993	0.98
278_G	286_D	0.990	0.98
120_L	225_L	0.988	0.98
159_L	221_L	0.986	0.98
153_G	211_I	0.985	0.98
48_V	64_K	0.980	0.98
104_D	107_Y	0.980	0.98
135_T	226_L	0.973	0.97
89_G	182_K	0.970	0.97
84_K	88_Q	0.968	0.97
96_V	112_M	0.965	0.97
83_E	86_I	0.959	0.97
84_K	101_T	0.956	0.97
195_T	202_E	0.950	0.97
65_I	107_Y	0.950	0.97
222_M	226_L	0.950	0.97
31_L	63_M	0.947	0.97
36_I	63_M	0.947	0.97
29_L	100_R	0.942	0.97
284_V	288_Q	0.941	0.97
299_E	302_R	0.938	0.97
36_I	49_E	0.936	0.97
29_L	34_F	0.928	0.97
158_D	178_G	0.926	0.97
85_Q	88_Q	0.925	0.97
92_S	302_R	0.924	0.97
160_K	176_D	0.923	0.97
234_G	243_I	0.923	0.97
293_F	298_W	0.923	0.97
214_D	219_G	0.920	0.96
61_F	100_R	0.920	0.96
53_L	100_R	0.919	0.96
195_T	198_Y	0.916	0.96
203_I	209_H	0.914	0.96
176_D	194_G	0.912	0.96
85_Q	182_K	0.911	0.96
51_V	111_L	0.909	0.96
162_E	197_E	0.907	0.96
194_G	202_E	0.905	0.96
203_I	213_A	0.905	0.96
97_R	113_E	0.905	0.96
261_A	292_W	0.895	0.96
242_N	246_R	0.895	0.96
203_I	217_S	0.888	0.96
143_V	298_W	0.884	0.96
247_G	250_M	0.883	0.96
117_G	170_G	0.877	0.95
181_K	191_T	0.872	0.95
39_T	49_E	0.867	0.95
145_A	150_H	0.862	0.95
92_S	95_I	0.858	0.95
92_S	145_A	0.854	0.95
227_T	230_P	0.845	0.94
115_C	173_K	0.841	0.94
258_A	261_A	0.839	0.94
36_I	51_V	0.838	0.94
213_A	217_S	0.829	0.94
253_F	265_I	0.828	0.94
226_L	257_I	0.828	0.94
222_M	265_I	0.828	0.94
146_F	218_L	0.826	0.94
269_C	276_R	0.824	0.94
197_E	230_P	0.819	0.93
60_T	318_T	0.819	0.93
261_A	264_L	0.816	0.93
80_I	108_L	0.815	0.93
37_I	50_L	0.814	0.93
71_I	80_I	0.813	0.93
226_L	265_I	0.813	0.93
259_K	262_A	0.812	0.93
230_P	243_I	0.810	0.93
265_I	269_C	0.804	0.93
239_K	242_N	0.801	0.93
31_L	36_I	0.800	0.92
199_V	240_T	0.799	0.92
324_D	328_E	0.799	0.92
66_L	80_I	0.797	0.92
223_Y	227_T	0.797	0.92
323_F	328_E	0.792	0.92
324_D	327_P	0.792	0.92
143_V	284_V	0.792	0.92
137_F	171_Y	0.791	0.92
268_L	277_L	0.790	0.92
223_Y	254_P	0.787	0.92
313_S	322_N	0.783	0.92
178_G	196_P	0.776	0.91
200_A	203_I	0.775	0.91
42_V	47_R	0.774	0.91
247_G	251_I	0.773	0.91
278_G	287_I	0.771	0.91
214_D	224_E	0.770	0.91
274_S	279_N	0.769	0.91
267_K	286_D	0.765	0.91
196_P	199_V	0.765	0.91
205_L	245_L	0.757	0.90
327_P	330_N	0.756	0.90
45_F	48_V	0.755	0.90
253_F	257_I	0.754	0.90
165_I	187_K	0.753	0.90
198_Y	201_P	0.751	0.90
198_Y	202_E	0.749	0.90
196_P	237_P	0.749	0.90
257_I	261_A	0.748	0.90
299_E	303_K	0.747	0.90
120_L	164_L	0.747	0.90
231_P	244_I	0.746	0.90
268_L	278_G	0.742	0.89
101_T	110_M	0.742	0.89
148_Y	152_K	0.742	0.89
23_A	26_F	0.741	0.89
160_K	165_I	0.739	0.89
287_I	290_H	0.738	0.89
221_L	230_P	0.737	0.89
164_L	172_A	0.737	0.89
37_I	52_Q	0.735	0.89
66_L	71_I	0.732	0.89
55_S	58_S	0.731	0.89
242_N	245_L	0.729	0.89
291_K	294_E	0.729	0.89
135_T	292_W	0.729	0.89
123_I	310_I	0.728	0.88
277_L	290_H	0.725	0.88
138_Y	225_L	0.715	0.88
113_E	117_G	0.715	0.88
68_K	102_F	0.711	0.87
298_W	301_L	0.708	0.87
98_L	101_T	0.705	0.87
146_F	149_L	0.703	0.87
87_M	112_M	0.701	0.87
194_G	200_A	0.696	0.86
64_K	83_E	0.695	0.86
164_L	174_L	0.693	0.86
82_S	86_I	0.691	0.86
229_S	233_S	0.689	0.86
40_L	43_G	0.688	0.86
194_G	201_P	0.687	0.85
115_C	165_I	0.685	0.85
146_F	156_Y	0.684	0.85
180_A	220_I	0.682	0.85
286_D	289_K	0.681	0.85
48_V	51_V	0.680	0.85
209_H	224_E	0.679	0.85
52_Q	318_T	0.678	0.85
70_H	74_T	0.677	0.85
159_L	218_L	0.677	0.85
120_L	130_F	0.676	0.85
308_P	311_I	0.676	0.85
300_G	306_L	0.674	0.84
188_K	208_G	0.674	0.84
233_S	240_T	0.672	0.84
140_A	143_V	0.672	0.84
199_V	224_E	0.671	0.84
132_D	261_A	0.671	0.84
283_G	286_D	0.671	0.84
222_M	292_W	0.670	0.84
144_E	306_L	0.670	0.84
102_F	111_L	0.666	0.84
100_R	103_K	0.664	0.83
30_K	34_F	0.662	0.83
137_F	150_H	0.661	0.83
116_L	314_V	0.660	0.83
40_L	46_G	0.659	0.83
79_H	191_T	0.652	0.82
149_L	174_L	0.651	0.82
198_Y	228_G	0.648	0.82
90_A	149_L	0.648	0.82
194_G	198_Y	0.646	0.82
236_D	239_K	0.644	0.82
192_F	241_Y	0.643	0.81
76_Q	125_R	0.643	0.81
120_L	217_S	0.642	0.81
321_S	329_D	0.642	0.81
220_I	224_E	0.641	0.81
199_V	241_Y	0.641	0.81
296_F	300_G	0.640	0.81
119_E	197_E	0.640	0.81
109_Y	167_D	0.639	0.81
230_P	233_S	0.637	0.81
298_W	309_P	0.637	0.81
155_I	183_I	0.636	0.81
260_N	291_K	0.633	0.80
253_F	266_K	0.633	0.80
141_C	172_A	0.632	0.80
188_K	210_D	0.631	0.80
158_D	161_P	0.631	0.80
41_G	48_V	0.631	0.80
166_L	322_N	0.628	0.80
52_Q	60_T	0.628	0.80
150_H	153_G	0.627	0.80
96_V	115_C	0.625	0.80
163_N	178_G	0.622	0.79
34_F	41_G	0.622	0.79
195_T	201_P	0.621	0.79
223_Y	229_S	0.619	0.79
130_F	137_F	0.618	0.79
278_G	293_F	0.618	0.79
63_M	100_R	0.615	0.79
293_F	296_F	0.614	0.78
297_N	303_K	0.614	0.78
276_R	290_H	0.610	0.78
122_T	126_D	0.609	0.78
273_P	276_R	0.609	0.78
77_Q	80_I	0.607	0.78
153_G	183_I	0.606	0.78
257_I	262_A	0.605	0.77
160_K	166_L	0.605	0.77
293_F	297_N	0.605	0.77
34_F	63_M	0.605	0.77
193_C	199_V	0.604	0.77
215_Y	287_I	0.603	0.77
227_T	265_I	0.602	0.77
280_L	283_G	0.602	0.77
324_D	330_N	0.600	0.77
276_R	293_F	0.599	0.77
168_H	203_I	0.599	0.77
45_F	178_G	0.599	0.77
227_T	254_P	0.599	0.77
123_I	127_R	0.597	0.76
121_W	230_P	0.597	0.76
34_F	61_F	0.596	0.76
189_T	193_C	0.596	0.76
94_F	137_F	0.594	0.76
250_M	266_K	0.592	0.76
215_Y	268_L	0.592	0.76
41_G	62_A	0.592	0.76
53_L	61_F	0.592	0.76
222_M	225_L	0.590	0.76
173_K	178_G	0.589	0.76
98_L	108_L	0.584	0.75
146_F	159_L	0.582	0.75
66_L	70_H	0.581	0.75
259_K	291_K	0.581	0.75
43_G	47_R	0.579	0.74
34_F	53_L	0.579	0.74
134_T	310_I	0.578	0.74
190_W	210_D	0.577	0.74
33_D	187_K	0.577	0.74
43_G	64_K	0.575	0.74
34_F	102_F	0.574	0.74
325_S	329_D	0.569	0.73
205_L	236_D	0.568	0.73
120_L	145_A	0.566	0.73
202_E	214_D	0.566	0.73
140_A	292_W	0.565	0.73
148_Y	151_S	0.565	0.73
61_F	99_Y	0.564	0.72
214_D	225_L	0.563	0.72
265_I	295_G	0.559	0.72
163_N	176_D	0.555	0.71
65_I	108_L	0.555	0.71
264_L	277_L	0.555	0.71
84_K	87_M	0.551	0.71
42_V	330_N	0.551	0.71
214_D	228_G	0.551	0.71
325_S	328_E	0.550	0.71
316_S	324_D	0.550	0.71
146_F	217_S	0.550	0.71
64_K	176_D	0.548	0.70
132_D	136_R	0.547	0.70
36_I	67_K	0.547	0.70
290_H	293_F	0.547	0.70
167_D	178_G	0.547	0.70
107_Y	292_W	0.546	0.70
214_D	223_Y	0.546	0.70
34_F	43_G	0.543	0.70
228_G	231_P	0.543	0.70
202_E	219_G	0.543	0.70
44_G	199_V	0.541	0.69
264_L	290_H	0.540	0.69
81_R	108_L	0.540	0.69
32_S	54_K	0.540	0.69
219_G	224_E	0.539	0.69
166_L	172_A	0.538	0.69
44_G	70_H	0.536	0.69
68_K	83_E	0.534	0.68
60_T	66_L	0.533	0.68
41_G	45_F	0.533	0.68
59_K	99_Y	0.532	0.68
42_V	213_A	0.532	0.68
159_L	189_T	0.532	0.68
322_N	326_F	0.531	0.68
115_C	119_E	0.529	0.68
130_F	224_E	0.528	0.67
160_K	178_G	0.527	0.67
313_S	321_S	0.527	0.67
40_L	74_T	0.527	0.67
209_H	215_Y	0.527	0.67
217_S	234_G	0.526	0.67
173_K	196_P	0.525	0.67
218_L	268_L	0.521	0.66
138_Y	312_P	0.520	0.66
76_Q	180_A	0.519	0.66
268_L	284_V	0.516	0.66
87_M	90_A	0.515	0.66
119_E	125_R	0.513	0.65
250_M	270_R	0.513	0.65
189_T	192_F	0.513	0.65
297_N	305_T	0.513	0.65
290_H	298_W	0.512	0.65
236_D	295_G	0.512	0.65
76_Q	95_I	0.512	0.65
316_S	321_S	0.511	0.65
94_F	104_D	0.511	0.65
292_W	298_W	0.510	0.65
239_K	243_I	0.510	0.65
85_Q	126_D	0.510	0.65
157_R	160_K	0.509	0.65
320_T	323_F	0.509	0.65
103_K	108_L	0.507	0.64
178_G	195_T	0.506	0.64
86_I	180_A	0.504	0.64
121_W	197_E	0.502	0.64
159_L	181_K	0.501	0.63
310_I	320_T	0.501	0.63
135_T	225_L	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pfq_A	1	0.8957	100	0.259	Contact Map
4lqs_A	1	0.9362	100	0.261	Contact Map
2i0e_A	1	0.8899	100	0.262	Contact Map
4gv1_A	1	0.913	100	0.276	Contact Map
2vd5_A	1	0.9594	100	0.281	Contact Map
3c4z_A	1	0.9594	100	0.282	Contact Map
3v5w_A	1	0.9565	100	0.286	Contact Map
2r5t_A	1	0.8174	100	0.287	Contact Map
4dc2_A	1	0.8986	100	0.288	Contact Map
4aw2_A	1	0.9507	100	0.291	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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