T0909_1_340 - CASP12 - GREMLIN Contacts

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T0909_1_340 - T0909 1-340

ID:	64	Sequences: LLPGQSPDEAFARNSVVFLVPGAEYNWKNVVIRKPVWIYGERCHGEDFRPRAIIHIMGDLDNPMDVRIQDLTFIGGDSPDRLVPFSAVLTNQMALWCIDPRITIRGCSFYNFGGAAIYLERSERDTGFRFGRGQVMITDCRFRGCRIGIANGGSVEYGLASQNNFSDCQICFNVVGGNWTRSGNVASNCRCMYLHTQGMWYEGAAGNFNPAHGSFTSNTLNHCDYGGNLWPTEFQLPDRVINLAGFYFDNAAARLPNFSGNSQWYGDMKLINFLPDSTFVINGGALYGGPGDTGVIAVATALAAKVFVIGCQGNAGQQIVNVPAANIIPEVGTRKDDATQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	340 (275)
Sequences:	52 (45)
Seq/√Len:	2.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
258_F	263_Q	3.868	0.65
71_L	117_I	3.122	0.48
28_K	308_V	3.008	0.45
66_V	306_V	2.870	0.42
107_C	137_I	2.721	0.38
14_N	107_C	2.649	0.37
30_V	258_F	2.591	0.35
258_F	279_F	2.570	0.35
75_G	310_G	2.526	0.34
171_C	184_N	2.506	0.34
296_I	322_V	2.490	0.33
172_F	243_L	2.478	0.33
168_C	261_N	2.314	0.30
16_V	273_F	2.293	0.29
137_I	286_L	2.272	0.29
268_M	286_L	2.181	0.27
11_F	36_V	2.172	0.27
73_F	109_F	2.056	0.25
95_L	220_L	2.030	0.24
145_C	184_N	2.006	0.24
19_L	25_Y	1.987	0.24
19_L	40_G	1.987	0.24
25_Y	40_G	1.987	0.24
192_M	255_L	1.966	0.23
117_I	137_I	1.919	0.22
32_I	177_G	1.909	0.22
12_A	38_I	1.894	0.22
11_F	111_N	1.879	0.22
4_G	38_I	1.841	0.21
11_F	32_I	1.831	0.21
261_N	284_G	1.829	0.21
105_R	138_T	1.813	0.21
16_V	271_I	1.790	0.20
99_D	112_F	1.754	0.20
256_P	261_N	1.747	0.20
168_C	256_P	1.739	0.20
54_I	117_I	1.721	0.19
37_W	273_F	1.695	0.19
184_N	230_W	1.690	0.19
16_V	37_W	1.680	0.19
111_N	171_C	1.626	0.18
7_P	121_R	1.611	0.18
102_I	217_S	1.607	0.18
6_S	43_C	1.599	0.18
42_R	145_C	1.597	0.17
45_G	71_L	1.595	0.17
40_G	165_F	1.592	0.17
25_Y	165_F	1.592	0.17
19_L	165_F	1.592	0.17
61_D	308_V	1.576	0.17
271_I	277_S	1.569	0.17
56_I	68_I	1.551	0.17
265_Y	281_I	1.551	0.17
265_Y	279_F	1.538	0.17
37_W	242_N	1.537	0.17
242_N	271_I	1.521	0.16
21_P	45_G	1.514	0.16
17_V	100_P	1.503	0.16
42_R	45_G	1.494	0.16
107_C	111_N	1.477	0.16
168_C	191_C	1.470	0.16
242_N	273_F	1.440	0.15
19_L	109_F	1.436	0.15
25_Y	109_F	1.436	0.15
40_G	109_F	1.436	0.15
144_G	241_I	1.433	0.15
71_L	104_I	1.427	0.15
148_G	261_N	1.416	0.15
7_P	45_G	1.402	0.15
154_S	217_S	1.390	0.15
184_N	238_D	1.384	0.15
72_T	104_I	1.383	0.15
185_V	238_D	1.378	0.15
47_D	315_A	1.378	0.15
32_I	73_F	1.377	0.15
38_I	296_I	1.372	0.15
19_L	256_P	1.366	0.15
25_Y	256_P	1.366	0.15
40_G	256_P	1.366	0.15
22_G	93_M	1.364	0.15
40_G	142_F	1.357	0.14
25_Y	142_F	1.357	0.14
19_L	142_F	1.357	0.14
171_C	196_T	1.352	0.14
6_S	142_F	1.351	0.14
145_C	177_G	1.341	0.14
107_C	117_I	1.328	0.14
16_V	242_N	1.325	0.14
144_G	160_A	1.313	0.14
65_D	149_I	1.310	0.14
62_N	99_D	1.310	0.14
102_I	135_V	1.309	0.14
242_N	277_S	1.304	0.14
30_V	263_Q	1.284	0.14
36_V	73_F	1.274	0.13
241_I	309_I	1.274	0.13
70_D	183_G	1.252	0.13
189_C	213_G	1.251	0.13
40_G	73_F	1.248	0.13
19_L	73_F	1.248	0.13
25_Y	73_F	1.248	0.13
104_I	117_I	1.232	0.13
31_V	282_N	1.226	0.13
153_G	215_F	1.223	0.13
47_D	186_A	1.220	0.13
17_V	147_I	1.215	0.13
37_W	271_I	1.193	0.13
183_G	286_L	1.182	0.12
21_P	177_G	1.179	0.12
39_Y	181_R	1.162	0.12
30_V	45_G	1.162	0.12
8_D	28_K	1.154	0.12
25_Y	43_C	1.152	0.12
19_L	43_C	1.152	0.12
40_G	43_C	1.152	0.12
17_V	53_I	1.139	0.12
23_A	240_V	1.133	0.12
218_N	306_V	1.133	0.12
16_V	277_S	1.129	0.12
57_M	197_Q	1.125	0.12
191_C	241_I	1.124	0.12
5_Q	62_N	1.118	0.12
103_T	149_I	1.118	0.12
234_F	238_D	1.114	0.12
107_C	236_L	1.102	0.12
25_Y	107_C	1.102	0.12
40_G	107_C	1.102	0.12
19_L	107_C	1.102	0.12
16_V	139_D	1.084	0.11
11_F	184_N	1.084	0.11
107_C	171_C	1.073	0.11
149_I	243_L	1.071	0.11
67_R	244_A	1.071	0.11
35_P	188_N	1.068	0.11
220_L	263_Q	1.067	0.11
1_L	12_A	1.063	0.11
106_G	279_F	1.059	0.11
28_K	243_L	1.052	0.11
283_G	299_A	1.049	0.11
73_F	168_C	1.047	0.11
21_P	270_L	1.046	0.11
194_L	322_V	1.040	0.11
145_C	256_P	1.040	0.11
11_F	17_V	1.033	0.11
8_D	73_F	1.030	0.11
54_I	213_G	1.017	0.11
36_V	187_S	1.009	0.11
4_G	149_I	1.008	0.11
109_F	165_F	1.005	0.11
235_Q	319_I	1.001	0.11
161_S	188_N	1.001	0.11
5_Q	27_W	0.992	0.11
250_N	255_L	0.992	0.11
160_A	243_L	0.988	0.11
45_G	310_G	0.974	0.10
111_N	137_I	0.968	0.10
96_W	300_T	0.963	0.10
30_V	240_V	0.955	0.10
220_L	233_E	0.953	0.10
15_S	32_I	0.952	0.10
6_S	213_G	0.951	0.10
1_L	193_Y	0.950	0.10
144_G	316_G	0.946	0.10
64_M	266_G	0.943	0.10
26_N	122_S	0.939	0.10
165_F	256_P	0.933	0.10
142_F	165_F	0.930	0.10
266_G	321_N	0.923	0.10
23_A	314_N	0.919	0.10
75_G	146_R	0.917	0.10
116_A	188_N	0.917	0.10
115_A	267_D	0.916	0.10
273_F	277_S	0.916	0.10
98_I	320_V	0.909	0.10
296_I	302_L	0.897	0.10
65_D	273_F	0.894	0.10
4_G	107_C	0.891	0.10
181_R	196_T	0.890	0.10
233_E	322_V	0.889	0.10
241_I	268_M	0.883	0.10
45_G	117_I	0.879	0.10
110_Y	315_A	0.876	0.10
117_I	298_V	0.875	0.10
181_R	240_V	0.873	0.10
17_V	97_C	0.873	0.10
184_N	261_N	0.868	0.10
215_F	244_A	0.867	0.10
172_F	185_V	0.864	0.10
203_G	231_P	0.862	0.10
9_E	52_A	0.859	0.09
40_G	261_N	0.857	0.09
25_Y	261_N	0.857	0.09
19_L	261_N	0.857	0.09
149_I	306_V	0.854	0.09
63_P	104_I	0.849	0.09
52_A	284_G	0.849	0.09
171_C	181_R	0.848	0.09
106_G	270_L	0.847	0.09
37_W	277_S	0.847	0.09
26_N	196_T	0.845	0.09
183_G	245_G	0.838	0.09
36_V	175_V	0.837	0.09
174_V	236_L	0.836	0.09
12_A	184_N	0.836	0.09
56_I	140_C	0.835	0.09
238_D	308_V	0.831	0.09
65_D	242_N	0.829	0.09
14_N	111_N	0.829	0.09
6_S	42_R	0.826	0.09
44_H	253_A	0.825	0.09
149_I	175_V	0.822	0.09
68_I	163_N	0.820	0.09
155_V	158_G	0.820	0.09
1_L	177_G	0.819	0.09
50_P	286_L	0.818	0.09
166_S	265_Y	0.816	0.09
13_R	30_V	0.814	0.09
92_Q	268_M	0.811	0.09
244_A	311_C	0.806	0.09
15_S	217_S	0.802	0.09
114_G	145_C	0.801	0.09
255_L	279_F	0.799	0.09
139_D	271_I	0.798	0.09
17_V	245_G	0.793	0.09
191_C	256_P	0.792	0.09
5_Q	111_N	0.790	0.09
109_F	256_P	0.789	0.09
11_F	47_D	0.786	0.09
111_N	262_S	0.786	0.09
10_A	76_G	0.782	0.09
101_R	135_V	0.781	0.09
241_I	322_V	0.781	0.09
50_P	141_R	0.781	0.09
21_P	306_V	0.780	0.09
4_G	151_N	0.780	0.09
102_I	119_L	0.779	0.09
146_R	190_R	0.777	0.09
109_F	142_F	0.777	0.09
38_I	56_I	0.768	0.09
215_F	315_A	0.768	0.09
36_V	308_V	0.766	0.09
137_I	241_I	0.765	0.09
29_N	227_G	0.761	0.09
5_Q	228_N	0.758	0.09
70_D	286_L	0.755	0.09
214_S	311_C	0.754	0.09
15_S	322_V	0.753	0.09
38_I	183_G	0.753	0.09
118_Y	255_L	0.750	0.09
73_F	165_F	0.748	0.09
155_V	177_G	0.745	0.09
4_G	228_N	0.745	0.09
254_R	265_Y	0.744	0.09
140_C	236_L	0.742	0.09
65_D	243_L	0.742	0.09
26_N	30_V	0.736	0.09
56_I	308_V	0.735	0.09
12_A	183_G	0.734	0.09
245_G	302_L	0.733	0.09
237_P	240_V	0.731	0.08
37_W	198_G	0.728	0.08
21_P	163_N	0.724	0.08
228_N	308_V	0.722	0.08
21_P	73_F	0.720	0.08
231_P	243_L	0.720	0.08
194_L	241_I	0.720	0.08
5_Q	180_T	0.718	0.08
163_N	260_G	0.715	0.08
114_G	184_N	0.712	0.08
75_G	158_G	0.712	0.08
142_F	256_P	0.710	0.08
111_N	227_G	0.706	0.08
135_V	251_A	0.700	0.08
99_D	114_G	0.699	0.08
97_C	180_T	0.699	0.08
29_N	151_N	0.697	0.08
96_W	304_A	0.691	0.08
185_V	319_I	0.689	0.08
5_Q	13_R	0.686	0.08
139_D	273_F	0.682	0.08
243_L	270_L	0.681	0.08
34_K	103_T	0.679	0.08
65_D	227_G	0.678	0.08
109_F	218_N	0.676	0.08
42_R	114_G	0.675	0.08
10_A	49_R	0.675	0.08
114_G	190_R	0.674	0.08
186_A	315_A	0.673	0.08
26_N	171_C	0.671	0.08
73_F	107_C	0.669	0.08
102_I	236_L	0.666	0.08
43_C	139_D	0.661	0.08
38_I	228_N	0.661	0.08
318_Q	322_V	0.658	0.08
34_K	111_N	0.658	0.08
6_S	40_G	0.657	0.08
6_S	25_Y	0.657	0.08
36_V	228_N	0.657	0.08
6_S	19_L	0.657	0.08
43_C	165_F	0.655	0.08
154_S	266_G	0.654	0.08
158_G	310_G	0.653	0.08
137_I	262_S	0.653	0.08
17_V	114_G	0.651	0.08
168_C	258_F	0.650	0.08
166_S	279_F	0.649	0.08
191_C	261_N	0.648	0.08
24_E	215_F	0.646	0.08
32_I	66_V	0.645	0.08
36_V	189_C	0.641	0.08
10_A	70_D	0.640	0.08
1_L	7_P	0.640	0.08
42_R	256_P	0.640	0.08
33_R	296_I	0.639	0.08
148_G	284_G	0.639	0.08
189_C	321_N	0.631	0.08
11_F	167_D	0.630	0.08
12_A	296_I	0.625	0.08
11_F	157_Y	0.623	0.08
50_P	231_P	0.620	0.08
188_N	316_G	0.618	0.08
105_R	166_S	0.617	0.08
35_P	184_N	0.616	0.08
112_F	218_N	0.615	0.08
151_N	194_L	0.614	0.08
24_E	308_V	0.614	0.08
115_A	321_N	0.613	0.08
14_N	289_G	0.611	0.08
38_I	165_F	0.610	0.08
45_G	158_G	0.606	0.08
24_E	143_R	0.605	0.08
172_F	311_C	0.601	0.08
197_Q	228_N	0.598	0.08
21_P	168_C	0.598	0.08
29_N	77_D	0.595	0.08
272_N	308_V	0.595	0.08
227_G	272_N	0.591	0.08
42_R	184_N	0.588	0.07
37_W	106_G	0.586	0.07
17_V	280_V	0.584	0.07
21_P	268_M	0.584	0.07
3_P	191_C	0.583	0.07
139_D	142_F	0.583	0.07
20_V	219_T	0.582	0.07
32_I	58_G	0.581	0.07
4_G	68_I	0.580	0.07
107_C	311_C	0.577	0.07
5_Q	264_W	0.577	0.07
145_C	218_N	0.576	0.07
116_A	276_D	0.576	0.07
281_I	313_G	0.576	0.07
117_I	149_I	0.575	0.07
146_R	290_P	0.573	0.07
11_F	220_L	0.571	0.07
36_V	239_R	0.570	0.07
73_F	256_P	0.570	0.07
105_R	281_I	0.569	0.07
73_F	181_R	0.565	0.07
27_W	115_A	0.564	0.07
73_F	142_F	0.564	0.07
48_F	236_L	0.562	0.07
13_R	49_R	0.561	0.07
105_R	277_S	0.561	0.07
58_G	296_I	0.558	0.07
166_S	281_I	0.558	0.07
13_R	185_V	0.557	0.07
183_G	314_N	0.556	0.07
36_V	157_Y	0.555	0.07
35_P	286_L	0.551	0.07
75_G	222_H	0.551	0.07
37_W	139_D	0.550	0.07
185_V	267_D	0.550	0.07
12_A	212_H	0.546	0.07
54_I	140_C	0.544	0.07
3_P	35_P	0.543	0.07
43_C	109_F	0.543	0.07
236_L	266_G	0.543	0.07
108_S	189_C	0.541	0.07
22_G	259_S	0.540	0.07
36_V	139_D	0.539	0.07
148_G	184_N	0.537	0.07
70_D	106_G	0.529	0.07
203_G	311_C	0.528	0.07
158_G	177_G	0.528	0.07
27_W	245_G	0.526	0.07
11_F	34_K	0.526	0.07
250_N	310_G	0.525	0.07
38_I	178_N	0.524	0.07
58_G	272_N	0.524	0.07
40_G	168_C	0.523	0.07
19_L	168_C	0.523	0.07
25_Y	168_C	0.523	0.07
67_R	100_P	0.523	0.07
27_W	38_I	0.523	0.07
241_I	296_I	0.521	0.07
121_R	263_Q	0.519	0.07
44_H	66_V	0.517	0.07
5_Q	309_I	0.516	0.07
42_R	158_G	0.514	0.07
21_P	40_G	0.512	0.07
21_P	25_Y	0.512	0.07
101_R	296_I	0.509	0.07
80_D	211_A	0.508	0.07
4_G	111_N	0.507	0.07
105_R	279_F	0.507	0.07
38_I	229_L	0.506	0.07
119_L	244_A	0.506	0.07
162_Q	264_W	0.505	0.07
105_R	265_Y	0.503	0.07
40_G	140_C	0.500	0.07
19_L	140_C	0.500	0.07
25_Y	140_C	0.500	0.07

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1dbg_A	1	0.8471	98.8	0.917	Contact Map
3zsc_A	1	0.8059	98.5	0.923	Contact Map
2pyg_A	1	0.7971	98.4	0.925	Contact Map
3vmv_A	1	0.7529	98.4	0.926	Contact Map
2inu_A	1	0.8588	98.3	0.928	Contact Map
4mxn_A	1	0.5265	98.3	0.928	Contact Map
4nk6_A	1	0.0382	98.3	0.928	Contact Map
1ru4_A	1	0.8471	98.3	0.929	Contact Map
1pcl_A	1	0.7882	98.3	0.929	Contact Map
3gq8_A	1	0.9294	97.7	0.938	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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