GREMLIN Database
T0909_1_340 - T0909 1-340
ID: 64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 340 (275)
Sequences: 52 (45)
Seq/√Len: 2.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_F263_Q3.8680.65
71_L117_I3.1220.48
28_K308_V3.0080.45
66_V306_V2.8700.42
107_C137_I2.7210.38
14_N107_C2.6490.37
30_V258_F2.5910.35
258_F279_F2.5700.35
75_G310_G2.5260.34
171_C184_N2.5060.34
296_I322_V2.4900.33
172_F243_L2.4780.33
168_C261_N2.3140.30
16_V273_F2.2930.29
137_I286_L2.2720.29
268_M286_L2.1810.27
11_F36_V2.1720.27
73_F109_F2.0560.25
95_L220_L2.0300.24
145_C184_N2.0060.24
19_L25_Y1.9870.24
19_L40_G1.9870.24
25_Y40_G1.9870.24
192_M255_L1.9660.23
117_I137_I1.9190.22
32_I177_G1.9090.22
12_A38_I1.8940.22
11_F111_N1.8790.22
4_G38_I1.8410.21
11_F32_I1.8310.21
261_N284_G1.8290.21
105_R138_T1.8130.21
16_V271_I1.7900.20
99_D112_F1.7540.20
256_P261_N1.7470.20
168_C256_P1.7390.20
54_I117_I1.7210.19
37_W273_F1.6950.19
184_N230_W1.6900.19
16_V37_W1.6800.19
111_N171_C1.6260.18
7_P121_R1.6110.18
102_I217_S1.6070.18
6_S43_C1.5990.18
42_R145_C1.5970.17
45_G71_L1.5950.17
40_G165_F1.5920.17
25_Y165_F1.5920.17
19_L165_F1.5920.17
61_D308_V1.5760.17
271_I277_S1.5690.17
56_I68_I1.5510.17
265_Y281_I1.5510.17
265_Y279_F1.5380.17
37_W242_N1.5370.17
242_N271_I1.5210.16
21_P45_G1.5140.16
17_V100_P1.5030.16
42_R45_G1.4940.16
107_C111_N1.4770.16
168_C191_C1.4700.16
242_N273_F1.4400.15
19_L109_F1.4360.15
25_Y109_F1.4360.15
40_G109_F1.4360.15
144_G241_I1.4330.15
71_L104_I1.4270.15
148_G261_N1.4160.15
7_P45_G1.4020.15
154_S217_S1.3900.15
184_N238_D1.3840.15
72_T104_I1.3830.15
185_V238_D1.3780.15
47_D315_A1.3780.15
32_I73_F1.3770.15
38_I296_I1.3720.15
19_L256_P1.3660.15
25_Y256_P1.3660.15
40_G256_P1.3660.15
22_G93_M1.3640.15
40_G142_F1.3570.14
25_Y142_F1.3570.14
19_L142_F1.3570.14
171_C196_T1.3520.14
6_S142_F1.3510.14
145_C177_G1.3410.14
107_C117_I1.3280.14
16_V242_N1.3250.14
144_G160_A1.3130.14
65_D149_I1.3100.14
62_N99_D1.3100.14
102_I135_V1.3090.14
242_N277_S1.3040.14
30_V263_Q1.2840.14
36_V73_F1.2740.13
241_I309_I1.2740.13
70_D183_G1.2520.13
189_C213_G1.2510.13
40_G73_F1.2480.13
19_L73_F1.2480.13
25_Y73_F1.2480.13
104_I117_I1.2320.13
31_V282_N1.2260.13
153_G215_F1.2230.13
47_D186_A1.2200.13
17_V147_I1.2150.13
37_W271_I1.1930.13
183_G286_L1.1820.12
21_P177_G1.1790.12
39_Y181_R1.1620.12
30_V45_G1.1620.12
8_D28_K1.1540.12
25_Y43_C1.1520.12
19_L43_C1.1520.12
40_G43_C1.1520.12
17_V53_I1.1390.12
23_A240_V1.1330.12
218_N306_V1.1330.12
16_V277_S1.1290.12
57_M197_Q1.1250.12
191_C241_I1.1240.12
5_Q62_N1.1180.12
103_T149_I1.1180.12
234_F238_D1.1140.12
107_C236_L1.1020.12
25_Y107_C1.1020.12
40_G107_C1.1020.12
19_L107_C1.1020.12
16_V139_D1.0840.11
11_F184_N1.0840.11
107_C171_C1.0730.11
149_I243_L1.0710.11
67_R244_A1.0710.11
35_P188_N1.0680.11
220_L263_Q1.0670.11
1_L12_A1.0630.11
106_G279_F1.0590.11
28_K243_L1.0520.11
283_G299_A1.0490.11
73_F168_C1.0470.11
21_P270_L1.0460.11
194_L322_V1.0400.11
145_C256_P1.0400.11
11_F17_V1.0330.11
8_D73_F1.0300.11
54_I213_G1.0170.11
36_V187_S1.0090.11
4_G149_I1.0080.11
109_F165_F1.0050.11
235_Q319_I1.0010.11
161_S188_N1.0010.11
5_Q27_W0.9920.11
250_N255_L0.9920.11
160_A243_L0.9880.11
45_G310_G0.9740.10
111_N137_I0.9680.10
96_W300_T0.9630.10
30_V240_V0.9550.10
220_L233_E0.9530.10
15_S32_I0.9520.10
6_S213_G0.9510.10
1_L193_Y0.9500.10
144_G316_G0.9460.10
64_M266_G0.9430.10
26_N122_S0.9390.10
165_F256_P0.9330.10
142_F165_F0.9300.10
266_G321_N0.9230.10
23_A314_N0.9190.10
75_G146_R0.9170.10
116_A188_N0.9170.10
115_A267_D0.9160.10
273_F277_S0.9160.10
98_I320_V0.9090.10
296_I302_L0.8970.10
65_D273_F0.8940.10
4_G107_C0.8910.10
181_R196_T0.8900.10
233_E322_V0.8890.10
241_I268_M0.8830.10
45_G117_I0.8790.10
110_Y315_A0.8760.10
117_I298_V0.8750.10
181_R240_V0.8730.10
17_V97_C0.8730.10
184_N261_N0.8680.10
215_F244_A0.8670.10
172_F185_V0.8640.10
203_G231_P0.8620.10
9_E52_A0.8590.09
40_G261_N0.8570.09
25_Y261_N0.8570.09
19_L261_N0.8570.09
149_I306_V0.8540.09
63_P104_I0.8490.09
52_A284_G0.8490.09
171_C181_R0.8480.09
106_G270_L0.8470.09
37_W277_S0.8470.09
26_N196_T0.8450.09
183_G245_G0.8380.09
36_V175_V0.8370.09
174_V236_L0.8360.09
12_A184_N0.8360.09
56_I140_C0.8350.09
238_D308_V0.8310.09
65_D242_N0.8290.09
14_N111_N0.8290.09
6_S42_R0.8260.09
44_H253_A0.8250.09
149_I175_V0.8220.09
68_I163_N0.8200.09
155_V158_G0.8200.09
1_L177_G0.8190.09
50_P286_L0.8180.09
166_S265_Y0.8160.09
13_R30_V0.8140.09
92_Q268_M0.8110.09
244_A311_C0.8060.09
15_S217_S0.8020.09
114_G145_C0.8010.09
255_L279_F0.7990.09
139_D271_I0.7980.09
17_V245_G0.7930.09
191_C256_P0.7920.09
5_Q111_N0.7900.09
109_F256_P0.7890.09
11_F47_D0.7860.09
111_N262_S0.7860.09
10_A76_G0.7820.09
101_R135_V0.7810.09
241_I322_V0.7810.09
50_P141_R0.7810.09
21_P306_V0.7800.09
4_G151_N0.7800.09
102_I119_L0.7790.09
146_R190_R0.7770.09
109_F142_F0.7770.09
38_I56_I0.7680.09
215_F315_A0.7680.09
36_V308_V0.7660.09
137_I241_I0.7650.09
29_N227_G0.7610.09
5_Q228_N0.7580.09
70_D286_L0.7550.09
214_S311_C0.7540.09
15_S322_V0.7530.09
38_I183_G0.7530.09
118_Y255_L0.7500.09
73_F165_F0.7480.09
155_V177_G0.7450.09
4_G228_N0.7450.09
254_R265_Y0.7440.09
140_C236_L0.7420.09
65_D243_L0.7420.09
26_N30_V0.7360.09
56_I308_V0.7350.09
12_A183_G0.7340.09
245_G302_L0.7330.09
237_P240_V0.7310.08
37_W198_G0.7280.08
21_P163_N0.7240.08
228_N308_V0.7220.08
21_P73_F0.7200.08
231_P243_L0.7200.08
194_L241_I0.7200.08
5_Q180_T0.7180.08
163_N260_G0.7150.08
114_G184_N0.7120.08
75_G158_G0.7120.08
142_F256_P0.7100.08
111_N227_G0.7060.08
135_V251_A0.7000.08
99_D114_G0.6990.08
97_C180_T0.6990.08
29_N151_N0.6970.08
96_W304_A0.6910.08
185_V319_I0.6890.08
5_Q13_R0.6860.08
139_D273_F0.6820.08
243_L270_L0.6810.08
34_K103_T0.6790.08
65_D227_G0.6780.08
109_F218_N0.6760.08
42_R114_G0.6750.08
10_A49_R0.6750.08
114_G190_R0.6740.08
186_A315_A0.6730.08
26_N171_C0.6710.08
73_F107_C0.6690.08
102_I236_L0.6660.08
43_C139_D0.6610.08
38_I228_N0.6610.08
318_Q322_V0.6580.08
34_K111_N0.6580.08
6_S40_G0.6570.08
6_S25_Y0.6570.08
36_V228_N0.6570.08
6_S19_L0.6570.08
43_C165_F0.6550.08
154_S266_G0.6540.08
158_G310_G0.6530.08
137_I262_S0.6530.08
17_V114_G0.6510.08
168_C258_F0.6500.08
166_S279_F0.6490.08
191_C261_N0.6480.08
24_E215_F0.6460.08
32_I66_V0.6450.08
36_V189_C0.6410.08
10_A70_D0.6400.08
1_L7_P0.6400.08
42_R256_P0.6400.08
33_R296_I0.6390.08
148_G284_G0.6390.08
189_C321_N0.6310.08
11_F167_D0.6300.08
12_A296_I0.6250.08
11_F157_Y0.6230.08
50_P231_P0.6200.08
188_N316_G0.6180.08
105_R166_S0.6170.08
35_P184_N0.6160.08
112_F218_N0.6150.08
151_N194_L0.6140.08
24_E308_V0.6140.08
115_A321_N0.6130.08
14_N289_G0.6110.08
38_I165_F0.6100.08
45_G158_G0.6060.08
24_E143_R0.6050.08
172_F311_C0.6010.08
197_Q228_N0.5980.08
21_P168_C0.5980.08
29_N77_D0.5950.08
272_N308_V0.5950.08
227_G272_N0.5910.08
42_R184_N0.5880.07
37_W106_G0.5860.07
17_V280_V0.5840.07
21_P268_M0.5840.07
3_P191_C0.5830.07
139_D142_F0.5830.07
20_V219_T0.5820.07
32_I58_G0.5810.07
4_G68_I0.5800.07
107_C311_C0.5770.07
5_Q264_W0.5770.07
145_C218_N0.5760.07
116_A276_D0.5760.07
281_I313_G0.5760.07
117_I149_I0.5750.07
146_R290_P0.5730.07
11_F220_L0.5710.07
36_V239_R0.5700.07
73_F256_P0.5700.07
105_R281_I0.5690.07
73_F181_R0.5650.07
27_W115_A0.5640.07
73_F142_F0.5640.07
48_F236_L0.5620.07
13_R49_R0.5610.07
105_R277_S0.5610.07
58_G296_I0.5580.07
166_S281_I0.5580.07
13_R185_V0.5570.07
183_G314_N0.5560.07
36_V157_Y0.5550.07
35_P286_L0.5510.07
75_G222_H0.5510.07
37_W139_D0.5500.07
185_V267_D0.5500.07
12_A212_H0.5460.07
54_I140_C0.5440.07
3_P35_P0.5430.07
43_C109_F0.5430.07
236_L266_G0.5430.07
108_S189_C0.5410.07
22_G259_S0.5400.07
36_V139_D0.5390.07
148_G184_N0.5370.07
70_D106_G0.5290.07
203_G311_C0.5280.07
158_G177_G0.5280.07
27_W245_G0.5260.07
11_F34_K0.5260.07
250_N310_G0.5250.07
38_I178_N0.5240.07
58_G272_N0.5240.07
40_G168_C0.5230.07
19_L168_C0.5230.07
25_Y168_C0.5230.07
67_R100_P0.5230.07
27_W38_I0.5230.07
241_I296_I0.5210.07
121_R263_Q0.5190.07
44_H66_V0.5170.07
5_Q309_I0.5160.07
42_R158_G0.5140.07
21_P40_G0.5120.07
21_P25_Y0.5120.07
101_R296_I0.5090.07
80_D211_A0.5080.07
4_G111_N0.5070.07
105_R279_F0.5070.07
38_I229_L0.5060.07
119_L244_A0.5060.07
162_Q264_W0.5050.07
105_R265_Y0.5030.07
40_G140_C0.5000.07
19_L140_C0.5000.07
25_Y140_C0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dbg_A 1 0.8471 98.8 0.917 Contact Map
3zsc_A 1 0.8059 98.5 0.923 Contact Map
2pyg_A 1 0.7971 98.4 0.925 Contact Map
3vmv_A 1 0.7529 98.4 0.926 Contact Map
2inu_A 1 0.8588 98.3 0.928 Contact Map
4mxn_A 1 0.5265 98.3 0.928 Contact Map
4nk6_A 1 0.0382 98.3 0.928 Contact Map
1ru4_A 1 0.8471 98.3 0.929 Contact Map
1pcl_A 1 0.7882 98.3 0.929 Contact Map
3gq8_A 1 0.9294 97.7 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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