GREMLIN Database
T0907_1_315 - T0907 1-315
ID: 62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 315 (289)
Sequences: 1900 (1394)
Seq/√Len: 82.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_Q45_K5.4561.00
173_E193_T5.0871.00
132_D166_R4.7991.00
43_T77_T4.6091.00
85_T109_E4.0831.00
253_Q294_E3.1931.00
146_N181_Q2.9671.00
47_N75_L2.7841.00
122_T136_N2.7841.00
87_P109_E2.7361.00
127_L165_A2.7051.00
119_V192_T2.6321.00
201_D305_R2.6271.00
89_K107_E2.5861.00
91_Y103_R2.4651.00
45_K77_T2.2561.00
151_I154_G2.2351.00
118_S140_P2.2281.00
205_Y237_A2.1821.00
127_L135_I2.1591.00
90_G106_F2.1591.00
93_E103_R2.1581.00
95_M101_K2.1541.00
25_N55_T2.1511.00
47_N73_M2.1361.00
38_V80_A2.1081.00
82_A86_Y2.0751.00
148_S181_Q2.0751.00
60_D67_L2.0681.00
248_T298_R2.0671.00
268_S277_Q2.0161.00
122_T162_L1.9961.00
87_P107_E1.9931.00
175_I191_K1.9921.00
175_I193_T1.9591.00
132_D164_I1.9401.00
26_S55_T1.9151.00
37_I113_T1.9121.00
43_T79_T1.8951.00
137_I149_A1.8701.00
24_V27_I1.8641.00
60_D93_E1.8271.00
131_I242_L1.8141.00
266_E276_R1.8041.00
61_V74_G1.8041.00
123_M244_E1.8001.00
177_S188_Q1.7991.00
89_K105_D1.7941.00
131_I243_L1.7901.00
96_G100_V1.7691.00
33_P44_Y1.7011.00
249_V297_A1.6921.00
96_G102_I1.6791.00
224_G227_E1.6581.00
268_S274_S1.6561.00
134_P243_L1.6531.00
93_E101_K1.6421.00
121_P194_L1.6391.00
139_V189_M1.6331.00
16_T19_L1.6061.00
139_V180_A1.5991.00
91_Y105_D1.5841.00
199_L238_L1.5811.00
153_N174_A1.5601.00
270_G274_S1.5551.00
40_S114_E1.5230.99
254_L281_I1.5180.99
197_R242_L1.5170.99
273_F281_I1.5160.99
135_I165_A1.5010.99
296_I306_K1.4650.99
25_N54_D1.4380.99
254_L277_Q1.4370.99
205_Y239_D1.4370.99
252_F268_S1.4310.99
151_I165_A1.4180.99
204_P295_V1.4110.99
25_N56_T1.3910.99
85_T111_F1.3810.99
159_R162_L1.3790.99
123_M134_P1.3660.99
234_I292_V1.3570.99
88_V108_S1.3560.99
83_P86_Y1.3560.99
251_K296_I1.3490.99
233_G273_F1.3450.99
188_Q191_K1.3420.99
18_N21_F1.3380.99
247_Y299_G1.2950.98
38_V44_Y1.2820.98
30_Q49_V1.2800.98
27_I52_S1.2780.98
285_G288_K1.2740.98
297_A307_I1.2720.98
137_I176_I1.2620.98
289_R293_T1.2350.98
94_M102_I1.2320.98
302_G305_R1.2290.98
250_V298_R1.2280.98
62_F67_L1.2260.98
121_P134_P1.2250.97
142_V180_A1.2240.97
225_K229_L1.2120.97
205_Y235_K1.1990.97
48_I88_V1.1810.97
76_F79_T1.1800.97
256_F280_Q1.1780.97
61_V92_I1.1600.97
181_Q184_G1.1520.96
254_L273_F1.1460.96
44_Y88_V1.1330.96
165_A176_I1.1330.96
125_N195_R1.1200.96
34_Q47_N1.1080.95
83_P114_E1.0900.95
284_L288_K1.0850.95
275_E279_R1.0820.95
122_T134_P1.0690.94
131_I199_L1.0680.94
177_S191_K1.0650.94
156_L165_A1.0640.94
273_F277_Q1.0630.94
183_G186_T1.0600.94
238_L247_Y1.0420.94
129_A168_T1.0420.94
199_L247_Y1.0400.94
129_A198_A1.0380.94
151_I174_A1.0360.94
198_A201_D1.0320.93
156_L159_R1.0260.93
80_A112_V1.0230.93
18_N22_Q1.0210.93
203_L239_D1.0190.93
123_M243_L1.0080.93
236_A249_V1.0050.92
135_I156_L1.0050.92
126_V197_R1.0010.92
143_A146_N1.0010.92
43_T80_A0.9850.92
90_G105_D0.9850.92
118_S139_V0.9770.91
302_G307_I0.9730.91
28_T73_M0.9690.91
129_A167_P0.9640.91
24_V52_S0.9550.90
29_A110_Y0.9520.90
296_I304_E0.9510.90
30_Q33_P0.9480.90
35_S42_D0.9480.90
118_S136_N0.9460.90
123_M131_I0.9440.90
253_Q261_G0.9430.90
45_K75_L0.9430.90
266_E280_Q0.9420.90
258_D261_G0.9400.90
274_S277_Q0.9380.90
40_S82_A0.9360.89
154_G165_A0.9290.89
206_I234_I0.9280.89
253_Q265_P0.9250.89
275_E278_K0.9200.89
139_V178_V0.9200.89
33_P36_Q0.9140.88
62_F91_Y0.9100.88
17_E21_F0.9080.88
165_A174_A0.9060.88
199_L299_G0.9030.88
174_A196_V0.9030.88
199_L241_D0.8940.87
62_F93_E0.8910.87
211_V239_D0.8890.87
182_S185_R0.8880.87
134_P241_D0.8880.87
24_V49_V0.8870.87
118_S121_P0.8840.87
14_L17_E0.8830.87
31_V36_Q0.8820.87
151_I156_L0.8820.87
63_V76_F0.8810.86
136_N192_T0.8800.86
179_T189_M0.8800.86
155_T159_R0.8700.86
299_G302_G0.8680.86
252_F277_Q0.8650.85
18_N24_V0.8630.85
80_A86_Y0.8580.85
124_M134_P0.8450.84
121_P124_M0.8450.84
35_S38_V0.8410.84
279_R282_Q0.8390.84
253_Q267_V0.8370.83
68_L71_E0.8370.83
28_T53_V0.8360.83
31_V46_A0.8340.83
44_Y108_S0.8330.83
142_V182_S0.8310.83
29_A33_P0.8180.82
298_R301_D0.8100.81
180_A189_M0.8080.81
199_L237_A0.8080.81
179_T188_Q0.7960.80
30_Q51_S0.7940.80
71_E75_L0.7920.80
142_V178_V0.7910.80
38_V42_D0.7900.80
295_V307_I0.7880.80
187_I190_A0.7880.80
150_T179_T0.7860.79
31_V108_S0.7820.79
179_T186_T0.7780.79
181_Q186_T0.7770.79
29_A46_A0.7690.78
158_R162_L0.7660.78
32_I49_V0.7630.77
205_Y211_V0.7620.77
36_Q108_S0.7610.77
131_I247_Y0.7580.77
253_Q293_T0.7580.77
301_D305_R0.7570.77
176_I194_L0.7560.77
260_M264_I0.7530.76
255_V263_S0.7520.76
62_F65_G0.7520.76
114_E192_T0.7520.76
256_F284_L0.7520.76
259_S288_K0.7510.76
256_F290_F0.7510.76
94_M104_R0.7480.76
17_E50_L0.7460.76
181_Q187_I0.7440.76
126_V195_R0.7340.75
225_K281_I0.7250.74
21_F24_V0.7250.74
33_P46_A0.7240.74
127_L167_P0.7230.74
38_V59_P0.7200.73
125_N134_P0.7190.73
62_F69_S0.7180.73
199_L246_N0.7180.73
279_R283_N0.7130.73
14_L24_V0.7090.72
206_I231_A0.7060.72
255_V291_Y0.7050.72
259_S283_N0.7050.72
18_N23_S0.7020.71
39_M113_T0.6970.71
207_E231_A0.6970.71
22_Q104_R0.6940.70
124_M243_L0.6930.70
55_T59_P0.6910.70
47_N104_R0.6900.70
124_M141_G0.6900.70
234_I249_V0.6880.70
149_A156_L0.6860.70
236_A297_A0.6860.70
235_K238_L0.6850.69
258_D288_K0.6810.69
148_S179_T0.6810.69
241_D245_V0.6800.69
40_S80_A0.6780.69
18_N25_N0.6780.69
238_L242_L0.6760.68
31_V106_F0.6760.68
255_V289_R0.6760.68
48_I90_G0.6730.68
276_R279_R0.6730.68
58_R61_V0.6670.67
255_V293_T0.6670.67
25_N30_Q0.6670.67
247_Y305_R0.6640.67
99_G167_P0.6620.67
42_D187_I0.6620.67
121_P243_L0.6610.67
30_Q47_N0.6600.67
127_L176_I0.6600.67
103_R106_F0.6600.67
250_V296_I0.6590.67
233_G272_S0.6590.67
155_T166_R0.6560.66
16_T20_Y0.6550.66
210_D213_G0.6540.66
151_I254_L0.6510.66
157_T166_R0.6510.66
152_N177_S0.6500.65
117_A121_P0.6490.65
154_G174_A0.6470.65
60_D175_I0.6470.65
86_Y110_Y0.6450.65
19_L27_I0.6430.65
17_E20_Y0.6420.65
115_P178_V0.6380.64
20_Y25_N0.6380.64
210_D227_E0.6370.64
224_G232_G0.6360.64
281_I284_L0.6270.63
119_V176_I0.6240.62
157_T168_T0.6190.62
29_A90_G0.6170.61
251_K267_V0.6160.61
120_A192_T0.6150.61
199_L245_V0.6140.61
284_L290_F0.6140.61
20_Y55_T0.6130.61
121_P136_N0.6120.61
137_I178_V0.6110.61
131_I245_V0.6070.60
305_R308_P0.6060.60
276_R288_K0.6030.60
226_R307_I0.6030.60
40_S48_I0.6020.60
139_V190_A0.6010.59
63_V144_Q0.6010.59
22_Q27_I0.6000.59
19_L22_Q0.5980.59
138_A141_G0.5970.59
285_G306_K0.5970.59
135_I176_I0.5970.59
14_L18_N0.5960.59
153_N167_P0.5950.59
50_L104_R0.5920.58
147_V180_A0.5920.58
13_D59_P0.5890.58
148_S189_M0.5880.58
123_M245_V0.5880.58
82_A85_T0.5850.57
273_F278_K0.5850.57
150_T156_L0.5840.57
143_A244_E0.5840.57
278_K282_Q0.5830.57
110_Y161_N0.5810.57
88_V248_T0.5800.57
136_N162_L0.5780.56
140_P212_Q0.5760.56
225_K249_V0.5760.56
214_N226_R0.5750.56
91_Y106_F0.5740.56
210_D224_G0.5720.56
13_D17_E0.5720.56
124_M195_R0.5720.56
225_K274_S0.5720.56
257_Y288_K0.5720.56
66_K69_S0.5710.56
253_Q263_S0.5680.55
207_E227_E0.5680.55
148_S158_R0.5670.55
40_S112_V0.5630.55
207_E233_G0.5600.54
16_T80_A0.5600.54
248_T299_G0.5590.54
24_V74_G0.5590.54
64_N89_K0.5580.54
262_N280_Q0.5560.54
42_D80_A0.5550.54
250_V304_E0.5550.54
46_A228_I0.5540.53
21_F55_T0.5530.53
137_I169_K0.5520.53
155_T168_T0.5510.53
245_V297_A0.5510.53
149_A176_I0.5510.53
24_V57_Q0.5500.53
150_T186_T0.5500.53
252_F295_V0.5490.53
264_I292_V0.5470.52
48_I53_V0.5470.52
15_G92_I0.5460.52
158_R164_I0.5450.52
40_S81_G0.5450.52
207_E235_K0.5430.52
210_D214_N0.5420.52
130_G301_D0.5420.52
52_S55_T0.5420.52
124_M130_G0.5390.51
277_Q280_Q0.5380.51
124_M242_L0.5370.51
52_S104_R0.5370.51
121_P135_I0.5360.51
304_E308_P0.5350.51
39_M42_D0.5350.51
50_L57_Q0.5350.51
201_D247_Y0.5340.51
266_E270_G0.5330.51
24_V59_P0.5330.51
237_A242_L0.5330.51
17_E24_V0.5310.50
152_N179_T0.5300.50
48_I61_V0.5300.50
29_A104_R0.5300.50
123_M242_L0.5260.50
78_A110_Y0.5250.50
27_I51_S0.5240.49
131_I164_I0.5240.49
147_V163_W0.5230.49
18_N54_D0.5210.49
13_D21_F0.5190.49
181_Q185_R0.5190.49
271_A276_R0.5190.49
233_G236_A0.5180.49
297_A300_P0.5180.49
278_K281_I0.5170.49
117_A192_T0.5170.49
125_N243_L0.5160.48
22_Q50_L0.5160.48
24_V28_T0.5160.48
256_F277_Q0.5140.48
85_T161_N0.5140.48
201_D256_F0.5140.48
307_I310_I0.5140.48
57_Q110_Y0.5130.48
202_P238_L0.5130.48
17_E52_S0.5120.48
135_I154_G0.5120.48
208_Y249_V0.5120.48
31_V88_V0.5100.48
21_F27_I0.5090.47
177_S192_T0.5090.47
229_L240_D0.5080.47
25_N50_L0.5080.47
223_L228_I0.5080.47
74_G92_I0.5080.47
27_I53_V0.5070.47
116_M139_V0.5070.47
24_V94_M0.5060.47
199_L243_L0.5060.47
119_V178_V0.5050.47
304_E307_I0.5050.47
206_I229_L0.5040.47
305_R309_A0.5030.47
185_R189_M0.5020.47
211_V214_N0.5020.47
44_Y202_P0.5020.47
202_P305_R0.5010.46
196_V262_N0.5000.46
131_I241_D0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pdd_A 1 0.5556 87.1 0.938 Contact Map
4p3w_A 1 0.5016 63.7 0.949 Contact Map
4m03_A 1 0.4889 48.1 0.954 Contact Map
4p99_A 1 0.8603 40 0.956 Contact Map
2k7q_A 1 0.5619 24.1 0.961 Contact Map
4m00_A 1 0.6063 21.2 0.962 Contact Map
1v05_A 1 0.2889 17.8 0.963 Contact Map
2di9_A 1 0.4 16.1 0.964 Contact Map
2j3s_A 1 0.5048 12.8 0.965 Contact Map
4kdw_A 1 0.2889 11.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.