T0907_1_315 - CASP12 - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

T0907_1_315 - T0907 1-315

ID:	62	Sequences: MGHHHHHHSSGVDLGTENLYFQSVNSITAQVIPQSQIVMSGDTYKANIVLSSVDTTQRPDVFVNGKLLSPENMGLFTATAGAPGTYPVKGYIEMMGNDGVKIRRDFESEYFVTEPMASVAPTMMNVLYAGIDNPINIAVPGVAQQNVSATINNGTLTRRGNLWIARPTKVGSEAIISVTAQSGGRTIQMAKTTLRVRALPDPLPYIEYKDVQGNTKRFKGGRLGKREILAAGGIKAALDDDLLEVNYTVVKFQLVFYDSMGNSIPEVSDGASFSERQKRQIQNLGKGKRFYVTEVIARGPDGIERKIPAIEVIVN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	315 (289)
Sequences:	1900 (1394)
Seq/√Len:	82.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_Q	45_K	5.456	1.00
173_E	193_T	5.087	1.00
132_D	166_R	4.799	1.00
43_T	77_T	4.609	1.00
85_T	109_E	4.083	1.00
253_Q	294_E	3.193	1.00
146_N	181_Q	2.967	1.00
47_N	75_L	2.784	1.00
122_T	136_N	2.784	1.00
87_P	109_E	2.736	1.00
127_L	165_A	2.705	1.00
119_V	192_T	2.632	1.00
201_D	305_R	2.627	1.00
89_K	107_E	2.586	1.00
91_Y	103_R	2.465	1.00
45_K	77_T	2.256	1.00
151_I	154_G	2.235	1.00
118_S	140_P	2.228	1.00
205_Y	237_A	2.182	1.00
127_L	135_I	2.159	1.00
90_G	106_F	2.159	1.00
93_E	103_R	2.158	1.00
95_M	101_K	2.154	1.00
25_N	55_T	2.151	1.00
47_N	73_M	2.136	1.00
38_V	80_A	2.108	1.00
82_A	86_Y	2.075	1.00
148_S	181_Q	2.075	1.00
60_D	67_L	2.068	1.00
248_T	298_R	2.067	1.00
268_S	277_Q	2.016	1.00
122_T	162_L	1.996	1.00
87_P	107_E	1.993	1.00
175_I	191_K	1.992	1.00
175_I	193_T	1.959	1.00
132_D	164_I	1.940	1.00
26_S	55_T	1.915	1.00
37_I	113_T	1.912	1.00
43_T	79_T	1.895	1.00
137_I	149_A	1.870	1.00
24_V	27_I	1.864	1.00
60_D	93_E	1.827	1.00
131_I	242_L	1.814	1.00
266_E	276_R	1.804	1.00
61_V	74_G	1.804	1.00
123_M	244_E	1.800	1.00
177_S	188_Q	1.799	1.00
89_K	105_D	1.794	1.00
131_I	243_L	1.790	1.00
96_G	100_V	1.769	1.00
33_P	44_Y	1.701	1.00
249_V	297_A	1.692	1.00
96_G	102_I	1.679	1.00
224_G	227_E	1.658	1.00
268_S	274_S	1.656	1.00
134_P	243_L	1.653	1.00
93_E	101_K	1.642	1.00
121_P	194_L	1.639	1.00
139_V	189_M	1.633	1.00
16_T	19_L	1.606	1.00
139_V	180_A	1.599	1.00
91_Y	105_D	1.584	1.00
199_L	238_L	1.581	1.00
153_N	174_A	1.560	1.00
270_G	274_S	1.555	1.00
40_S	114_E	1.523	0.99
254_L	281_I	1.518	0.99
197_R	242_L	1.517	0.99
273_F	281_I	1.516	0.99
135_I	165_A	1.501	0.99
296_I	306_K	1.465	0.99
25_N	54_D	1.438	0.99
254_L	277_Q	1.437	0.99
205_Y	239_D	1.437	0.99
252_F	268_S	1.431	0.99
151_I	165_A	1.418	0.99
204_P	295_V	1.411	0.99
25_N	56_T	1.391	0.99
85_T	111_F	1.381	0.99
159_R	162_L	1.379	0.99
123_M	134_P	1.366	0.99
234_I	292_V	1.357	0.99
88_V	108_S	1.356	0.99
83_P	86_Y	1.356	0.99
251_K	296_I	1.349	0.99
233_G	273_F	1.345	0.99
188_Q	191_K	1.342	0.99
18_N	21_F	1.338	0.99
247_Y	299_G	1.295	0.98
38_V	44_Y	1.282	0.98
30_Q	49_V	1.280	0.98
27_I	52_S	1.278	0.98
285_G	288_K	1.274	0.98
297_A	307_I	1.272	0.98
137_I	176_I	1.262	0.98
289_R	293_T	1.235	0.98
94_M	102_I	1.232	0.98
302_G	305_R	1.229	0.98
250_V	298_R	1.228	0.98
62_F	67_L	1.226	0.98
121_P	134_P	1.225	0.97
142_V	180_A	1.224	0.97
225_K	229_L	1.212	0.97
205_Y	235_K	1.199	0.97
48_I	88_V	1.181	0.97
76_F	79_T	1.180	0.97
256_F	280_Q	1.178	0.97
61_V	92_I	1.160	0.97
181_Q	184_G	1.152	0.96
254_L	273_F	1.146	0.96
44_Y	88_V	1.133	0.96
165_A	176_I	1.133	0.96
125_N	195_R	1.120	0.96
34_Q	47_N	1.108	0.95
83_P	114_E	1.090	0.95
284_L	288_K	1.085	0.95
275_E	279_R	1.082	0.95
122_T	134_P	1.069	0.94
131_I	199_L	1.068	0.94
177_S	191_K	1.065	0.94
156_L	165_A	1.064	0.94
273_F	277_Q	1.063	0.94
183_G	186_T	1.060	0.94
238_L	247_Y	1.042	0.94
129_A	168_T	1.042	0.94
199_L	247_Y	1.040	0.94
129_A	198_A	1.038	0.94
151_I	174_A	1.036	0.94
198_A	201_D	1.032	0.93
156_L	159_R	1.026	0.93
80_A	112_V	1.023	0.93
18_N	22_Q	1.021	0.93
203_L	239_D	1.019	0.93
123_M	243_L	1.008	0.93
236_A	249_V	1.005	0.92
135_I	156_L	1.005	0.92
126_V	197_R	1.001	0.92
143_A	146_N	1.001	0.92
43_T	80_A	0.985	0.92
90_G	105_D	0.985	0.92
118_S	139_V	0.977	0.91
302_G	307_I	0.973	0.91
28_T	73_M	0.969	0.91
129_A	167_P	0.964	0.91
24_V	52_S	0.955	0.90
29_A	110_Y	0.952	0.90
296_I	304_E	0.951	0.90
30_Q	33_P	0.948	0.90
35_S	42_D	0.948	0.90
118_S	136_N	0.946	0.90
123_M	131_I	0.944	0.90
253_Q	261_G	0.943	0.90
45_K	75_L	0.943	0.90
266_E	280_Q	0.942	0.90
258_D	261_G	0.940	0.90
274_S	277_Q	0.938	0.90
40_S	82_A	0.936	0.89
154_G	165_A	0.929	0.89
206_I	234_I	0.928	0.89
253_Q	265_P	0.925	0.89
275_E	278_K	0.920	0.89
139_V	178_V	0.920	0.89
33_P	36_Q	0.914	0.88
62_F	91_Y	0.910	0.88
17_E	21_F	0.908	0.88
165_A	174_A	0.906	0.88
199_L	299_G	0.903	0.88
174_A	196_V	0.903	0.88
199_L	241_D	0.894	0.87
62_F	93_E	0.891	0.87
211_V	239_D	0.889	0.87
182_S	185_R	0.888	0.87
134_P	241_D	0.888	0.87
24_V	49_V	0.887	0.87
118_S	121_P	0.884	0.87
14_L	17_E	0.883	0.87
31_V	36_Q	0.882	0.87
151_I	156_L	0.882	0.87
63_V	76_F	0.881	0.86
136_N	192_T	0.880	0.86
179_T	189_M	0.880	0.86
155_T	159_R	0.870	0.86
299_G	302_G	0.868	0.86
252_F	277_Q	0.865	0.85
18_N	24_V	0.863	0.85
80_A	86_Y	0.858	0.85
124_M	134_P	0.845	0.84
121_P	124_M	0.845	0.84
35_S	38_V	0.841	0.84
279_R	282_Q	0.839	0.84
253_Q	267_V	0.837	0.83
68_L	71_E	0.837	0.83
28_T	53_V	0.836	0.83
31_V	46_A	0.834	0.83
44_Y	108_S	0.833	0.83
142_V	182_S	0.831	0.83
29_A	33_P	0.818	0.82
298_R	301_D	0.810	0.81
180_A	189_M	0.808	0.81
199_L	237_A	0.808	0.81
179_T	188_Q	0.796	0.80
30_Q	51_S	0.794	0.80
71_E	75_L	0.792	0.80
142_V	178_V	0.791	0.80
38_V	42_D	0.790	0.80
295_V	307_I	0.788	0.80
187_I	190_A	0.788	0.80
150_T	179_T	0.786	0.79
31_V	108_S	0.782	0.79
179_T	186_T	0.778	0.79
181_Q	186_T	0.777	0.79
29_A	46_A	0.769	0.78
158_R	162_L	0.766	0.78
32_I	49_V	0.763	0.77
205_Y	211_V	0.762	0.77
36_Q	108_S	0.761	0.77
131_I	247_Y	0.758	0.77
253_Q	293_T	0.758	0.77
301_D	305_R	0.757	0.77
176_I	194_L	0.756	0.77
260_M	264_I	0.753	0.76
255_V	263_S	0.752	0.76
62_F	65_G	0.752	0.76
114_E	192_T	0.752	0.76
256_F	284_L	0.752	0.76
259_S	288_K	0.751	0.76
256_F	290_F	0.751	0.76
94_M	104_R	0.748	0.76
17_E	50_L	0.746	0.76
181_Q	187_I	0.744	0.76
126_V	195_R	0.734	0.75
225_K	281_I	0.725	0.74
21_F	24_V	0.725	0.74
33_P	46_A	0.724	0.74
127_L	167_P	0.723	0.74
38_V	59_P	0.720	0.73
125_N	134_P	0.719	0.73
62_F	69_S	0.718	0.73
199_L	246_N	0.718	0.73
279_R	283_N	0.713	0.73
14_L	24_V	0.709	0.72
206_I	231_A	0.706	0.72
255_V	291_Y	0.705	0.72
259_S	283_N	0.705	0.72
18_N	23_S	0.702	0.71
39_M	113_T	0.697	0.71
207_E	231_A	0.697	0.71
22_Q	104_R	0.694	0.70
124_M	243_L	0.693	0.70
55_T	59_P	0.691	0.70
47_N	104_R	0.690	0.70
124_M	141_G	0.690	0.70
234_I	249_V	0.688	0.70
149_A	156_L	0.686	0.70
236_A	297_A	0.686	0.70
235_K	238_L	0.685	0.69
258_D	288_K	0.681	0.69
148_S	179_T	0.681	0.69
241_D	245_V	0.680	0.69
40_S	80_A	0.678	0.69
18_N	25_N	0.678	0.69
238_L	242_L	0.676	0.68
31_V	106_F	0.676	0.68
255_V	289_R	0.676	0.68
48_I	90_G	0.673	0.68
276_R	279_R	0.673	0.68
58_R	61_V	0.667	0.67
255_V	293_T	0.667	0.67
25_N	30_Q	0.667	0.67
247_Y	305_R	0.664	0.67
99_G	167_P	0.662	0.67
42_D	187_I	0.662	0.67
121_P	243_L	0.661	0.67
30_Q	47_N	0.660	0.67
127_L	176_I	0.660	0.67
103_R	106_F	0.660	0.67
250_V	296_I	0.659	0.67
233_G	272_S	0.659	0.67
155_T	166_R	0.656	0.66
16_T	20_Y	0.655	0.66
210_D	213_G	0.654	0.66
151_I	254_L	0.651	0.66
157_T	166_R	0.651	0.66
152_N	177_S	0.650	0.65
117_A	121_P	0.649	0.65
154_G	174_A	0.647	0.65
60_D	175_I	0.647	0.65
86_Y	110_Y	0.645	0.65
19_L	27_I	0.643	0.65
17_E	20_Y	0.642	0.65
115_P	178_V	0.638	0.64
20_Y	25_N	0.638	0.64
210_D	227_E	0.637	0.64
224_G	232_G	0.636	0.64
281_I	284_L	0.627	0.63
119_V	176_I	0.624	0.62
157_T	168_T	0.619	0.62
29_A	90_G	0.617	0.61
251_K	267_V	0.616	0.61
120_A	192_T	0.615	0.61
199_L	245_V	0.614	0.61
284_L	290_F	0.614	0.61
20_Y	55_T	0.613	0.61
121_P	136_N	0.612	0.61
137_I	178_V	0.611	0.61
131_I	245_V	0.607	0.60
305_R	308_P	0.606	0.60
276_R	288_K	0.603	0.60
226_R	307_I	0.603	0.60
40_S	48_I	0.602	0.60
139_V	190_A	0.601	0.59
63_V	144_Q	0.601	0.59
22_Q	27_I	0.600	0.59
19_L	22_Q	0.598	0.59
138_A	141_G	0.597	0.59
285_G	306_K	0.597	0.59
135_I	176_I	0.597	0.59
14_L	18_N	0.596	0.59
153_N	167_P	0.595	0.59
50_L	104_R	0.592	0.58
147_V	180_A	0.592	0.58
13_D	59_P	0.589	0.58
148_S	189_M	0.588	0.58
123_M	245_V	0.588	0.58
82_A	85_T	0.585	0.57
273_F	278_K	0.585	0.57
150_T	156_L	0.584	0.57
143_A	244_E	0.584	0.57
278_K	282_Q	0.583	0.57
110_Y	161_N	0.581	0.57
88_V	248_T	0.580	0.57
136_N	162_L	0.578	0.56
140_P	212_Q	0.576	0.56
225_K	249_V	0.576	0.56
214_N	226_R	0.575	0.56
91_Y	106_F	0.574	0.56
210_D	224_G	0.572	0.56
13_D	17_E	0.572	0.56
124_M	195_R	0.572	0.56
225_K	274_S	0.572	0.56
257_Y	288_K	0.572	0.56
66_K	69_S	0.571	0.56
253_Q	263_S	0.568	0.55
207_E	227_E	0.568	0.55
148_S	158_R	0.567	0.55
40_S	112_V	0.563	0.55
207_E	233_G	0.560	0.54
16_T	80_A	0.560	0.54
248_T	299_G	0.559	0.54
24_V	74_G	0.559	0.54
64_N	89_K	0.558	0.54
262_N	280_Q	0.556	0.54
42_D	80_A	0.555	0.54
250_V	304_E	0.555	0.54
46_A	228_I	0.554	0.53
21_F	55_T	0.553	0.53
137_I	169_K	0.552	0.53
155_T	168_T	0.551	0.53
245_V	297_A	0.551	0.53
149_A	176_I	0.551	0.53
24_V	57_Q	0.550	0.53
150_T	186_T	0.550	0.53
252_F	295_V	0.549	0.53
264_I	292_V	0.547	0.52
48_I	53_V	0.547	0.52
15_G	92_I	0.546	0.52
158_R	164_I	0.545	0.52
40_S	81_G	0.545	0.52
207_E	235_K	0.543	0.52
210_D	214_N	0.542	0.52
130_G	301_D	0.542	0.52
52_S	55_T	0.542	0.52
124_M	130_G	0.539	0.51
277_Q	280_Q	0.538	0.51
124_M	242_L	0.537	0.51
52_S	104_R	0.537	0.51
121_P	135_I	0.536	0.51
304_E	308_P	0.535	0.51
39_M	42_D	0.535	0.51
50_L	57_Q	0.535	0.51
201_D	247_Y	0.534	0.51
266_E	270_G	0.533	0.51
24_V	59_P	0.533	0.51
237_A	242_L	0.533	0.51
17_E	24_V	0.531	0.50
152_N	179_T	0.530	0.50
48_I	61_V	0.530	0.50
29_A	104_R	0.530	0.50
123_M	242_L	0.526	0.50
78_A	110_Y	0.525	0.50
27_I	51_S	0.524	0.49
131_I	164_I	0.524	0.49
147_V	163_W	0.523	0.49
18_N	54_D	0.521	0.49
13_D	21_F	0.519	0.49
181_Q	185_R	0.519	0.49
271_A	276_R	0.519	0.49
233_G	236_A	0.518	0.49
297_A	300_P	0.518	0.49
278_K	281_I	0.517	0.49
117_A	192_T	0.517	0.49
125_N	243_L	0.516	0.48
22_Q	50_L	0.516	0.48
24_V	28_T	0.516	0.48
256_F	277_Q	0.514	0.48
85_T	161_N	0.514	0.48
201_D	256_F	0.514	0.48
307_I	310_I	0.514	0.48
57_Q	110_Y	0.513	0.48
202_P	238_L	0.513	0.48
17_E	52_S	0.512	0.48
135_I	154_G	0.512	0.48
208_Y	249_V	0.512	0.48
31_V	88_V	0.510	0.48
21_F	27_I	0.509	0.47
177_S	192_T	0.509	0.47
229_L	240_D	0.508	0.47
25_N	50_L	0.508	0.47
223_L	228_I	0.508	0.47
74_G	92_I	0.508	0.47
27_I	53_V	0.507	0.47
116_M	139_V	0.507	0.47
24_V	94_M	0.506	0.47
199_L	243_L	0.506	0.47
119_V	178_V	0.505	0.47
304_E	307_I	0.505	0.47
206_I	229_L	0.504	0.47
305_R	309_A	0.503	0.47
185_R	189_M	0.502	0.47
211_V	214_N	0.502	0.47
44_Y	202_P	0.502	0.47
202_P	305_R	0.501	0.46
196_V	262_N	0.500	0.46
131_I	241_D	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pdd_A	1	0.5556	87.1	0.938	Contact Map
4p3w_A	1	0.5016	63.7	0.949	Contact Map
4m03_A	1	0.4889	48.1	0.954	Contact Map
4p99_A	1	0.8603	40	0.956	Contact Map
2k7q_A	1	0.5619	24.1	0.961	Contact Map
4m00_A	1	0.6063	21.2	0.962	Contact Map
1v05_A	1	0.2889	17.8	0.963	Contact Map
2di9_A	1	0.4	16.1	0.964	Contact Map
2j3s_A	1	0.5048	12.8	0.965	Contact Map
4kdw_A	1	0.2889	11.8	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.