GREMLIN Database
T0908_1_137 - T0908 1-137
ID: 61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (117)
Sequences: 2040 (1255)
Seq/√Len: 116.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_G125_T3.2541.00
69_F84_M3.2161.00
13_V87_L2.7391.00
19_L127_V2.4711.00
121_W127_V2.4401.00
37_W82_L2.3781.00
49_V69_F2.3761.00
39_R93_A2.3211.00
7_E122_G2.2691.00
121_W124_G2.2691.00
25_A35_M2.1621.00
35_M80_V2.1491.00
40_Q46_R2.0941.00
14_Q17_G2.0571.00
118_Y126_K2.0411.00
20_R81_Y1.9221.00
38_F48_F1.8581.00
91_D95_Y1.8031.00
123_Q128_T1.7821.00
13_V17_G1.7791.00
101_F104_Y1.7191.00
120_Y123_Q1.6981.00
119_D126_K1.6281.00
117_K126_K1.4361.00
20_R83_Q1.4031.00
49_V65_V1.4001.00
18_S87_L1.3901.00
24_A79_T1.3861.00
125_T129_V1.3511.00
117_K120_Y1.3471.00
67_G70_T1.3271.00
121_W126_K1.3271.00
34_V51_A1.3211.00
118_Y121_W1.3171.00
39_R47_E1.2981.00
124_G127_V1.2891.00
50_T71_I1.2580.99
43_G46_R1.2480.99
23_C97_C1.2390.99
51_A60_H1.2320.99
44_K85_N1.2170.99
120_Y126_K1.2010.99
120_Y128_T1.2000.99
32_S55_S1.1800.99
56_G59_I1.1750.99
40_Q82_L1.1690.99
25_A30_F1.1680.99
119_D128_T1.1670.99
34_V53_S1.1600.99
81_Y90_E1.1290.99
84_M94_V1.1220.99
121_W125_T1.1100.99
5_L37_W1.1030.98
30_F35_M1.1000.98
7_E125_T1.0920.98
25_A78_N1.0900.98
124_G129_V1.0890.98
37_W97_C1.0810.98
91_D96_T1.0560.98
34_V60_H1.0490.98
33_Y58_S1.0340.98
63_D66_K1.0160.97
71_I84_M1.0150.97
7_E11_G1.0030.97
49_V73_R0.9950.97
61_Y65_V0.9810.97
40_Q43_G0.9720.97
100_G103_G0.9560.96
56_G60_H0.9510.96
11_G19_L0.9480.96
102_A117_K0.9440.96
84_M88_K0.9400.96
68_R88_K0.9160.95
123_Q126_K0.8920.94
51_A58_S0.8740.94
16_G67_G0.8590.93
117_K121_W0.8560.93
36_G48_F0.8470.93
24_A81_Y0.8450.93
21_L37_W0.8430.93
5_L75_N0.8330.92
54_W100_G0.8320.92
102_A105_G0.8320.92
69_F82_L0.8310.92
2_Q104_Y0.8200.92
119_D124_G0.8050.91
5_L78_N0.7970.90
86_S94_V0.7960.90
96_T124_G0.7930.90
30_F78_N0.7870.90
65_V69_F0.7820.89
122_G127_V0.7770.89
53_S60_H0.7730.89
28_R32_S0.7680.89
60_H63_D0.7620.88
16_G20_R0.7610.88
7_E10_G0.7590.88
64_S72_S0.7570.88
123_Q127_V0.7560.88
95_Y98_V0.7500.87
24_A42_P0.7490.87
35_M69_F0.7330.86
67_G87_L0.7280.86
121_W129_V0.7080.84
33_Y102_A0.7030.84
38_F99_A0.7020.84
68_R84_M0.7010.84
19_L83_Q0.6990.83
36_G98_V0.6990.83
17_G81_Y0.6970.83
23_C37_W0.6960.83
10_G88_K0.6920.83
119_D123_Q0.6890.83
25_A48_F0.6870.82
62_A79_T0.6830.82
51_A80_V0.6830.82
122_G129_V0.6750.81
17_G89_P0.6750.81
81_Y88_K0.6670.81
82_L95_Y0.6520.79
28_R80_V0.6520.79
68_R86_S0.6500.79
15_A87_L0.6500.79
91_D97_C0.6440.78
36_G60_H0.6340.77
126_K129_V0.6320.77
26_S49_V0.6300.77
36_G51_A0.6190.75
9_G123_Q0.6180.75
77_K81_Y0.6140.75
4_Q61_Y0.6110.74
55_S58_S0.6060.74
29_T38_F0.6040.74
33_Y99_A0.6010.73
11_G14_Q0.5940.72
101_F105_G0.5930.72
36_G80_V0.5930.72
100_G104_Y0.5910.72
31_S100_G0.5840.71
36_G79_T0.5830.71
39_R61_Y0.5830.71
9_G12_L0.5820.71
2_Q6_V0.5820.71
18_S83_Q0.5810.71
2_Q51_A0.5770.70
13_V19_L0.5750.70
20_R87_L0.5750.70
66_K70_T0.5710.69
41_A90_E0.5710.69
90_E94_V0.5700.69
18_S27_G0.5660.69
8_S11_G0.5580.68
25_A75_N0.5570.68
51_A70_T0.5560.67
75_N78_N0.5530.67
24_A77_K0.5520.67
52_I73_R0.5510.67
3_V44_K0.5480.66
46_R96_T0.5430.66
120_Y125_T0.5390.65
68_R95_Y0.5390.65
32_S101_F0.5380.65
24_A41_A0.5370.65
28_R31_S0.5360.65
40_Q83_Q0.5340.64
15_A96_T0.5320.64
53_S58_S0.5320.64
49_V105_G0.5280.63
100_G119_D0.5270.63
51_A56_G0.5260.63
25_A93_A0.5230.63
27_G127_V0.5160.62
96_T100_G0.5100.61
65_V75_N0.5040.60
79_T102_A0.5010.59
101_F117_K0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pfe_A 1 0.0584 99.8 0.224 Contact Map
2yc1_A 1 0.854 99.8 0.264 Contact Map
4b41_A 1 0.854 99.8 0.274 Contact Map
4qo1_A 1 0.927 99.8 0.276 Contact Map
3k74_B 1 0.8394 99.8 0.278 Contact Map
4ut7_H 1 0.9781 99.8 0.278 Contact Map
4lgp_B 1 0.8467 99.8 0.283 Contact Map
1yjd_C 1 0.8394 99.8 0.285 Contact Map
4jvp_A 1 0.9562 99.8 0.287 Contact Map
1zvy_A 1 0.9124 99.8 0.289 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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