GREMLIN Database
T0878_20-315_1_296 - T0878_20-315 1-296
ID: 60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 296 (266)
Sequences: 1244 (874)
Seq/√Len: 53.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_L191_T4.4151.00
135_L143_L3.8421.00
215_V219_L3.8071.00
51_L106_L3.2381.00
223_M272_G3.1951.00
71_Y105_W3.1051.00
110_W130_F2.9901.00
7_A51_L2.8761.00
268_H286_N2.8311.00
245_T248_I2.4741.00
97_D101_S2.3971.00
213_D216_G2.3231.00
146_Q199_V2.3121.00
245_T251_I2.3021.00
123_T126_Y2.2511.00
89_H268_H2.2351.00
221_A274_T2.2231.00
89_H128_Q2.1931.00
244_K248_I2.1791.00
90_T151_Q2.1571.00
239_S242_V2.1491.00
212_N216_G2.1401.00
89_H286_N2.1151.00
74_E112_K2.1091.00
212_N215_V2.0811.00
128_Q268_H2.0691.00
248_I251_I2.0301.00
245_T250_F2.0191.00
213_D219_L2.0091.00
237_L241_G2.0061.00
89_H270_K1.9871.00
270_K286_N1.9601.00
13_L16_D1.8850.99
29_Y32_R1.8820.99
94_I140_A1.8420.99
247_D251_I1.8370.99
215_V218_T1.8240.99
58_V104_L1.8000.99
76_P271_W1.7980.99
210_F215_V1.7790.99
54_T57_S1.7680.99
169_L173_T1.7600.99
238_D241_G1.7300.99
19_S29_Y1.7080.99
160_T163_L1.7060.99
71_Y88_G1.7060.99
128_Q286_N1.6980.99
216_G219_L1.6820.99
73_D270_K1.6580.99
180_A184_S1.6520.99
132_C281_C1.6330.98
246_Y249_K1.6240.98
232_K241_G1.6010.98
210_F285_I1.5960.98
128_Q270_K1.5920.98
157_L161_G1.5390.98
232_K239_S1.5200.97
229_I264_E1.5110.97
129_T283_G1.5100.97
141_G168_P1.5060.97
237_L240_D1.4970.97
263_P266_Q1.4930.97
245_T249_K1.4930.97
212_N219_L1.4910.97
93_V106_L1.4840.97
151_Q284_D1.4670.97
219_L223_M1.4550.97
247_D250_F1.4550.97
8_Y88_G1.4440.97
191_T197_F1.4320.96
2_V5_W1.4250.96
156_Y161_G1.4230.96
98_I101_S1.4180.96
73_D89_H1.3900.96
209_D212_N1.3320.95
211_W215_V1.3130.94
57_S104_L1.3120.94
208_K213_D1.3110.94
251_I256_L1.3080.94
170_Y174_Q1.3070.94
237_L242_V1.3060.94
71_Y107_L1.2850.93
136_D139_T1.2820.93
256_L260_W1.2800.93
230_R288_M1.2780.93
188_D193_G1.2750.93
73_D286_N1.2740.93
13_L19_S1.2730.93
56_D60_G1.2660.93
191_T194_G1.2520.92
74_E226_E1.2500.92
213_D217_P1.2410.92
246_Y251_I1.2320.92
177_N180_A1.2220.92
73_D268_H1.2150.91
119_P122_P1.2140.91
9_K54_T1.2120.91
211_W272_G1.2120.91
129_T282_V1.2100.91
163_L166_T1.1900.90
236_V288_M1.1850.90
211_W219_L1.1790.90
188_D198_K1.1690.90
122_P126_Y1.1690.90
88_G270_K1.1640.89
111_P270_K1.1580.89
79_A84_N1.1530.89
29_Y33_Q1.1430.89
12_K19_S1.1400.88
7_A130_F1.1390.88
114_A284_D1.1320.88
103_A114_A1.1230.88
214_L219_L1.1230.88
216_G223_M1.1190.87
281_C287_R1.1170.87
166_T169_L1.1160.87
202_K228_W1.1080.87
255_K259_P1.1010.87
68_W157_L1.0870.86
109_S123_T1.0870.86
253_L256_L1.0820.86
67_G161_G1.0770.85
268_H283_G1.0700.85
186_S193_G1.0690.85
109_S128_Q1.0650.85
14_T17_A1.0560.84
50_A57_S1.0550.84
283_G286_N1.0490.84
232_K236_V1.0450.84
232_K237_L1.0310.83
12_K15_K1.0220.82
102_S134_S1.0160.82
270_K284_D1.0120.82
151_Q215_V1.0120.82
58_V95_A1.0100.81
244_K250_F0.9990.81
31_D91_K0.9980.81
66_T140_A0.9920.80
145_A168_P0.9910.80
108_H281_C0.9870.80
267_D281_C0.9820.80
151_Q210_F0.9820.80
229_I265_T0.9750.79
232_K235_P0.9750.79
111_P268_H0.9710.79
76_P156_Y0.9660.78
159_R163_L0.9630.78
168_P171_A0.9620.78
216_G221_A0.9580.78
172_L176_L0.9430.77
235_P241_G0.9390.76
55_L113_Y0.9380.76
214_L217_P0.9350.76
200_I215_V0.9330.76
140_A169_L0.9300.76
160_T166_T0.9230.75
146_Q185_D0.9220.75
69_I90_T0.9120.74
219_L279_W0.9110.74
88_G128_Q0.9110.74
19_S30_Y0.9080.74
19_S31_D0.9080.74
184_S214_L0.9040.74
111_P114_A0.9000.73
108_H287_R0.8960.73
158_P173_T0.8900.72
73_D91_K0.8860.72
169_L172_L0.8840.72
165_H168_P0.8830.72
159_R164_D0.8780.71
29_Y91_K0.8720.71
88_G149_L0.8700.71
235_P239_S0.8700.71
11_P127_G0.8690.71
165_H169_L0.8680.71
238_D247_D0.8630.70
88_G268_H0.8480.69
159_R162_G0.8470.69
106_L114_A0.8400.68
73_D111_P0.8380.68
126_Y226_E0.8370.68
15_K19_S0.8320.67
127_G230_R0.8300.67
156_Y159_R0.8280.67
8_Y37_V0.8240.67
35_G181_P0.8230.66
90_T133_L0.8210.66
179_S182_G0.8210.66
222_D276_T0.8200.66
69_I155_V0.8200.66
69_I215_V0.8090.65
166_T176_L0.8070.65
37_V241_G0.8060.65
1_S4_L0.8050.65
6_F269_A0.8050.65
70_L94_I0.8040.65
139_T142_K0.8030.65
37_V71_Y0.8010.64
6_F37_V0.8000.64
121_V125_L0.8000.64
270_K283_G0.7930.64
29_Y34_V0.7930.64
89_H228_W0.7850.63
232_K242_V0.7790.62
105_W108_H0.7770.62
209_D287_R0.7730.62
108_H111_P0.7730.62
72_N210_F0.7700.61
70_L274_T0.7700.61
246_Y250_F0.7690.61
11_P271_W0.7640.61
221_A275_T0.7630.61
89_H111_P0.7620.60
8_Y127_G0.7610.60
243_H247_D0.7590.60
170_Y173_T0.7500.59
6_F110_W0.7420.58
248_I271_W0.7390.58
18_D29_Y0.7370.58
244_K249_K0.7330.58
13_L35_G0.7320.57
109_S114_A0.7300.57
69_I167_S0.7290.57
11_P55_L0.7260.57
211_W216_G0.7250.57
68_W102_S0.7230.56
126_Y266_Q0.7230.56
94_I106_L0.7220.56
261_A264_E0.7210.56
222_D275_T0.7200.56
74_E89_H0.7180.56
250_F256_L0.7140.56
213_D218_T0.7120.55
3_D109_S0.7040.54
19_S182_G0.7040.54
88_G286_N0.7010.54
89_H227_T0.6980.54
210_F273_I0.6940.53
168_P176_L0.6940.53
238_D242_V0.6920.53
12_K18_D0.6920.53
167_S170_Y0.6900.53
107_L129_T0.6890.53
209_D214_L0.6870.53
186_S191_T0.6860.53
16_D29_Y0.6850.52
95_A104_L0.6820.52
236_V239_S0.6790.52
8_Y109_S0.6790.52
243_H251_I0.6690.51
209_D216_G0.6670.51
157_L160_T0.6660.50
111_P286_N0.6660.50
144_A172_L0.6660.50
40_S50_A0.6650.50
138_A142_K0.6630.50
156_Y160_T0.6620.50
200_I218_T0.6610.50
65_T220_K0.6610.50
251_I255_K0.6590.50
214_L218_T0.6570.49
8_Y129_T0.6570.49
128_Q131_L0.6550.49
206_W214_L0.6550.49
105_W271_W0.6520.49
29_Y35_G0.6510.49
186_S190_K0.6490.49
74_E128_Q0.6490.49
185_D189_F0.6490.49
122_P125_L0.6470.48
109_S270_K0.6460.48
53_Y211_W0.6430.48
85_A225_V0.6420.48
73_D88_G0.6420.48
108_H267_D0.6420.48
125_L155_V0.6410.48
108_H113_Y0.6390.48
244_K251_I0.6390.48
186_S198_K0.6370.47
209_D219_L0.6310.47
260_W263_P0.6310.47
209_D215_V0.6310.47
72_N75_M0.6290.47
115_S119_P0.6270.46
212_N217_P0.6240.46
69_I169_L0.6240.46
103_A140_A0.6240.46
230_R264_E0.6230.46
129_T151_Q0.6220.46
236_V240_D0.6200.46
67_G96_F0.6190.45
128_Q227_T0.6160.45
188_D192_R0.6150.45
255_K261_A0.6150.45
84_N112_K0.6150.45
87_L154_Q0.6140.45
74_E268_H0.6130.45
30_Y33_Q0.6100.45
110_W121_V0.6050.44
134_S224_Y0.6030.44
112_K229_I0.6020.44
160_T164_D0.6010.44
167_S182_G0.6000.43
164_D167_S0.5990.43
56_D101_S0.5980.43
54_T269_A0.5960.43
90_T153_P0.5960.43
45_N113_Y0.5940.43
135_L140_A0.5930.43
110_W135_L0.5930.43
74_E286_N0.5920.43
127_G267_D0.5860.42
156_Y271_W0.5860.42
13_L18_D0.5860.42
71_Y90_T0.5850.42
44_M145_A0.5830.42
51_L54_T0.5820.42
74_E203_N0.5790.41
255_K258_A0.5790.41
12_K181_P0.5780.41
52_F59_F0.5770.41
19_S181_P0.5760.41
124_P147_M0.5740.41
8_Y144_A0.5700.40
66_T147_M0.5700.40
12_K16_D0.5660.40
111_P202_K0.5650.40
91_K253_L0.5640.40
66_T146_Q0.5620.40
175_P182_G0.5620.40
49_G53_Y0.5610.39
185_D205_K0.5600.39
169_L174_Q0.5600.39
38_Q41_P0.5590.39
67_G102_S0.5580.39
230_R265_T0.5580.39
171_A176_L0.5560.39
113_Y156_Y0.5540.39
108_H271_W0.5530.39
175_P178_A0.5520.39
70_L156_Y0.5520.39
156_Y285_I0.5500.38
140_A143_L0.5490.38
13_L17_A0.5450.38
131_L144_A0.5430.38
167_S175_P0.5420.38
87_L152_Q0.5420.38
146_Q201_A0.5410.37
37_V110_W0.5400.37
89_H202_K0.5390.37
170_Y176_L0.5380.37
109_S286_N0.5370.37
202_K270_K0.5370.37
87_L221_A0.5370.37
230_R247_D0.5360.37
72_N284_D0.5360.37
158_P203_N0.5360.37
190_K193_G0.5360.37
227_T231_G0.5350.37
89_H284_D0.5350.37
109_S113_Y0.5340.37
163_L174_Q0.5330.37
200_I210_F0.5330.37
72_N154_Q0.5320.37
212_N218_T0.5310.36
59_F282_V0.5290.36
10_V72_N0.5290.36
230_R236_V0.5280.36
110_W123_T0.5260.36
133_L197_F0.5220.36
171_A188_D0.5210.35
8_Y71_Y0.5200.35
101_S187_L0.5200.35
96_F143_L0.5190.35
125_L261_A0.5170.35
172_L282_V0.5170.35
185_D190_K0.5160.35
107_L283_G0.5150.35
6_F10_V0.5150.35
16_D19_S0.5140.35
72_N111_P0.5140.35
146_Q223_M0.5130.35
138_A190_K0.5130.35
106_L222_D0.5110.35
241_G247_D0.5110.35
11_P113_Y0.5080.34
151_Q172_L0.5070.34
76_P267_D0.5070.34
8_Y282_V0.5060.34
143_L208_K0.5060.34
283_G287_R0.5050.34
3_D191_T0.5040.34
78_D119_P0.5030.34
84_N152_Q0.5030.34
126_Y142_K0.5030.34
97_D102_S0.5020.34
169_L176_L0.5020.34
5_W65_T0.5000.33
267_D271_W0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1by6_A 1 0.1216 4.2 0.972 Contact Map
2rkl_A 1 0.1351 3.4 0.973 Contact Map
3ksk_A 1 0.1791 2.1 0.976 Contact Map
2bsj_A 1 0.2939 1.7 0.977 Contact Map
4z29_A 1 0 1.6 0.978 Contact Map
4xc5_A 1 0.3615 1.5 0.978 Contact Map
2dco_A 1 0.0405 1.5 0.978 Contact Map
4jhn_A 1 0.2128 1.5 0.978 Contact Map
3jxf_A 1 0.1757 1.4 0.979 Contact Map
3s6x_A 1 0.375 1.3 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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