GREMLIN Database
T0865_1_75 - T0865 1-75
ID: 6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (71)
Sequences: 114 (78)
Seq/√Len: 9.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_E69_K3.7830.98
54_E58_R2.5540.83
36_M50_E2.3910.78
72_L75_K2.3760.78
20_E23_R2.2370.73
64_E70_K2.0900.68
6_K10_E1.8610.58
64_E68_I1.7720.54
4_E10_E1.7680.54
4_E7_P1.7230.52
63_M75_K1.6460.49
51_L61_L1.6430.49
29_L53_E1.6380.48
8_K42_R1.6220.48
43_E51_L1.5810.46
5_G9_M1.5720.45
65_V68_I1.4840.42
60_R65_V1.3450.36
68_I75_K1.3080.34
68_I72_L1.2340.31
40_Q52_D1.2080.30
39_Q62_Q1.2060.30
10_E13_A1.1640.29
50_E58_R1.1540.28
4_E9_M1.1510.28
49_S60_R1.1440.28
51_L54_E1.1440.28
11_P50_E1.1250.27
42_R74_S1.0940.26
17_A34_E1.0630.25
20_E28_E1.0580.25
39_Q43_E1.0390.25
42_R48_L1.0300.24
46_Q68_I1.0210.24
21_E25_Q1.0130.24
35_T38_D1.0010.23
19_V26_V0.9990.23
66_N69_K0.9950.23
4_E8_K0.9930.23
25_Q29_L0.9860.23
5_G14_S0.9850.23
45_K49_S0.9850.23
45_K72_L0.9600.22
63_M71_A0.9580.22
7_P13_A0.9540.22
55_K58_R0.9530.22
29_L34_E0.9390.21
9_M14_S0.9330.21
9_M24_T0.9220.21
46_Q57_I0.9120.21
35_T62_Q0.9080.20
36_M41_K0.9070.20
43_E61_L0.9030.20
64_E67_D0.8740.20
32_I35_T0.8640.19
22_L55_K0.8610.19
38_D49_S0.8600.19
22_L53_E0.8560.19
41_K62_Q0.8490.19
39_Q57_I0.8440.19
40_Q60_R0.8150.18
19_V34_E0.8120.18
35_T39_Q0.8040.18
33_I61_L0.8040.18
7_P10_E0.7800.17
5_G8_K0.7760.17
42_R58_R0.7500.16
53_E58_R0.7500.16
66_N70_K0.7480.16
29_L42_R0.7080.15
36_M57_I0.7060.15
35_T60_R0.6950.15
65_V69_K0.6880.15
24_T56_K0.6820.15
63_M73_Q0.6620.14
44_I56_K0.6570.14
29_L58_R0.6570.14
52_D59_L0.6540.14
52_D62_Q0.6470.14
45_K56_K0.6290.14
36_M62_Q0.6240.13
14_S24_T0.5950.13
13_A44_I0.5840.13
47_L52_D0.5680.12
30_R67_D0.5630.12
31_S35_T0.5610.12
20_E25_Q0.5600.12
19_V75_K0.5590.12
27_R31_S0.5530.12
9_M17_A0.5500.12
33_I72_L0.5490.12
29_L63_M0.5480.12
41_K46_Q0.5480.12
46_Q60_R0.5450.12
43_E58_R0.5400.12
22_L54_E0.5390.12
38_D60_R0.5370.12
7_P14_S0.5310.12
7_P12_A0.5300.12
28_E34_E0.5180.11
28_E35_T0.5100.11
28_E33_I0.5100.11
10_E55_K0.5080.11
8_K14_S0.5020.11
9_M13_A0.5010.11
25_Q43_E0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4etp_A 1 0.76 61.2 0.808 Contact Map
4etp_B 1 0.7467 57.4 0.813 Contact Map
3i00_A 1 0.8267 52.6 0.818 Contact Map
2eqb_B 1 0.7333 52.4 0.819 Contact Map
3u06_A 1 0.7733 44.9 0.826 Contact Map
3uf1_A 1 0.8667 42.8 0.828 Contact Map
3qpr_A 1 0 40.8 0.831 Contact Map
5cj0_A 1 0.8933 40.1 0.831 Contact Map
4x01_A 1 0.6533 36.1 0.835 Contact Map
2dfs_A 1 0.9867 36.1 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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