GREMLIN Database
T0878_13-333_1_321 - T0878_13-333 1-321
ID: 59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 321 (272)
Sequences: 1115 (772)
Seq/√Len: 46.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_L198_T4.8951.00
230_M279_G3.8541.00
222_V226_L3.6991.00
2_R8_S3.4821.00
142_L150_L3.4781.00
78_Y112_W3.2461.00
58_L113_L3.1301.00
14_A58_L3.0221.00
117_W137_F3.0201.00
81_E119_K2.6011.00
251_K255_I2.4651.00
252_T255_I2.4091.00
246_S249_V2.3461.00
275_H293_N2.3421.00
96_H277_K2.2751.00
244_L248_G2.2731.00
153_Q206_V2.2651.00
135_Q275_H2.2651.00
130_T133_Y2.2601.00
228_A281_T2.2541.00
223_G226_L2.2311.00
97_T158_Q2.1741.00
83_P278_W2.1561.00
252_T257_F2.1561.00
260_L263_L2.1321.00
96_H275_H2.0551.00
217_F222_V2.0420.99
96_H135_Q2.0270.99
65_V111_L2.0260.99
136_T290_G1.9990.99
277_K293_N1.9900.99
216_D219_N1.9700.99
61_T64_S1.9590.99
135_Q293_N1.9390.99
96_H293_N1.9370.99
19_K26_S1.9090.99
104_D108_S1.8730.99
252_T258_I1.8350.99
239_K248_G1.8140.99
226_L230_M1.7580.98
1_P10_D1.7570.98
126_P129_P1.7470.98
80_D277_K1.7230.98
135_Q277_K1.7130.98
245_D248_G1.7120.98
20_L23_D1.6740.98
222_V225_T1.6620.98
16_K61_T1.6530.98
78_Y95_G1.6490.98
81_E233_E1.6370.98
100_V113_L1.6300.97
220_D223_G1.6090.97
80_D96_H1.6000.97
20_L26_S1.5840.97
253_Y256_K1.5650.97
116_S130_T1.5630.97
195_D205_K1.5380.96
198_T201_G1.5270.96
236_I271_E1.5120.96
80_D293_N1.5070.96
139_C288_C1.5060.96
217_F292_I1.5050.96
1_P11_L1.5020.96
116_S135_Q1.4950.96
254_D258_I1.4770.95
78_Y114_L1.4550.95
6_N11_L1.4500.95
237_R295_M1.4150.94
244_L247_D1.4040.94
220_D226_L1.3970.94
176_L179_L1.3900.94
255_I258_I1.3860.94
195_D200_G1.3610.93
215_K220_D1.3510.93
95_G277_K1.3440.92
158_Q291_D1.3370.92
164_L168_G1.3340.92
258_I263_L1.3060.91
80_D275_H1.3050.91
64_S111_L1.3000.91
177_Y181_Q1.2970.91
207_I222_V1.2960.91
143_D146_T1.2880.91
4_E47_S1.2790.90
6_N9_V1.2710.90
218_W279_G1.2640.90
251_K257_F1.2620.90
148_G175_P1.2610.90
221_L226_L1.2520.90
173_T176_L1.2340.89
36_Y98_K1.2320.89
239_K246_S1.2310.89
158_Q222_V1.2200.88
105_I108_S1.2190.88
95_G293_N1.2160.88
254_D257_F1.2050.88
1_P6_N1.2040.88
15_Y95_G1.1970.87
243_V295_M1.1960.87
191_S221_L1.1930.87
245_D254_D1.1890.87
80_D95_G1.1880.87
167_T173_T1.1860.87
184_N187_A1.1820.87
218_W222_V1.1720.86
20_L25_D1.1670.86
118_P277_K1.1670.86
193_S198_T1.1500.85
270_P273_Q1.1490.85
167_T170_L1.1480.85
101_I147_A1.1450.85
63_D67_G1.1420.85
14_A137_F1.1300.84
118_P275_H1.1240.84
109_S141_S1.1160.83
95_G135_Q1.0980.82
95_G275_H1.0940.82
77_L101_I1.0910.82
209_K235_W1.0820.81
252_T260_L1.0750.81
229_D283_T1.0690.81
136_T289_V1.0680.80
223_G230_M1.0670.80
252_T256_K1.0530.80
253_Y257_F1.0510.79
62_L120_Y1.0490.79
198_T204_F1.0450.79
239_K243_V1.0390.79
158_Q217_F1.0380.79
80_D98_K1.0340.78
243_V246_S1.0340.78
239_K244_L1.0330.78
129_P133_Y1.0280.78
15_Y269_W1.0280.78
242_P246_S1.0260.78
110_A121_A1.0220.77
15_Y134_G1.0210.77
76_I97_T1.0210.77
96_H118_P1.0150.77
179_L183_L1.0110.77
290_G293_N1.0100.77
153_Q192_D1.0090.77
75_W164_L1.0080.76
175_P178_A1.0060.76
121_A291_D0.9960.76
110_A147_A0.9940.75
176_L180_T0.9930.75
65_V102_A0.9920.75
275_H290_G0.9910.75
146_T149_K0.9900.75
163_Y168_G0.9830.75
95_G156_L0.9810.74
118_P293_N0.9810.74
115_H139_C0.9760.74
9_V12_W0.9760.74
18_P134_G0.9740.74
115_H288_C0.9740.74
26_S188_P0.9640.73
15_Y44_V0.9570.73
216_D294_R0.9450.72
80_D118_P0.9280.70
74_G168_G0.9230.70
253_Y258_I0.9230.70
57_A64_S0.9160.69
13_F276_A0.9130.69
21_T24_A0.9120.69
226_L286_W0.9040.68
76_I162_V0.8930.67
277_K291_D0.8900.67
36_Y57_A0.8830.66
244_L249_V0.8810.66
172_H175_P0.8690.65
113_L143_D0.8670.65
76_I230_M0.8640.65
1_P9_V0.8610.64
175_P183_L0.8570.64
220_D224_P0.8510.64
10_D116_S0.8490.63
288_C294_R0.8430.63
102_A111_L0.8350.62
276_A288_C0.8320.62
223_G228_A0.8310.62
236_I272_T0.8280.61
13_F117_W0.8280.61
170_L173_T0.8240.61
221_L224_P0.8190.61
257_F263_L0.8140.60
78_Y97_T0.8130.60
74_G103_F0.8080.59
22_K26_S0.8050.59
141_S278_W0.8000.59
242_P248_G0.7940.58
121_A230_M0.7900.58
218_W226_L0.7880.58
86_A91_N0.7840.57
239_K249_V0.7830.57
229_D282_T0.7790.57
23_D26_S0.7760.56
115_H294_R0.7730.56
26_S189_G0.7730.56
139_C274_D0.7700.56
196_F279_G0.7660.55
116_S291_D0.7660.55
217_F280_I0.7660.55
151_A179_L0.7610.55
122_S126_P0.7600.55
237_R254_D0.7600.55
142_L196_F0.7590.55
231_Y254_D0.7570.55
250_H255_I0.7560.54
221_L225_T0.7540.54
179_L182_P0.7520.54
51_M280_I0.7520.54
25_D42_G0.7500.54
18_P62_L0.7490.54
165_P180_T0.7460.53
96_H116_S0.7430.53
193_S205_K0.7370.53
26_S57_A0.7300.52
80_D116_S0.7280.52
228_A282_T0.7280.52
15_Y78_Y0.7270.52
47_S50_L0.7270.52
81_E96_H0.7240.51
85_D260_L0.7210.51
243_V247_D0.7210.51
196_F228_A0.7210.51
51_M152_A0.7200.51
140_L204_F0.7190.51
213_W221_L0.7180.51
192_D197_K0.7150.50
134_G237_R0.7120.50
217_F291_D0.7080.50
6_N197_K0.7080.50
207_I217_F0.7040.49
18_P278_W0.7030.49
153_Q208_A0.7000.49
26_S36_Y0.6980.49
72_T227_K0.6970.49
22_K43_A0.6930.48
43_A53_D0.6920.48
19_K25_D0.6900.48
118_P135_Q0.6890.48
211_R227_K0.6880.48
81_E135_Q0.6880.48
219_N223_G0.6880.48
166_R171_D0.6870.48
6_N10_D0.6860.48
15_Y136_T0.6850.47
81_E293_N0.6830.47
45_Q174_S0.6810.47
145_A149_K0.6800.47
170_L174_S0.6750.46
160_P163_Y0.6740.46
104_D109_S0.6730.46
92_A138_L0.6720.46
203_P227_K0.6710.46
81_E277_K0.6710.46
135_Q138_L0.6710.46
76_I179_L0.6700.46
98_K277_K0.6680.46
249_V256_K0.6680.46
187_A191_S0.6670.46
117_W142_L0.6670.46
4_E150_L0.6660.46
8_S11_L0.6650.45
58_L61_T0.6630.45
83_P274_D0.6590.45
133_Y237_R0.6580.45
24_A43_A0.6580.45
178_A183_L0.6520.44
73_T147_A0.6510.44
111_L141_S0.6500.44
37_Y186_S0.6500.44
133_Y273_Q0.6490.44
152_A175_P0.6480.44
143_D280_I0.6460.44
127_G260_L0.6450.43
12_W72_T0.6430.43
96_H234_T0.6430.43
239_K242_P0.6400.43
6_N60_Y0.6400.43
44_V248_G0.6390.43
38_D265_A0.6390.43
237_R271_E0.6380.43
251_K256_K0.6380.43
98_K293_N0.6350.43
5_Q38_D0.6320.42
274_D288_C0.6270.42
209_K277_K0.6260.42
146_T203_P0.6250.42
81_E275_H0.6210.41
163_Y278_W0.6200.41
141_S199_R0.6180.41
18_P78_Y0.6180.41
116_S269_W0.6170.41
109_S160_P0.6160.41
229_D247_D0.6150.41
51_M227_K0.6140.40
113_L204_F0.6130.40
48_P260_L0.6130.40
61_T137_F0.6110.40
44_V78_Y0.6110.40
79_N82_M0.6110.40
120_Y163_Y0.6100.40
43_A104_D0.6070.40
77_L163_Y0.6070.40
132_L162_V0.6040.40
182_P185_A0.6020.39
192_D195_D0.6020.39
59_F121_A0.6000.39
51_M237_R0.6000.39
75_W109_S0.5990.39
38_D181_Q0.5950.39
44_V244_L0.5940.39
15_Y286_W0.5940.39
73_T154_M0.5940.39
11_L81_E0.5930.38
173_T183_L0.5920.38
174_S177_Y0.5900.38
133_Y233_E0.5900.38
79_N291_D0.5890.38
116_S275_H0.5860.38
48_P54_P0.5830.38
237_R272_T0.5820.37
207_I225_T0.5810.37
230_M286_W0.5800.37
95_G153_Q0.5790.37
218_W223_G0.5780.37
135_Q234_T0.5780.37
104_D290_G0.5780.37
96_H235_W0.5780.37
239_K247_D0.5770.37
110_A290_G0.5770.37
115_H274_D0.5760.37
166_R169_G0.5750.37
114_L136_T0.5750.37
172_H183_L0.5730.37
114_L160_P0.5670.36
5_Q8_S0.5660.36
230_M244_L0.5640.36
237_R242_P0.5620.36
250_H253_Y0.5570.35
97_T140_L0.5560.35
197_K252_T0.5510.35
177_Y180_T0.5480.34
15_Y153_Q0.5470.34
128_V132_L0.5450.34
235_W277_K0.5450.34
83_P163_Y0.5440.34
4_E231_Y0.5440.34
172_H182_P0.5430.34
79_N161_Q0.5430.34
255_I278_W0.5420.34
22_K25_D0.5420.34
166_R170_L0.5380.33
141_S198_T0.5370.33
96_H291_D0.5360.33
186_S260_L0.5360.33
19_K22_K0.5350.33
250_H258_I0.5350.33
79_N118_P0.5350.33
2_R168_G0.5350.33
135_Q235_W0.5350.33
151_A156_L0.5350.33
16_K118_P0.5340.33
142_L147_A0.5340.33
82_M161_Q0.5340.33
94_L162_V0.5340.33
75_W278_W0.5330.33
248_G256_K0.5320.33
145_A170_L0.5320.33
66_F113_L0.5310.33
197_K203_P0.5300.33
53_D260_L0.5290.33
7_R100_V0.5270.33
7_R212_K0.5270.33
63_D108_S0.5260.32
150_L154_M0.5250.32
21_T25_D0.5240.32
95_G118_P0.5240.32
20_L24_A0.5230.32
42_G188_P0.5210.32
216_D221_L0.5210.32
128_V131_P0.5190.32
103_F295_M0.5180.32
175_P182_P0.5170.32
178_A181_Q0.5160.32
36_Y269_W0.5160.32
208_A213_W0.5150.31
193_S200_G0.5150.31
43_A46_K0.5150.31
153_Q230_M0.5150.31
13_F83_P0.5140.31
63_D281_T0.5130.31
126_P211_R0.5120.31
141_S231_Y0.5120.31
76_I222_V0.5110.31
112_W140_L0.5110.31
193_S197_K0.5090.31
47_S65_V0.5090.31
178_A195_D0.5090.31
94_L161_Q0.5080.31
65_V128_V0.5070.31
178_A182_P0.5070.31
91_N94_L0.5050.31
134_G274_D0.5000.30
54_P249_V0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jid_A 1 0.1558 4.5 0.974 Contact Map
1by6_A 1 0.1121 3.5 0.976 Contact Map
1lf6_A 1 0.1651 3.2 0.976 Contact Map
2rkl_A 1 0.1589 2.3 0.978 Contact Map
5e1l_A 1 0.2118 1.9 0.979 Contact Map
2dzl_A 1 0.0779 1.9 0.979 Contact Map
1yph_E 1 0.2087 1.9 0.979 Contact Map
5azf_A 1 0.1994 1.7 0.979 Contact Map
2cxy_A 1 0.2336 1.6 0.98 Contact Map
2wbr_A 1 0.0997 1.6 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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