GREMLIN Database
T0906_1_363 - T0906 1-363
ID: 57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 363 (360)
Sequences: 907 (435)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_M294_G5.9941.00
168_I191_I4.8161.00
70_A74_K4.6641.00
87_G300_R3.7201.00
142_Y188_L3.6591.00
61_R65_N3.2271.00
356_K359_E3.0891.00
318_A321_A3.0561.00
5_L124_F2.9370.99
187_R361_E2.9350.99
242_T252_F2.7880.99
184_A191_I2.6820.99
12_I79_G2.6790.99
32_V75_A2.6690.99
259_A323_V2.6140.99
141_L238_A2.5820.99
137_F292_V2.4680.98
126_V239_I2.4440.98
167_R207_W2.3790.98
61_R67_E2.3770.98
218_V238_A2.3620.98
1_M60_T2.3620.98
208_S211_H2.3570.97
184_A188_L2.3400.97
294_G310_L2.3060.97
7_V56_L2.2700.97
133_E263_A2.2650.97
183_D209_R2.2360.97
265_D272_M2.2150.96
165_R209_R2.1980.96
5_L116_F2.1800.96
198_S336_Y2.1640.96
157_S245_I2.1460.96
3_V42_L2.1410.96
114_M214_Q2.1090.95
165_R181_E2.0550.94
318_A325_E1.9930.93
58_S304_L1.9850.93
258_L333_Q1.9530.93
168_I184_A1.9270.92
137_F238_A1.9030.92
161_R190_D1.8800.91
322_K332_R1.8780.91
133_E199_H1.8570.91
167_R181_E1.8500.90
213_E246_F1.8490.90
24_K27_A1.8350.90
254_P285_T1.8050.89
261_Y330_M1.7960.89
165_R183_D1.7820.89
125_M310_L1.7610.88
250_E288_C1.7590.88
12_I25_V1.7500.88
28_K82_V1.7470.88
353_E356_K1.7310.87
29_V55_L1.6910.86
49_I281_T1.6910.86
47_F56_L1.6900.86
186_E209_R1.6770.85
322_K325_E1.6710.85
114_M217_V1.6490.84
45_Y297_F1.6450.84
7_V126_V1.6430.84
54_V128_A1.6410.84
47_F293_C1.6390.84
14_S20_L1.6330.84
194_L355_L1.6320.84
326_K329_E1.6250.84
182_L191_I1.6230.84
29_V75_A1.5960.82
160_L246_F1.5950.82
171_L202_A1.5840.82
47_F295_L1.5830.82
82_V86_E1.5800.82
319_V324_V1.5780.82
48_H282_P1.5660.81
358_L361_E1.5580.81
29_V53_I1.5120.79
25_V79_G1.5080.79
197_D343_M1.5000.78
105_H221_T1.4980.78
28_K31_E1.4790.77
74_K77_R1.4620.76
47_F128_A1.4410.75
20_L282_P1.4260.75
85_A301_E1.4250.75
26_L53_I1.4220.74
296_A310_L1.4200.74
205_S217_V1.4170.74
193_T354_R1.4070.74
40_L68_V1.4060.73
104_L111_V1.4040.73
56_L239_I1.3820.72
141_L218_V1.3800.72
337_G343_M1.3700.71
182_L194_L1.3690.71
326_K333_Q1.3670.71
124_F299_L1.3520.70
169_M179_Y1.3500.70
250_E287_F1.3290.69
203_I206_I1.3180.68
150_Y254_P1.3170.68
33_V55_L1.3150.68
167_R204_E1.3150.68
61_R68_V1.3080.68
149_M335_F1.2920.67
42_L299_L1.2850.66
254_P339_A1.2840.66
25_V90_G1.2840.66
260_P274_L1.2770.66
42_L58_S1.2760.66
129_A137_F1.2740.66
261_Y329_E1.2740.66
7_V237_V1.2670.65
28_K78_E1.2630.65
340_M346_L1.2610.65
179_Y363_S1.2520.64
173_Q178_S1.2510.64
42_L60_T1.2490.64
279_A312_A1.2490.64
219_S237_V1.2440.64
137_F218_V1.2420.64
66_Q70_A1.2360.63
201_F355_L1.2340.63
21_P25_V1.2310.63
285_T339_A1.2300.63
255_V319_V1.2240.63
198_S271_H1.2240.63
250_E289_V1.2190.62
341_L347_E1.2070.61
87_G301_E1.2060.61
129_A238_A1.2060.61
194_L362_F1.1960.61
5_L58_S1.1790.60
143_L147_D1.1600.58
162_P210_K1.1480.58
151_S266_T1.1440.57
343_M349_T1.1390.57
144_A256_F1.1370.57
355_L362_F1.1350.57
49_I54_V1.1300.56
8_L57_L1.1280.56
169_M204_E1.1250.56
45_Y295_L1.1170.55
214_Q217_V1.1150.55
145_F240_V1.1090.55
33_V44_A1.0900.54
125_M249_T1.0840.53
3_V299_L1.0840.53
180_I362_F1.0800.53
2_K115_E1.0780.53
31_E68_V1.0770.53
25_V53_I1.0760.53
75_A79_G1.0730.52
310_L315_V1.0730.52
43_D122_E1.0720.52
162_P357_A1.0690.52
134_P157_S1.0630.52
77_R97_K1.0630.52
183_D186_E1.0610.52
171_L263_A1.0540.51
171_L222_R1.0470.51
137_F221_T1.0420.50
44_A71_L1.0410.50
335_F339_A1.0400.50
349_T352_A1.0350.50
111_V221_T1.0250.49
63_V205_S1.0240.49
200_R222_R1.0220.49
168_I182_L1.0170.48
29_V79_G1.0150.48
57_L104_L1.0140.48
56_L126_V1.0060.48
89_Y123_P1.0050.48
5_L355_L0.9990.47
20_L48_H0.9980.47
25_V82_V0.9970.47
197_D337_G0.9960.47
133_E202_A0.9940.47
142_Y213_E0.9880.46
32_V78_E0.9860.46
116_F299_L0.9800.46
70_A77_R0.9770.46
1_M117_T0.9680.45
284_S315_V0.9680.45
134_P245_I0.9670.45
111_V226_I0.9630.45
141_L206_I0.9610.45
315_V328_Q0.9560.44
193_T351_I0.9540.44
135_G198_S0.9540.44
229_R353_E0.9480.44
329_E333_Q0.9470.44
63_V114_M0.9450.44
321_A325_E0.9450.44
19_T308_V0.9450.44
112_A290_P0.9400.43
311_F314_P0.9390.43
7_V47_F0.9380.43
273_P327_A0.9370.43
162_P209_R0.9330.43
3_V122_E0.9320.43
280_N314_P0.9300.43
41_L57_L0.9210.42
266_T272_M0.9210.42
337_G340_M0.9210.42
318_A324_V0.9160.42
157_S244_K0.9160.42
12_I54_V0.9150.42
198_S222_R0.9150.42
157_S246_F0.9130.41
250_E266_T0.9070.41
14_S90_G0.9070.41
258_L332_R0.9020.41
238_A281_T0.9020.41
168_I195_L0.9000.40
55_L75_A0.8980.40
129_A198_S0.8950.40
63_V115_E0.8950.40
167_R205_S0.8940.40
249_T310_L0.8910.40
56_L124_F0.8900.40
346_L351_I0.8890.40
99_A105_H0.8880.40
199_H344_E0.8860.40
110_Q137_F0.8820.39
48_H280_N0.8740.39
5_L201_F0.8730.39
21_P246_F0.8730.39
279_A295_L0.8690.38
46_V55_L0.8670.38
284_S308_V0.8610.38
328_Q339_A0.8580.38
81_E85_A0.8580.38
62_G115_E0.8560.38
22_S86_E0.8550.38
57_L72_A0.8550.38
77_R81_E0.8550.38
346_L354_R0.8530.37
110_Q231_V0.8530.37
73_W77_R0.8510.37
343_M351_I0.8500.37
144_A206_I0.8490.37
266_T287_F0.8450.37
351_I355_L0.8420.37
208_S224_R0.8420.37
143_L149_M0.8410.37
195_L203_I0.8410.37
49_I159_E0.8410.37
211_H245_I0.8400.37
330_M333_Q0.8380.36
190_D357_A0.8370.36
31_E35_E0.8350.36
21_P133_E0.8310.36
39_R321_A0.8250.36
253_G287_F0.8250.36
346_L352_A0.8180.35
159_E244_K0.8120.35
167_R179_Y0.8110.35
213_E244_K0.8060.34
170_D200_R0.8050.34
179_Y204_E0.8050.34
140_P260_P0.8020.34
129_A263_A0.8000.34
210_K213_E0.8000.34
281_T324_V0.8000.34
47_F54_V0.7970.34
283_A312_A0.7970.34
23_R27_A0.7960.34
253_G316_W0.7930.34
149_M192_A0.7920.34
266_T289_V0.7920.34
253_G286_F0.7920.34
286_F289_V0.7870.33
344_E349_T0.7840.33
248_A266_T0.7830.33
15_V21_P0.7820.33
180_I194_L0.7820.33
285_T328_Q0.7810.33
127_L240_V0.7790.33
14_S19_T0.7760.33
29_V46_V0.7720.32
28_K32_V0.7650.32
300_R305_S0.7630.32
83_A337_G0.7590.32
182_L226_I0.7570.31
27_A30_E0.7550.31
180_I355_L0.7520.31
258_L329_E0.7500.31
129_A141_L0.7500.31
90_G337_G0.7480.31
79_G87_G0.7480.31
180_I361_E0.7370.30
71_L79_G0.7340.30
83_A90_G0.7330.30
214_Q246_F0.7320.30
34_R37_V0.7300.30
171_L198_S0.7260.30
49_I283_A0.7240.29
75_A217_V0.7220.29
89_Y120_P0.7190.29
20_L312_A0.7190.29
135_G138_N0.7180.29
107_L171_L0.7170.29
35_E38_G0.7160.29
144_A261_Y0.7150.29
47_F126_V0.7110.29
78_E81_E0.7090.29
3_V60_T0.7080.29
242_T249_T0.7080.29
15_V19_T0.7070.28
21_P315_V0.7060.28
42_L302_G0.7060.28
266_T288_C0.7020.28
41_L203_I0.7010.28
26_L30_E0.7000.28
253_G289_V0.6990.28
24_K82_V0.6990.28
73_W98_D0.6970.28
250_E285_T0.6900.28
38_G78_E0.6900.28
16_G296_A0.6890.27
161_R357_A0.6850.27
63_V214_Q0.6850.27
240_V252_F0.6840.27
272_M287_F0.6830.27
250_E253_G0.6820.27
75_A97_K0.6800.27
79_G83_A0.6800.27
312_A318_A0.6800.27
156_L346_L0.6790.27
14_S21_P0.6780.27
16_G20_L0.6780.27
49_I333_Q0.6770.27
353_E357_A0.6770.27
89_Y121_A0.6770.27
13_G17_G0.6730.27
260_P336_Y0.6730.27
278_R312_A0.6720.27
328_Q332_R0.6700.26
78_E191_I0.6690.26
192_A335_F0.6690.26
318_A328_Q0.6680.26
156_L340_M0.6680.26
79_G284_S0.6670.26
77_R323_V0.6660.26
23_R39_R0.6640.26
285_T335_F0.6640.26
33_V37_V0.6630.26
23_R30_E0.6610.26
25_V83_A0.6610.26
116_F158_P0.6610.26
137_F205_S0.6590.26
106_G235_D0.6580.26
254_P335_F0.6570.26
1_M207_W0.6560.26
87_G120_P0.6530.26
184_A198_S0.6520.25
272_M327_A0.6510.25
49_I171_L0.6500.25
64_R117_T0.6500.25
297_F307_P0.6480.25
28_K75_A0.6460.25
203_I261_Y0.6450.25
258_L326_K0.6440.25
78_E82_V0.6420.25
21_P26_L0.6420.25
6_S107_L0.6390.25
37_V44_A0.6390.25
16_G249_T0.6380.25
135_G222_R0.6380.25
16_G19_T0.6360.25
78_E242_T0.6360.25
285_T288_C0.6360.25
324_V362_F0.6340.25
7_V293_C0.6330.24
318_A322_K0.6320.24
32_V217_V0.6320.24
137_F141_L0.6310.24
249_T298_S0.6300.24
143_L150_Y0.6260.24
245_I288_C0.6250.24
98_D345_E0.6250.24
178_S359_E0.6250.24
27_A31_E0.6250.24
350_G354_R0.6240.24
32_V36_E0.6240.24
259_A306_E0.6230.24
139_L253_G0.6230.24
316_W319_V0.6200.24
79_G194_L0.6190.24
278_R283_A0.6190.24
254_P328_Q0.6180.24
208_S214_Q0.6180.24
86_E305_S0.6150.24
190_D193_T0.6140.24
277_V283_A0.6130.23
26_L301_E0.6130.23
28_K79_G0.6100.23
20_L308_V0.6090.23
181_E363_S0.6090.23
245_I250_E0.6090.23
35_E159_E0.6090.23
30_E34_R0.6090.23
144_A315_V0.6080.23
285_T289_V0.6080.23
32_V35_E0.6070.23
159_E171_L0.6060.23
23_R81_E0.6060.23
160_L182_L0.6030.23
183_D229_R0.6020.23
56_L128_A0.6020.23
253_G288_C0.6010.23
19_T296_A0.6000.23
250_E286_F0.5990.23
64_R105_H0.5960.23
98_D244_K0.5960.23
272_M290_P0.5950.23
207_W214_Q0.5940.23
343_M355_L0.5930.22
319_V328_Q0.5920.22
122_E217_V0.5920.22
265_D288_C0.5910.22
165_R210_K0.5910.22
26_L48_H0.5900.22
310_L313_D0.5900.22
312_A321_A0.5900.22
283_A315_V0.5890.22
48_H283_A0.5870.22
24_K28_K0.5860.22
3_V14_S0.5850.22
217_V299_L0.5840.22
282_P312_A0.5830.22
230_Y233_K0.5820.22
125_M252_F0.5820.22
272_M288_C0.5780.22
46_V218_V0.5780.22
138_N277_V0.5770.22
16_G21_P0.5770.22
30_E44_A0.5760.22
29_V33_V0.5760.22
322_K363_S0.5720.21
98_D183_D0.5710.21
255_V283_A0.5700.21
105_H152_S0.5700.21
21_P282_P0.5700.21
35_E239_I0.5690.21
165_R292_V0.5680.21
253_G266_T0.5670.21
1_M359_E0.5660.21
21_P53_I0.5650.21
142_Y203_I0.5640.21
97_K107_L0.5640.21
7_V128_A0.5620.21
285_T315_V0.5620.21
71_L75_A0.5620.21
226_I229_R0.5600.21
129_A171_L0.5600.21
59_H62_G0.5580.21
198_S201_F0.5580.21
104_L133_E0.5580.21
271_H330_M0.5580.21
27_A34_R0.5580.21
250_E265_D0.5560.21
193_T343_M0.5530.21
133_E246_F0.5510.21
49_I315_V0.5510.21
197_D244_K0.5500.20
20_L26_L0.5500.20
114_M124_F0.5500.20
122_E140_P0.5490.20
91_A230_Y0.5490.20
111_V158_P0.5480.20
7_V239_I0.5440.20
129_A222_R0.5420.20
151_S265_D0.5420.20
213_E222_R0.5400.20
232_G235_D0.5390.20
337_G342_P0.5390.20
134_P158_P0.5380.20
133_E308_V0.5380.20
167_R342_P0.5370.20
172_A263_A0.5370.20
156_L350_G0.5350.20
282_P314_P0.5330.20
41_L74_K0.5330.20
99_A120_P0.5320.20
134_P263_A0.5310.20
100_F132_T0.5310.20
152_S265_D0.5290.20
185_P189_Y0.5290.20
244_K263_A0.5290.20
9_K18_H0.5290.20
68_V75_A0.5280.20
15_V20_L0.5280.20
19_T337_G0.5280.20
36_E39_R0.5280.20
141_L246_F0.5270.19
106_G234_D0.5270.19
322_K356_K0.5270.19
125_M238_A0.5270.19
152_S221_T0.5250.19
53_I75_A0.5240.19
43_D297_F0.5210.19
187_R358_L0.5210.19
146_A188_L0.5180.19
323_V329_E0.5180.19
20_L68_V0.5180.19
27_A39_R0.5170.19
40_L61_R0.5160.19
150_Y201_F0.5160.19
134_P244_K0.5160.19
129_A197_D0.5160.19
159_E191_I0.5150.19
105_H274_L0.5130.19
278_R282_P0.5130.19
15_V22_S0.5120.19
67_E152_S0.5120.19
271_H338_P0.5120.19
1_M79_G0.5110.19
310_L314_P0.5110.19
99_A121_A0.5100.19
129_A132_T0.5090.19
212_G218_V0.5080.19
280_N312_A0.5070.19
21_P308_V0.5070.19
167_R178_S0.5060.19
184_A361_E0.5050.19
356_K360_R0.5050.19
41_L303_R0.5030.18
134_P202_A0.5030.18
314_P324_V0.5020.18
16_G22_S0.5020.18
15_V308_V0.5010.18
284_S311_F0.5010.18
106_G232_G0.5010.18
257_A328_Q0.5000.18
250_E272_M0.5000.18
273_P313_D0.5000.18
57_L110_Q0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r1m_A 1 0.9725 100 -0.015 Contact Map
3t2c_A 1 0.9917 100 -0.008 Contact Map
2m9x_A 1 0.2149 36.2 0.98 Contact Map
5ees_A 1 0.2507 34.8 0.981 Contact Map
5cb3_A 1 0.3747 31.5 0.981 Contact Map
4ear_A 1 0.1212 27.8 0.982 Contact Map
2vof_A 1 0.1377 24 0.982 Contact Map
2d1c_A 1 0.2534 22.7 0.982 Contact Map
3i41_A 1 0.1736 19.9 0.983 Contact Map
3ozf_A 1 0.2369 18.9 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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