GREMLIN Database
T0905_1_353 - T0905 1-353
ID: 56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 353 (302)
Sequences: 235 (205)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_V273_F3.4180.98
53_W183_I3.1640.97
238_C270_C3.0860.96
48_Q177_E2.9860.95
230_T259_A2.8550.94
184_I228_V2.7350.92
50_D178_A2.5800.90
159_S213_Y2.5590.90
65_Q94_E2.5550.90
231_I280_I2.4450.87
56_D60_S2.4240.87
65_Q93_T2.3910.86
52_L180_L2.3870.86
320_T331_H2.3110.84
321_Y328_I2.3110.84
59_G153_G2.3080.84
50_D180_L2.3040.84
276_T280_I2.2360.82
30_S33_N2.2090.81
50_D175_R2.2080.81
211_Q215_D2.1910.81
50_D57_N2.1280.79
72_F88_M2.0990.78
93_T277_L2.0910.77
89_A182_V2.0860.77
65_Q151_G2.0640.76
157_A255_L2.0580.76
61_M187_D2.0280.75
306_V330_F1.9600.72
182_V280_I1.9480.72
28_S34_D1.9320.71
72_F76_I1.9040.70
79_F91_T1.8980.70
341_N344_I1.8840.69
181_A226_Y1.8410.67
211_Q344_I1.7850.65
185_V214_V1.7750.64
257_E261_L1.7660.64
85_D175_R1.7630.64
330_F336_P1.7610.64
72_F75_F1.7420.63
328_I344_I1.7410.63
259_A279_L1.7390.63
57_N93_T1.7380.63
158_F254_R1.7300.62
65_Q92_T1.7300.62
60_S187_D1.7260.62
52_L254_R1.6850.60
90_V188_E1.6830.60
55_I231_I1.6830.60
186_S230_T1.6760.60
190_D254_R1.6680.59
185_V320_T1.6590.59
175_R178_A1.6510.59
252_S255_L1.6440.58
54_V306_V1.6340.58
78_R81_Q1.6200.57
88_M175_R1.5910.56
211_Q214_V1.5710.55
61_M304_I1.5650.54
64_S184_I1.5400.53
148_G151_G1.5370.53
29_Y32_L1.5350.53
55_I68_L1.5230.52
164_A182_V1.5090.52
217_L302_I1.4800.50
53_W297_P1.4730.50
92_T330_F1.4710.50
156_R188_E1.4600.49
143_T327_T1.4540.49
54_V57_N1.4520.49
211_Q261_L1.4520.49
54_V85_D1.4490.49
186_S255_L1.4310.48
342_I346_F1.4270.48
290_V306_V1.4270.48
92_T148_G1.4250.47
89_A166_L1.4240.47
290_V327_T1.4240.47
293_L297_P1.4210.47
233_V262_T1.4060.47
184_I230_T1.3890.46
56_D186_S1.3870.46
46_P328_I1.3800.45
57_N180_L1.3730.45
256_P259_A1.3720.45
208_H231_I1.3610.44
189_E222_G1.3540.44
280_I298_Q1.3510.44
103_A106_K1.3500.44
51_I317_N1.3410.43
65_Q188_E1.3380.43
165_L319_W1.3320.43
50_D93_T1.3250.43
151_G155_E1.3120.42
64_S230_T1.3030.41
137_L183_I1.2930.41
89_A307_N1.2880.41
157_A188_E1.2830.41
260_T296_E1.2730.40
228_V232_T1.2390.38
330_F346_F1.2340.38
161_F182_V1.2320.38
104_S107_A1.2260.38
30_S35_A1.2200.38
54_V92_T1.2190.37
28_S31_L1.2170.37
65_Q269_L1.2160.37
89_A92_T1.2130.37
51_I175_R1.2100.37
58_S75_F1.2050.37
28_S33_N1.1990.37
71_N273_F1.1980.36
87_H185_V1.1970.36
53_W77_S1.1870.36
54_V178_A1.1870.36
33_N37_D1.1860.36
164_A170_N1.1820.36
77_S260_T1.1810.36
47_K160_S1.1770.36
64_S176_S1.1760.35
165_L216_F1.1700.35
165_L259_A1.1690.35
52_L175_R1.1670.35
31_L34_D1.1610.35
93_T188_E1.1610.35
297_P344_I1.1510.34
192_S277_L1.1450.34
155_E188_E1.1420.34
89_A220_Y1.1420.34
208_H344_I1.1320.34
78_R274_G1.1300.33
158_F339_D1.1290.33
28_S32_L1.1240.33
306_V328_I1.1230.33
232_T319_W1.1210.33
55_I233_V1.1200.33
188_E330_F1.1160.33
94_E190_D1.1140.33
139_D143_T1.1020.32
307_N328_I1.0870.32
48_Q348_P1.0840.31
220_Y258_L1.0730.31
195_S317_N1.0720.31
68_L178_A1.0690.31
187_D277_L1.0650.31
89_A185_V1.0610.30
82_Y229_S1.0550.30
156_R289_S1.0470.30
87_H270_C1.0430.30
291_F336_P1.0390.30
179_F328_I1.0350.29
185_V230_T1.0340.29
56_D318_G1.0330.29
215_D219_G1.0290.29
57_N65_Q1.0280.29
186_S342_I1.0240.29
185_V251_I1.0240.29
135_A139_D1.0140.28
89_A333_S1.0090.28
66_D185_V1.0060.28
88_M293_L1.0000.28
230_T255_L0.9940.28
218_D258_L0.9870.27
237_A249_R0.9830.27
148_G158_F0.9760.27
152_N252_S0.9750.27
177_E218_D0.9740.27
28_S37_D0.9730.27
111_D335_V0.9710.27
39_K177_E0.9660.27
229_S233_V0.9650.27
157_A346_F0.9620.26
251_I268_S0.9570.26
65_Q68_L0.9560.26
141_F276_T0.9530.26
84_Y162_K0.9520.26
330_F339_D0.9410.26
93_T297_P0.9390.26
289_S348_P0.9370.25
290_V332_G0.9350.25
56_D187_D0.9350.25
82_Y230_T0.9330.25
59_G271_S0.9310.25
158_F190_D0.9280.25
88_M113_A0.9280.25
54_V190_D0.9280.25
58_S187_D0.9200.25
155_E190_D0.9160.25
88_M183_I0.9130.25
136_N226_Y0.9110.24
160_S225_N0.9110.24
339_D346_F0.9080.24
56_D155_E0.9070.24
209_T344_I0.9070.24
61_M65_Q0.9060.24
230_T261_L0.9060.24
223_S271_S0.9040.24
74_S223_S0.9040.24
259_A262_T0.9020.24
157_A231_I0.8910.24
159_S284_I0.8910.24
210_V254_R0.8890.24
40_Q142_S0.8890.24
58_S73_Q0.8860.24
157_A178_A0.8860.24
40_Q284_I0.8850.24
182_V212_S0.8840.24
79_F151_G0.8780.23
314_D333_S0.8740.23
29_Y34_D0.8720.23
149_T276_T0.8720.23
335_V347_Y0.8700.23
52_L182_V0.8690.23
136_N296_E0.8620.23
157_A289_S0.8610.23
49_I178_A0.8570.23
162_K216_F0.8540.22
82_Y289_S0.8520.22
50_D85_D0.8490.22
188_E192_S0.8480.22
65_Q190_D0.8470.22
160_S303_V0.8460.22
183_I237_A0.8450.22
65_Q90_V0.8450.22
112_G166_L0.8390.22
322_D326_L0.8350.22
274_G327_T0.8350.22
159_S191_F0.8340.22
112_G115_L0.8340.22
42_A250_K0.8270.22
60_S318_G0.8260.21
228_V233_V0.8230.21
65_Q228_V0.8200.21
64_S71_N0.8200.21
89_A171_A0.8170.21
62_K66_D0.8170.21
29_Y33_N0.8150.21
165_L321_Y0.8130.21
172_G292_K0.8110.21
56_D75_F0.8110.21
60_S304_I0.8110.21
55_I160_S0.8090.21
91_T330_F0.8080.21
54_V93_T0.8050.21
184_I348_P0.8040.21
90_V94_E0.8010.21
106_K109_I0.8000.21
269_L346_F0.7990.21
186_S214_V0.7940.20
116_Q136_N0.7940.20
112_G150_L0.7930.20
83_N184_I0.7880.20
74_S230_T0.7870.20
58_S280_I0.7840.20
233_V348_P0.7820.20
235_D274_G0.7670.20
55_I263_A0.7620.19
54_V79_F0.7600.19
177_E302_I0.7590.19
41_Q345_D0.7590.19
106_K315_A0.7590.19
342_I345_D0.7580.19
143_T177_E0.7560.19
180_L254_R0.7520.19
301_T313_N0.7510.19
155_E335_V0.7380.19
219_G272_N0.7360.19
51_I72_F0.7350.19
85_D178_A0.7320.19
52_L91_T0.7300.18
54_V141_F0.7280.18
312_P318_G0.7260.18
59_G104_S0.7260.18
336_P346_F0.7240.18
87_H175_R0.7230.18
258_L281_S0.7230.18
259_A328_I0.7220.18
135_A165_L0.7170.18
113_A116_Q0.7170.18
57_N68_L0.7100.18
76_I79_F0.7080.18
291_F334_S0.7080.18
175_R346_F0.7070.18
135_A275_S0.7070.18
306_V346_F0.7020.18
259_A276_T0.7000.18
115_L136_N0.6990.18
53_W75_F0.6970.17
220_Y261_L0.6970.17
337_A340_A0.6930.17
39_K320_T0.6910.17
79_F294_N0.6910.17
71_N86_F0.6910.17
182_V265_V0.6900.17
85_D92_T0.6870.17
195_S198_F0.6840.17
82_Y154_D0.6830.17
51_I183_I0.6830.17
99_Q307_N0.6800.17
183_I234_P0.6770.17
309_V314_D0.6750.17
48_Q176_S0.6730.17
44_F346_F0.6720.17
274_G277_L0.6720.17
231_I318_G0.6710.17
305_T310_S0.6700.17
36_E40_Q0.6680.17
38_Y330_F0.6670.17
188_E289_S0.6670.17
51_I75_F0.6650.17
182_V290_V0.6640.17
89_A260_T0.6630.17
138_G340_A0.6620.16
175_R269_L0.6610.16
138_G176_S0.6610.16
155_E232_T0.6610.16
229_S280_I0.6590.16
190_D289_S0.6570.16
340_A346_F0.6490.16
61_M68_L0.6470.16
221_V306_V0.6460.16
229_S258_L0.6460.16
259_A340_A0.6440.16
277_L293_L0.6440.16
155_E184_I0.6430.16
338_A343_T0.6430.16
30_S34_D0.6420.16
157_A293_L0.6370.16
86_F194_S0.6360.16
101_N143_T0.6350.16
315_A328_I0.6340.16
229_S298_Q0.6340.16
97_E107_A0.6340.16
260_T325_N0.6270.16
148_G166_L0.6270.16
161_F217_L0.6260.16
138_G329_T0.6260.16
165_L284_I0.6240.15
270_C330_F0.6240.15
57_N269_L0.6230.15
87_H269_L0.6210.15
129_I321_Y0.6200.15
307_N342_I0.6200.15
50_D273_F0.6160.15
52_L178_A0.6140.15
62_K145_A0.6140.15
35_A38_Y0.6130.15
44_F322_D0.6130.15
94_E330_F0.6130.15
139_D302_I0.6100.15
156_R262_T0.6080.15
47_K297_P0.6070.15
156_R161_F0.6070.15
257_E290_V0.6060.15
51_I275_S0.6040.15
47_K51_I0.6030.15
56_D61_M0.6010.15
195_S325_N0.5980.15
88_M160_S0.5960.15
28_S35_A0.5950.15
104_S177_E0.5950.15
59_G187_D0.5930.15
165_L312_P0.5920.15
47_K227_S0.5920.15
143_T251_I0.5910.15
69_A85_D0.5910.15
221_V302_I0.5910.15
77_S310_S0.5900.15
102_S175_R0.5880.15
67_N309_V0.5850.14
344_I347_Y0.5840.14
294_N307_N0.5830.14
110_K170_N0.5800.14
161_F280_I0.5780.14
302_I344_I0.5780.14
86_F275_S0.5770.14
223_S342_I0.5760.14
53_W139_D0.5760.14
58_S233_V0.5760.14
45_I185_V0.5750.14
272_N291_F0.5750.14
214_V284_I0.5740.14
93_T190_D0.5730.14
292_K327_T0.5730.14
137_L284_I0.5710.14
28_S40_Q0.5700.14
28_S41_Q0.5690.14
58_S61_M0.5690.14
74_S182_V0.5670.14
94_E188_E0.5650.14
163_E193_S0.5640.14
34_D39_K0.5630.14
46_P97_E0.5620.14
149_T176_S0.5620.14
259_A264_G0.5610.14
216_F219_G0.5610.14
59_G257_E0.5600.14
183_I200_E0.5600.14
284_I330_F0.5560.14
256_P266_K0.5520.14
236_D321_Y0.5510.14
258_L264_G0.5490.14
72_F237_A0.5470.14
158_F164_A0.5450.14
251_I266_K0.5430.13
50_D91_T0.5430.13
89_A180_L0.5420.13
53_W88_M0.5420.13
133_N311_V0.5410.13
64_S233_V0.5400.13
89_A286_Q0.5380.13
93_T192_S0.5370.13
240_T274_G0.5360.13
140_V151_G0.5340.13
46_P255_L0.5330.13
49_I86_F0.5320.13
68_L158_F0.5310.13
60_S75_F0.5280.13
109_I336_P0.5260.13
257_E343_T0.5260.13
186_S193_S0.5230.13
43_V270_C0.5230.13
209_T311_V0.5230.13
184_I226_Y0.5230.13
50_D92_T0.5220.13
302_I312_P0.5200.13
217_L341_N0.5190.13
66_D303_V0.5190.13
133_N136_N0.5180.13
314_D326_L0.5170.13
71_N188_E0.5140.13
61_M93_T0.5110.13
28_S67_N0.5090.13
139_D142_S0.5090.13
257_E279_L0.5090.13
186_S216_F0.5080.13
157_A220_Y0.5080.13
250_K307_N0.5070.13
72_F183_I0.5070.13
151_G297_P0.5060.13
47_K321_Y0.5060.13
62_K250_K0.5050.13
29_Y76_I0.5030.13
99_Q236_D0.5030.13
81_Q286_Q0.5030.13
134_T137_L0.5010.13
261_L344_I0.5010.13
200_E207_L0.5010.13
190_D348_P0.5000.13
303_V342_I0.5000.13
151_G154_D0.5000.13
227_S283_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q0p_A 1 0.5014 99.6 0.801 Contact Map
2b2x_A 1 0.5241 99.6 0.804 Contact Map
1v7p_C 1 0.5297 99.5 0.811 Contact Map
1pt6_A 1 0.5269 99.5 0.812 Contact Map
1mjn_A 1 0.4929 99.5 0.813 Contact Map
3fcs_B 1 0.898 99.5 0.813 Contact Map
1shu_X 1 0.5127 99.5 0.813 Contact Map
1rrk_A 1 0.7224 99.5 0.815 Contact Map
4igi_A 1 0.5354 99.5 0.815 Contact Map
1n3y_A 1 0.5156 99.5 0.817 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0121 seconds.