GREMLIN Database
T0904_1_341 - T0904 1-341
ID: 55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 341 (314)
Sequences: 60 (41)
Seq/√Len: 2.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
301_E308_Q3.2090.43
28_V31_W3.1330.42
278_G308_Q3.0970.41
308_Q312_A2.9460.38
303_V311_A2.8840.37
278_G301_E2.7250.33
323_L335_A2.7030.33
278_G284_D2.6950.33
197_I200_S2.6010.31
278_G302_A2.5910.31
278_G286_L2.5690.30
301_E312_A2.4840.29
47_L50_K2.4770.29
318_H322_G2.4490.28
42_E50_K2.4320.28
42_E47_L2.4320.28
42_E48_Q2.4320.28
278_G312_A2.4170.28
284_D308_Q2.3960.27
240_L310_T2.2750.25
301_E310_T2.2710.25
46_T80_S2.1680.23
330_L333_G2.1630.23
296_A312_A2.1530.23
194_V260_L2.1420.23
74_L145_I2.1220.23
149_S152_T2.0960.22
93_S114_L2.0680.22
268_Q273_L2.0310.21
40_E139_E1.9840.21
278_G310_T1.9810.21
45_C193_L1.9800.21
278_G311_A1.9580.20
282_V305_L1.9490.20
303_V307_A1.9430.20
70_L93_S1.9410.20
81_L173_L1.9370.20
319_R323_L1.9350.20
142_L149_S1.8810.19
262_T322_G1.8800.19
232_V266_A1.8760.19
178_T305_L1.8610.19
258_R264_C1.8550.19
302_A308_Q1.8430.19
51_S322_G1.8360.19
36_R117_F1.8170.18
101_P171_V1.7970.18
281_I311_A1.7920.18
49_H190_V1.7300.17
273_L302_A1.7290.17
232_V262_T1.7040.17
166_S183_R1.6970.17
284_D311_A1.6930.17
286_L312_A1.6770.17
227_L272_Q1.6720.17
286_L308_Q1.6500.16
160_H163_N1.6240.16
308_Q334_L1.5860.16
197_I273_L1.5770.15
277_G280_E1.5520.15
278_G307_A1.5430.15
31_W50_K1.5300.15
31_W47_L1.5300.15
31_W48_Q1.5300.15
284_D301_E1.5130.15
184_L194_V1.4960.15
282_V296_A1.4730.14
228_S231_F1.4720.14
36_R270_I1.4670.14
167_L182_L1.4650.14
152_T256_A1.4640.14
172_Q209_N1.4640.14
197_I334_L1.4620.14
305_L327_A1.4530.14
308_Q311_A1.4500.14
83_V120_T1.4320.14
31_W42_E1.4070.14
301_E309_I1.4050.14
46_T49_H1.4000.14
148_V160_H1.3990.13
301_E311_A1.3950.13
240_L265_C1.3900.13
278_G282_V1.3890.13
278_G309_I1.3800.13
193_L227_L1.3640.13
265_C273_L1.3610.13
60_Y80_S1.3330.13
257_L284_D1.3300.13
142_L151_D1.3270.13
244_V258_R1.3230.13
305_L311_A1.3170.13
286_L301_E1.3120.13
228_S245_L1.2920.12
228_S235_E1.2910.12
286_L302_A1.2740.12
149_S213_V1.2730.12
278_G303_V1.2720.12
114_L145_I1.2630.12
227_L244_V1.2550.12
270_I309_I1.2480.12
172_Q182_L1.2440.12
215_T219_I1.2420.12
113_H263_L1.2150.12
240_L286_L1.2120.12
281_I302_A1.2080.12
94_G110_L1.2040.12
284_D302_A1.1940.12
110_L196_S1.1770.11
55_E209_N1.1760.11
111_L174_L1.1730.11
257_L286_L1.1700.11
256_A273_L1.1670.11
261_A328_E1.1550.11
231_F236_A1.1540.11
198_E314_H1.1540.11
153_R159_Q1.1380.11
323_L329_S1.1290.11
106_G341_E1.1290.11
66_A330_L1.1270.11
240_L278_G1.1230.11
241_L313_W1.1190.11
51_S318_H1.1090.11
40_E256_A1.1040.11
286_L307_A1.1020.11
145_I178_T1.0940.11
178_T186_F1.0920.11
239_T266_A1.0890.11
239_T262_T1.0880.11
320_V323_L1.0840.11
46_T177_H1.0840.11
277_G281_I1.0830.11
148_V156_L1.0750.10
55_E167_L1.0750.10
291_A305_L1.0740.10
79_L88_S1.0710.10
122_E209_N1.0680.10
69_K149_S1.0610.10
230_A263_L1.0580.10
284_D312_A1.0570.10
303_V308_Q1.0560.10
309_I312_A1.0510.10
110_L315_G1.0500.10
228_S234_N1.0500.10
110_L136_R1.0480.10
294_R298_E1.0460.10
114_L119_A1.0460.10
307_A311_A1.0410.10
35_Q63_T1.0390.10
206_L213_V1.0340.10
254_A261_A1.0310.10
83_V90_R1.0260.10
286_L311_A1.0200.10
325_D330_L1.0190.10
62_I237_V1.0150.10
284_D299_R1.0100.10
257_L278_G1.0100.10
235_E268_Q1.0050.10
50_K258_R1.0040.10
48_Q258_R1.0040.10
47_L258_R1.0040.10
216_L284_D0.9960.10
262_T269_A0.9920.10
146_R305_L0.9840.10
152_T279_I0.9820.10
232_V237_V0.9810.10
298_E313_W0.9770.10
306_L314_H0.9750.10
216_L240_L0.9740.10
325_D334_L0.9720.10
150_K154_Y0.9710.10
238_R242_V0.9700.10
282_V308_Q0.9690.10
239_T269_A0.9680.10
302_A312_A0.9670.10
306_L326_C0.9650.10
93_S98_S0.9620.10
303_V312_A0.9600.10
258_R273_L0.9530.10
111_L172_Q0.9520.10
199_Q270_I0.9520.10
281_I298_E0.9490.10
215_T334_L0.9420.09
78_A174_L0.9420.09
46_T60_Y0.9400.09
237_V243_V0.9400.09
257_L274_G0.9360.09
139_E182_L0.9340.09
95_L165_E0.9310.09
34_E171_V0.9290.09
285_I301_E0.9280.09
301_E334_L0.9250.09
98_S174_L0.9210.09
296_A308_Q0.9180.09
307_A312_A0.9180.09
277_G305_L0.9100.09
258_R272_Q0.9080.09
149_S161_Y0.9070.09
114_L209_N0.8990.09
93_S167_L0.8960.09
299_R331_V0.8960.09
89_E183_R0.8950.09
40_E279_I0.8920.09
78_A270_I0.8900.09
42_E258_R0.8870.09
148_V163_N0.8840.09
287_Q304_S0.8810.09
278_G334_L0.8800.09
236_A295_G0.8770.09
151_D156_L0.8730.09
283_R302_A0.8710.09
242_V269_A0.8710.09
67_V279_I0.8680.09
37_W140_Q0.8660.09
70_L95_L0.8620.09
277_G311_A0.8600.09
64_T68_C0.8590.09
234_N242_V0.8580.09
54_Q254_A0.8560.09
305_L312_A0.8560.09
144_Q154_Y0.8540.09
211_N273_L0.8540.09
105_A271_N0.8540.09
142_L152_T0.8540.09
227_L237_V0.8530.09
240_L308_Q0.8460.09
323_L332_A0.8460.09
302_A311_A0.8450.09
281_I291_A0.8320.09
31_W310_T0.8250.09
146_R175_K0.8240.09
270_I310_T0.8180.09
39_G335_A0.8180.09
152_T161_Y0.8180.09
80_S95_L0.8180.09
40_E192_V0.8180.09
121_L145_I0.8180.09
79_L314_H0.8170.09
329_S338_L0.8170.09
282_V286_L0.8120.09
52_I199_Q0.8120.09
66_A152_T0.8110.09
251_S294_R0.8080.08
205_L335_A0.8050.08
39_G253_R0.8030.08
146_R152_T0.8010.08
106_G109_Q0.8000.08
282_V312_A0.7990.08
28_V48_Q0.7980.08
28_V47_L0.7980.08
28_V50_K0.7980.08
228_S232_V0.7980.08
296_A304_S0.7960.08
67_V150_K0.7960.08
258_R270_I0.7950.08
263_L280_E0.7950.08
302_A310_T0.7930.08
27_P31_W0.7900.08
37_W79_L0.7860.08
228_S273_L0.7860.08
228_S243_V0.7790.08
284_D310_T0.7790.08
196_S209_N0.7780.08
55_E205_L0.7770.08
243_V307_A0.7770.08
278_G281_I0.7760.08
240_L257_L0.7750.08
278_G299_R0.7730.08
51_S55_E0.7710.08
86_E110_L0.7690.08
239_T246_D0.7680.08
246_D268_Q0.7680.08
243_V256_A0.7660.08
277_G330_L0.7630.08
306_L313_W0.7620.08
131_A190_V0.7590.08
258_R268_Q0.7540.08
240_L258_R0.7530.08
143_E163_N0.7520.08
257_L262_T0.7520.08
81_L194_V0.7510.08
143_E159_Q0.7480.08
84_H244_V0.7470.08
227_L233_Q0.7460.08
74_L114_L0.7430.08
317_E333_G0.7430.08
209_N270_I0.7400.08
40_E47_L0.7400.08
40_E50_K0.7400.08
40_E48_Q0.7400.08
156_L159_Q0.7380.08
244_V268_Q0.7370.08
219_I334_L0.7330.08
198_E250_S0.7310.08
323_L341_E0.7290.08
229_D272_Q0.7270.08
54_Q198_E0.7270.08
181_T236_A0.7260.08
197_I214_A0.7240.08
197_I272_Q0.7230.08
52_I169_D0.7210.08
29_A145_I0.7190.08
228_S266_A0.7190.08
87_R104_L0.7180.08
150_K155_S0.7180.08
283_R304_S0.7150.08
179_L190_V0.7110.08
34_E340_P0.7110.08
237_V256_A0.7100.08
24_H140_Q0.7080.08
76_Q164_L0.7080.08
67_V144_Q0.7070.08
103_A139_E0.7070.08
278_G305_L0.7040.08
111_L114_L0.7030.08
293_E296_A0.6980.08
107_A159_Q0.6970.08
234_N245_L0.6960.08
149_S338_L0.6960.08
190_V197_I0.6900.08
236_A265_C0.6890.08
52_I213_V0.6890.08
46_T174_L0.6880.08
281_I297_I0.6880.08
238_R263_L0.6870.08
256_A268_Q0.6870.08
198_E302_A0.6850.08
281_I303_V0.6850.08
232_V239_T0.6830.08
104_L182_L0.6830.08
218_N241_L0.6820.08
68_C295_G0.6820.08
322_G333_G0.6810.08
37_W172_Q0.6800.08
218_N323_L0.6790.08
171_V296_A0.6790.08
177_H188_R0.6750.08
197_I253_R0.6710.08
98_S182_L0.6710.08
55_E140_Q0.6700.08
72_R323_L0.6680.08
213_V320_V0.6680.08
111_L175_K0.6670.08
152_T325_D0.6660.08
37_W88_S0.6640.08
257_L270_I0.6620.08
34_E116_D0.6610.08
238_R246_D0.6610.08
35_Q264_C0.6590.08
240_L261_A0.6580.08
45_C113_H0.6580.08
297_I311_A0.6570.08
284_D303_V0.6560.08
122_E270_I0.6560.08
87_R182_L0.6560.08
71_V158_R0.6530.07
36_R314_H0.6500.07
118_T132_K0.6440.07
55_E165_E0.6430.07
322_G329_S0.6410.07
279_I308_Q0.6390.07
268_Q272_Q0.6330.07
133_I279_I0.6320.07
320_V333_G0.6300.07
151_D159_Q0.6300.07
158_R334_L0.6250.07
277_G282_V0.6250.07
25_P185_I0.6250.07
298_E311_A0.6230.07
32_M238_R0.6220.07
262_T266_A0.6170.07
28_V42_E0.6160.07
88_S140_Q0.6140.07
60_Y118_T0.6100.07
318_H323_L0.6100.07
218_N322_G0.6090.07
249_Q272_Q0.6090.07
107_A282_V0.6070.07
26_E76_Q0.6060.07
158_R169_D0.6050.07
128_F153_R0.6030.07
228_S268_Q0.5980.07
93_S118_T0.5960.07
32_M280_E0.5960.07
277_G297_I0.5960.07
87_R261_A0.5950.07
271_N333_G0.5950.07
51_S105_A0.5940.07
323_L334_L0.5930.07
183_R186_F0.5920.07
301_E307_A0.5920.07
275_S334_L0.5910.07
279_I307_A0.5900.07
65_S323_L0.5900.07
53_A79_L0.5890.07
213_V315_G0.5880.07
86_E95_L0.5880.07
39_G171_V0.5880.07
51_S294_R0.5870.07
97_A115_D0.5860.07
239_T243_V0.5850.07
310_T334_L0.5850.07
152_T305_L0.5850.07
159_Q162_I0.5830.07
237_V241_L0.5820.07
55_E202_C0.5810.07
174_L182_L0.5800.07
257_L326_C0.5780.07
241_L311_A0.5750.07
232_V267_P0.5730.07
26_E30_S0.5710.07
110_L167_L0.5690.07
40_E64_T0.5680.07
254_A314_H0.5670.07
287_Q303_V0.5650.07
253_R269_A0.5640.07
230_A244_V0.5620.07
75_Q331_V0.5620.07
51_S251_S0.5620.07
246_D262_T0.5610.07
246_D266_A0.5610.07
75_Q306_L0.5580.07
262_T318_H0.5560.07
78_A336_A0.5560.07
240_L264_C0.5530.07
47_L308_Q0.5530.07
48_Q308_Q0.5530.07
50_K308_Q0.5530.07
92_L101_P0.5510.07
318_H324_R0.5510.07
213_V217_M0.5500.07
284_D291_A0.5490.07
198_E313_W0.5490.07
123_R131_A0.5460.07
84_H112_S0.5440.07
232_V252_V0.5410.07
31_W264_C0.5400.07
95_L131_A0.5400.07
93_S199_Q0.5400.07
170_D270_I0.5390.07
72_R85_F0.5380.07
232_V333_G0.5370.07
220_D223_G0.5360.07
43_V194_V0.5350.07
54_Q211_N0.5350.07
33_S100_L0.5320.07
100_L135_R0.5300.07
206_L210_I0.5300.07
36_R91_V0.5290.07
86_E190_V0.5280.07
42_E309_I0.5270.07
208_A252_V0.5270.07
257_L261_A0.5270.07
143_E162_I0.5270.07
29_A263_L0.5250.07
69_K152_T0.5250.07
151_D162_I0.5250.07
305_L308_Q0.5240.07
228_S237_V0.5220.07
286_L310_T0.5200.07
231_F237_V0.5200.07
203_D261_A0.5190.07
75_Q117_F0.5140.07
249_Q267_P0.5140.07
224_F228_S0.5120.07
96_Q101_P0.5120.07
275_S282_V0.5110.07
305_L313_W0.5070.07
167_L190_V0.5040.07
34_E81_L0.5020.07
216_L308_Q0.5020.07
320_V334_L0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sf4_D 1 0.132 99.7 0.851 Contact Map
4a1s_C 1 0.088 99.3 0.886 Contact Map
1xqr_A 1 0.5836 98 0.928 Contact Map
4hxt_A 1 0.5279 97.7 0.933 Contact Map
3ro3_B 1 0.0469 97.7 0.933 Contact Map
4v3q_A 1 0.5455 97.6 0.933 Contact Map
3tt9_A 1 0.5601 97.6 0.933 Contact Map
4db6_A 1 0.522 97.6 0.934 Contact Map
4rv1_A 1 0.5279 97.6 0.934 Contact Map
1xm9_A 1 0.4252 97.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.