GREMLIN Database
T0903_1_382 - T0903 1-382
ID: 54 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 382 (371)
Sequences: 2726 (2466)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_Q258_K2.5991.00
34_D37_A2.5501.00
72_D75_K2.4281.00
114_D171_T2.3701.00
178_Q218_Q2.3511.00
129_Q186_D2.2591.00
125_T182_K2.2521.00
178_Q258_K2.1391.00
211_Q251_E2.1261.00
89_S226_E2.0841.00
258_K298_N2.0761.00
43_Q81_K2.0561.00
121_E178_Q2.0381.00
175_E255_E2.0251.00
182_K222_R1.9961.00
211_Q291_N1.9751.00
121_E258_K1.9451.00
121_E218_Q1.9341.00
187_L307_L1.9241.00
171_T211_Q1.9101.00
89_S186_D1.9081.00
112_R115_E1.9051.00
298_N338_E1.9011.00
125_T262_A1.8881.00
226_E266_E1.8771.00
186_D226_E1.8571.00
178_Q338_E1.8541.00
89_S129_Q1.8381.00
226_E306_E1.8241.00
182_K262_A1.8191.00
114_D211_Q1.8181.00
130_L307_L1.8121.00
267_L307_L1.8031.00
187_L267_L1.8001.00
369_M372_S1.7921.00
329_G332_R1.7811.00
89_S266_E1.7791.00
114_D291_N1.7781.00
218_Q298_N1.7661.00
289_E292_T1.7651.00
255_E295_E1.7651.00
186_D266_E1.7591.00
112_R169_A1.7511.00
81_K121_E1.7451.00
172_R252_D1.7081.00
178_Q298_N1.7041.00
171_T251_E1.6941.00
85_T125_T1.6901.00
126_L263_L1.6851.00
222_R302_A1.6801.00
266_E306_E1.6751.00
118_I215_E1.6651.00
215_E255_E1.6651.00
121_E298_N1.6601.00
169_A249_Q1.6571.00
183_L263_L1.6561.00
129_Q266_E1.6551.00
262_A302_A1.6491.00
223_I303_I1.6421.00
130_L267_L1.6281.00
251_E331_E1.6271.00
186_D306_E1.6201.00
129_Q226_E1.6201.00
169_A209_D1.6041.00
175_E215_E1.6011.00
74_N171_T1.5941.00
185_R265_V1.5941.00
209_D289_E1.5771.00
222_R262_A1.5771.00
74_N211_Q1.5731.00
251_E291_N1.5651.00
81_K218_Q1.5601.00
85_T222_R1.5591.00
74_N114_D1.5561.00
74_N291_N1.5551.00
90_M227_F1.5531.00
112_R209_D1.5501.00
209_D212_A1.5351.00
114_D251_E1.5311.00
128_R185_R1.5211.00
129_Q306_E1.5021.00
126_L303_I1.5021.00
118_I175_E1.4901.00
291_N331_E1.4891.00
88_K225_R1.4791.00
74_N151_G1.4761.00
122_R179_E1.4731.00
211_Q331_E1.4601.00
167_K247_L1.4541.00
115_E172_R1.4501.00
128_R225_R1.4461.00
258_K338_E1.4391.00
151_G171_T1.4361.00
151_G211_Q1.4291.00
81_K258_K1.4281.00
36_R114_D1.4241.00
114_D331_E1.4071.00
169_A172_R1.4021.00
263_L303_I1.3971.00
249_Q329_G1.3961.00
185_R305_Q1.3941.00
86_L223_I1.3781.00
212_A292_T1.3771.00
171_T291_N1.3721.00
128_R265_V1.3651.00
126_L183_L1.3611.00
249_Q289_E1.3581.00
110_M207_L1.3511.00
136_E233_E1.3481.00
110_M167_K1.3471.00
187_L347_L1.3341.00
75_K172_R1.3321.00
175_E295_E1.3231.00
183_L223_I1.3171.00
209_D249_Q1.3151.00
112_R249_Q1.3141.00
88_K128_R1.3121.00
220_R300_H1.3031.00
47_Q85_T1.3031.00
126_L223_I1.3031.00
118_I335_K1.3001.00
302_A342_Q1.2981.00
125_T222_R1.2981.00
145_N205_Y1.2971.00
226_E346_E1.2941.00
81_K178_Q1.2921.00
185_R225_R1.2861.00
74_N251_E1.2831.00
215_E295_E1.2821.00
113_F210_F1.2791.00
47_Q125_T1.2791.00
249_Q252_D1.2741.00
170_L210_F1.2721.00
176_F256_H1.2711.00
130_L187_L1.2711.00
85_T182_K1.2691.00
125_T302_A1.2671.00
225_R265_V1.2581.00
229_D269_E1.2511.00
78_Q255_E1.2421.00
96_E136_E1.2421.00
118_I295_E1.2391.00
140_L237_N1.2311.00
115_E252_D1.2271.00
132_D229_D1.2210.99
218_Q338_E1.2150.99
183_L303_I1.2130.99
72_D169_A1.2100.99
262_A342_Q1.2090.99
43_Q258_K1.2040.99
115_E212_A1.2020.99
78_Q175_E1.2020.99
300_H340_H1.1960.99
88_K305_Q1.1850.99
223_I263_L1.1840.99
170_L250_F1.1840.99
119_C176_F1.1780.99
81_K298_N1.1740.99
225_R305_Q1.1710.99
73_Y210_F1.1680.99
121_E338_E1.1620.99
97_A137_G1.1560.99
119_C296_Y1.1550.99
200_L280_L1.1380.99
122_R219_E1.1370.99
118_I255_E1.1370.99
86_L303_I1.1360.99
149_A152_K1.1340.99
117_A254_A1.1240.99
174_V334_L1.1220.99
219_E299_R1.1220.99
306_E346_E1.1210.99
96_E193_Q1.1210.99
100_S277_C1.1190.99
87_A99_S1.1130.99
210_F250_F1.1110.99
171_T331_E1.1070.99
146_V246_F1.1070.99
15_G18_M1.1050.99
68_F145_N1.1040.99
146_V206_L1.1030.99
214_I254_A1.0980.99
70_L110_M1.0980.99
35_C113_F1.0960.99
100_S317_C1.0960.99
215_E335_K1.0950.99
198_G239_N1.0930.99
117_A214_I1.0900.99
167_K287_L1.0870.99
89_S306_E1.0830.99
235_R315_R1.0820.99
129_Q346_E1.0730.99
43_Q178_Q1.0710.99
72_D209_D1.0710.99
140_L277_C1.0680.99
43_Q121_E1.0670.99
25_E29_L1.0650.99
86_L183_L1.0600.99
140_L197_C1.0580.99
93_R133_R1.0570.99
267_L347_L1.0540.98
303_I343_L1.0530.98
217_H297_H1.0430.98
259_R339_Q1.0420.98
169_A289_E1.0420.98
295_E335_K1.0330.98
180_N260_T1.0320.98
266_E346_E1.0310.98
155_G175_E1.0290.98
77_M214_I1.0280.98
36_R74_N1.0220.98
122_R259_R1.0200.98
299_R339_Q1.0160.98
246_F326_A1.0150.98
82_H122_R1.0100.98
354_S361_S1.0090.98
77_M103_L1.0060.98
195_R275_Q1.0030.98
255_E335_K1.0030.98
265_V305_Q1.0010.98
179_E259_R1.0010.98
296_Y336_Y0.9960.98
151_G291_N0.9920.98
193_Q273_E0.9900.98
176_F216_H0.9900.98
96_E233_E0.9900.98
254_A294_I0.9850.98
172_R212_A0.9840.98
176_F336_Y0.9830.98
36_R171_T0.9830.98
214_I334_L0.9810.98
49_G59_I0.9710.97
78_Q295_E0.9700.97
252_D292_T0.9660.97
73_Y113_F0.9620.97
114_D151_G0.9550.97
100_S237_N0.9540.97
191_G231_A0.9520.97
67_Y244_H0.9500.97
78_Q118_I0.9500.97
77_M294_I0.9490.97
219_E259_R0.9480.97
73_Y170_L0.9450.97
212_A252_D0.9390.97
196_A276_S0.9330.97
82_H179_E0.9300.97
109_V246_F0.9290.97
82_H259_R0.9280.97
79_Y216_H0.9260.97
206_L326_A0.9260.97
152_K212_A0.9250.97
39_V63_L0.9240.97
3_D43_Q0.9180.96
197_C277_C0.9170.96
120_C217_H0.9150.96
126_L343_L0.9140.96
177_Y257_Y0.9140.96
36_R251_E0.9100.96
115_E292_T0.9050.96
117_A294_I0.9050.96
99_S139_A0.9020.96
176_F296_Y0.9020.96
78_Q215_E0.9010.96
50_T185_R0.9010.96
216_H296_Y0.9000.96
207_L327_I0.8990.96
269_E309_D0.8980.96
216_H256_H0.8980.96
88_K185_R0.8970.96
13_D51_E0.8940.96
197_C237_N0.8930.96
175_E335_K0.8920.96
183_L343_L0.8920.96
233_E273_E0.8890.96
72_D249_Q0.8870.96
207_L287_L0.8850.96
127_A184_M0.8850.96
86_L263_L0.8840.96
67_Y107_L0.8750.95
179_E339_Q0.8710.95
106_T203_T0.8700.95
174_V294_I0.8680.95
256_H296_Y0.8670.95
96_E273_E0.8660.95
136_E313_E0.8600.95
263_L343_L0.8570.95
100_S197_C0.8520.95
85_T262_A0.8510.95
122_R339_Q0.8500.94
105_N142_N0.8490.94
250_F290_F0.8480.94
85_T302_A0.8470.94
181_L261_L0.8470.94
170_L290_F0.8460.94
125_T342_Q0.8460.94
103_L240_L0.8450.94
50_T265_V0.8440.94
191_G271_E0.8440.94
235_R275_Q0.8430.94
47_Q222_R0.8420.94
100_S140_L0.8400.94
224_A304_A0.8340.94
179_E219_E0.8330.94
179_E299_R0.8310.94
197_C317_C0.8290.94
56_L96_E0.8290.94
190_R310_R0.8270.94
119_C216_H0.8250.94
107_L204_Y0.8210.93
82_H339_Q0.8190.93
277_C357_R0.8150.93
99_S276_S0.8150.93
47_Q182_K0.8130.93
144_G244_H0.8110.93
237_N317_C0.8090.93
209_D329_G0.8070.93
117_A154_L0.8070.93
155_G215_E0.8010.93
264_A276_S0.7990.92
214_I294_I0.7980.92
203_T283_T0.7970.92
246_F286_L0.7970.92
273_E313_E0.7960.92
86_L126_L0.7950.92
168_E248_G0.7950.92
274_A314_A0.7950.92
139_A236_A0.7940.92
189_D309_D0.7940.92
72_D289_E0.7940.92
225_R345_K0.7920.92
182_K342_Q0.7900.92
265_V345_K0.7880.92
60_Y140_L0.7880.92
136_E193_Q0.7860.92
87_A127_A0.7810.92
53_L56_L0.7800.92
130_L347_L0.7780.91
41_F176_F0.7730.91
44_A82_H0.7690.91
70_L207_L0.7680.91
195_R315_R0.7660.91
234_R274_A0.7660.91
220_R260_T0.7610.91
123_H180_N0.7590.90
112_R329_G0.7570.90
77_M117_A0.7540.90
233_E313_E0.7540.90
40_A78_Q0.7530.90
143_L283_T0.7530.90
140_L317_C0.7520.90
216_H336_Y0.7500.90
48_A303_I0.7480.90
224_A236_A0.7460.90
109_V166_V0.7440.90
127_A139_A0.7440.90
111_G148_H0.7430.89
139_A196_A0.7420.89
161_K189_D0.7420.89
107_L144_G0.7390.89
86_L343_L0.7360.89
39_V174_V0.7360.89
92_D162_F0.7360.89
222_R342_Q0.7320.89
259_R299_R0.7310.89
155_G335_K0.7310.89
77_M174_V0.7300.89
132_D269_E0.7290.89
52_D132_D0.7280.88
221_L301_L0.7270.88
72_D112_R0.7270.88
96_E313_E0.7270.88
270_R310_R0.7250.88
294_I334_L0.7250.88
155_G255_E0.7230.88
117_A174_V0.7210.88
82_H219_E0.7190.88
60_Y277_C0.7190.88
40_A118_I0.7190.88
42_F120_C0.7180.88
180_N300_H0.7170.88
182_K302_A0.7170.88
184_M196_A0.7160.88
103_L280_L0.7150.88
136_E273_E0.7140.88
240_L280_L0.7120.87
200_L240_L0.7110.87
271_E311_I0.7100.87
113_F250_F0.7090.87
208_G248_G0.7080.87
56_L136_E0.7060.87
43_Q218_Q0.7040.87
48_A86_L0.7030.87
174_V200_L0.7030.87
223_I343_L0.7020.87
257_Y337_A0.7000.86
245_I325_S0.7000.86
77_M154_L0.6970.86
101_G141_Y0.6970.86
180_N220_R0.6950.86
144_G204_Y0.6950.86
51_E161_K0.6950.86
60_Y317_C0.6950.86
118_I155_G0.6940.86
305_Q345_K0.6940.86
195_R235_R0.6920.86
133_R270_R0.6880.86
36_R291_N0.6870.85
88_K265_V0.6870.85
113_F170_L0.6870.85
101_G238_S0.6850.85
92_D132_D0.6830.85
128_R305_Q0.6770.85
36_R211_Q0.6760.85
149_A169_A0.6750.84
112_R289_E0.6750.84
184_M264_A0.6740.84
166_V286_L0.6730.84
120_C177_Y0.6700.84
69_Y206_L0.6700.84
123_H220_R0.6690.84
291_N371_D0.6680.84
289_E329_G0.6680.84
99_S196_A0.6660.84
204_Y284_Y0.6640.83
83_D180_N0.6630.83
207_L247_L0.6620.83
167_K207_L0.6610.83
109_V286_L0.6580.83
151_G251_E0.6570.83
110_M247_L0.6530.82
84_L301_L0.6490.82
149_A209_D0.6480.82
137_G194_G0.6460.82
250_F330_H0.6450.82
177_Y297_H0.6410.81
99_S236_A0.6400.81
138_R195_R0.6390.81
141_Y198_G0.6380.81
36_R151_G0.6350.81
363_L367_L0.6320.80
275_Q315_R0.6310.80
70_L147_Y0.6310.80
150_K250_F0.6290.80
77_M254_A0.6280.80
304_A316_A0.6250.80
59_I316_A0.6250.80
172_R292_T0.6250.80
60_Y100_S0.6250.80
138_R275_Q0.6230.79
149_A249_Q0.6230.79
130_L158_N0.6190.79
70_L167_K0.6180.79
50_T128_R0.6150.79
50_T88_K0.6150.79
256_H336_Y0.6140.78
247_L327_I0.6140.78
122_R299_R0.6130.78
47_Q302_A0.6130.78
74_N331_E0.6130.78
284_Y324_H0.6120.78
127_A264_A0.6120.78
174_V214_I0.6110.78
206_L246_F0.6110.78
70_L327_I0.6090.78
48_A126_L0.6060.78
331_E371_D0.6040.77
75_K212_A0.6020.77
242_N282_N0.6010.77
63_L320_L0.6000.77
73_Y290_F0.5990.77
160_G163_G0.5990.77
44_A122_R0.5980.77
155_G295_E0.5950.76
73_Y150_K0.5940.76
56_L193_Q0.5930.76
193_Q313_E0.5920.76
132_D349_D0.5910.76
159_P227_F0.5910.76
224_A264_A0.5900.76
185_R219_E0.5870.75
210_F290_F0.5860.75
205_Y285_T0.5850.75
67_Y144_G0.5840.75
237_N277_C0.5820.75
167_K327_I0.5810.75
124_L181_L0.5810.75
9_G21_E0.5810.75
39_V214_I0.5800.74
261_L341_L0.5790.74
107_L244_H0.5770.74
254_A334_L0.5760.74
92_D269_E0.5760.74
186_D346_E0.5740.74
109_V206_L0.5730.74
174_V254_A0.5690.73
80_H217_H0.5690.73
83_D260_T0.5680.73
60_Y197_C0.5680.73
142_N202_N0.5670.73
77_M106_T0.5670.73
56_L273_E0.5660.73
119_C336_Y0.5660.73
78_Q155_G0.5650.73
321_G337_A0.5650.73
236_A316_A0.5640.72
202_N282_N0.5640.72
203_T323_A0.5630.72
316_A356_A0.5630.72
206_L286_L0.5620.72
280_L360_I0.5620.72
289_E369_M0.5610.72
29_L144_G0.5600.72
40_A215_E0.5580.72
32_A287_L0.5560.71
124_L221_L0.5540.71
158_N347_L0.5540.71
142_N242_N0.5510.71
113_F290_F0.5510.71
75_K115_E0.5460.70
247_L287_L0.5450.70
236_A276_S0.5450.70
260_T300_H0.5440.70
107_L284_Y0.5420.69
29_L67_Y0.5400.69
219_E339_Q0.5390.69
197_C357_R0.5380.69
191_G311_I0.5350.68
87_A224_A0.5350.68
34_D112_R0.5330.68
80_H120_C0.5290.68
184_M224_A0.5280.67
210_F330_H0.5280.67
50_T225_R0.5260.67
128_R345_K0.5240.67
60_Y237_N0.5240.67
89_S346_E0.5210.66
26_G42_F0.5200.66
57_S97_A0.5180.66
40_A255_E0.5170.66
83_D123_H0.5170.66
278_Y319_S0.5160.66
292_T332_R0.5160.66
196_A236_A0.5150.66
119_C256_H0.5130.65
106_T243_S0.5100.65
66_A283_T0.5090.65
196_A316_A0.5080.64
50_T305_Q0.5080.64
154_L214_I0.5080.64
65_N202_N0.5080.64
138_R235_R0.5070.64
138_R315_R0.5060.64
97_A234_R0.5040.64
98_K235_R0.5030.64
93_R96_E0.5010.63
48_A223_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wnd_A 1 0.8534 100 0.395 Contact Map
4ui9_O 1 0.9267 100 0.49 Contact Map
3v6t_A 1 0.788 100 0.496 Contact Map
4a1s_A 1 0.856 100 0.51 Contact Map
4jhr_A 1 0.6728 100 0.531 Contact Map
3zpj_A 1 0.8351 100 0.559 Contact Map
4i1a_A 1 0.7042 100 0.561 Contact Map
1w3b_A 1 0.8848 100 0.563 Contact Map
4ui9_C 1 0.9005 100 0.564 Contact Map
4gyo_A 1 0.8403 100 0.566 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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