GREMLIN Database
T0902_1_315 - T0902 1-315
ID: 53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 315 (273)
Sequences: 2826 (2115)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_K91_E5.0721.00
162_K190_T4.5111.00
193_Y202_Q4.3951.00
90_D280_V3.5071.00
95_A287_V3.0231.00
158_A192_V2.9581.00
81_K278_N2.7241.00
58_I123_I2.6841.00
249_V290_V2.6491.00
262_I275_K2.6141.00
46_K74_A2.5741.00
60_G63_E2.4741.00
219_L243_V2.3831.00
65_K83_V2.2741.00
244_G298_F2.2171.00
122_L126_H2.1831.00
32_A120_V2.1561.00
260_E263_E2.1481.00
178_V243_V2.0751.00
163_A301_V2.0711.00
62_G89_S2.0701.00
278_N285_E2.0641.00
59_V66_P2.0581.00
61_E89_S2.0561.00
50_F111_A2.0331.00
95_A254_Q1.9691.00
120_V288_L1.8801.00
87_R281_M1.8711.00
23_D110_P1.8441.00
102_G105_Q1.8251.00
65_K278_N1.8181.00
274_L281_M1.7801.00
51_S73_S1.7531.00
192_V203_P1.7521.00
94_W255_R1.7311.00
64_V277_H1.7221.00
158_A190_T1.7221.00
34_L179_A1.7211.00
245_D248_R1.7211.00
85_Q276_G1.7111.00
180_L221_V1.7051.00
40_T79_P1.6951.00
164_V178_V1.6861.00
65_K285_E1.6851.00
49_V73_S1.6821.00
88_V107_L1.6691.00
177_G222_G1.6671.00
193_Y200_A1.6511.00
248_R297_S1.6381.00
262_I265_G1.6221.00
164_V219_L1.6161.00
32_A253_F1.6071.00
180_L241_A1.6021.00
36_P247_S1.5981.00
194_P200_A1.5841.00
120_V286_A1.5831.00
88_V93_M1.5751.00
260_E283_R1.5521.00
58_I82_V1.5441.00
58_I131_A1.5381.00
119_A123_I1.5101.00
227_V242_I1.5101.00
156_A159_D1.5101.00
35_S251_W1.4941.00
12_E96_D1.4811.00
178_V217_R1.4471.00
275_K283_R1.4421.00
125_F179_A1.4411.00
59_V83_V1.4351.00
184_F239_V1.4201.00
72_V106_D1.4191.00
262_I283_R1.4041.00
254_Q287_V1.3951.00
36_P250_H1.3861.00
20_A23_D1.3651.00
240_K302_K1.3531.00
158_A203_P1.3441.00
265_G274_L1.3361.00
123_I131_A1.3321.00
15_G46_K1.3281.00
242_I300_V1.3191.00
160_L178_V1.3171.00
161_V189_S1.3151.00
49_V75_F1.3131.00
165_G186_F1.2901.00
183_A229_G1.2781.00
292_I298_F1.2691.00
94_W287_V1.2651.00
264_Y275_K1.2651.00
104_L108_I1.2561.00
273_D276_G1.2501.00
30_V121_D1.2481.00
177_G246_F1.2471.00
12_E72_V1.2411.00
46_K76_T1.2411.00
174_V182_P1.2391.00
61_E91_E1.2341.00
34_L177_G1.2210.99
250_H293_E1.2090.99
50_F106_D1.1930.99
246_F298_F1.1910.99
119_A122_L1.1710.99
182_P225_S1.1700.99
84_T115_S1.1600.99
77_A252_G1.1520.99
163_A178_V1.1430.99
241_A301_V1.1370.99
162_K186_F1.1370.99
262_I273_D1.1360.99
123_I288_L1.1320.99
77_A289_Y1.1270.99
64_V276_G1.1250.99
90_D278_N1.1240.99
53_V111_A1.1160.99
163_A299_A1.1150.99
120_V253_F1.1050.99
85_Q283_R1.0690.99
35_S124_A1.0590.99
31_L125_F1.0540.98
85_Q281_M1.0490.98
157_T203_P1.0490.98
273_D277_H1.0470.98
278_N283_R1.0450.98
177_G220_N1.0440.98
67_S276_G1.0420.98
143_L242_I1.0410.98
261_L282_V1.0390.98
56_A84_T1.0340.98
51_S71_D1.0300.98
276_G281_M1.0270.98
87_R274_L1.0260.98
163_A243_V1.0230.98
56_A119_A1.0230.98
8_V71_D1.0200.98
90_D260_E1.0190.98
90_D94_W1.0080.98
240_K303_E1.0050.98
180_L184_F1.0010.98
79_P254_Q0.9990.98
262_I274_L0.9910.98
179_A246_F0.9900.98
112_L284_A0.9860.98
62_G279_E0.9760.98
126_H228_S0.9760.98
32_A251_W0.9610.97
56_A82_V0.9610.97
242_I298_F0.9550.97
239_V302_K0.9550.97
208_A214_D0.9550.97
121_D224_S0.9450.97
160_L241_A0.9440.97
44_P78_Q0.9380.97
24_R113_G0.9360.97
34_L222_G0.9280.97
168_A225_S0.9230.97
116_I284_A0.9220.96
165_G182_P0.9210.96
67_S85_Q0.9210.96
208_A213_L0.9210.96
179_A224_S0.9190.96
185_S223_A0.9180.96
59_V81_K0.9140.96
164_V243_V0.9130.96
124_A251_W0.9110.96
187_A191_E0.9070.96
58_I288_L0.8970.96
34_L246_F0.8910.96
91_E287_V0.8900.96
167_I176_N0.8880.96
182_P223_A0.8820.95
160_L243_V0.8800.95
82_V123_I0.8770.95
59_V65_K0.8760.95
58_I80_I0.8740.95
8_V69_S0.8680.95
90_D263_E0.8670.95
169_G182_P0.8640.95
68_A84_T0.8580.95
121_D226_T0.8570.95
240_K300_V0.8530.95
25_A113_G0.8530.95
193_Y204_M0.8470.94
208_A211_A0.8460.94
91_E278_N0.8450.94
92_F96_D0.8430.94
93_M280_V0.8400.94
82_V119_A0.8390.94
108_I113_G0.8360.94
264_Y281_M0.8330.94
181_D229_G0.8330.94
202_Q207_A0.8310.94
260_E275_K0.8300.94
143_L227_V0.8240.94
132_T144_N0.8200.93
40_T252_G0.8170.93
105_Q108_I0.8140.93
173_Q297_S0.8130.93
187_A190_T0.8120.93
178_V216_W0.8110.93
56_A115_S0.8110.93
88_V282_V0.8100.93
157_T161_V0.8100.93
81_K90_D0.8080.93
167_I299_A0.8020.93
248_R294_S0.8000.92
83_V285_E0.7970.92
185_S221_V0.7960.92
152_A159_D0.7950.92
176_N243_V0.7950.92
179_A227_V0.7950.92
55_R122_L0.7880.92
37_E251_W0.7870.92
56_A116_I0.7850.92
216_W221_V0.7830.92
48_A74_A0.7820.92
31_L35_S0.7820.92
36_P293_E0.7800.92
178_V219_L0.7800.92
94_W258_P0.7770.91
5_F8_V0.7760.91
255_R258_P0.7750.91
169_G225_S0.7750.91
94_W254_Q0.7740.91
104_L261_L0.7730.91
32_A37_E0.7720.91
124_A288_L0.7680.91
79_P252_G0.7640.91
161_V217_R0.7630.91
161_V190_T0.7630.91
87_R264_Y0.7610.91
44_P76_T0.7580.90
81_K285_E0.7560.90
23_D114_A0.7550.90
90_D255_R0.7540.90
159_D303_E0.7540.90
252_G291_A0.7530.90
59_V63_E0.7490.90
178_V241_A0.7480.90
181_D184_F0.7480.90
142_S242_I0.7450.90
62_G91_E0.7450.90
93_M282_V0.7450.90
125_F142_S0.7430.89
93_M103_V0.7420.89
54_P115_S0.7420.89
262_I281_M0.7420.89
58_I130_P0.7400.89
261_L280_V0.7370.89
123_I130_P0.7370.89
15_G44_P0.7360.89
143_L300_V0.7340.89
235_P238_G0.7340.89
125_F224_S0.7340.89
274_L279_E0.7280.88
91_E95_A0.7210.88
55_R115_S0.7130.87
88_V92_F0.7120.87
186_F190_T0.7060.87
165_G189_S0.7030.87
46_K78_Q0.7000.86
179_A242_I0.6990.86
157_T204_M0.6960.86
210_F215_N0.6960.86
32_A124_A0.6940.86
12_E101_L0.6910.86
81_K287_V0.6890.86
9_G13_L0.6870.85
123_I127_G0.6850.85
130_P133_G0.6800.85
166_L299_A0.6790.85
94_W285_E0.6790.85
84_T112_L0.6750.84
202_Q206_P0.6730.84
57_K66_P0.6730.84
96_D102_G0.6720.84
191_E204_M0.6710.84
87_R265_G0.6700.84
65_K81_K0.6680.84
29_G121_D0.6670.84
264_Y274_L0.6620.83
260_E264_Y0.6620.83
259_I284_A0.6590.83
230_A237_S0.6540.83
228_S238_G0.6510.82
166_L183_A0.6510.82
83_V278_N0.6510.82
58_I119_A0.6500.82
54_P70_V0.6500.82
39_P256_N0.6480.82
28_S113_G0.6470.82
47_G77_A0.6470.82
253_F256_N0.6470.82
263_E280_V0.6460.82
144_N147_K0.6460.82
125_F226_T0.6440.82
79_P289_Y0.6410.81
18_I257_F0.6400.81
85_Q262_I0.6380.81
45_V48_A0.6370.81
96_D103_V0.6370.81
167_I243_V0.6360.81
126_H143_L0.6360.81
168_A223_A0.6360.81
13_L92_F0.6350.81
159_D301_V0.6310.80
14_P21_V0.6300.80
230_A236_A0.6280.80
120_V124_A0.6280.80
153_T303_E0.6280.80
80_I130_P0.6260.80
25_A117_G0.6260.80
82_V288_L0.6190.79
160_L216_W0.6160.79
275_K281_M0.6110.78
38_Q106_D0.6110.78
230_A235_P0.6100.78
253_F286_A0.6100.78
118_R226_T0.6090.78
205_Y213_L0.6080.78
112_L259_I0.6070.78
257_F284_A0.6070.78
184_F241_A0.6060.78
207_A282_V0.6050.77
206_P210_F0.6020.77
32_A249_V0.6010.77
201_G204_M0.6000.77
164_V217_R0.6000.77
113_G117_G0.6000.77
167_I173_Q0.5990.77
15_G76_T0.5950.76
106_D111_A0.5930.76
205_Y209_G0.5920.76
129_D133_G0.5910.76
35_S290_V0.5910.76
205_Y214_D0.5910.76
90_D283_R0.5910.76
33_K222_G0.5890.76
194_P201_G0.5860.75
162_K259_I0.5860.75
253_F288_L0.5860.75
161_V203_P0.5840.75
203_P217_R0.5790.74
157_T217_R0.5770.74
7_S71_D0.5760.74
230_A238_G0.5760.74
66_P83_V0.5740.74
50_F72_V0.5740.74
157_T188_L0.5730.74
192_V200_A0.5710.73
167_I174_V0.5680.73
265_G281_M0.5660.73
30_V224_S0.5660.73
148_N299_A0.5650.73
57_K84_T0.5640.72
36_P110_P0.5630.72
30_V33_K0.5570.71
25_A114_A0.5550.71
148_N166_L0.5500.71
236_A305_A0.5490.70
16_S19_G0.5480.70
160_L217_R0.5480.70
184_F240_K0.5470.70
18_I22_R0.5460.70
183_A226_T0.5450.70
292_I295_L0.5440.70
158_A201_G0.5440.70
28_S117_G0.5420.69
21_V47_G0.5410.69
165_G187_A0.5380.69
22_R294_S0.5370.69
90_D285_E0.5370.69
132_T292_I0.5360.69
167_I244_G0.5340.68
6_L9_G0.5300.68
103_V106_D0.5280.67
122_L226_T0.5280.67
174_V225_S0.5270.67
105_Q250_H0.5260.67
161_V186_F0.5250.67
127_G130_P0.5250.67
54_P84_T0.5220.67
16_S45_V0.5220.67
63_E277_H0.5220.67
249_V298_F0.5210.66
26_I111_A0.5200.66
157_T216_W0.5200.66
55_R119_A0.5190.66
163_A166_L0.5180.66
155_S184_F0.5180.66
114_A184_F0.5170.66
31_L224_S0.5170.66
40_T77_A0.5170.66
179_A222_G0.5150.66
69_S87_R0.5110.65
75_F291_A0.5110.65
172_L225_S0.5110.65
35_S249_V0.5090.65
111_A293_E0.5080.64
264_Y273_D0.5080.64
81_K95_A0.5060.64
170_A296_D0.5060.64
44_P79_P0.5060.64
143_L228_S0.5050.64
56_A123_I0.5050.64
13_L96_D0.5040.64
65_K283_R0.5030.64
262_I276_G0.5030.64
181_D240_K0.5020.64
149_I302_K0.5010.63
178_V289_Y0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qpr_A 1 0.7937 100 0.235 Contact Map
1ohg_A 1 0.8635 100 0.245 Contact Map
3j4u_A 1 0.6889 99.7 0.647 Contact Map
4bml_A 1 0.8794 99.5 0.698 Contact Map
4an5_A 1 0.6857 99.4 0.723 Contact Map
3j7w_A 1 0.8921 99.2 0.741 Contact Map
2xd8_A 1 0.8952 99.2 0.75 Contact Map
3j40_A 1 0.7143 98.5 0.804 Contact Map
4pt2_P 1 0.8349 98.4 0.812 Contact Map
2e0z_A 1 0.7302 98.3 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.