T0902_1_315 - CASP12 - GREMLIN Contacts

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T0902_1_315 - T0902 1-315

ID:	53	Sequences: MADDFLSVGKLELPGSMIGAVRDRAIDSGVLAKLSPEQPTIFGPVKGAVFSGVPRAKIVGEGEVKPSASVDVSAFTAQPIKVVTQQRVSDEFMWADADYRLGVLQDLISPALGASIGRAVDLIAFHGIDPATGKAASAVHTSLNKTKNIVDATDSATADLVKAVGLIAGAGLQVPNGVALDPAFSFALSTEVYPKGSPLAGQPMYPAAGFAGLDNWRGLNVGASSTVSGAPEMSPASGVKAIVGDFSRVHWGFQRNFPIELIEYGDPDQTGRDLKGHNEVMVRAEAVLYVAIESLDSFAVVKEKAAPKPNPPAEN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	315 (273)
Sequences:	2826 (2115)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_K	91_E	5.072	1.00
162_K	190_T	4.511	1.00
193_Y	202_Q	4.395	1.00
90_D	280_V	3.507	1.00
95_A	287_V	3.023	1.00
158_A	192_V	2.958	1.00
81_K	278_N	2.724	1.00
58_I	123_I	2.684	1.00
249_V	290_V	2.649	1.00
262_I	275_K	2.614	1.00
46_K	74_A	2.574	1.00
60_G	63_E	2.474	1.00
219_L	243_V	2.383	1.00
65_K	83_V	2.274	1.00
244_G	298_F	2.217	1.00
122_L	126_H	2.183	1.00
32_A	120_V	2.156	1.00
260_E	263_E	2.148	1.00
178_V	243_V	2.075	1.00
163_A	301_V	2.071	1.00
62_G	89_S	2.070	1.00
278_N	285_E	2.064	1.00
59_V	66_P	2.058	1.00
61_E	89_S	2.056	1.00
50_F	111_A	2.033	1.00
95_A	254_Q	1.969	1.00
120_V	288_L	1.880	1.00
87_R	281_M	1.871	1.00
23_D	110_P	1.844	1.00
102_G	105_Q	1.825	1.00
65_K	278_N	1.818	1.00
274_L	281_M	1.780	1.00
51_S	73_S	1.753	1.00
192_V	203_P	1.752	1.00
94_W	255_R	1.731	1.00
64_V	277_H	1.722	1.00
158_A	190_T	1.722	1.00
34_L	179_A	1.721	1.00
245_D	248_R	1.721	1.00
85_Q	276_G	1.711	1.00
180_L	221_V	1.705	1.00
40_T	79_P	1.695	1.00
164_V	178_V	1.686	1.00
65_K	285_E	1.685	1.00
49_V	73_S	1.682	1.00
88_V	107_L	1.669	1.00
177_G	222_G	1.667	1.00
193_Y	200_A	1.651	1.00
248_R	297_S	1.638	1.00
262_I	265_G	1.622	1.00
164_V	219_L	1.616	1.00
32_A	253_F	1.607	1.00
180_L	241_A	1.602	1.00
36_P	247_S	1.598	1.00
194_P	200_A	1.584	1.00
120_V	286_A	1.583	1.00
88_V	93_M	1.575	1.00
260_E	283_R	1.552	1.00
58_I	82_V	1.544	1.00
58_I	131_A	1.538	1.00
119_A	123_I	1.510	1.00
227_V	242_I	1.510	1.00
156_A	159_D	1.510	1.00
35_S	251_W	1.494	1.00
12_E	96_D	1.481	1.00
178_V	217_R	1.447	1.00
275_K	283_R	1.442	1.00
125_F	179_A	1.441	1.00
59_V	83_V	1.435	1.00
184_F	239_V	1.420	1.00
72_V	106_D	1.419	1.00
262_I	283_R	1.404	1.00
254_Q	287_V	1.395	1.00
36_P	250_H	1.386	1.00
20_A	23_D	1.365	1.00
240_K	302_K	1.353	1.00
158_A	203_P	1.344	1.00
265_G	274_L	1.336	1.00
123_I	131_A	1.332	1.00
15_G	46_K	1.328	1.00
242_I	300_V	1.319	1.00
160_L	178_V	1.317	1.00
161_V	189_S	1.315	1.00
49_V	75_F	1.313	1.00
165_G	186_F	1.290	1.00
183_A	229_G	1.278	1.00
292_I	298_F	1.269	1.00
94_W	287_V	1.265	1.00
264_Y	275_K	1.265	1.00
104_L	108_I	1.256	1.00
273_D	276_G	1.250	1.00
30_V	121_D	1.248	1.00
177_G	246_F	1.247	1.00
12_E	72_V	1.241	1.00
46_K	76_T	1.241	1.00
174_V	182_P	1.239	1.00
61_E	91_E	1.234	1.00
34_L	177_G	1.221	0.99
250_H	293_E	1.209	0.99
50_F	106_D	1.193	0.99
246_F	298_F	1.191	0.99
119_A	122_L	1.171	0.99
182_P	225_S	1.170	0.99
84_T	115_S	1.160	0.99
77_A	252_G	1.152	0.99
163_A	178_V	1.143	0.99
241_A	301_V	1.137	0.99
162_K	186_F	1.137	0.99
262_I	273_D	1.136	0.99
123_I	288_L	1.132	0.99
77_A	289_Y	1.127	0.99
64_V	276_G	1.125	0.99
90_D	278_N	1.124	0.99
53_V	111_A	1.116	0.99
163_A	299_A	1.115	0.99
120_V	253_F	1.105	0.99
85_Q	283_R	1.069	0.99
35_S	124_A	1.059	0.99
31_L	125_F	1.054	0.98
85_Q	281_M	1.049	0.98
157_T	203_P	1.049	0.98
273_D	277_H	1.047	0.98
278_N	283_R	1.045	0.98
177_G	220_N	1.044	0.98
67_S	276_G	1.042	0.98
143_L	242_I	1.041	0.98
261_L	282_V	1.039	0.98
56_A	84_T	1.034	0.98
51_S	71_D	1.030	0.98
276_G	281_M	1.027	0.98
87_R	274_L	1.026	0.98
163_A	243_V	1.023	0.98
56_A	119_A	1.023	0.98
8_V	71_D	1.020	0.98
90_D	260_E	1.019	0.98
90_D	94_W	1.008	0.98
240_K	303_E	1.005	0.98
180_L	184_F	1.001	0.98
79_P	254_Q	0.999	0.98
262_I	274_L	0.991	0.98
179_A	246_F	0.990	0.98
112_L	284_A	0.986	0.98
62_G	279_E	0.976	0.98
126_H	228_S	0.976	0.98
32_A	251_W	0.961	0.97
56_A	82_V	0.961	0.97
242_I	298_F	0.955	0.97
239_V	302_K	0.955	0.97
208_A	214_D	0.955	0.97
121_D	224_S	0.945	0.97
160_L	241_A	0.944	0.97
44_P	78_Q	0.938	0.97
24_R	113_G	0.936	0.97
34_L	222_G	0.928	0.97
168_A	225_S	0.923	0.97
116_I	284_A	0.922	0.96
165_G	182_P	0.921	0.96
67_S	85_Q	0.921	0.96
208_A	213_L	0.921	0.96
179_A	224_S	0.919	0.96
185_S	223_A	0.918	0.96
59_V	81_K	0.914	0.96
164_V	243_V	0.913	0.96
124_A	251_W	0.911	0.96
187_A	191_E	0.907	0.96
58_I	288_L	0.897	0.96
34_L	246_F	0.891	0.96
91_E	287_V	0.890	0.96
167_I	176_N	0.888	0.96
182_P	223_A	0.882	0.95
160_L	243_V	0.880	0.95
82_V	123_I	0.877	0.95
59_V	65_K	0.876	0.95
58_I	80_I	0.874	0.95
8_V	69_S	0.868	0.95
90_D	263_E	0.867	0.95
169_G	182_P	0.864	0.95
68_A	84_T	0.858	0.95
121_D	226_T	0.857	0.95
240_K	300_V	0.853	0.95
25_A	113_G	0.853	0.95
193_Y	204_M	0.847	0.94
208_A	211_A	0.846	0.94
91_E	278_N	0.845	0.94
92_F	96_D	0.843	0.94
93_M	280_V	0.840	0.94
82_V	119_A	0.839	0.94
108_I	113_G	0.836	0.94
264_Y	281_M	0.833	0.94
181_D	229_G	0.833	0.94
202_Q	207_A	0.831	0.94
260_E	275_K	0.830	0.94
143_L	227_V	0.824	0.94
132_T	144_N	0.820	0.93
40_T	252_G	0.817	0.93
105_Q	108_I	0.814	0.93
173_Q	297_S	0.813	0.93
187_A	190_T	0.812	0.93
178_V	216_W	0.811	0.93
56_A	115_S	0.811	0.93
88_V	282_V	0.810	0.93
157_T	161_V	0.810	0.93
81_K	90_D	0.808	0.93
167_I	299_A	0.802	0.93
248_R	294_S	0.800	0.92
83_V	285_E	0.797	0.92
185_S	221_V	0.796	0.92
152_A	159_D	0.795	0.92
176_N	243_V	0.795	0.92
179_A	227_V	0.795	0.92
55_R	122_L	0.788	0.92
37_E	251_W	0.787	0.92
56_A	116_I	0.785	0.92
216_W	221_V	0.783	0.92
48_A	74_A	0.782	0.92
31_L	35_S	0.782	0.92
36_P	293_E	0.780	0.92
178_V	219_L	0.780	0.92
94_W	258_P	0.777	0.91
5_F	8_V	0.776	0.91
255_R	258_P	0.775	0.91
169_G	225_S	0.775	0.91
94_W	254_Q	0.774	0.91
104_L	261_L	0.773	0.91
32_A	37_E	0.772	0.91
124_A	288_L	0.768	0.91
79_P	252_G	0.764	0.91
161_V	217_R	0.763	0.91
161_V	190_T	0.763	0.91
87_R	264_Y	0.761	0.91
44_P	76_T	0.758	0.90
81_K	285_E	0.756	0.90
23_D	114_A	0.755	0.90
90_D	255_R	0.754	0.90
159_D	303_E	0.754	0.90
252_G	291_A	0.753	0.90
59_V	63_E	0.749	0.90
178_V	241_A	0.748	0.90
181_D	184_F	0.748	0.90
142_S	242_I	0.745	0.90
62_G	91_E	0.745	0.90
93_M	282_V	0.745	0.90
125_F	142_S	0.743	0.89
93_M	103_V	0.742	0.89
54_P	115_S	0.742	0.89
262_I	281_M	0.742	0.89
58_I	130_P	0.740	0.89
261_L	280_V	0.737	0.89
123_I	130_P	0.737	0.89
15_G	44_P	0.736	0.89
143_L	300_V	0.734	0.89
235_P	238_G	0.734	0.89
125_F	224_S	0.734	0.89
274_L	279_E	0.728	0.88
91_E	95_A	0.721	0.88
55_R	115_S	0.713	0.87
88_V	92_F	0.712	0.87
186_F	190_T	0.706	0.87
165_G	189_S	0.703	0.87
46_K	78_Q	0.700	0.86
179_A	242_I	0.699	0.86
157_T	204_M	0.696	0.86
210_F	215_N	0.696	0.86
32_A	124_A	0.694	0.86
12_E	101_L	0.691	0.86
81_K	287_V	0.689	0.86
9_G	13_L	0.687	0.85
123_I	127_G	0.685	0.85
130_P	133_G	0.680	0.85
166_L	299_A	0.679	0.85
94_W	285_E	0.679	0.85
84_T	112_L	0.675	0.84
202_Q	206_P	0.673	0.84
57_K	66_P	0.673	0.84
96_D	102_G	0.672	0.84
191_E	204_M	0.671	0.84
87_R	265_G	0.670	0.84
65_K	81_K	0.668	0.84
29_G	121_D	0.667	0.84
264_Y	274_L	0.662	0.83
260_E	264_Y	0.662	0.83
259_I	284_A	0.659	0.83
230_A	237_S	0.654	0.83
228_S	238_G	0.651	0.82
166_L	183_A	0.651	0.82
83_V	278_N	0.651	0.82
58_I	119_A	0.650	0.82
54_P	70_V	0.650	0.82
39_P	256_N	0.648	0.82
28_S	113_G	0.647	0.82
47_G	77_A	0.647	0.82
253_F	256_N	0.647	0.82
263_E	280_V	0.646	0.82
144_N	147_K	0.646	0.82
125_F	226_T	0.644	0.82
79_P	289_Y	0.641	0.81
18_I	257_F	0.640	0.81
85_Q	262_I	0.638	0.81
45_V	48_A	0.637	0.81
96_D	103_V	0.637	0.81
167_I	243_V	0.636	0.81
126_H	143_L	0.636	0.81
168_A	223_A	0.636	0.81
13_L	92_F	0.635	0.81
159_D	301_V	0.631	0.80
14_P	21_V	0.630	0.80
230_A	236_A	0.628	0.80
120_V	124_A	0.628	0.80
153_T	303_E	0.628	0.80
80_I	130_P	0.626	0.80
25_A	117_G	0.626	0.80
82_V	288_L	0.619	0.79
160_L	216_W	0.616	0.79
275_K	281_M	0.611	0.78
38_Q	106_D	0.611	0.78
230_A	235_P	0.610	0.78
253_F	286_A	0.610	0.78
118_R	226_T	0.609	0.78
205_Y	213_L	0.608	0.78
112_L	259_I	0.607	0.78
257_F	284_A	0.607	0.78
184_F	241_A	0.606	0.78
207_A	282_V	0.605	0.77
206_P	210_F	0.602	0.77
32_A	249_V	0.601	0.77
201_G	204_M	0.600	0.77
164_V	217_R	0.600	0.77
113_G	117_G	0.600	0.77
167_I	173_Q	0.599	0.77
15_G	76_T	0.595	0.76
106_D	111_A	0.593	0.76
205_Y	209_G	0.592	0.76
129_D	133_G	0.591	0.76
35_S	290_V	0.591	0.76
205_Y	214_D	0.591	0.76
90_D	283_R	0.591	0.76
33_K	222_G	0.589	0.76
194_P	201_G	0.586	0.75
162_K	259_I	0.586	0.75
253_F	288_L	0.586	0.75
161_V	203_P	0.584	0.75
203_P	217_R	0.579	0.74
157_T	217_R	0.577	0.74
7_S	71_D	0.576	0.74
230_A	238_G	0.576	0.74
66_P	83_V	0.574	0.74
50_F	72_V	0.574	0.74
157_T	188_L	0.573	0.74
192_V	200_A	0.571	0.73
167_I	174_V	0.568	0.73
265_G	281_M	0.566	0.73
30_V	224_S	0.566	0.73
148_N	299_A	0.565	0.73
57_K	84_T	0.564	0.72
36_P	110_P	0.563	0.72
30_V	33_K	0.557	0.71
25_A	114_A	0.555	0.71
148_N	166_L	0.550	0.71
236_A	305_A	0.549	0.70
16_S	19_G	0.548	0.70
160_L	217_R	0.548	0.70
184_F	240_K	0.547	0.70
18_I	22_R	0.546	0.70
183_A	226_T	0.545	0.70
292_I	295_L	0.544	0.70
158_A	201_G	0.544	0.70
28_S	117_G	0.542	0.69
21_V	47_G	0.541	0.69
165_G	187_A	0.538	0.69
22_R	294_S	0.537	0.69
90_D	285_E	0.537	0.69
132_T	292_I	0.536	0.69
167_I	244_G	0.534	0.68
6_L	9_G	0.530	0.68
103_V	106_D	0.528	0.67
122_L	226_T	0.528	0.67
174_V	225_S	0.527	0.67
105_Q	250_H	0.526	0.67
161_V	186_F	0.525	0.67
127_G	130_P	0.525	0.67
54_P	84_T	0.522	0.67
16_S	45_V	0.522	0.67
63_E	277_H	0.522	0.67
249_V	298_F	0.521	0.66
26_I	111_A	0.520	0.66
157_T	216_W	0.520	0.66
55_R	119_A	0.519	0.66
163_A	166_L	0.518	0.66
155_S	184_F	0.518	0.66
114_A	184_F	0.517	0.66
31_L	224_S	0.517	0.66
40_T	77_A	0.517	0.66
179_A	222_G	0.515	0.66
69_S	87_R	0.511	0.65
75_F	291_A	0.511	0.65
172_L	225_S	0.511	0.65
35_S	249_V	0.509	0.65
111_A	293_E	0.508	0.64
264_Y	273_D	0.508	0.64
81_K	95_A	0.506	0.64
170_A	296_D	0.506	0.64
44_P	79_P	0.506	0.64
143_L	228_S	0.505	0.64
56_A	123_I	0.505	0.64
13_L	96_D	0.504	0.64
65_K	283_R	0.503	0.64
262_I	276_G	0.503	0.64
181_D	240_K	0.502	0.64
149_I	302_K	0.501	0.63
178_V	289_Y	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qpr_A	1	0.7937	100	0.235	Contact Map
1ohg_A	1	0.8635	100	0.245	Contact Map
3j4u_A	1	0.6889	99.7	0.647	Contact Map
4bml_A	1	0.8794	99.5	0.698	Contact Map
4an5_A	1	0.6857	99.4	0.723	Contact Map
3j7w_A	1	0.8921	99.2	0.741	Contact Map
2xd8_A	1	0.8952	99.2	0.75	Contact Map
3j40_A	1	0.7143	98.5	0.804	Contact Map
4pt2_P	1	0.8349	98.4	0.812	Contact Map
2e0z_A	1	0.7302	98.3	0.815	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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