GREMLIN Database
T0901_1_328 - T0901 1-328
ID: 52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 328 (287)
Sequences: 368 (327)
Seq/√Len: 19.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_A256_I5.5791.00
249_L256_I3.7081.00
296_D307_Y3.6041.00
249_L252_A3.3321.00
52_D56_S3.2050.99
252_A259_R3.1260.99
135_G230_Y2.9360.99
183_T187_N2.9330.99
46_D162_L2.7500.98
46_D157_R2.6810.98
248_N251_S2.5520.97
64_L165_I2.5360.97
85_A101_F2.5230.97
166_A203_W2.4860.97
46_D160_A2.4100.96
284_G320_V2.3400.96
249_L253_V2.2770.95
49_W165_I2.2650.95
129_G133_E2.2170.94
172_D229_S2.1730.93
310_A314_A2.1540.93
270_S283_N2.1510.93
128_A133_E2.0810.92
51_V64_L1.9990.90
61_Q89_T1.9970.90
52_D57_M1.9950.90
232_G236_T1.9910.90
207_F322_F1.9910.90
205_F234_A1.9880.90
50_I88_T1.9810.90
133_E170_E1.9350.88
289_R296_D1.9250.88
75_L87_V1.9160.88
157_R160_A1.8820.87
45_V82_Y1.8780.87
50_I142_A1.8500.86
168_S230_Y1.8290.85
296_D301_S1.8040.85
54_S168_S1.7600.83
53_N61_Q1.7400.82
310_A324_P1.7330.82
50_I53_N1.7030.81
53_N89_T1.6860.80
59_K182_I1.6770.80
230_Y243_S1.6700.80
50_I172_D1.6650.79
88_T126_G1.6430.78
244_I259_R1.6340.78
118_S121_N1.6060.77
61_Q88_T1.6020.77
206_N230_Y1.5790.76
164_V256_I1.5720.75
68_V72_V1.5630.75
47_I249_L1.5610.75
49_W88_T1.5370.73
170_E230_Y1.5260.73
84_M89_T1.5040.72
64_L160_A1.4970.71
54_S57_M1.4810.71
60_H206_N1.4740.70
61_Q129_G1.4680.70
253_V269_L1.4650.70
51_V108_V1.4350.68
50_I87_V1.4340.68
310_A313_A1.4190.67
108_V112_T1.4120.67
57_M169_D1.4030.66
77_T165_I1.3970.66
44_K159_D1.3770.65
306_F312_P1.3740.65
238_G294_G1.3720.65
135_G170_E1.3580.64
128_A131_N1.3510.63
244_I255_N1.3440.63
107_Y110_S1.3400.63
273_P306_F1.3280.62
210_V219_T1.3260.62
237_S295_W1.3230.62
81_D157_R1.3080.61
119_L123_M1.3070.61
128_A132_L1.2980.60
231_M234_A1.2910.60
138_S141_N1.2900.60
83_H303_V1.2820.59
55_T58_L1.2810.59
91_M138_S1.2780.59
90_S206_N1.2640.58
61_Q170_E1.2550.57
204_V237_S1.2530.57
146_N154_G1.2470.57
269_L315_D1.2380.56
56_S169_D1.2300.56
163_V201_R1.2270.56
167_L186_T1.2150.55
318_I322_F1.2150.55
90_S172_D1.2090.55
204_V209_G1.1860.53
46_D306_F1.1770.53
85_A299_A1.1740.52
112_T277_S1.1710.52
184_Y290_D1.1640.52
168_S208_I1.1590.51
234_A295_W1.1570.51
135_G172_D1.1530.51
49_W273_P1.1480.51
68_V71_L1.1460.51
67_Q157_R1.1410.50
256_I317_S1.1380.50
274_L277_S1.1380.50
126_G253_V1.1310.50
217_C245_C1.1270.49
164_V200_S1.1220.49
122_R144_S1.1210.49
165_I276_E1.1210.49
117_N181_G1.1140.49
42_N304_I1.1110.48
116_V147_Y1.1100.48
74_K77_T1.1020.48
72_V171_D1.0940.47
248_N256_I1.0890.47
90_S129_G1.0740.46
291_T296_D1.0690.46
121_N226_A1.0600.45
73_S286_S1.0600.45
247_T267_F1.0570.45
162_L253_V1.0560.45
85_A164_V1.0520.45
136_L172_D1.0510.45
265_T310_A1.0450.44
118_S165_I1.0430.44
43_N47_I1.0410.44
52_D169_D1.0360.44
170_E310_A1.0330.43
51_V139_M1.0320.43
130_S214_T1.0320.43
320_V323_K1.0320.43
250_S313_A1.0290.43
188_L192_I1.0220.43
44_K297_Y1.0180.42
75_L270_S1.0160.42
49_W84_M1.0150.42
64_L167_L1.0110.42
76_N262_Q1.0070.42
143_L295_W1.0050.42
159_D176_S0.9950.41
172_D189_L0.9950.41
176_S267_F0.9940.41
181_G219_T0.9920.41
88_T306_F0.9900.41
108_V193_K0.9860.40
94_T284_G0.9820.40
249_L257_R0.9780.40
47_I105_P0.9770.40
162_L306_F0.9740.40
86_V113_P0.9710.40
110_S285_V0.9660.39
177_S185_Y0.9630.39
120_K139_M0.9580.39
86_V272_V0.9550.39
279_T286_S0.9540.39
299_A306_F0.9490.38
265_T324_P0.9430.38
252_A257_R0.9420.38
67_Q261_Y0.9420.38
87_V239_G0.9410.38
98_G134_R0.9410.38
48_L88_T0.9380.38
69_P73_S0.9360.37
233_L239_G0.9360.37
53_N244_I0.9290.37
114_D303_V0.9260.37
311_V314_A0.9220.37
319_K323_K0.9210.37
231_M237_S0.9210.37
234_A237_S0.9150.36
290_D314_A0.9110.36
227_G230_Y0.9090.36
48_L142_A0.9050.36
121_N262_Q0.8990.35
75_L90_S0.8990.35
148_L164_V0.8980.35
289_R307_Y0.8900.35
103_G308_G0.8860.35
281_S286_S0.8840.34
225_S232_G0.8820.34
34_N37_Q0.8770.34
143_L245_C0.8760.34
161_L207_F0.8740.34
203_W233_L0.8730.34
137_E173_F0.8730.34
198_D203_W0.8730.34
202_S310_A0.8730.34
136_L229_S0.8720.34
34_N205_F0.8710.34
161_L304_I0.8700.34
87_V267_F0.8690.34
72_V75_L0.8690.34
102_I143_L0.8680.33
134_R265_T0.8670.33
210_V304_I0.8610.33
162_L229_S0.8600.33
52_D133_E0.8600.33
47_I118_S0.8590.33
244_I252_A0.8580.33
235_D272_V0.8580.33
60_H170_E0.8570.33
139_M164_V0.8510.33
62_Q232_G0.8510.33
129_G132_L0.8440.32
88_T118_S0.8420.32
239_G312_P0.8420.32
170_E265_T0.8380.32
71_L249_L0.8350.32
247_T256_I0.8280.31
168_S318_I0.8230.31
70_D164_V0.8220.31
228_L304_I0.8220.31
238_G273_P0.8180.31
245_C249_L0.8170.31
246_S293_N0.8110.30
306_F322_F0.8080.30
49_W274_L0.8060.30
286_S309_T0.8050.30
182_I229_S0.8020.30
160_A244_I0.8020.30
49_W91_M0.8010.30
108_V190_D0.8000.30
170_E237_S0.7980.30
125_V165_I0.7940.29
142_A162_L0.7920.29
46_D245_C0.7900.29
248_N261_Y0.7820.29
298_L305_R0.7810.29
225_S318_I0.7810.29
293_N320_V0.7810.29
135_G168_S0.7800.29
52_D168_S0.7750.28
251_S304_I0.7740.28
117_N299_A0.7710.28
45_V78_L0.7680.28
127_E318_I0.7670.28
44_K238_G0.7650.28
62_Q113_P0.7650.28
133_E172_D0.7640.28
190_D236_T0.7630.28
136_L160_A0.7580.28
62_Q72_V0.7560.27
46_D83_H0.7510.27
64_L209_G0.7500.27
42_N203_W0.7430.27
157_R185_Y0.7410.27
94_T267_F0.7380.27
302_N315_D0.7370.27
317_S321_D0.7370.27
83_H167_L0.7340.26
64_L84_M0.7300.26
117_N121_N0.7300.26
201_R233_L0.7290.26
71_L84_M0.7290.26
301_S313_A0.7240.26
297_Y305_R0.7230.26
135_G322_F0.7160.25
99_G103_G0.7160.25
119_L174_S0.7160.25
309_T316_A0.7160.25
244_I249_L0.7140.25
216_Q219_T0.7120.25
183_T304_I0.7120.25
202_S309_T0.7110.25
180_A256_I0.7110.25
48_L157_R0.7090.25
244_I253_V0.7090.25
101_F114_D0.7090.25
100_K254_G0.7090.25
285_V303_V0.7080.25
78_L204_V0.7060.25
134_R170_E0.7060.25
80_M206_N0.7050.25
68_V119_L0.7040.25
63_R109_T0.7010.25
85_A308_G0.7010.25
76_N81_D0.6990.25
269_L322_F0.6990.25
208_I245_C0.6990.25
116_V120_K0.6950.24
135_G166_A0.6920.24
82_Y89_T0.6910.24
313_A316_A0.6890.24
87_V243_S0.6890.24
177_S301_S0.6860.24
84_M163_V0.6830.24
214_T218_K0.6820.24
83_H245_C0.6820.24
46_D81_D0.6810.24
285_V321_D0.6800.24
129_G172_D0.6790.24
167_L172_D0.6790.24
269_L273_P0.6690.23
60_H166_A0.6670.23
209_G304_I0.6670.23
297_Y304_I0.6670.23
47_I165_I0.6660.23
66_E318_I0.6650.23
134_R202_S0.6620.23
87_V97_D0.6620.23
48_L162_L0.6610.23
54_S208_I0.6590.23
143_L188_L0.6570.23
55_T257_R0.6560.23
49_W57_M0.6550.23
53_N173_F0.6550.23
165_I196_W0.6510.22
304_I318_I0.6500.22
103_G307_Y0.6480.22
278_I307_Y0.6480.22
73_S177_S0.6460.22
181_G320_V0.6440.22
86_V165_I0.6420.22
51_V238_G0.6410.22
250_S253_V0.6410.22
136_L233_L0.6410.22
266_D303_V0.6380.22
164_V308_G0.6380.22
255_N265_T0.6370.22
162_L167_L0.6360.22
168_S255_N0.6360.22
246_S260_I0.6340.22
315_D322_F0.6320.22
68_V167_L0.6310.22
66_E69_P0.6300.22
108_V158_N0.6260.21
279_T298_L0.6240.21
121_N278_I0.6230.21
108_V140_E0.6220.21
47_I293_N0.6180.21
160_A306_F0.6170.21
35_F111_K0.6160.21
57_M61_Q0.6160.21
311_V316_A0.6150.21
111_K287_I0.6130.21
316_A321_D0.6100.21
250_S303_V0.6100.21
272_V299_A0.6100.21
54_S169_D0.6090.21
290_D293_N0.6080.21
113_P309_T0.6060.21
300_A320_V0.5980.20
84_M308_G0.5940.20
47_I136_L0.5930.20
260_I299_A0.5920.20
172_D306_F0.5890.20
273_P282_I0.5890.20
64_L279_T0.5890.20
72_V319_K0.5860.20
108_V116_V0.5860.20
50_I159_D0.5840.20
192_I195_P0.5830.20
132_L218_K0.5830.20
85_A207_F0.5800.19
73_S247_T0.5780.19
321_D324_P0.5770.19
93_G299_A0.5760.19
189_L233_L0.5740.19
106_K147_Y0.5680.19
126_G318_I0.5630.19
88_T233_L0.5620.19
89_T202_S0.5610.19
116_V287_I0.5600.19
267_F306_F0.5600.19
175_K229_S0.5580.19
190_D291_T0.5570.19
101_F155_F0.5560.19
293_N309_T0.5550.18
75_L179_S0.5520.18
115_L122_R0.5510.18
190_D210_V0.5500.18
81_D160_A0.5480.18
86_V152_G0.5460.18
192_I203_W0.5460.18
153_K167_L0.5440.18
76_N141_N0.5430.18
39_I191_G0.5410.18
214_T217_C0.5400.18
302_N318_I0.5370.18
84_M157_R0.5360.18
293_N307_Y0.5340.18
89_T174_S0.5320.18
234_A276_E0.5320.18
149_A207_F0.5320.18
208_I255_N0.5320.18
68_V84_M0.5320.18
48_L61_Q0.5310.18
102_I261_Y0.5310.18
85_A89_T0.5310.18
86_V147_Y0.5300.18
60_H202_S0.5290.18
44_K64_L0.5290.18
40_T303_V0.5290.18
254_G315_D0.5290.18
97_D184_Y0.5270.17
50_I89_T0.5270.17
83_H316_A0.5260.17
35_F304_I0.5250.17
214_T234_A0.5240.17
268_K300_A0.5240.17
78_L205_F0.5240.17
60_H168_S0.5230.17
113_P117_N0.5230.17
90_S273_P0.5220.17
67_Q249_L0.5210.17
163_V167_L0.5190.17
143_L162_L0.5180.17
180_A269_L0.5160.17
235_D238_G0.5140.17
312_P315_D0.5140.17
178_S263_I0.5130.17
111_K127_E0.5120.17
160_A312_P0.5120.17
56_S280_V0.5120.17
304_I320_V0.5100.17
48_L182_I0.5080.17
119_L208_I0.5060.17
51_V158_N0.5050.17
81_D178_S0.5040.17
137_E319_K0.5020.17
283_N286_S0.5020.17
231_M254_G0.5020.17
85_A235_D0.5010.17
136_L139_M0.5000.16
114_D228_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fcs_B 1 0.9085 99.6 0.776 Contact Map
1q0p_A 1 0.561 99.6 0.779 Contact Map
4neh_B 1 0.8811 99.6 0.784 Contact Map
4um9_B 1 0.8933 99.6 0.784 Contact Map
4wk0_B 1 0.9146 99.6 0.785 Contact Map
2b2x_A 1 0.5671 99.6 0.787 Contact Map
4um8_B 1 0.9055 99.6 0.789 Contact Map
4okr_A 1 0.689 99.5 0.791 Contact Map
3t3p_B 1 0.9299 99.5 0.793 Contact Map
2x31_A 1 0.5518 99.5 0.793 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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