T0901_1_328 - CASP12 - GREMLIN Contacts

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T0901_1_328 - T0901 1-328

ID:	52	Sequences: MKKDFQLLVVAAASSLLMACAQNVSFDLPETQDNFGQSITYNNKVDILWIVDNSTSMLKHQQRLSEQVPDLVSKLNTLKMDYHMAVVTTSMGGTSPDGGKFIGSPKYVTSKTPDLVNSLKNRMIVGEAGSNLERGLESMENALSANYLANEGKGFFRNDALLVVIALSDEDDFSKSSSSAGITYYTNLLDGIKEPWVDGSRSWVFNFIGVLSLTSQCKTFNDFASAGLSYMGLADTSGGVKESICSTNLSSAVGNIRSRIYQILTDFKLSKVPLEESITVSINGVSIPRDTTNGWDYLAASNVIRFYGTAVPAADASIKVDFKPKDAN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	328 (287)
Sequences:	368 (327)
Seq/√Len:	19.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
252_A	256_I	5.579	1.00
249_L	256_I	3.708	1.00
296_D	307_Y	3.604	1.00
249_L	252_A	3.332	1.00
52_D	56_S	3.205	0.99
252_A	259_R	3.126	0.99
135_G	230_Y	2.936	0.99
183_T	187_N	2.933	0.99
46_D	162_L	2.750	0.98
46_D	157_R	2.681	0.98
248_N	251_S	2.552	0.97
64_L	165_I	2.536	0.97
85_A	101_F	2.523	0.97
166_A	203_W	2.486	0.97
46_D	160_A	2.410	0.96
284_G	320_V	2.340	0.96
249_L	253_V	2.277	0.95
49_W	165_I	2.265	0.95
129_G	133_E	2.217	0.94
172_D	229_S	2.173	0.93
310_A	314_A	2.154	0.93
270_S	283_N	2.151	0.93
128_A	133_E	2.081	0.92
51_V	64_L	1.999	0.90
61_Q	89_T	1.997	0.90
52_D	57_M	1.995	0.90
232_G	236_T	1.991	0.90
207_F	322_F	1.991	0.90
205_F	234_A	1.988	0.90
50_I	88_T	1.981	0.90
133_E	170_E	1.935	0.88
289_R	296_D	1.925	0.88
75_L	87_V	1.916	0.88
157_R	160_A	1.882	0.87
45_V	82_Y	1.878	0.87
50_I	142_A	1.850	0.86
168_S	230_Y	1.829	0.85
296_D	301_S	1.804	0.85
54_S	168_S	1.760	0.83
53_N	61_Q	1.740	0.82
310_A	324_P	1.733	0.82
50_I	53_N	1.703	0.81
53_N	89_T	1.686	0.80
59_K	182_I	1.677	0.80
230_Y	243_S	1.670	0.80
50_I	172_D	1.665	0.79
88_T	126_G	1.643	0.78
244_I	259_R	1.634	0.78
118_S	121_N	1.606	0.77
61_Q	88_T	1.602	0.77
206_N	230_Y	1.579	0.76
164_V	256_I	1.572	0.75
68_V	72_V	1.563	0.75
47_I	249_L	1.561	0.75
49_W	88_T	1.537	0.73
170_E	230_Y	1.526	0.73
84_M	89_T	1.504	0.72
64_L	160_A	1.497	0.71
54_S	57_M	1.481	0.71
60_H	206_N	1.474	0.70
61_Q	129_G	1.468	0.70
253_V	269_L	1.465	0.70
51_V	108_V	1.435	0.68
50_I	87_V	1.434	0.68
310_A	313_A	1.419	0.67
108_V	112_T	1.412	0.67
57_M	169_D	1.403	0.66
77_T	165_I	1.397	0.66
44_K	159_D	1.377	0.65
306_F	312_P	1.374	0.65
238_G	294_G	1.372	0.65
135_G	170_E	1.358	0.64
128_A	131_N	1.351	0.63
244_I	255_N	1.344	0.63
107_Y	110_S	1.340	0.63
273_P	306_F	1.328	0.62
210_V	219_T	1.326	0.62
237_S	295_W	1.323	0.62
81_D	157_R	1.308	0.61
119_L	123_M	1.307	0.61
128_A	132_L	1.298	0.60
231_M	234_A	1.291	0.60
138_S	141_N	1.290	0.60
83_H	303_V	1.282	0.59
55_T	58_L	1.281	0.59
91_M	138_S	1.278	0.59
90_S	206_N	1.264	0.58
61_Q	170_E	1.255	0.57
204_V	237_S	1.253	0.57
146_N	154_G	1.247	0.57
269_L	315_D	1.238	0.56
56_S	169_D	1.230	0.56
163_V	201_R	1.227	0.56
167_L	186_T	1.215	0.55
318_I	322_F	1.215	0.55
90_S	172_D	1.209	0.55
204_V	209_G	1.186	0.53
46_D	306_F	1.177	0.53
85_A	299_A	1.174	0.52
112_T	277_S	1.171	0.52
184_Y	290_D	1.164	0.52
168_S	208_I	1.159	0.51
234_A	295_W	1.157	0.51
135_G	172_D	1.153	0.51
49_W	273_P	1.148	0.51
68_V	71_L	1.146	0.51
67_Q	157_R	1.141	0.50
256_I	317_S	1.138	0.50
274_L	277_S	1.138	0.50
126_G	253_V	1.131	0.50
217_C	245_C	1.127	0.49
164_V	200_S	1.122	0.49
122_R	144_S	1.121	0.49
165_I	276_E	1.121	0.49
117_N	181_G	1.114	0.49
42_N	304_I	1.111	0.48
116_V	147_Y	1.110	0.48
74_K	77_T	1.102	0.48
72_V	171_D	1.094	0.47
248_N	256_I	1.089	0.47
90_S	129_G	1.074	0.46
291_T	296_D	1.069	0.46
121_N	226_A	1.060	0.45
73_S	286_S	1.060	0.45
247_T	267_F	1.057	0.45
162_L	253_V	1.056	0.45
85_A	164_V	1.052	0.45
136_L	172_D	1.051	0.45
265_T	310_A	1.045	0.44
118_S	165_I	1.043	0.44
43_N	47_I	1.041	0.44
52_D	169_D	1.036	0.44
170_E	310_A	1.033	0.43
51_V	139_M	1.032	0.43
130_S	214_T	1.032	0.43
320_V	323_K	1.032	0.43
250_S	313_A	1.029	0.43
188_L	192_I	1.022	0.43
44_K	297_Y	1.018	0.42
75_L	270_S	1.016	0.42
49_W	84_M	1.015	0.42
64_L	167_L	1.011	0.42
76_N	262_Q	1.007	0.42
143_L	295_W	1.005	0.42
159_D	176_S	0.995	0.41
172_D	189_L	0.995	0.41
176_S	267_F	0.994	0.41
181_G	219_T	0.992	0.41
88_T	306_F	0.990	0.41
108_V	193_K	0.986	0.40
94_T	284_G	0.982	0.40
249_L	257_R	0.978	0.40
47_I	105_P	0.977	0.40
162_L	306_F	0.974	0.40
86_V	113_P	0.971	0.40
110_S	285_V	0.966	0.39
177_S	185_Y	0.963	0.39
120_K	139_M	0.958	0.39
86_V	272_V	0.955	0.39
279_T	286_S	0.954	0.39
299_A	306_F	0.949	0.38
265_T	324_P	0.943	0.38
252_A	257_R	0.942	0.38
67_Q	261_Y	0.942	0.38
87_V	239_G	0.941	0.38
98_G	134_R	0.941	0.38
48_L	88_T	0.938	0.38
69_P	73_S	0.936	0.37
233_L	239_G	0.936	0.37
53_N	244_I	0.929	0.37
114_D	303_V	0.926	0.37
311_V	314_A	0.922	0.37
319_K	323_K	0.921	0.37
231_M	237_S	0.921	0.37
234_A	237_S	0.915	0.36
290_D	314_A	0.911	0.36
227_G	230_Y	0.909	0.36
48_L	142_A	0.905	0.36
121_N	262_Q	0.899	0.35
75_L	90_S	0.899	0.35
148_L	164_V	0.898	0.35
289_R	307_Y	0.890	0.35
103_G	308_G	0.886	0.35
281_S	286_S	0.884	0.34
225_S	232_G	0.882	0.34
34_N	37_Q	0.877	0.34
143_L	245_C	0.876	0.34
161_L	207_F	0.874	0.34
203_W	233_L	0.873	0.34
137_E	173_F	0.873	0.34
198_D	203_W	0.873	0.34
202_S	310_A	0.873	0.34
136_L	229_S	0.872	0.34
34_N	205_F	0.871	0.34
161_L	304_I	0.870	0.34
87_V	267_F	0.869	0.34
72_V	75_L	0.869	0.34
102_I	143_L	0.868	0.33
134_R	265_T	0.867	0.33
210_V	304_I	0.861	0.33
162_L	229_S	0.860	0.33
52_D	133_E	0.860	0.33
47_I	118_S	0.859	0.33
244_I	252_A	0.858	0.33
235_D	272_V	0.858	0.33
60_H	170_E	0.857	0.33
139_M	164_V	0.851	0.33
62_Q	232_G	0.851	0.33
129_G	132_L	0.844	0.32
88_T	118_S	0.842	0.32
239_G	312_P	0.842	0.32
170_E	265_T	0.838	0.32
71_L	249_L	0.835	0.32
247_T	256_I	0.828	0.31
168_S	318_I	0.823	0.31
70_D	164_V	0.822	0.31
228_L	304_I	0.822	0.31
238_G	273_P	0.818	0.31
245_C	249_L	0.817	0.31
246_S	293_N	0.811	0.30
306_F	322_F	0.808	0.30
49_W	274_L	0.806	0.30
286_S	309_T	0.805	0.30
182_I	229_S	0.802	0.30
160_A	244_I	0.802	0.30
49_W	91_M	0.801	0.30
108_V	190_D	0.800	0.30
170_E	237_S	0.798	0.30
125_V	165_I	0.794	0.29
142_A	162_L	0.792	0.29
46_D	245_C	0.790	0.29
248_N	261_Y	0.782	0.29
298_L	305_R	0.781	0.29
225_S	318_I	0.781	0.29
293_N	320_V	0.781	0.29
135_G	168_S	0.780	0.29
52_D	168_S	0.775	0.28
251_S	304_I	0.774	0.28
117_N	299_A	0.771	0.28
45_V	78_L	0.768	0.28
127_E	318_I	0.767	0.28
44_K	238_G	0.765	0.28
62_Q	113_P	0.765	0.28
133_E	172_D	0.764	0.28
190_D	236_T	0.763	0.28
136_L	160_A	0.758	0.28
62_Q	72_V	0.756	0.27
46_D	83_H	0.751	0.27
64_L	209_G	0.750	0.27
42_N	203_W	0.743	0.27
157_R	185_Y	0.741	0.27
94_T	267_F	0.738	0.27
302_N	315_D	0.737	0.27
317_S	321_D	0.737	0.27
83_H	167_L	0.734	0.26
64_L	84_M	0.730	0.26
117_N	121_N	0.730	0.26
201_R	233_L	0.729	0.26
71_L	84_M	0.729	0.26
301_S	313_A	0.724	0.26
297_Y	305_R	0.723	0.26
135_G	322_F	0.716	0.25
99_G	103_G	0.716	0.25
119_L	174_S	0.716	0.25
309_T	316_A	0.716	0.25
244_I	249_L	0.714	0.25
216_Q	219_T	0.712	0.25
183_T	304_I	0.712	0.25
202_S	309_T	0.711	0.25
180_A	256_I	0.711	0.25
48_L	157_R	0.709	0.25
244_I	253_V	0.709	0.25
101_F	114_D	0.709	0.25
100_K	254_G	0.709	0.25
285_V	303_V	0.708	0.25
78_L	204_V	0.706	0.25
134_R	170_E	0.706	0.25
80_M	206_N	0.705	0.25
68_V	119_L	0.704	0.25
63_R	109_T	0.701	0.25
85_A	308_G	0.701	0.25
76_N	81_D	0.699	0.25
269_L	322_F	0.699	0.25
208_I	245_C	0.699	0.25
116_V	120_K	0.695	0.24
135_G	166_A	0.692	0.24
82_Y	89_T	0.691	0.24
313_A	316_A	0.689	0.24
87_V	243_S	0.689	0.24
177_S	301_S	0.686	0.24
84_M	163_V	0.683	0.24
214_T	218_K	0.682	0.24
83_H	245_C	0.682	0.24
46_D	81_D	0.681	0.24
285_V	321_D	0.680	0.24
129_G	172_D	0.679	0.24
167_L	172_D	0.679	0.24
269_L	273_P	0.669	0.23
60_H	166_A	0.667	0.23
209_G	304_I	0.667	0.23
297_Y	304_I	0.667	0.23
47_I	165_I	0.666	0.23
66_E	318_I	0.665	0.23
134_R	202_S	0.662	0.23
87_V	97_D	0.662	0.23
48_L	162_L	0.661	0.23
54_S	208_I	0.659	0.23
143_L	188_L	0.657	0.23
55_T	257_R	0.656	0.23
49_W	57_M	0.655	0.23
53_N	173_F	0.655	0.23
165_I	196_W	0.651	0.22
304_I	318_I	0.650	0.22
103_G	307_Y	0.648	0.22
278_I	307_Y	0.648	0.22
73_S	177_S	0.646	0.22
181_G	320_V	0.644	0.22
86_V	165_I	0.642	0.22
51_V	238_G	0.641	0.22
250_S	253_V	0.641	0.22
136_L	233_L	0.641	0.22
266_D	303_V	0.638	0.22
164_V	308_G	0.638	0.22
255_N	265_T	0.637	0.22
162_L	167_L	0.636	0.22
168_S	255_N	0.636	0.22
246_S	260_I	0.634	0.22
315_D	322_F	0.632	0.22
68_V	167_L	0.631	0.22
66_E	69_P	0.630	0.22
108_V	158_N	0.626	0.21
279_T	298_L	0.624	0.21
121_N	278_I	0.623	0.21
108_V	140_E	0.622	0.21
47_I	293_N	0.618	0.21
160_A	306_F	0.617	0.21
35_F	111_K	0.616	0.21
57_M	61_Q	0.616	0.21
311_V	316_A	0.615	0.21
111_K	287_I	0.613	0.21
316_A	321_D	0.610	0.21
250_S	303_V	0.610	0.21
272_V	299_A	0.610	0.21
54_S	169_D	0.609	0.21
290_D	293_N	0.608	0.21
113_P	309_T	0.606	0.21
300_A	320_V	0.598	0.20
84_M	308_G	0.594	0.20
47_I	136_L	0.593	0.20
260_I	299_A	0.592	0.20
172_D	306_F	0.589	0.20
273_P	282_I	0.589	0.20
64_L	279_T	0.589	0.20
72_V	319_K	0.586	0.20
108_V	116_V	0.586	0.20
50_I	159_D	0.584	0.20
192_I	195_P	0.583	0.20
132_L	218_K	0.583	0.20
85_A	207_F	0.580	0.19
73_S	247_T	0.578	0.19
321_D	324_P	0.577	0.19
93_G	299_A	0.576	0.19
189_L	233_L	0.574	0.19
106_K	147_Y	0.568	0.19
126_G	318_I	0.563	0.19
88_T	233_L	0.562	0.19
89_T	202_S	0.561	0.19
116_V	287_I	0.560	0.19
267_F	306_F	0.560	0.19
175_K	229_S	0.558	0.19
190_D	291_T	0.557	0.19
101_F	155_F	0.556	0.19
293_N	309_T	0.555	0.18
75_L	179_S	0.552	0.18
115_L	122_R	0.551	0.18
190_D	210_V	0.550	0.18
81_D	160_A	0.548	0.18
86_V	152_G	0.546	0.18
192_I	203_W	0.546	0.18
153_K	167_L	0.544	0.18
76_N	141_N	0.543	0.18
39_I	191_G	0.541	0.18
214_T	217_C	0.540	0.18
302_N	318_I	0.537	0.18
84_M	157_R	0.536	0.18
293_N	307_Y	0.534	0.18
89_T	174_S	0.532	0.18
234_A	276_E	0.532	0.18
149_A	207_F	0.532	0.18
208_I	255_N	0.532	0.18
68_V	84_M	0.532	0.18
48_L	61_Q	0.531	0.18
102_I	261_Y	0.531	0.18
85_A	89_T	0.531	0.18
86_V	147_Y	0.530	0.18
60_H	202_S	0.529	0.18
44_K	64_L	0.529	0.18
40_T	303_V	0.529	0.18
254_G	315_D	0.529	0.18
97_D	184_Y	0.527	0.17
50_I	89_T	0.527	0.17
83_H	316_A	0.526	0.17
35_F	304_I	0.525	0.17
214_T	234_A	0.524	0.17
268_K	300_A	0.524	0.17
78_L	205_F	0.524	0.17
60_H	168_S	0.523	0.17
113_P	117_N	0.523	0.17
90_S	273_P	0.522	0.17
67_Q	249_L	0.521	0.17
163_V	167_L	0.519	0.17
143_L	162_L	0.518	0.17
180_A	269_L	0.516	0.17
235_D	238_G	0.514	0.17
312_P	315_D	0.514	0.17
178_S	263_I	0.513	0.17
111_K	127_E	0.512	0.17
160_A	312_P	0.512	0.17
56_S	280_V	0.512	0.17
304_I	320_V	0.510	0.17
48_L	182_I	0.508	0.17
119_L	208_I	0.506	0.17
51_V	158_N	0.505	0.17
81_D	178_S	0.504	0.17
137_E	319_K	0.502	0.17
283_N	286_S	0.502	0.17
231_M	254_G	0.502	0.17
85_A	235_D	0.501	0.17
136_L	139_M	0.500	0.16
114_D	228_L	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fcs_B	1	0.9085	99.6	0.776	Contact Map
1q0p_A	1	0.561	99.6	0.779	Contact Map
4neh_B	1	0.8811	99.6	0.784	Contact Map
4um9_B	1	0.8933	99.6	0.784	Contact Map
4wk0_B	1	0.9146	99.6	0.785	Contact Map
2b2x_A	1	0.5671	99.6	0.787	Contact Map
4um8_B	1	0.9055	99.6	0.789	Contact Map
4okr_A	1	0.689	99.5	0.791	Contact Map
3t3p_B	1	0.9299	99.5	0.793	Contact Map
2x31_A	1	0.5518	99.5	0.793	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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