GREMLIN Database
T0898_1_169 - T0898 1-169
ID: 50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (152)
Sequences: 32 (30)
Seq/√Len: 2.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_C142_C4.0110.63
116_C139_C4.0110.63
116_C142_C4.0110.63
7_K136_V3.2490.46
52_F124_M3.1200.43
36_L96_F3.0630.42
11_E58_M2.9960.40
116_C119_C2.2520.26
119_C142_C2.2520.26
63_Y74_E2.2520.26
119_C139_C2.2520.26
125_Q135_T2.0610.23
29_L121_W1.9340.21
53_S113_E1.8870.20
105_E123_E1.8730.20
16_L58_M1.8150.19
105_E137_Y1.7910.19
14_D27_D1.7440.18
39_D64_P1.7130.18
11_E56_I1.7090.18
32_L162_P1.6310.17
104_L138_L1.6040.16
63_Y127_L1.5760.16
18_H44_K1.5560.16
9_I100_I1.4940.15
35_W150_N1.4870.15
32_L124_M1.4750.15
2_S6_K1.4710.15
31_V34_S1.4590.15
51_D150_N1.4270.14
60_P64_P1.4080.14
131_N144_C1.4030.14
77_Y123_E1.3870.14
9_I102_D1.3840.14
39_D100_I1.3720.14
122_G125_Q1.3710.14
75_I96_F1.3700.14
14_D149_D1.3700.14
76_I107_L1.3700.14
50_Y145_A1.3190.13
52_F116_C1.3060.13
52_F139_C1.3060.13
52_F142_C1.3060.13
27_D92_K1.2780.13
36_L128_E1.2770.13
59_N107_L1.2720.13
15_A107_L1.2650.12
56_I100_I1.2420.12
19_L111_H1.2410.12
20_N82_I1.2320.12
72_R161_I1.2270.12
152_Q161_I1.2250.12
68_S109_I1.1940.12
100_I140_T1.1900.12
29_L119_C1.1870.12
45_F149_D1.1820.12
116_C124_M1.1740.12
124_M139_C1.1740.12
124_M142_C1.1740.12
114_R117_P1.1730.12
28_L126_K1.1380.11
63_Y137_Y1.1370.11
35_W136_V1.1270.11
2_S5_E1.1230.11
123_E143_G1.1170.11
38_N105_E1.0980.11
68_S126_K1.0900.11
25_S126_K1.0880.11
52_F87_S1.0830.11
50_Y140_T1.0730.11
112_I152_Q1.0720.11
7_K106_Y1.0700.11
112_I122_G1.0510.11
9_I35_W1.0370.10
6_K157_T1.0310.10
77_Y115_V1.0130.10
97_V110_E1.0090.10
75_I92_K1.0010.10
68_S112_I0.9810.10
71_N114_R0.9650.10
148_N157_T0.9590.10
7_K119_C0.9590.10
51_D54_K0.9580.10
65_V102_D0.9530.10
52_F143_G0.9520.10
6_K148_N0.9470.10
127_L141_Q0.9460.10
33_I161_I0.9290.10
44_K57_E0.9260.10
50_Y120_E0.9150.09
55_Y93_F0.9140.09
122_G162_P0.9100.09
101_R141_Q0.8930.09
9_I87_S0.8910.09
34_S151_S0.8860.09
32_L136_V0.8840.09
29_L105_E0.8830.09
74_E105_E0.8780.09
2_S21_H0.8750.09
35_W143_G0.8700.09
22_N81_N0.8640.09
3_N6_K0.8510.09
19_L29_L0.8460.09
96_F153_F0.8380.09
27_D37_S0.8350.09
36_L117_P0.8300.09
108_F138_L0.8270.09
100_I111_H0.8170.09
145_A162_P0.8130.09
28_L128_E0.8110.09
117_P142_C0.8020.09
117_P139_C0.8020.09
119_C136_V0.8020.09
61_D112_I0.8000.09
36_L63_Y0.8000.09
11_E109_I0.7980.09
35_W100_I0.7910.09
40_I99_Y0.7890.09
63_Y114_R0.7880.08
13_N82_I0.7880.08
58_M100_I0.7870.08
96_F114_R0.7850.08
12_L35_W0.7850.08
60_P63_Y0.7850.08
53_S150_N0.7840.08
32_L116_C0.7790.08
32_L139_C0.7790.08
32_L142_C0.7790.08
43_D58_M0.7760.08
78_L154_L0.7730.08
72_R80_N0.7730.08
7_K47_I0.7710.08
122_G135_T0.7690.08
75_I161_I0.7560.08
123_E162_P0.7550.08
58_M122_G0.7530.08
4_F25_S0.7490.08
38_N60_P0.7470.08
15_A38_N0.7460.08
6_K21_H0.7410.08
58_M75_I0.7370.08
39_D63_Y0.7360.08
70_L128_E0.7350.08
29_L68_S0.7320.08
3_N95_Y0.7280.08
111_H158_P0.7270.08
32_L52_F0.7240.08
117_P162_P0.7210.08
92_K149_D0.7180.08
121_W140_T0.7160.08
47_I148_N0.7160.08
107_L113_E0.7000.08
80_N110_E0.6980.08
47_I92_K0.6930.08
27_D46_K0.6870.08
24_T57_E0.6820.08
107_L154_L0.6740.08
17_S134_E0.6720.08
12_L143_G0.6670.08
14_D38_N0.6660.08
25_S106_Y0.6600.08
134_E160_T0.6580.08
10_L26_F0.6540.08
55_Y128_E0.6540.08
40_I53_S0.6510.08
107_L145_A0.6490.08
107_L114_R0.6430.08
27_D149_D0.6410.08
28_L145_A0.6380.08
112_I124_M0.6380.08
15_A133_H0.6290.07
109_I125_Q0.6240.07
9_I127_L0.6150.07
30_K131_N0.6140.07
137_Y143_G0.6080.07
123_E137_Y0.6030.07
17_S160_T0.6010.07
13_N18_H0.5990.07
100_I143_G0.5980.07
54_K80_N0.5970.07
142_C162_P0.5970.07
116_C162_P0.5970.07
139_C162_P0.5970.07
76_I156_K0.5970.07
21_H47_I0.5970.07
63_Y139_C0.5940.07
63_Y142_C0.5940.07
63_Y116_C0.5940.07
7_K16_L0.5850.07
16_L19_L0.5820.07
23_S146_F0.5820.07
118_Y144_C0.5810.07
41_V68_S0.5780.07
17_S131_N0.5770.07
63_Y96_F0.5750.07
51_D143_G0.5690.07
67_K76_I0.5670.07
13_N26_F0.5630.07
118_Y131_N0.5590.07
37_S46_K0.5590.07
32_L112_I0.5590.07
33_I81_N0.5540.07
23_S144_C0.5520.07
39_D58_M0.5500.07
33_I50_Y0.5490.07
35_W116_C0.5470.07
35_W139_C0.5470.07
35_W142_C0.5470.07
41_V118_Y0.5450.07
51_D160_T0.5440.07
74_E161_I0.5430.07
21_H159_L0.5350.07
52_F150_N0.5350.07
7_K21_H0.5290.07
100_I119_C0.5220.07
58_M129_E0.5210.07
109_I150_N0.5210.07
77_Y138_L0.5190.07
67_K131_N0.5180.07
20_N46_K0.5160.07
39_D109_I0.5140.07
9_I65_V0.5130.07
104_L123_E0.5080.07
45_F75_I0.5070.07
22_N33_I0.5060.07
81_N125_Q0.5040.07
14_D92_K0.5030.07
77_Y150_N0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pqv_S 1 0.787 87.4 0.907 Contact Map
3po3_S 1 0.787 86 0.909 Contact Map
1k81_A 1 0.213 85.6 0.909 Contact Map
4c2m_I 1 0.3491 80.2 0.914 Contact Map
1tfi_A 1 0.2663 74.7 0.919 Contact Map
1qyp_A 1 0.3077 73.8 0.919 Contact Map
3cw2_K 1 0.6272 70.4 0.921 Contact Map
1nee_A 1 0.7751 66.8 0.923 Contact Map
5fmf_R 1 0.6509 65.9 0.924 Contact Map
4rv9_A 1 0.3373 61.6 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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