T0864_1_246 - CASP12 - GREMLIN Contacts

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T0864_1_246 - T0864 1-246

ID:	5	Sequences: GHMASGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	246 (241)
Sequences:	467 (328)
Seq/√Len:	21.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_N	61_D	6.611	1.00
129_E	132_K	5.427	1.00
65_C	105_D	4.782	1.00
148_D	151_H	4.612	1.00
209_S	213_S	3.619	1.00
103_T	183_L	3.352	1.00
168_S	192_Y	3.337	1.00
135_E	167_S	3.316	1.00
12_A	141_E	3.189	1.00
49_H	52_G	3.146	1.00
61_D	109_T	3.049	0.99
46_R	56_E	2.668	0.99
158_L	173_L	2.650	0.98
124_D	199_Y	2.608	0.98
26_L	60_T	2.585	0.98
104_T	146_F	2.492	0.98
169_F	193_H	2.325	0.96
47_I	171_L	2.303	0.96
131_L	137_I	2.244	0.96
122_T	201_L	2.207	0.95
4_A	9_K	2.200	0.95
9_K	48_Q	2.005	0.92
142_E	159_S	1.932	0.91
29_E	60_T	1.907	0.90
103_T	229_S	1.907	0.90
107_K	202_R	1.889	0.89
130_K	194_E	1.879	0.89
74_K	240_E	1.867	0.89
207_R	229_S	1.866	0.89
38_M	149_E	1.855	0.89
136_Q	146_F	1.848	0.88
60_T	101_T	1.745	0.85
185_R	208_E	1.735	0.85
55_I	191_L	1.678	0.83
142_E	160_V	1.624	0.81
48_Q	54_G	1.597	0.80
184_I	214_L	1.587	0.79
234_I	237_A	1.574	0.79
22_D	42_D	1.558	0.78
130_K	192_Y	1.556	0.78
18_M	30_L	1.541	0.77
203_E	237_A	1.537	0.77
137_I	165_M	1.530	0.77
135_E	168_S	1.512	0.76
17_I	149_E	1.488	0.75
229_S	233_P	1.481	0.74
19_K	22_D	1.465	0.73
124_D	201_L	1.426	0.71
176_F	228_I	1.400	0.70
13_S	44_V	1.398	0.70
119_V	122_T	1.359	0.67
187_N	206_S	1.358	0.67
77_C	181_G	1.348	0.67
133_A	136_Q	1.343	0.67
215_M	218_P	1.342	0.66
25_K	29_E	1.341	0.66
184_I	227_E	1.336	0.66
98_Y	103_T	1.318	0.65
58_N	155_V	1.307	0.64
11_T	48_Q	1.298	0.64
91_S	98_Y	1.296	0.64
143_V	160_V	1.285	0.63
6_G	203_E	1.278	0.63
204_Y	239_C	1.266	0.62
40_F	147_E	1.266	0.62
140_F	161_K	1.260	0.61
106_Y	145_L	1.256	0.61
228_I	232_L	1.249	0.61
47_I	169_F	1.247	0.61
103_T	121_P	1.240	0.60
12_A	176_F	1.218	0.59
132_K	201_L	1.209	0.58
45_L	171_L	1.204	0.58
137_I	152_D	1.202	0.58
46_R	181_G	1.188	0.57
66_V	97_P	1.187	0.57
210_K	213_S	1.173	0.56
72_M	179_I	1.166	0.55
24_E	158_L	1.152	0.54
106_Y	109_T	1.148	0.54
32_M	98_Y	1.144	0.54
20_S	124_D	1.143	0.54
141_E	161_K	1.134	0.53
99_D	108_G	1.131	0.53
14_K	141_E	1.129	0.53
107_K	204_Y	1.122	0.52
160_V	173_L	1.117	0.52
144_L	156_S	1.115	0.52
131_L	165_M	1.111	0.52
128_T	167_S	1.102	0.51
151_H	156_S	1.100	0.51
15_T	18_M	1.099	0.51
12_A	45_L	1.097	0.51
5_S	16_H	1.097	0.51
75_V	185_R	1.095	0.51
110_L	122_T	1.094	0.51
16_H	32_M	1.086	0.50
3_M	184_I	1.085	0.50
59_A	84_S	1.073	0.49
8_W	47_I	1.059	0.48
29_E	64_R	1.050	0.48
18_M	148_D	1.049	0.48
123_T	181_G	1.048	0.48
12_A	158_L	1.031	0.46
62_A	78_A	1.031	0.46
146_F	198_T	1.011	0.45
131_L	152_D	1.005	0.45
27_A	124_D	0.995	0.44
126_I	232_L	0.992	0.44
20_S	199_Y	0.991	0.44
168_S	193_H	0.984	0.43
38_M	101_T	0.973	0.43
87_E	220_S	0.973	0.43
149_E	177_L	0.972	0.43
104_T	109_T	0.971	0.42
74_K	102_Y	0.968	0.42
185_R	189_T	0.964	0.42
104_T	158_L	0.958	0.42
78_A	98_Y	0.957	0.42
35_L	179_I	0.954	0.41
22_D	41_G	0.953	0.41
211_I	227_E	0.948	0.41
138_K	195_A	0.948	0.41
18_M	98_Y	0.947	0.41
104_T	186_M	0.942	0.41
194_E	242_L	0.936	0.40
33_P	102_Y	0.932	0.40
101_T	130_K	0.930	0.40
206_S	236_E	0.924	0.39
122_T	238_V	0.919	0.39
28_D	196_D	0.915	0.39
127_D	181_G	0.914	0.39
10_L	123_T	0.911	0.39
31_H	102_Y	0.910	0.39
144_L	155_V	0.910	0.39
189_T	202_R	0.909	0.39
147_E	150_L	0.908	0.38
10_L	47_I	0.904	0.38
199_Y	241_K	0.897	0.38
60_T	78_A	0.895	0.38
23_V	98_Y	0.894	0.38
43_N	74_K	0.892	0.37
18_M	41_G	0.883	0.37
25_K	28_D	0.876	0.36
7_P	52_G	0.875	0.36
53_F	192_Y	0.874	0.36
140_F	207_R	0.873	0.36
55_I	200_M	0.868	0.36
163_R	180_D	0.864	0.36
73_L	207_R	0.863	0.36
62_A	75_V	0.854	0.35
72_M	222_F	0.850	0.35
29_E	144_L	0.849	0.35
45_L	162_I	0.846	0.35
93_E	96_K	0.845	0.35
240_E	244_F	0.841	0.34
7_P	238_V	0.835	0.34
77_C	127_D	0.829	0.34
9_K	50_G	0.827	0.33
110_L	237_A	0.825	0.33
162_I	171_L	0.824	0.33
42_D	102_Y	0.824	0.33
38_M	66_V	0.824	0.33
110_L	121_P	0.823	0.33
231_Y	234_I	0.820	0.33
152_D	190_R	0.820	0.33
186_M	225_P	0.817	0.33
41_G	211_I	0.813	0.33
16_H	188_D	0.813	0.33
45_L	169_F	0.812	0.33
130_K	176_F	0.811	0.33
39_M	126_I	0.808	0.32
206_S	228_I	0.807	0.32
47_I	120_V	0.807	0.32
143_V	201_L	0.804	0.32
34_S	37_E	0.800	0.32
28_D	113_E	0.798	0.32
197_K	234_I	0.797	0.32
3_M	10_L	0.796	0.32
184_I	216_H	0.791	0.31
163_R	190_R	0.791	0.31
107_K	238_V	0.791	0.31
79_E	83_E	0.791	0.31
181_G	194_E	0.790	0.31
179_I	207_R	0.788	0.31
54_G	129_E	0.787	0.31
149_E	152_D	0.786	0.31
77_C	222_F	0.782	0.31
146_F	160_V	0.778	0.31
148_D	167_S	0.775	0.30
151_H	224_E	0.773	0.30
58_N	109_T	0.767	0.30
45_L	49_H	0.757	0.29
183_L	213_S	0.756	0.29
145_L	185_R	0.749	0.29
173_L	179_I	0.747	0.29
156_S	175_F	0.747	0.29
77_C	153_H	0.739	0.28
3_M	162_I	0.739	0.28
74_K	225_P	0.737	0.28
241_K	244_F	0.736	0.28
154_G	172_L	0.736	0.28
43_N	96_K	0.736	0.28
14_K	41_G	0.735	0.28
93_E	161_K	0.732	0.28
149_E	156_S	0.730	0.28
74_K	77_C	0.729	0.28
41_G	143_V	0.728	0.28
224_E	229_S	0.727	0.28
84_S	183_L	0.724	0.28
240_E	245_P	0.724	0.28
55_I	171_L	0.718	0.27
13_S	162_I	0.717	0.27
225_P	228_I	0.716	0.27
46_R	54_G	0.716	0.27
149_E	182_V	0.714	0.27
16_H	22_D	0.711	0.27
26_L	30_L	0.705	0.27
201_L	240_E	0.701	0.26
152_D	180_D	0.700	0.26
88_G	220_S	0.696	0.26
108_G	154_G	0.693	0.26
81_W	152_D	0.693	0.26
50_G	219_P	0.691	0.26
207_R	234_I	0.688	0.26
172_L	180_D	0.687	0.26
18_M	35_L	0.685	0.26
109_T	145_L	0.680	0.25
58_N	138_K	0.674	0.25
103_T	185_R	0.672	0.25
74_K	177_L	0.672	0.25
223_T	226_N	0.666	0.25
61_D	110_L	0.662	0.24
55_I	221_L	0.662	0.24
8_W	90_H	0.661	0.24
225_P	242_L	0.657	0.24
73_L	204_Y	0.656	0.24
8_W	177_L	0.656	0.24
150_L	185_R	0.655	0.24
53_F	188_D	0.652	0.24
123_T	210_K	0.651	0.24
223_T	229_S	0.646	0.24
121_P	238_V	0.644	0.24
56_E	111_L	0.642	0.24
110_L	201_L	0.641	0.23
112_G	191_L	0.641	0.23
54_G	111_L	0.640	0.23
125_H	156_S	0.639	0.23
102_Y	127_D	0.638	0.23
45_L	173_L	0.637	0.23
109_T	129_E	0.636	0.23
15_T	162_I	0.633	0.23
188_D	229_S	0.631	0.23
88_G	216_H	0.629	0.23
18_M	60_T	0.628	0.23
83_E	158_L	0.626	0.23
225_P	237_A	0.626	0.23
74_K	166_P	0.626	0.23
27_A	77_C	0.623	0.23
45_L	144_L	0.622	0.23
99_D	154_G	0.622	0.23
6_G	123_T	0.622	0.23
34_S	173_L	0.621	0.23
151_H	175_F	0.621	0.23
151_H	211_I	0.620	0.22
61_D	186_M	0.619	0.22
67_N	176_F	0.618	0.22
170_F	188_D	0.618	0.22
45_L	214_L	0.617	0.22
96_K	176_F	0.616	0.22
221_L	229_S	0.616	0.22
27_A	35_L	0.615	0.22
8_W	165_M	0.613	0.22
130_K	168_S	0.610	0.22
97_P	139_F	0.609	0.22
80_E	165_M	0.608	0.22
66_V	96_K	0.607	0.22
84_S	192_Y	0.605	0.22
186_M	231_Y	0.604	0.22
158_L	184_I	0.602	0.22
61_D	106_Y	0.600	0.22
221_L	233_P	0.599	0.22
54_G	196_D	0.596	0.21
16_H	33_P	0.596	0.21
119_V	140_F	0.595	0.21
18_M	141_E	0.594	0.21
218_P	245_P	0.594	0.21
47_I	233_P	0.591	0.21
191_L	200_M	0.590	0.21
148_D	211_I	0.590	0.21
80_E	85_R	0.588	0.21
16_H	127_D	0.584	0.21
57_F	189_T	0.584	0.21
174_R	188_D	0.581	0.21
41_G	98_Y	0.581	0.21
85_R	88_G	0.580	0.21
18_M	151_H	0.579	0.21
142_E	161_K	0.579	0.21
15_T	128_T	0.577	0.21
152_D	165_M	0.573	0.20
10_L	63_L	0.571	0.20
66_V	100_W	0.571	0.20
125_H	239_C	0.570	0.20
39_M	127_D	0.570	0.20
125_H	161_K	0.568	0.20
105_D	183_L	0.565	0.20
37_E	59_A	0.560	0.20
131_L	139_F	0.559	0.20
22_D	98_Y	0.559	0.20
76_A	182_V	0.558	0.20
105_D	162_I	0.557	0.20
165_M	180_D	0.557	0.20
107_K	240_E	0.557	0.20
45_L	202_R	0.557	0.20
51_S	231_Y	0.556	0.20
221_L	243_I	0.553	0.20
35_L	68_N	0.551	0.19
239_C	242_L	0.549	0.19
81_W	100_W	0.549	0.19
47_I	55_I	0.548	0.19
59_A	181_G	0.548	0.19
118_K	215_M	0.547	0.19
140_F	143_V	0.546	0.19
82_Q	89_E	0.544	0.19
110_L	242_L	0.543	0.19
66_V	149_E	0.543	0.19
128_T	237_A	0.542	0.19
60_T	213_S	0.542	0.19
78_A	232_L	0.542	0.19
77_C	151_H	0.540	0.19
4_A	125_H	0.540	0.19
230_Q	243_I	0.538	0.19
98_Y	241_K	0.537	0.19
127_D	194_E	0.537	0.19
148_D	216_H	0.535	0.19
15_T	171_L	0.534	0.19
187_N	204_Y	0.533	0.19
160_V	243_I	0.531	0.19
107_K	121_P	0.528	0.18
17_I	38_M	0.527	0.18
89_E	160_V	0.522	0.18
51_S	201_L	0.521	0.18
198_T	209_S	0.520	0.18
124_D	241_K	0.519	0.18
11_T	18_M	0.519	0.18
78_A	134_R	0.517	0.18
80_E	213_S	0.517	0.18
142_E	162_I	0.516	0.18
169_F	199_Y	0.516	0.18
160_V	236_E	0.516	0.18
65_C	78_A	0.515	0.18
193_H	197_K	0.512	0.18
5_S	195_A	0.509	0.18
73_L	179_I	0.509	0.18
163_R	174_R	0.508	0.18
229_S	235_K	0.508	0.18
8_W	166_P	0.508	0.18
65_C	157_S	0.504	0.18
10_L	45_L	0.503	0.18
80_E	210_K	0.501	0.17
77_C	84_S	0.500	0.17
3_M	219_P	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3og2_A	1	0.3171	35.3	0.963	Contact Map
3ke2_A	1	0.1463	18.9	0.968	Contact Map
4e6n_A	1	0.2154	15.1	0.969	Contact Map
1tg7_A	1	0.3171	11.5	0.971	Contact Map
4kgm_A	1	0.3577	8.5	0.972	Contact Map
2kts_A	1	0.252	5.6	0.974	Contact Map
3wbz_A	1	0.3699	4.8	0.975	Contact Map
1gu3_A	1	0.5244	4.4	0.976	Contact Map
1nkg_A	1	0.2683	4.4	0.976	Contact Map
1kcq_A	1	0.2276	4.2	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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