GREMLIN Database
T0864_1_246 - T0864 1-246
ID: 5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 246 (241)
Sequences: 467 (328)
Seq/√Len: 21.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_N61_D6.6111.00
129_E132_K5.4271.00
65_C105_D4.7821.00
148_D151_H4.6121.00
209_S213_S3.6191.00
103_T183_L3.3521.00
168_S192_Y3.3371.00
135_E167_S3.3161.00
12_A141_E3.1891.00
49_H52_G3.1461.00
61_D109_T3.0490.99
46_R56_E2.6680.99
158_L173_L2.6500.98
124_D199_Y2.6080.98
26_L60_T2.5850.98
104_T146_F2.4920.98
169_F193_H2.3250.96
47_I171_L2.3030.96
131_L137_I2.2440.96
122_T201_L2.2070.95
4_A9_K2.2000.95
9_K48_Q2.0050.92
142_E159_S1.9320.91
29_E60_T1.9070.90
103_T229_S1.9070.90
107_K202_R1.8890.89
130_K194_E1.8790.89
74_K240_E1.8670.89
207_R229_S1.8660.89
38_M149_E1.8550.89
136_Q146_F1.8480.88
60_T101_T1.7450.85
185_R208_E1.7350.85
55_I191_L1.6780.83
142_E160_V1.6240.81
48_Q54_G1.5970.80
184_I214_L1.5870.79
234_I237_A1.5740.79
22_D42_D1.5580.78
130_K192_Y1.5560.78
18_M30_L1.5410.77
203_E237_A1.5370.77
137_I165_M1.5300.77
135_E168_S1.5120.76
17_I149_E1.4880.75
229_S233_P1.4810.74
19_K22_D1.4650.73
124_D201_L1.4260.71
176_F228_I1.4000.70
13_S44_V1.3980.70
119_V122_T1.3590.67
187_N206_S1.3580.67
77_C181_G1.3480.67
133_A136_Q1.3430.67
215_M218_P1.3420.66
25_K29_E1.3410.66
184_I227_E1.3360.66
98_Y103_T1.3180.65
58_N155_V1.3070.64
11_T48_Q1.2980.64
91_S98_Y1.2960.64
143_V160_V1.2850.63
6_G203_E1.2780.63
204_Y239_C1.2660.62
40_F147_E1.2660.62
140_F161_K1.2600.61
106_Y145_L1.2560.61
228_I232_L1.2490.61
47_I169_F1.2470.61
103_T121_P1.2400.60
12_A176_F1.2180.59
132_K201_L1.2090.58
45_L171_L1.2040.58
137_I152_D1.2020.58
46_R181_G1.1880.57
66_V97_P1.1870.57
210_K213_S1.1730.56
72_M179_I1.1660.55
24_E158_L1.1520.54
106_Y109_T1.1480.54
32_M98_Y1.1440.54
20_S124_D1.1430.54
141_E161_K1.1340.53
99_D108_G1.1310.53
14_K141_E1.1290.53
107_K204_Y1.1220.52
160_V173_L1.1170.52
144_L156_S1.1150.52
131_L165_M1.1110.52
128_T167_S1.1020.51
151_H156_S1.1000.51
15_T18_M1.0990.51
12_A45_L1.0970.51
5_S16_H1.0970.51
75_V185_R1.0950.51
110_L122_T1.0940.51
16_H32_M1.0860.50
3_M184_I1.0850.50
59_A84_S1.0730.49
8_W47_I1.0590.48
29_E64_R1.0500.48
18_M148_D1.0490.48
123_T181_G1.0480.48
12_A158_L1.0310.46
62_A78_A1.0310.46
146_F198_T1.0110.45
131_L152_D1.0050.45
27_A124_D0.9950.44
126_I232_L0.9920.44
20_S199_Y0.9910.44
168_S193_H0.9840.43
38_M101_T0.9730.43
87_E220_S0.9730.43
149_E177_L0.9720.43
104_T109_T0.9710.42
74_K102_Y0.9680.42
185_R189_T0.9640.42
104_T158_L0.9580.42
78_A98_Y0.9570.42
35_L179_I0.9540.41
22_D41_G0.9530.41
211_I227_E0.9480.41
138_K195_A0.9480.41
18_M98_Y0.9470.41
104_T186_M0.9420.41
194_E242_L0.9360.40
33_P102_Y0.9320.40
101_T130_K0.9300.40
206_S236_E0.9240.39
122_T238_V0.9190.39
28_D196_D0.9150.39
127_D181_G0.9140.39
10_L123_T0.9110.39
31_H102_Y0.9100.39
144_L155_V0.9100.39
189_T202_R0.9090.39
147_E150_L0.9080.38
10_L47_I0.9040.38
199_Y241_K0.8970.38
60_T78_A0.8950.38
23_V98_Y0.8940.38
43_N74_K0.8920.37
18_M41_G0.8830.37
25_K28_D0.8760.36
7_P52_G0.8750.36
53_F192_Y0.8740.36
140_F207_R0.8730.36
55_I200_M0.8680.36
163_R180_D0.8640.36
73_L207_R0.8630.36
62_A75_V0.8540.35
72_M222_F0.8500.35
29_E144_L0.8490.35
45_L162_I0.8460.35
93_E96_K0.8450.35
240_E244_F0.8410.34
7_P238_V0.8350.34
77_C127_D0.8290.34
9_K50_G0.8270.33
110_L237_A0.8250.33
162_I171_L0.8240.33
42_D102_Y0.8240.33
38_M66_V0.8240.33
110_L121_P0.8230.33
231_Y234_I0.8200.33
152_D190_R0.8200.33
186_M225_P0.8170.33
41_G211_I0.8130.33
16_H188_D0.8130.33
45_L169_F0.8120.33
130_K176_F0.8110.33
39_M126_I0.8080.32
206_S228_I0.8070.32
47_I120_V0.8070.32
143_V201_L0.8040.32
34_S37_E0.8000.32
28_D113_E0.7980.32
197_K234_I0.7970.32
3_M10_L0.7960.32
184_I216_H0.7910.31
163_R190_R0.7910.31
107_K238_V0.7910.31
79_E83_E0.7910.31
181_G194_E0.7900.31
179_I207_R0.7880.31
54_G129_E0.7870.31
149_E152_D0.7860.31
77_C222_F0.7820.31
146_F160_V0.7780.31
148_D167_S0.7750.30
151_H224_E0.7730.30
58_N109_T0.7670.30
45_L49_H0.7570.29
183_L213_S0.7560.29
145_L185_R0.7490.29
173_L179_I0.7470.29
156_S175_F0.7470.29
77_C153_H0.7390.28
3_M162_I0.7390.28
74_K225_P0.7370.28
241_K244_F0.7360.28
154_G172_L0.7360.28
43_N96_K0.7360.28
14_K41_G0.7350.28
93_E161_K0.7320.28
149_E156_S0.7300.28
74_K77_C0.7290.28
41_G143_V0.7280.28
224_E229_S0.7270.28
84_S183_L0.7240.28
240_E245_P0.7240.28
55_I171_L0.7180.27
13_S162_I0.7170.27
225_P228_I0.7160.27
46_R54_G0.7160.27
149_E182_V0.7140.27
16_H22_D0.7110.27
26_L30_L0.7050.27
201_L240_E0.7010.26
152_D180_D0.7000.26
88_G220_S0.6960.26
108_G154_G0.6930.26
81_W152_D0.6930.26
50_G219_P0.6910.26
207_R234_I0.6880.26
172_L180_D0.6870.26
18_M35_L0.6850.26
109_T145_L0.6800.25
58_N138_K0.6740.25
103_T185_R0.6720.25
74_K177_L0.6720.25
223_T226_N0.6660.25
61_D110_L0.6620.24
55_I221_L0.6620.24
8_W90_H0.6610.24
225_P242_L0.6570.24
73_L204_Y0.6560.24
8_W177_L0.6560.24
150_L185_R0.6550.24
53_F188_D0.6520.24
123_T210_K0.6510.24
223_T229_S0.6460.24
121_P238_V0.6440.24
56_E111_L0.6420.24
110_L201_L0.6410.23
112_G191_L0.6410.23
54_G111_L0.6400.23
125_H156_S0.6390.23
102_Y127_D0.6380.23
45_L173_L0.6370.23
109_T129_E0.6360.23
15_T162_I0.6330.23
188_D229_S0.6310.23
88_G216_H0.6290.23
18_M60_T0.6280.23
83_E158_L0.6260.23
225_P237_A0.6260.23
74_K166_P0.6260.23
27_A77_C0.6230.23
45_L144_L0.6220.23
99_D154_G0.6220.23
6_G123_T0.6220.23
34_S173_L0.6210.23
151_H175_F0.6210.23
151_H211_I0.6200.22
61_D186_M0.6190.22
67_N176_F0.6180.22
170_F188_D0.6180.22
45_L214_L0.6170.22
96_K176_F0.6160.22
221_L229_S0.6160.22
27_A35_L0.6150.22
8_W165_M0.6130.22
130_K168_S0.6100.22
97_P139_F0.6090.22
80_E165_M0.6080.22
66_V96_K0.6070.22
84_S192_Y0.6050.22
186_M231_Y0.6040.22
158_L184_I0.6020.22
61_D106_Y0.6000.22
221_L233_P0.5990.22
54_G196_D0.5960.21
16_H33_P0.5960.21
119_V140_F0.5950.21
18_M141_E0.5940.21
218_P245_P0.5940.21
47_I233_P0.5910.21
191_L200_M0.5900.21
148_D211_I0.5900.21
80_E85_R0.5880.21
16_H127_D0.5840.21
57_F189_T0.5840.21
174_R188_D0.5810.21
41_G98_Y0.5810.21
85_R88_G0.5800.21
18_M151_H0.5790.21
142_E161_K0.5790.21
15_T128_T0.5770.21
152_D165_M0.5730.20
10_L63_L0.5710.20
66_V100_W0.5710.20
125_H239_C0.5700.20
39_M127_D0.5700.20
125_H161_K0.5680.20
105_D183_L0.5650.20
37_E59_A0.5600.20
131_L139_F0.5590.20
22_D98_Y0.5590.20
76_A182_V0.5580.20
105_D162_I0.5570.20
165_M180_D0.5570.20
107_K240_E0.5570.20
45_L202_R0.5570.20
51_S231_Y0.5560.20
221_L243_I0.5530.20
35_L68_N0.5510.19
239_C242_L0.5490.19
81_W100_W0.5490.19
47_I55_I0.5480.19
59_A181_G0.5480.19
118_K215_M0.5470.19
140_F143_V0.5460.19
82_Q89_E0.5440.19
110_L242_L0.5430.19
66_V149_E0.5430.19
128_T237_A0.5420.19
60_T213_S0.5420.19
78_A232_L0.5420.19
77_C151_H0.5400.19
4_A125_H0.5400.19
230_Q243_I0.5380.19
98_Y241_K0.5370.19
127_D194_E0.5370.19
148_D216_H0.5350.19
15_T171_L0.5340.19
187_N204_Y0.5330.19
160_V243_I0.5310.19
107_K121_P0.5280.18
17_I38_M0.5270.18
89_E160_V0.5220.18
51_S201_L0.5210.18
198_T209_S0.5200.18
124_D241_K0.5190.18
11_T18_M0.5190.18
78_A134_R0.5170.18
80_E213_S0.5170.18
142_E162_I0.5160.18
169_F199_Y0.5160.18
160_V236_E0.5160.18
65_C78_A0.5150.18
193_H197_K0.5120.18
5_S195_A0.5090.18
73_L179_I0.5090.18
163_R174_R0.5080.18
229_S235_K0.5080.18
8_W166_P0.5080.18
65_C157_S0.5040.18
10_L45_L0.5030.18
80_E210_K0.5010.17
77_C84_S0.5000.17
3_M219_P0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3og2_A 1 0.3171 35.3 0.963 Contact Map
3ke2_A 1 0.1463 18.9 0.968 Contact Map
4e6n_A 1 0.2154 15.1 0.969 Contact Map
1tg7_A 1 0.3171 11.5 0.971 Contact Map
4kgm_A 1 0.3577 8.5 0.972 Contact Map
2kts_A 1 0.252 5.6 0.974 Contact Map
3wbz_A 1 0.3699 4.8 0.975 Contact Map
1gu3_A 1 0.5244 4.4 0.976 Contact Map
1nkg_A 1 0.2683 4.4 0.976 Contact Map
1kcq_A 1 0.2276 4.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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