GREMLIN Database
T0893_1_242 - T0893 1-242
ID: 44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 242 (238)
Sequences: 2923 (1975)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_R142_G4.9251.00
112_P151_R4.8991.00
32_L52_I4.2871.00
182_P185_V4.0021.00
83_G149_T3.8931.00
181_I185_V3.5901.00
226_R229_E3.5851.00
112_P239_V3.3351.00
181_I189_I3.3101.00
223_V233_F3.1451.00
189_I223_V3.0481.00
29_Q56_G2.9931.00
136_V145_V2.8001.00
190_F221_I2.7951.00
153_T168_D2.7301.00
171_F234_R2.6371.00
136_V177_D2.4891.00
128_L174_V2.4441.00
106_D148_R2.4261.00
181_I187_G2.2131.00
35_L49_L2.2021.00
129_A145_V2.1841.00
36_L50_N2.1741.00
83_G107_Y2.1481.00
104_I144_V2.1481.00
107_Y149_T2.1401.00
102_K144_V2.0961.00
150_A171_F2.0071.00
155_D158_I1.9911.00
224_H234_R1.9741.00
175_S232_A1.9731.00
173_E232_A1.9661.00
173_E234_R1.9641.00
90_E94_R1.9531.00
154_R167_G1.9481.00
111_L151_R1.9301.00
35_L45_S1.8851.00
168_D239_V1.8701.00
198_P201_E1.8701.00
183_P186_M1.8561.00
182_P227_P1.8071.00
3_Q6_K1.8021.00
124_A235_I1.7791.00
82_L172_I1.7381.00
151_R239_V1.7241.00
136_V142_G1.6711.00
148_R173_E1.6641.00
148_R175_S1.6531.00
79_V115_R1.6521.00
80_L116_A1.6481.00
189_I233_F1.6451.00
36_L53_R1.6371.00
104_I146_R1.4921.00
36_L46_Y1.4671.00
29_Q53_R1.4571.00
214_V221_I1.4511.00
210_V221_I1.4431.00
121_L172_I1.4321.00
124_A210_V1.4221.00
81_D84_E1.3861.00
24_L59_A1.3821.00
32_L49_L1.3711.00
81_D113_Q1.3661.00
75_V217_S1.3531.00
106_D146_R1.3461.00
123_T213_I1.3341.00
97_L103_L1.3321.00
185_V189_I1.3141.00
82_L170_A1.3061.00
27_A55_T1.2871.00
88_E122_E1.2731.00
213_I217_S1.2671.00
152_L171_F1.2601.00
158_I224_H1.2140.99
93_L129_A1.1930.99
114_V237_L1.1820.99
46_Y50_N1.1620.99
89_F122_E1.1570.99
111_L170_A1.1560.99
33_D53_R1.1470.99
35_L52_I1.1460.99
114_V170_A1.1330.99
108_G149_T1.1310.99
1_L4_A1.1280.99
28_I56_G1.1270.99
137_R141_G1.1120.99
186_M225_S1.0970.99
152_L236_F1.0890.99
93_L103_L1.0820.99
90_E103_L1.0800.99
61_D65_K1.0720.99
78_E118_K1.0720.99
181_I186_M1.0650.99
39_H45_S1.0640.99
170_A239_V1.0530.98
137_R179_P1.0420.98
4_A7_M1.0410.98
151_R170_A1.0390.98
116_A217_S1.0360.98
80_L121_L1.0340.98
82_L114_V1.0330.98
146_R177_D1.0290.98
86_I149_T1.0250.98
124_A213_I1.0120.98
31_R52_I1.0120.98
68_A73_Q1.0000.98
31_R51_E0.9890.98
5_Q8_Q0.9870.98
175_S224_H0.9860.98
183_P187_G0.9790.98
89_F126_M0.9750.97
92_L96_L0.9740.97
98_R133_R0.9740.97
57_V61_D0.9660.97
166_D169_T0.9580.97
77_R217_S0.9500.97
111_L149_T0.9380.97
151_R168_D0.9360.97
171_F236_F0.9340.97
211_Y215_K0.9300.97
29_Q33_D0.9270.97
189_I221_I0.9200.96
29_Q49_L0.9130.96
190_F233_F0.9090.96
148_R224_H0.9080.96
27_A34_Q0.9070.96
214_V237_L0.9060.96
31_R48_G0.9050.96
168_D241_E0.8990.96
222_H234_R0.8970.96
68_A75_V0.8960.96
113_Q240_Y0.8920.96
34_Q48_G0.8910.96
75_V216_Q0.8880.96
134_D197_K0.8830.96
150_A173_E0.8700.95
76_Q79_V0.8630.95
113_Q151_R0.8610.95
14_A123_T0.8600.95
77_R116_A0.8560.95
79_V113_Q0.8540.95
73_Q216_Q0.8510.95
224_H232_A0.8500.94
124_A214_V0.8490.94
186_M233_F0.8400.94
8_Q12_Q0.8310.94
158_I162_F0.8290.94
188_K191_D0.8280.94
50_N54_Q0.8220.93
108_G111_L0.8060.93
225_S231_A0.8040.93
53_R57_V0.8040.93
21_F27_A0.8000.92
83_G108_G0.7920.92
26_T63_V0.7910.92
14_A209_T0.7870.92
112_P170_A0.7830.92
93_L97_L0.7830.92
125_V172_I0.7800.92
154_R166_D0.7800.92
33_D36_L0.7790.91
95_R99_E0.7770.91
29_Q57_V0.7760.91
67_L117_D0.7710.91
30_L34_Q0.7660.91
71_R122_E0.7660.91
169_T236_F0.7640.91
28_I55_T0.7640.91
165_A169_T0.7620.91
130_V209_T0.7610.91
186_M223_V0.7600.90
38_R45_S0.7570.90
3_Q9_A0.7530.90
116_A121_L0.7510.90
83_G87_S0.7450.90
142_G179_P0.7410.89
35_L48_G0.7400.89
90_E105_T0.7400.89
134_D195_T0.7380.89
8_Q14_A0.7360.89
185_V194_F0.7350.89
32_L53_R0.7320.89
68_A120_Q0.7210.88
154_R169_T0.7170.88
224_H229_E0.7140.88
27_A31_R0.7130.87
26_T72_K0.7100.87
99_E123_T0.7070.87
176_D180_G0.7050.87
31_R55_T0.7020.87
40_P46_Y0.6990.86
135_A195_T0.6970.86
80_L85_L0.6940.86
214_V235_I0.6900.86
83_G111_L0.6830.85
82_L111_L0.6800.85
5_Q14_A0.6770.85
16_G22_N0.6740.84
2_S9_A0.6740.84
13_L16_G0.6730.84
154_R158_I0.6720.84
198_P203_T0.6720.84
110_D151_R0.6700.84
10_I70_S0.6680.84
41_V46_Y0.6610.83
102_K145_V0.6520.82
72_K191_D0.6480.82
74_T77_R0.6470.82
27_A63_V0.6460.82
127_N202_G0.6460.82
134_D201_E0.6440.82
40_P43_D0.6430.81
2_S12_Q0.6410.81
212_G216_Q0.6400.81
48_G59_A0.6400.81
144_V175_S0.6380.81
123_T130_V0.6370.81
59_A74_T0.6370.81
87_S90_E0.6360.81
116_A237_L0.6350.81
15_G208_A0.6310.80
183_P241_E0.6310.80
109_R168_D0.6310.80
65_K123_T0.6300.80
134_D196_T0.6290.80
52_I65_K0.6280.80
111_L239_V0.6240.80
181_I207_L0.6230.79
12_Q63_V0.6220.79
135_A196_T0.6220.79
222_H236_F0.6190.79
65_K209_T0.6160.79
136_V143_G0.6160.79
80_L114_V0.6150.79
74_T99_E0.6130.78
146_R175_S0.6130.78
6_K9_A0.6120.78
30_L56_G0.6090.78
209_T213_I0.6070.78
127_N203_T0.6060.78
73_Q208_A0.6040.77
115_R240_Y0.6020.77
123_T217_S0.6010.77
71_R203_T0.5990.77
52_I55_T0.5970.76
158_I222_H0.5970.76
33_D56_G0.5960.76
71_R200_G0.5940.76
26_T34_Q0.5940.76
28_I59_A0.5930.76
87_S229_E0.5900.76
184_D227_P0.5890.76
99_E209_T0.5890.76
159_Q162_F0.5880.75
61_D64_R0.5880.75
108_G150_A0.5870.75
104_I109_R0.5830.75
179_P227_P0.5820.75
16_G58_R0.5800.74
36_L49_L0.5800.74
82_L116_A0.5790.74
26_T29_Q0.5760.74
225_S228_N0.5750.74
84_E88_E0.5750.74
63_V67_L0.5730.74
52_I124_A0.5700.73
157_A163_P0.5700.73
123_T214_V0.5680.73
24_L207_L0.5680.73
86_I147_I0.5680.73
94_R99_E0.5670.73
51_E54_Q0.5670.73
22_N135_A0.5660.73
85_L122_E0.5650.73
96_L126_M0.5640.72
121_L213_I0.5640.72
26_T119_S0.5630.72
227_P231_A0.5610.72
102_K105_T0.5600.72
66_L208_A0.5600.72
76_Q118_K0.5590.72
63_V98_R0.5570.71
82_L121_L0.5560.71
38_R48_G0.5550.71
39_H44_P0.5540.71
200_G203_T0.5530.71
74_T123_T0.5520.71
5_Q143_G0.5520.71
185_V188_K0.5520.71
94_R102_K0.5520.71
87_S108_G0.5520.71
51_E55_T0.5510.71
76_Q130_V0.5500.71
179_P231_A0.5500.71
214_V220_W0.5490.70
79_V240_Y0.5490.70
77_R118_K0.5480.70
80_L119_S0.5480.70
131_N176_D0.5480.70
124_A217_S0.5470.70
118_K217_S0.5430.70
32_L36_L0.5430.70
106_D168_D0.5420.69
27_A51_E0.5420.69
86_I172_I0.5410.69
12_Q188_K0.5400.69
26_T48_G0.5370.69
131_N204_G0.5370.69
82_L123_T0.5370.69
156_E160_L0.5370.69
131_N206_G0.5350.68
27_A59_A0.5330.68
92_L130_V0.5320.68
129_A147_I0.5300.68
30_L211_Y0.5300.68
70_S74_T0.5290.68
26_T56_G0.5280.67
106_D110_D0.5280.67
153_T156_E0.5270.67
8_Q15_G0.5270.67
197_K203_T0.5260.67
135_A197_K0.5250.67
126_M130_V0.5250.67
72_K209_T0.5240.67
65_K92_L0.5240.67
61_D91_V0.5240.67
12_Q66_L0.5240.67
39_H49_L0.5240.67
16_G69_F0.5230.67
43_D46_Y0.5220.67
32_L56_G0.5210.66
35_L55_T0.5200.66
18_A23_N0.5200.66
21_F63_V0.5190.66
110_D226_R0.5190.66
15_G20_D0.5180.66
162_F222_H0.5170.66
134_D203_T0.5160.66
114_V186_M0.5150.66
212_G215_K0.5140.65
19_H23_N0.5120.65
131_N180_G0.5120.65
79_V87_S0.5120.65
195_T200_G0.5120.65
45_S49_L0.5110.65
155_D162_F0.5070.64
131_N178_G0.5050.64
106_D150_A0.5040.64
145_V177_D0.5040.64
70_S161_G0.5040.64
121_L217_S0.5030.64
17_V191_D0.5030.64
15_G211_Y0.5020.64
156_E159_Q0.5010.63
31_R59_A0.5000.63
97_L129_A0.5000.63
192_P197_K0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a0r_A 1 0.8926 100 0.368 Contact Map
4gcz_A 1 0.9298 100 0.387 Contact Map
4i5s_A 1 0.8719 100 0.405 Contact Map
3d36_A 1 0.876 100 0.413 Contact Map
4u7o_A 1 0.9174 100 0.426 Contact Map
4q20_A 1 0.9091 100 0.428 Contact Map
4mpc_A 1 0.8843 100 0.43 Contact Map
2e0a_A 1 0.9174 100 0.434 Contact Map
4e01_A 1 0.9091 100 0.435 Contact Map
2q8g_A 1 0.9008 100 0.446 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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