T0893_1_242 - CASP12 - GREMLIN Contacts

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T0893_1_242 - T0893 1-242

ID:	44	Sequences: LSQAQKMQAIGQLAGGVAHDFNNLLTAIQLRLDQLLHRHPVGDPSYEGLNEIRQTGVRAADLVRKLLAFSRKQTVQREVLDLGELISEFEVLLRRLLREDVKLITDYGRDLPQVRADKSQLETAVMNLAVNARDAVRAAKGGGVVRIRTARLTRDEAIQLGFPAADGDTAFIEVSDDGPGIPPDVMGKIFDPFFTTKPVGEGTGLGLATVYGIVKQSDGWIHVHSRPNEGAAFRIFLPVYEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	242 (238)
Sequences:	2923 (1975)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
137_R	142_G	4.925	1.00
112_P	151_R	4.899	1.00
32_L	52_I	4.287	1.00
182_P	185_V	4.002	1.00
83_G	149_T	3.893	1.00
181_I	185_V	3.590	1.00
226_R	229_E	3.585	1.00
112_P	239_V	3.335	1.00
181_I	189_I	3.310	1.00
223_V	233_F	3.145	1.00
189_I	223_V	3.048	1.00
29_Q	56_G	2.993	1.00
136_V	145_V	2.800	1.00
190_F	221_I	2.795	1.00
153_T	168_D	2.730	1.00
171_F	234_R	2.637	1.00
136_V	177_D	2.489	1.00
128_L	174_V	2.444	1.00
106_D	148_R	2.426	1.00
181_I	187_G	2.213	1.00
35_L	49_L	2.202	1.00
129_A	145_V	2.184	1.00
36_L	50_N	2.174	1.00
83_G	107_Y	2.148	1.00
104_I	144_V	2.148	1.00
107_Y	149_T	2.140	1.00
102_K	144_V	2.096	1.00
150_A	171_F	2.007	1.00
155_D	158_I	1.991	1.00
224_H	234_R	1.974	1.00
175_S	232_A	1.973	1.00
173_E	232_A	1.966	1.00
173_E	234_R	1.964	1.00
90_E	94_R	1.953	1.00
154_R	167_G	1.948	1.00
111_L	151_R	1.930	1.00
35_L	45_S	1.885	1.00
168_D	239_V	1.870	1.00
198_P	201_E	1.870	1.00
183_P	186_M	1.856	1.00
182_P	227_P	1.807	1.00
3_Q	6_K	1.802	1.00
124_A	235_I	1.779	1.00
82_L	172_I	1.738	1.00
151_R	239_V	1.724	1.00
136_V	142_G	1.671	1.00
148_R	173_E	1.664	1.00
148_R	175_S	1.653	1.00
79_V	115_R	1.652	1.00
80_L	116_A	1.648	1.00
189_I	233_F	1.645	1.00
36_L	53_R	1.637	1.00
104_I	146_R	1.492	1.00
36_L	46_Y	1.467	1.00
29_Q	53_R	1.457	1.00
214_V	221_I	1.451	1.00
210_V	221_I	1.443	1.00
121_L	172_I	1.432	1.00
124_A	210_V	1.422	1.00
81_D	84_E	1.386	1.00
24_L	59_A	1.382	1.00
32_L	49_L	1.371	1.00
81_D	113_Q	1.366	1.00
75_V	217_S	1.353	1.00
106_D	146_R	1.346	1.00
123_T	213_I	1.334	1.00
97_L	103_L	1.332	1.00
185_V	189_I	1.314	1.00
82_L	170_A	1.306	1.00
27_A	55_T	1.287	1.00
88_E	122_E	1.273	1.00
213_I	217_S	1.267	1.00
152_L	171_F	1.260	1.00
158_I	224_H	1.214	0.99
93_L	129_A	1.193	0.99
114_V	237_L	1.182	0.99
46_Y	50_N	1.162	0.99
89_F	122_E	1.157	0.99
111_L	170_A	1.156	0.99
33_D	53_R	1.147	0.99
35_L	52_I	1.146	0.99
114_V	170_A	1.133	0.99
108_G	149_T	1.131	0.99
1_L	4_A	1.128	0.99
28_I	56_G	1.127	0.99
137_R	141_G	1.112	0.99
186_M	225_S	1.097	0.99
152_L	236_F	1.089	0.99
93_L	103_L	1.082	0.99
90_E	103_L	1.080	0.99
61_D	65_K	1.072	0.99
78_E	118_K	1.072	0.99
181_I	186_M	1.065	0.99
39_H	45_S	1.064	0.99
170_A	239_V	1.053	0.98
137_R	179_P	1.042	0.98
4_A	7_M	1.041	0.98
151_R	170_A	1.039	0.98
116_A	217_S	1.036	0.98
80_L	121_L	1.034	0.98
82_L	114_V	1.033	0.98
146_R	177_D	1.029	0.98
86_I	149_T	1.025	0.98
124_A	213_I	1.012	0.98
31_R	52_I	1.012	0.98
68_A	73_Q	1.000	0.98
31_R	51_E	0.989	0.98
5_Q	8_Q	0.987	0.98
175_S	224_H	0.986	0.98
183_P	187_G	0.979	0.98
89_F	126_M	0.975	0.97
92_L	96_L	0.974	0.97
98_R	133_R	0.974	0.97
57_V	61_D	0.966	0.97
166_D	169_T	0.958	0.97
77_R	217_S	0.950	0.97
111_L	149_T	0.938	0.97
151_R	168_D	0.936	0.97
171_F	236_F	0.934	0.97
211_Y	215_K	0.930	0.97
29_Q	33_D	0.927	0.97
189_I	221_I	0.920	0.96
29_Q	49_L	0.913	0.96
190_F	233_F	0.909	0.96
148_R	224_H	0.908	0.96
27_A	34_Q	0.907	0.96
214_V	237_L	0.906	0.96
31_R	48_G	0.905	0.96
168_D	241_E	0.899	0.96
222_H	234_R	0.897	0.96
68_A	75_V	0.896	0.96
113_Q	240_Y	0.892	0.96
34_Q	48_G	0.891	0.96
75_V	216_Q	0.888	0.96
134_D	197_K	0.883	0.96
150_A	173_E	0.870	0.95
76_Q	79_V	0.863	0.95
113_Q	151_R	0.861	0.95
14_A	123_T	0.860	0.95
77_R	116_A	0.856	0.95
79_V	113_Q	0.854	0.95
73_Q	216_Q	0.851	0.95
224_H	232_A	0.850	0.94
124_A	214_V	0.849	0.94
186_M	233_F	0.840	0.94
8_Q	12_Q	0.831	0.94
158_I	162_F	0.829	0.94
188_K	191_D	0.828	0.94
50_N	54_Q	0.822	0.93
108_G	111_L	0.806	0.93
225_S	231_A	0.804	0.93
53_R	57_V	0.804	0.93
21_F	27_A	0.800	0.92
83_G	108_G	0.792	0.92
26_T	63_V	0.791	0.92
14_A	209_T	0.787	0.92
112_P	170_A	0.783	0.92
93_L	97_L	0.783	0.92
125_V	172_I	0.780	0.92
154_R	166_D	0.780	0.92
33_D	36_L	0.779	0.91
95_R	99_E	0.777	0.91
29_Q	57_V	0.776	0.91
67_L	117_D	0.771	0.91
30_L	34_Q	0.766	0.91
71_R	122_E	0.766	0.91
169_T	236_F	0.764	0.91
28_I	55_T	0.764	0.91
165_A	169_T	0.762	0.91
130_V	209_T	0.761	0.91
186_M	223_V	0.760	0.90
38_R	45_S	0.757	0.90
3_Q	9_A	0.753	0.90
116_A	121_L	0.751	0.90
83_G	87_S	0.745	0.90
142_G	179_P	0.741	0.89
35_L	48_G	0.740	0.89
90_E	105_T	0.740	0.89
134_D	195_T	0.738	0.89
8_Q	14_A	0.736	0.89
185_V	194_F	0.735	0.89
32_L	53_R	0.732	0.89
68_A	120_Q	0.721	0.88
154_R	169_T	0.717	0.88
224_H	229_E	0.714	0.88
27_A	31_R	0.713	0.87
26_T	72_K	0.710	0.87
99_E	123_T	0.707	0.87
176_D	180_G	0.705	0.87
31_R	55_T	0.702	0.87
40_P	46_Y	0.699	0.86
135_A	195_T	0.697	0.86
80_L	85_L	0.694	0.86
214_V	235_I	0.690	0.86
83_G	111_L	0.683	0.85
82_L	111_L	0.680	0.85
5_Q	14_A	0.677	0.85
16_G	22_N	0.674	0.84
2_S	9_A	0.674	0.84
13_L	16_G	0.673	0.84
154_R	158_I	0.672	0.84
198_P	203_T	0.672	0.84
110_D	151_R	0.670	0.84
10_I	70_S	0.668	0.84
41_V	46_Y	0.661	0.83
102_K	145_V	0.652	0.82
72_K	191_D	0.648	0.82
74_T	77_R	0.647	0.82
27_A	63_V	0.646	0.82
127_N	202_G	0.646	0.82
134_D	201_E	0.644	0.82
40_P	43_D	0.643	0.81
2_S	12_Q	0.641	0.81
212_G	216_Q	0.640	0.81
48_G	59_A	0.640	0.81
144_V	175_S	0.638	0.81
123_T	130_V	0.637	0.81
59_A	74_T	0.637	0.81
87_S	90_E	0.636	0.81
116_A	237_L	0.635	0.81
15_G	208_A	0.631	0.80
183_P	241_E	0.631	0.80
109_R	168_D	0.631	0.80
65_K	123_T	0.630	0.80
134_D	196_T	0.629	0.80
52_I	65_K	0.628	0.80
111_L	239_V	0.624	0.80
181_I	207_L	0.623	0.79
12_Q	63_V	0.622	0.79
135_A	196_T	0.622	0.79
222_H	236_F	0.619	0.79
65_K	209_T	0.616	0.79
136_V	143_G	0.616	0.79
80_L	114_V	0.615	0.79
74_T	99_E	0.613	0.78
146_R	175_S	0.613	0.78
6_K	9_A	0.612	0.78
30_L	56_G	0.609	0.78
209_T	213_I	0.607	0.78
127_N	203_T	0.606	0.78
73_Q	208_A	0.604	0.77
115_R	240_Y	0.602	0.77
123_T	217_S	0.601	0.77
71_R	203_T	0.599	0.77
52_I	55_T	0.597	0.76
158_I	222_H	0.597	0.76
33_D	56_G	0.596	0.76
71_R	200_G	0.594	0.76
26_T	34_Q	0.594	0.76
28_I	59_A	0.593	0.76
87_S	229_E	0.590	0.76
184_D	227_P	0.589	0.76
99_E	209_T	0.589	0.76
159_Q	162_F	0.588	0.75
61_D	64_R	0.588	0.75
108_G	150_A	0.587	0.75
104_I	109_R	0.583	0.75
179_P	227_P	0.582	0.75
16_G	58_R	0.580	0.74
36_L	49_L	0.580	0.74
82_L	116_A	0.579	0.74
26_T	29_Q	0.576	0.74
225_S	228_N	0.575	0.74
84_E	88_E	0.575	0.74
63_V	67_L	0.573	0.74
52_I	124_A	0.570	0.73
157_A	163_P	0.570	0.73
123_T	214_V	0.568	0.73
24_L	207_L	0.568	0.73
86_I	147_I	0.568	0.73
94_R	99_E	0.567	0.73
51_E	54_Q	0.567	0.73
22_N	135_A	0.566	0.73
85_L	122_E	0.565	0.73
96_L	126_M	0.564	0.72
121_L	213_I	0.564	0.72
26_T	119_S	0.563	0.72
227_P	231_A	0.561	0.72
102_K	105_T	0.560	0.72
66_L	208_A	0.560	0.72
76_Q	118_K	0.559	0.72
63_V	98_R	0.557	0.71
82_L	121_L	0.556	0.71
38_R	48_G	0.555	0.71
39_H	44_P	0.554	0.71
200_G	203_T	0.553	0.71
74_T	123_T	0.552	0.71
5_Q	143_G	0.552	0.71
185_V	188_K	0.552	0.71
94_R	102_K	0.552	0.71
87_S	108_G	0.552	0.71
51_E	55_T	0.551	0.71
76_Q	130_V	0.550	0.71
179_P	231_A	0.550	0.71
214_V	220_W	0.549	0.70
79_V	240_Y	0.549	0.70
77_R	118_K	0.548	0.70
80_L	119_S	0.548	0.70
131_N	176_D	0.548	0.70
124_A	217_S	0.547	0.70
118_K	217_S	0.543	0.70
32_L	36_L	0.543	0.70
106_D	168_D	0.542	0.69
27_A	51_E	0.542	0.69
86_I	172_I	0.541	0.69
12_Q	188_K	0.540	0.69
26_T	48_G	0.537	0.69
131_N	204_G	0.537	0.69
82_L	123_T	0.537	0.69
156_E	160_L	0.537	0.69
131_N	206_G	0.535	0.68
27_A	59_A	0.533	0.68
92_L	130_V	0.532	0.68
129_A	147_I	0.530	0.68
30_L	211_Y	0.530	0.68
70_S	74_T	0.529	0.68
26_T	56_G	0.528	0.67
106_D	110_D	0.528	0.67
153_T	156_E	0.527	0.67
8_Q	15_G	0.527	0.67
197_K	203_T	0.526	0.67
135_A	197_K	0.525	0.67
126_M	130_V	0.525	0.67
72_K	209_T	0.524	0.67
65_K	92_L	0.524	0.67
61_D	91_V	0.524	0.67
12_Q	66_L	0.524	0.67
39_H	49_L	0.524	0.67
16_G	69_F	0.523	0.67
43_D	46_Y	0.522	0.67
32_L	56_G	0.521	0.66
35_L	55_T	0.520	0.66
18_A	23_N	0.520	0.66
21_F	63_V	0.519	0.66
110_D	226_R	0.519	0.66
15_G	20_D	0.518	0.66
162_F	222_H	0.517	0.66
134_D	203_T	0.516	0.66
114_V	186_M	0.515	0.66
212_G	215_K	0.514	0.65
19_H	23_N	0.512	0.65
131_N	180_G	0.512	0.65
79_V	87_S	0.512	0.65
195_T	200_G	0.512	0.65
45_S	49_L	0.511	0.65
155_D	162_F	0.507	0.64
131_N	178_G	0.505	0.64
106_D	150_A	0.504	0.64
145_V	177_D	0.504	0.64
70_S	161_G	0.504	0.64
121_L	217_S	0.503	0.64
17_V	191_D	0.503	0.64
15_G	211_Y	0.502	0.64
156_E	159_Q	0.501	0.63
31_R	59_A	0.500	0.63
97_L	129_A	0.500	0.63
192_P	197_K	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a0r_A	1	0.8926	100	0.368	Contact Map
4gcz_A	1	0.9298	100	0.387	Contact Map
4i5s_A	1	0.8719	100	0.405	Contact Map
3d36_A	1	0.876	100	0.413	Contact Map
4u7o_A	1	0.9174	100	0.426	Contact Map
4q20_A	1	0.9091	100	0.428	Contact Map
4mpc_A	1	0.8843	100	0.43	Contact Map
2e0a_A	1	0.9174	100	0.434	Contact Map
4e01_A	1	0.9091	100	0.435	Contact Map
2q8g_A	1	0.9008	100	0.446	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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