GREMLIN Database
T0892_1_193 - T0892 1-193
ID: 43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 193 (191)
Sequences: 531 (408)
Seq/√Len: 29.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_H185_Y8.0281.00
52_K56_E7.4761.00
158_L174_A3.4561.00
115_F174_A3.2921.00
20_E83_R3.0501.00
111_C123_C2.6801.00
126_T182_K2.5280.99
12_F17_Y2.4620.99
12_F15_P2.4600.99
19_V167_F2.4450.99
160_A187_V2.4300.99
83_R86_T2.2850.99
24_T76_F2.2080.98
25_A76_F2.1900.98
177_L182_K2.1650.98
158_L178_A2.0960.98
34_Y89_V2.0860.98
176_D180_K2.0270.97
124_S127_L1.9640.97
131_H174_A1.7850.94
16_P19_V1.7640.94
16_P21_L1.7060.93
78_L81_S1.6580.91
77_K81_S1.5970.90
79_A86_T1.5810.89
127_L130_S1.5260.88
120_E133_K1.5110.87
115_F156_V1.5030.87
24_T36_L1.5010.87
19_V174_A1.4880.86
122_Y128_D1.4690.85
57_K62_L1.4340.84
177_L183_A1.4320.84
15_P83_R1.4120.83
113_Q166_S1.4110.83
3_S89_V1.3990.82
161_D164_S1.3860.82
4_I20_E1.3660.81
160_A171_H1.3620.81
12_F20_E1.3610.81
146_D188_R1.3590.81
92_H147_R1.3500.80
148_K184_S1.3410.80
24_T34_Y1.3410.80
42_K172_E1.3380.79
15_P20_E1.3220.79
37_L74_S1.3190.78
123_C146_D1.3180.78
136_G151_V1.3170.78
139_Q176_D1.3130.78
6_V82_L1.3070.78
71_E115_F1.2970.77
2_P15_P1.2930.77
80_L119_G1.2870.77
115_F129_T1.2770.76
160_A185_Y1.2770.76
114_W145_F1.2670.76
115_F176_D1.2600.75
23_E147_R1.2520.75
20_E34_Y1.2410.74
154_R170_F1.2400.74
174_A183_A1.2150.72
4_I94_Q1.2070.72
29_N32_I1.1910.71
21_L58_F1.1820.70
125_P128_D1.1770.70
49_T56_E1.1760.70
33_Y189_Y1.1650.69
17_Y21_L1.1560.69
10_A158_L1.1560.69
49_T53_A1.1310.67
76_F147_R1.1220.66
78_L107_T1.1180.66
156_V183_A1.1080.65
13_P93_Y1.0990.65
39_R65_D1.0720.63
140_L156_V1.0710.63
148_K166_S1.0690.62
5_N18_L1.0670.62
33_Y147_R1.0630.62
82_L171_H1.0610.62
21_L40_I1.0600.62
114_W190_R1.0470.61
119_G164_S1.0340.60
130_S187_V1.0310.60
21_L83_R1.0300.59
113_Q170_F1.0260.59
119_G165_K1.0210.59
8_L18_L1.0190.59
11_A15_P1.0180.59
34_Y91_A1.0180.59
139_Q169_P1.0060.58
114_W144_P1.0040.57
31_T95_Y1.0030.57
132_G180_K1.0010.57
23_E146_D0.9920.57
113_Q126_T0.9860.56
37_L171_H0.9850.56
173_V181_G0.9810.56
40_I81_S0.9810.56
147_R150_G0.9800.56
85_A91_A0.9710.55
6_V35_S0.9560.54
162_I189_Y0.9490.53
90_E97_T0.9330.52
33_Y187_V0.9330.52
23_E123_C0.9240.51
25_A36_L0.9140.50
23_E33_Y0.9130.50
54_L66_G0.9100.50
44_H56_E0.9090.50
167_F174_A0.9040.50
89_V130_S0.9030.50
5_N11_A0.8980.49
37_L183_A0.8940.49
44_H50_T0.8850.48
50_T94_Q0.8840.48
171_H178_A0.8820.48
123_C189_Y0.8770.48
53_A149_F0.8750.47
26_A29_N0.8740.47
161_D191_R0.8700.47
56_E109_E0.8640.47
117_I156_V0.8600.46
46_A173_V0.8600.46
70_P176_D0.8550.46
27_S84_T0.8540.46
72_A95_Y0.8510.46
10_A33_Y0.8500.45
70_P178_A0.8500.45
75_A156_V0.8500.45
90_E143_L0.8480.45
119_G151_V0.8480.45
126_T173_V0.8460.45
33_Y150_G0.8430.45
90_E158_L0.8300.44
127_L136_G0.8170.43
60_E70_P0.8140.43
156_V174_A0.8130.43
24_T74_S0.8100.42
40_I98_A0.8080.42
81_S191_R0.8050.42
85_A115_F0.8030.42
6_V18_L0.8030.42
147_R186_R0.7990.41
62_L86_T0.7980.41
122_Y150_G0.7980.41
68_M131_H0.7950.41
63_R183_A0.7930.41
77_K189_Y0.7910.41
125_P170_F0.7860.40
8_L11_A0.7840.40
147_R189_Y0.7810.40
10_A14_S0.7800.40
29_N33_Y0.7790.40
72_A144_P0.7710.39
77_K94_Q0.7700.39
105_S126_T0.7670.39
10_A20_E0.7670.39
16_P51_D0.7610.39
116_L119_G0.7600.39
56_E148_K0.7590.38
140_L157_I0.7570.38
89_V174_A0.7570.38
38_D171_H0.7550.38
23_E28_D0.7530.38
98_A184_S0.7380.37
45_F98_A0.7310.36
51_D54_L0.7300.36
88_R92_H0.7280.36
2_P80_L0.7230.36
19_V170_F0.7220.36
171_H186_R0.7140.35
15_P34_Y0.7060.35
54_L67_H0.7040.34
133_K179_K0.7040.34
113_Q118_D0.7010.34
124_S192_S0.7010.34
87_P145_F0.6960.34
154_R157_I0.6960.34
159_Y188_R0.6940.34
157_I165_K0.6930.34
167_F171_H0.6860.33
11_A34_Y0.6860.33
79_A149_F0.6840.33
15_P19_V0.6830.33
57_K108_Q0.6810.33
3_S50_T0.6810.33
39_R183_A0.6800.33
35_S91_A0.6750.32
37_L156_V0.6720.32
24_T85_A0.6700.32
49_T172_E0.6690.32
93_Y123_C0.6660.32
59_L77_K0.6640.32
84_T132_G0.6640.32
130_S150_G0.6630.32
53_A141_R0.6620.32
36_L91_A0.6610.31
70_P125_P0.6590.31
86_T96_Y0.6590.31
62_L179_K0.6590.31
58_F155_D0.6480.31
90_E164_S0.6430.30
125_P173_V0.6400.30
34_Y191_R0.6390.30
59_L156_V0.6360.30
44_H120_E0.6340.30
49_T60_E0.6330.30
39_R67_H0.6320.30
6_V121_Q0.6310.29
38_D88_R0.6290.29
51_D79_A0.6270.29
50_T66_G0.6230.29
14_S189_Y0.6180.29
90_E161_D0.6160.28
92_H145_F0.6150.28
34_Y95_Y0.6120.28
78_L113_Q0.6110.28
95_Y143_L0.6100.28
174_A177_L0.6080.28
56_E126_T0.6080.28
142_T148_K0.6040.28
10_A157_I0.5980.27
64_D69_D0.5960.27
117_I157_I0.5950.27
167_F187_V0.5930.27
42_K75_A0.5890.27
45_F185_Y0.5870.27
46_A95_Y0.5850.27
28_D75_A0.5840.26
119_G160_A0.5800.26
161_D189_Y0.5760.26
42_K126_T0.5760.26
43_G178_A0.5750.26
24_T189_Y0.5730.26
23_E188_R0.5730.26
53_A161_D0.5710.26
101_E104_L0.5700.26
110_G142_T0.5690.26
167_F177_L0.5680.26
3_S85_A0.5680.26
9_K41_A0.5680.26
95_Y152_G0.5650.25
19_V149_F0.5630.25
58_F67_H0.5600.25
79_A92_H0.5590.25
129_T182_K0.5570.25
8_L42_K0.5560.25
67_H126_T0.5550.25
136_G187_V0.5550.25
38_D175_M0.5540.25
56_E63_R0.5500.24
82_L185_Y0.5420.24
116_L139_Q0.5400.24
171_H175_M0.5400.24
47_E176_D0.5370.24
77_K123_C0.5370.24
173_V192_S0.5370.24
6_V10_A0.5360.24
126_T168_A0.5360.24
97_T141_R0.5360.24
38_D82_L0.5350.24
4_I12_F0.5340.24
108_Q118_D0.5320.23
11_A16_P0.5320.23
129_T176_D0.5310.23
77_K162_I0.5290.23
127_L182_K0.5280.23
52_K118_D0.5240.23
55_Y62_L0.5240.23
50_T59_L0.5230.23
149_F178_A0.5210.23
42_K162_I0.5190.23
166_S176_D0.5180.23
41_A168_A0.5170.23
5_N13_P0.5170.23
91_A191_R0.5170.23
140_L192_S0.5130.22
154_R174_A0.5090.22
18_L58_F0.5070.22
37_L66_G0.5070.22
12_F37_L0.5040.22
130_S153_S0.5010.22
164_S167_F0.5000.22
64_D68_M0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gyk_A 1 0.3109 64.8 0.919 Contact Map
3f4s_A 1 0.3057 61.2 0.921 Contact Map
1z6m_A 1 0.342 60.4 0.921 Contact Map
3gha_A 1 0.3109 58.7 0.922 Contact Map
5c00_A 1 0.3731 50.9 0.925 Contact Map
4z7x_A 1 0.3731 47.7 0.927 Contact Map
4ihu_A 1 0.3264 45 0.928 Contact Map
2rem_A 1 0.3316 10.9 0.947 Contact Map
4p3y_B 1 0.3212 8.4 0.949 Contact Map
3gv1_A 1 0.2487 8 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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