GREMLIN Database
T0891_1_130 - T0891 1-130
ID: 42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (118)
Sequences: 1200 (934)
Seq/√Len: 86.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_K93_E4.6741.00
49_T91_Q3.0771.00
21_K26_E3.0141.00
21_K24_S2.7141.00
47_I91_Q2.6701.00
108_L115_D2.4691.00
16_V128_T2.4341.00
31_T36_D2.4021.00
40_T49_T2.3211.00
25_D121_Q2.2961.00
8_P11_H2.1911.00
11_H41_I2.1621.00
23_N121_Q2.0361.00
19_A120_I2.0201.00
64_E102_N1.9011.00
100_R123_E1.8881.00
30_A105_M1.8851.00
47_I93_E1.8231.00
106_H117_E1.7841.00
106_H115_D1.7701.00
12_V38_K1.7081.00
24_S121_Q1.6451.00
20_Y123_E1.6291.00
13_F41_I1.6021.00
54_D57_F1.5701.00
48_I124_V1.5661.00
22_D121_Q1.5591.00
114_Y118_F1.5281.00
17_I124_V1.4900.99
76_K91_Q1.4340.99
96_E99_K1.4260.99
109_I112_L1.4170.99
100_R121_Q1.3550.99
8_P41_I1.3370.99
49_T89_V1.3370.99
103_M120_I1.3140.99
18_K27_E1.3040.99
17_I34_I1.2590.98
12_V40_T1.2450.98
22_D119_K1.2310.98
51_T89_V1.2290.98
78_L91_Q1.2260.98
30_A34_I1.1950.97
62_K104_Q1.1950.97
81_D84_K1.1740.97
35_K53_K1.1450.97
15_A39_L1.1250.96
20_Y121_Q1.1100.96
104_Q119_K1.1090.96
125_N128_T1.0990.96
10_K41_I1.0700.95
65_D69_P1.0610.95
29_Y32_V1.0570.95
27_E31_T1.0520.95
21_K29_Y1.0490.95
74_D77_V1.0430.94
14_D76_K0.9950.93
63_V92_F0.9770.92
14_D38_K0.9530.91
50_A92_F0.9410.91
46_R122_F0.9400.91
62_K74_D0.9390.91
35_K87_T0.9310.90
41_I46_R0.9290.90
97_L126_M0.9200.90
106_H116_K0.9000.89
57_F109_I0.8920.88
17_I37_P0.8790.88
105_M120_I0.8760.87
65_D70_G0.8720.87
31_T37_P0.8670.87
52_L58_F0.8590.86
61_L103_M0.8530.86
107_I118_F0.8520.86
30_A120_I0.8520.86
40_T91_Q0.8500.86
110_P115_D0.8500.86
92_F101_Y0.8430.85
38_K49_T0.8300.84
64_E70_G0.8300.84
19_A36_D0.8260.84
77_V80_E0.8220.84
39_L94_V0.8160.83
21_K28_S0.8130.83
33_Y52_L0.8110.83
15_A41_I0.8030.82
8_P39_L0.7900.81
107_I112_L0.7830.81
81_D87_T0.7790.81
39_L46_R0.7750.80
108_L111_T0.7710.80
20_Y25_D0.7670.79
33_Y55_S0.7640.79
29_Y107_I0.7600.79
112_L118_F0.7590.79
21_K121_Q0.7580.79
79_S89_V0.7540.78
29_Y105_M0.7500.78
18_K100_R0.7500.78
19_A124_V0.7500.78
15_A124_V0.7450.77
48_I94_V0.7430.77
25_D100_R0.7410.77
10_K13_F0.7300.76
41_I44_G0.7270.76
72_F104_Q0.7240.75
25_D128_T0.7200.75
18_K89_V0.7110.74
106_H113_G0.7040.73
19_A122_F0.7010.73
33_Y110_P0.6950.72
60_Y74_D0.6890.72
57_F107_I0.6810.71
22_D26_E0.6720.70
38_K45_K0.6620.69
59_D103_M0.6550.68
34_I58_F0.6520.68
24_S77_V0.6500.67
85_H92_F0.6450.67
59_D115_D0.6450.67
29_Y118_F0.6440.67
62_K72_F0.6440.67
18_K125_N0.6440.67
33_Y87_T0.6370.66
30_A109_I0.6350.66
9_K14_D0.6220.64
14_D37_P0.6200.64
17_I35_K0.6150.63
34_I116_K0.6060.62
15_A48_I0.6000.61
33_Y61_L0.5900.60
20_Y27_E0.5870.60
14_D101_Y0.5860.59
104_Q117_E0.5830.59
39_L82_K0.5830.59
56_D85_H0.5820.59
109_I116_K0.5780.58
120_I126_M0.5780.58
101_Y124_V0.5750.58
51_T88_K0.5740.58
14_D128_T0.5730.58
23_N26_E0.5690.57
116_K119_K0.5620.56
34_I50_A0.5580.56
77_V88_K0.5550.55
10_K43_N0.5520.55
90_I105_M0.5520.55
98_G126_M0.5520.55
48_I92_F0.5520.55
18_K123_E0.5450.54
69_P101_Y0.5420.54
77_V81_D0.5400.53
59_D108_L0.5400.53
116_K120_I0.5400.53
34_I52_L0.5390.53
71_V95_G0.5310.52
33_Y114_Y0.5280.52
22_D120_I0.5210.51
92_F103_M0.5200.51
16_V36_D0.5180.50
80_E97_L0.5170.50
101_Y104_Q0.5160.50
54_D110_P0.5160.50
84_K87_T0.5150.50
27_E33_Y0.5150.50
46_R94_V0.5150.50
19_A50_A0.5140.50
8_P13_F0.5140.50
39_L55_S0.5120.50
35_K54_D0.5100.49
77_V83_R0.5100.49
46_R99_K0.5090.49
9_K12_V0.5060.49
54_D114_Y0.5060.49
115_D118_F0.5030.48
80_E84_K0.5020.48
79_S99_K0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h8q_A 1 0.9077 100 0.054 Contact Map
3sz6_A 1 0.8846 99.9 0.095 Contact Map
4myp_A 1 0.9077 99.9 0.102 Contact Map
2o1a_A 1 0.9 99.9 0.107 Contact Map
3qzm_A 1 0.9231 99.9 0.138 Contact Map
2k78_A 1 0.9 99.9 0.15 Contact Map
3qug_A 1 0.8615 99.9 0.151 Contact Map
2o6p_A 1 0.8769 99.9 0.165 Contact Map
4xs0_C 1 0.9077 99.9 0.165 Contact Map
3rtl_A 1 0.8692 99.9 0.166 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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