GREMLIN Database
T0890_1_191 - T0890 1-191
ID: 41 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 191 (189)
Sequences: 51 (34)
Seq/√Len: 2.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_E161_G4.0510.65
109_C136_I3.6270.56
33_K174_A3.0470.43
108_E151_Q2.9950.42
52_N184_A2.7190.36
68_D91_I2.4730.31
106_F134_W2.3790.29
70_L177_P2.3750.29
135_D139_N2.3460.28
5_T156_L2.2570.27
96_D108_E2.2000.26
9_L35_A2.1250.24
20_T175_Y1.8740.20
63_M189_L1.8590.20
136_I174_A1.8180.20
14_K18_E1.7870.19
39_L46_V1.7810.19
23_I96_D1.7720.19
35_A39_L1.7580.19
21_L177_P1.7440.19
66_F142_L1.6680.17
9_L39_L1.6620.17
52_N58_S1.6610.17
86_L182_L1.6500.17
109_C174_A1.6470.17
28_D50_T1.6450.17
140_K148_T1.5560.16
29_P146_K1.5530.16
28_D47_L1.5450.16
20_T23_I1.4880.15
66_F124_K1.4860.15
24_L122_R1.4770.15
156_L170_M1.4660.15
99_S170_M1.4640.15
34_L41_G1.4490.15
77_E113_V1.4430.15
80_K139_N1.4310.15
87_S146_K1.4260.15
6_V37_K1.4200.14
25_K161_G1.4190.14
59_I73_F1.4040.14
10_G87_S1.3990.14
123_T174_A1.3910.14
5_T127_K1.3830.14
34_L37_K1.3800.14
89_D96_D1.3690.14
15_E108_E1.3680.14
8_G123_T1.3500.14
42_S76_E1.3470.14
42_S69_F1.3430.14
81_Q93_N1.3180.13
30_D34_L1.3180.13
5_T44_K1.3130.13
135_D161_G1.2680.13
8_G20_T1.2650.13
56_I61_E1.2620.13
82_N85_Y1.2580.13
24_L28_D1.2530.13
76_E162_K1.2510.13
9_L38_G1.2490.13
43_A124_K1.2490.13
25_K51_K1.2400.13
15_E96_D1.2370.12
51_K173_W1.2330.12
150_K179_V1.2240.12
71_E169_E1.2220.12
22_K136_I1.2080.12
107_V114_A1.2010.12
87_S168_L1.2000.12
80_K122_R1.1970.12
23_I68_D1.1820.12
18_E36_I1.1810.12
91_I104_A1.1760.12
113_V169_E1.1720.12
9_L118_Y1.1710.12
21_L70_L1.1700.12
97_K166_V1.1600.12
23_I126_P1.1520.12
27_R86_L1.1360.12
34_L39_L1.1350.12
62_A65_T1.1340.11
37_K41_G1.1170.11
61_E183_K1.1160.11
15_E162_K1.1120.11
24_L50_T1.1020.11
3_V126_P1.0940.11
50_T55_K1.0930.11
145_L179_V1.0860.11
53_E60_K1.0860.11
114_A124_K1.0820.11
79_S108_E1.0820.11
5_T37_K1.0720.11
80_K135_D1.0710.11
107_V188_K1.0710.11
27_R177_P1.0700.11
16_A76_E1.0680.11
138_R167_H1.0580.11
12_K167_H1.0580.11
12_K17_A1.0580.11
11_F167_H1.0580.11
17_A138_R1.0580.11
11_F138_R1.0580.11
12_K138_R1.0580.11
11_F17_A1.0580.11
17_A167_H1.0580.11
79_S123_T1.0500.11
74_D175_Y1.0490.11
153_G171_I1.0370.11
45_R118_Y1.0240.11
147_E174_A1.0040.10
137_V158_D0.9930.10
46_V157_F0.9890.10
89_D189_L0.9880.10
56_I147_E0.9880.10
29_P37_K0.9840.10
46_V49_S0.9830.10
24_L139_N0.9780.10
110_Y142_L0.9720.10
52_N166_V0.9710.10
57_K114_A0.9560.10
13_D70_L0.9560.10
93_N148_T0.9540.10
15_E115_K0.9520.10
40_L109_C0.9420.10
4_E37_K0.9350.10
72_T133_S0.9310.10
81_Q166_V0.9240.10
40_L123_T0.9130.10
39_L45_R0.9080.10
122_R139_N0.9010.09
60_K90_L0.8990.09
36_I162_K0.8940.09
54_D191_K0.8930.09
21_L115_K0.8830.09
82_N183_K0.8800.09
80_K116_G0.8790.09
116_G122_R0.8760.09
88_L142_L0.8740.09
68_D105_E0.8740.09
14_K145_L0.8630.09
55_K85_Y0.8630.09
79_S151_Q0.8550.09
58_S166_V0.8540.09
16_A98_P0.8490.09
110_Y121_L0.8470.09
37_K40_L0.8460.09
55_K163_P0.8400.09
21_L103_A0.8400.09
57_K90_L0.8340.09
59_I155_K0.8300.09
87_S111_D0.8300.09
81_Q97_K0.8240.09
35_A46_V0.8230.09
79_S113_V0.8200.09
108_E170_M0.8200.09
105_E169_E0.8160.09
77_E115_K0.8150.09
58_S184_A0.8130.09
8_G168_L0.8130.09
42_S58_S0.8120.09
33_K74_D0.8100.09
47_L91_I0.8090.09
129_D183_K0.8010.09
94_L149_V0.7990.09
73_F175_Y0.7980.09
90_L158_D0.7910.09
165_K190_E0.7910.09
51_K108_E0.7890.09
84_A132_T0.7880.09
21_L36_I0.7870.09
60_K155_K0.7830.09
71_E84_A0.7830.09
3_V98_P0.7760.09
110_Y134_W0.7740.09
62_A66_F0.7680.08
56_I66_F0.7680.08
43_A62_A0.7670.08
106_F110_Y0.7660.08
140_K145_L0.7640.08
171_I178_N0.7560.08
15_E19_K0.7550.08
72_T166_V0.7480.08
66_F133_S0.7480.08
93_N166_V0.7450.08
83_M146_K0.7390.08
44_K70_L0.7370.08
3_V8_G0.7360.08
59_I175_Y0.7320.08
150_K176_S0.7310.08
20_T68_D0.7300.08
154_E166_V0.7290.08
46_V118_Y0.7260.08
53_E182_L0.7240.08
19_K190_E0.7200.08
46_V56_I0.7050.08
43_A79_S0.7030.08
62_A96_D0.7010.08
55_K82_N0.6990.08
102_L144_K0.6980.08
156_L185_Y0.6970.08
46_V61_E0.6950.08
61_E157_F0.6810.08
94_L168_L0.6810.08
21_L83_M0.6750.08
147_E180_D0.6740.08
79_S140_K0.6730.08
54_D188_K0.6690.08
24_L135_D0.6680.08
16_A162_K0.6600.08
39_L51_K0.6590.08
30_D73_F0.6540.08
11_F32_Q0.6540.08
32_Q138_R0.6540.08
32_Q167_H0.6540.08
12_K32_Q0.6540.08
17_A32_Q0.6540.08
166_V184_A0.6510.08
9_L46_V0.6500.08
14_K116_G0.6500.08
35_A118_Y0.6480.08
32_Q44_K0.6370.08
54_D181_K0.6350.08
180_D186_C0.6320.08
43_A66_F0.6240.08
14_K78_R0.6230.08
151_Q171_I0.6160.07
40_L143_L0.6140.07
13_D17_A0.6130.07
13_D138_R0.6130.07
13_D167_H0.6130.07
82_N175_Y0.6120.07
89_D188_K0.6110.07
68_D77_E0.6110.07
83_M94_L0.6090.07
24_L80_K0.6030.07
21_L102_L0.6020.07
20_T168_L0.5990.07
56_I175_Y0.5950.07
28_D45_R0.5940.07
73_F155_K0.5940.07
102_L115_K0.5900.07
57_K108_E0.5880.07
22_K124_K0.5800.07
67_E135_D0.5800.07
48_P188_K0.5770.07
151_Q188_K0.5760.07
98_P133_S0.5750.07
15_E51_K0.5690.07
23_I180_D0.5680.07
168_L174_A0.5680.07
99_S159_S0.5640.07
4_E148_T0.5640.07
16_A42_S0.5600.07
155_K160_D0.5580.07
19_K92_K0.5570.07
119_K175_Y0.5560.07
50_T163_P0.5540.07
16_A69_F0.5540.07
87_S113_V0.5510.07
20_T70_L0.5510.07
20_T156_L0.5400.07
71_E104_A0.5380.07
144_K190_E0.5320.07
54_D103_A0.5290.07
38_G173_W0.5290.07
58_S117_N0.5280.07
65_T152_N0.5250.07
80_K119_K0.5250.07
85_Y139_N0.5220.07
33_K41_G0.5220.07
103_A188_K0.5160.07
70_L105_E0.5130.07
55_K122_R0.5130.07
10_G106_F0.5120.07
59_I173_W0.5120.07
69_F76_E0.5100.07
90_L131_S0.5060.07
92_K180_D0.5030.07
84_A177_P0.5030.07
53_E180_D0.5010.07
18_E69_F0.5000.07
11_F27_R0.5000.07
17_A27_R0.5000.07
27_R138_R0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4un2_B 1 0.1885 9.9 0.969 Contact Map
2dna_A 1 0.2461 9.1 0.97 Contact Map
4e0t_A 1 0.8063 8.8 0.97 Contact Map
2cwb_A 1 0.2147 8 0.97 Contact Map
2g3q_A 1 0.199 8 0.97 Contact Map
3c1x_A 1 0.4503 7.4 0.971 Contact Map
2jy5_A 1 0.2042 7.2 0.971 Contact Map
4q0w_A 1 0.6021 6.9 0.971 Contact Map
1wii_A 1 0.3717 6.5 0.971 Contact Map
1vg5_A 1 0.2251 6.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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