GREMLIN Database
T0863_1_670 - T0863 1-670
ID: 4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 670 (609)
Sequences: 114 (64)
Seq/√Len: 2.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
610_W619_N4.1280.69
619_N626_R4.0120.66
610_W626_R3.7260.60
609_H616_L3.6230.58
616_L620_P3.4020.53
609_H620_P3.2400.49
610_W620_P3.2200.48
527_D539_D3.2030.48
615_T619_N3.1710.47
612_L626_R3.1230.46
609_H619_N3.1130.46
616_L619_N3.1030.46
374_L377_G3.0960.45
607_R615_T3.0390.44
615_T620_P3.0380.44
610_W616_L2.9950.43
61_R73_G2.9730.43
607_R626_R2.9180.41
620_P626_R2.8690.40
511_R539_D2.8660.40
616_L626_R2.8610.40
368_R377_G2.8540.40
348_A405_Y2.8290.39
612_L622_L2.7840.38
494_Y559_V2.7620.38
610_W615_T2.7090.37
609_H615_T2.6950.36
619_N622_L2.6760.36
609_H626_R2.6570.36
609_H612_L2.6330.35
533_R536_E2.5610.34
364_M515_T2.5470.33
615_T626_R2.4820.32
616_L622_L2.4750.32
609_H622_L2.4400.31
157_S261_Y2.4220.31
346_V459_V2.4210.31
188_P196_L2.3990.30
107_S541_G2.3970.30
607_R612_L2.3370.29
622_L626_R2.3350.29
605_R613_L2.3250.29
78_V376_R2.3250.29
42_I47_I2.3000.28
607_R610_W2.2830.28
193_L196_L2.2810.28
137_P171_C2.2490.27
428_A433_I2.2310.27
70_G531_L2.2200.27
612_L619_N2.2190.27
409_F541_G2.2090.27
610_W614_Y2.1910.26
612_L616_L2.1380.25
74_L200_Y2.1350.25
511_R527_D2.1280.25
61_R72_T2.0790.24
607_R627_K2.0730.24
63_K509_I2.0720.24
180_Y423_I2.0700.24
95_G155_L2.0680.24
187_L236_K2.0670.24
465_Q485_N2.0520.24
77_P95_G2.0500.24
504_G511_R2.0430.24
525_R539_D2.0290.24
141_C196_L2.0150.23
612_L615_T2.0130.23
607_R619_N1.9830.23
607_R616_L1.9790.23
378_D515_T1.9680.22
536_E539_D1.9600.22
149_G533_R1.9370.22
504_G539_D1.9310.22
149_G536_E1.9290.22
500_N504_G1.9270.22
229_V559_V1.9020.21
271_F494_Y1.8910.21
95_G149_G1.8870.21
80_F354_L1.8750.21
483_L517_L1.8700.21
80_F407_A1.8680.21
398_C421_F1.8430.21
228_Y326_D1.8430.21
72_T487_G1.8020.20
607_R622_L1.8000.20
193_L416_I1.7890.20
489_L557_H1.7780.20
413_G567_L1.7650.19
429_V617_V1.7380.19
612_L620_P1.7100.19
156_L498_L1.7100.19
489_L493_S1.7050.19
606_A610_W1.6800.18
406_Q500_N1.6690.18
135_Y140_A1.6600.18
610_W627_K1.6550.18
113_F622_L1.6520.18
155_L416_I1.6490.18
188_P558_P1.6460.18
95_G141_C1.6220.17
73_G255_R1.6220.17
558_P620_P1.6190.17
72_T484_N1.6080.17
485_N541_G1.5980.17
137_P504_G1.5960.17
172_P272_P1.5950.17
149_G463_L1.5870.17
141_C188_P1.5860.17
408_A542_Y1.5730.17
511_R525_R1.5640.17
191_A334_V1.5540.16
197_S200_Y1.5520.16
519_N555_Q1.5450.16
171_C196_L1.5400.16
191_A474_I1.5370.16
81_L351_L1.5360.16
56_A60_R1.5150.16
612_L627_K1.5090.16
190_I204_L1.4950.16
234_K433_I1.4900.16
615_T622_L1.4860.16
352_S363_S1.4820.16
378_D525_R1.4810.16
200_Y502_M1.4810.16
171_C504_G1.4750.15
129_L166_W1.4750.15
408_A435_P1.4720.15
345_Y359_M1.4500.15
46_A315_L1.4440.15
435_P500_N1.4410.15
367_H370_N1.4370.15
140_A541_G1.4360.15
536_E560_M1.4310.15
531_L539_D1.4260.15
200_Y232_I1.4260.15
345_Y370_N1.4140.15
190_I548_Y1.4140.15
544_C617_V1.4110.15
465_Q473_F1.4010.15
79_N101_L1.3940.15
421_F444_L1.3920.14
60_R70_G1.3890.14
77_P94_Y1.3850.14
204_L505_V1.3820.14
39_L43_C1.3810.14
528_I548_Y1.3810.14
610_W613_L1.3700.14
197_S204_L1.3700.14
523_L552_E1.3640.14
147_K409_F1.3550.14
511_R558_P1.3530.14
229_V525_R1.3490.14
22_K35_A1.3450.14
240_K568_L1.3450.14
156_L367_H1.3440.14
412_L519_N1.3430.14
357_L364_M1.3400.14
133_T352_S1.3390.14
137_P141_C1.3380.14
104_M163_I1.3370.14
619_N627_K1.3250.14
609_H623_V1.3210.14
361_M557_H1.3200.14
395_A404_S1.3190.14
63_K230_K1.3180.14
141_C153_G1.3160.14
614_Y627_K1.3150.14
421_F529_S1.3090.14
368_R374_L1.3090.14
76_S407_A1.3070.14
99_C285_A1.3060.14
31_C616_L1.3060.14
200_Y557_H1.3040.13
44_I47_I1.3020.13
533_R560_M1.2940.13
453_P557_H1.2920.13
178_Y371_L1.2920.13
35_A53_L1.2860.13
157_S165_V1.2850.13
275_L462_A1.2800.13
396_L459_V1.2800.13
200_Y521_V1.2750.13
255_R509_I1.2720.13
553_V557_H1.2700.13
281_V525_R1.2650.13
172_P501_V1.2650.13
527_D531_L1.2550.13
352_S361_M1.2470.13
242_S483_L1.2400.13
539_D558_P1.2360.13
369_S528_I1.2350.13
504_G536_E1.2300.13
563_F567_L1.2260.13
525_R606_A1.2250.13
75_L424_C1.2230.13
377_G558_P1.2170.13
610_W622_L1.2080.12
372_K537_A1.2060.12
271_F559_V1.2050.12
276_A487_G1.2030.12
615_T627_K1.1920.12
136_Y352_S1.1850.12
485_N549_L1.1820.12
383_F475_R1.1810.12
232_I472_L1.1800.12
359_M363_S1.1790.12
61_R71_L1.1780.12
195_F234_K1.1760.12
453_P531_L1.1750.12
57_I61_R1.1730.12
378_D410_L1.1720.12
401_G525_R1.1710.12
148_V166_W1.1710.12
504_G531_L1.1710.12
91_V487_G1.1680.12
598_N636_S1.1670.12
132_P156_L1.1660.12
519_N522_H1.1650.12
607_R620_P1.1650.12
125_I463_L1.1600.12
552_E557_H1.1580.12
439_G564_C1.1570.12
504_G527_D1.1570.12
202_L618_N1.1530.12
270_R312_I1.1510.12
331_V433_I1.1470.12
100_K617_V1.1460.12
273_L562_A1.1440.12
405_Y464_I1.1410.12
139_L183_L1.1390.12
541_G567_L1.1320.12
163_I556_S1.1280.12
427_F509_I1.1260.12
526_L536_E1.1250.12
365_V501_V1.1250.12
148_V164_L1.1210.12
43_C568_L1.1130.12
616_L627_K1.1120.12
78_V187_L1.1090.12
137_P153_G1.1090.12
509_I628_H1.1050.11
382_V404_S1.1040.11
156_L160_H1.0980.11
180_Y560_M1.0970.11
196_L435_P1.0950.11
205_F376_R1.0930.11
200_Y587_G1.0920.11
188_P541_G1.0900.11
139_L525_R1.0890.11
132_P519_N1.0870.11
112_P272_P1.0870.11
494_Y598_N1.0850.11
506_V535_V1.0790.11
232_I382_V1.0790.11
35_A231_K1.0770.11
55_L141_C1.0770.11
368_R408_A1.0760.11
228_Y455_W1.0750.11
229_V294_I1.0740.11
501_V534_N1.0730.11
636_S643_S1.0720.11
305_R331_V1.0700.11
405_Y488_S1.0690.11
180_Y193_L1.0680.11
229_V378_D1.0660.11
151_V166_W1.0610.11
193_L269_F1.0610.11
429_V607_R1.0600.11
483_L607_R1.0590.11
294_I378_D1.0580.11
401_G499_V1.0550.11
153_G511_R1.0540.11
268_V423_I1.0520.11
423_I427_F1.0520.11
220_L295_S1.0480.11
77_P558_P1.0460.11
501_V560_M1.0450.11
41_H47_I1.0430.11
86_H149_G1.0410.11
432_I437_L1.0390.11
428_A437_L1.0380.11
287_Y555_Q1.0380.11
509_I533_R1.0360.11
288_Q549_L1.0350.11
203_L348_A1.0350.11
271_F526_L1.0310.11
638_I642_L1.0310.11
304_V315_L1.0260.11
165_V266_E1.0260.11
79_N448_I1.0260.11
526_L534_N1.0250.11
550_K557_H1.0240.11
227_D316_L1.0230.11
79_N544_C1.0210.11
306_R627_K1.0190.11
205_F372_K1.0190.11
144_L490_F1.0180.11
54_V320_N1.0160.11
284_I535_V1.0130.11
473_F485_N1.0110.11
94_Y483_L1.0060.11
141_C406_Q1.0060.11
45_A402_F1.0050.11
473_F558_P1.0000.11
620_P627_K0.9970.10
31_C48_S0.9940.10
229_V232_I0.9930.10
262_I529_S0.9920.10
301_L434_I0.9900.10
153_G171_C0.9880.10
95_G416_I0.9880.10
394_P407_A0.9850.10
615_T618_N0.9810.10
505_V509_I0.9800.10
465_Q610_W0.9800.10
316_L327_R0.9790.10
98_F127_A0.9790.10
57_I643_S0.9770.10
287_Y610_W0.9760.10
466_H525_R0.9750.10
102_V283_F0.9730.10
99_C328_Q0.9690.10
383_F482_D0.9690.10
405_Y472_L0.9660.10
500_N622_L0.9660.10
545_Y552_E0.9620.10
141_C171_C0.9610.10
188_P193_L0.9610.10
377_G404_S0.9590.10
126_L197_S0.9570.10
145_H604_K0.9570.10
412_L555_Q0.9560.10
153_G196_L0.9560.10
294_I613_L0.9540.10
60_R505_V0.9510.10
551_I560_M0.9480.10
515_T538_F0.9460.10
52_M376_R0.9460.10
443_M454_F0.9460.10
228_Y491_L0.9450.10
128_L140_A0.9420.10
232_I440_T0.9420.10
367_H498_L0.9410.10
286_L580_R0.9400.10
77_P137_P0.9400.10
290_A300_T0.9390.10
75_L544_C0.9390.10
377_G408_A0.9390.10
76_S351_L0.9390.10
299_P316_L0.9370.10
153_G539_D0.9370.10
166_W612_L0.9310.10
271_F283_F0.9290.10
350_T551_I0.9280.10
430_F522_H0.9270.10
141_C500_N0.9240.10
274_K407_A0.9230.10
228_Y327_R0.9210.10
471_F599_K0.9200.10
511_R619_N0.9200.10
454_F501_V0.9190.10
39_L195_F0.9170.10
269_F622_L0.9160.10
579_Q601_S0.9140.10
549_L563_F0.9140.10
593_Q613_L0.9140.10
57_I509_I0.9110.10
496_L549_L0.9110.10
149_G155_L0.9110.10
129_L566_L0.9080.10
612_L628_H0.9080.10
479_G524_G0.9040.10
609_H613_L0.9040.10
344_C489_L0.9020.10
416_I512_V0.9010.10
606_A626_R0.9000.10
426_L449_G0.9000.10
350_T470_R0.8990.10
465_Q614_Y0.8990.10
376_R601_S0.8950.10
181_Y461_A0.8950.10
223_S568_L0.8920.10
153_G188_P0.8900.10
497_F504_G0.8890.10
130_Y526_L0.8870.10
43_C48_S0.8850.10
495_I498_L0.8820.10
407_A525_R0.8810.10
291_L351_L0.8790.09
27_V509_I0.8790.09
202_L232_I0.8780.09
489_L553_V0.8770.09
223_S242_S0.8770.09
284_I508_G0.8760.09
151_V483_L0.8760.09
435_P542_Y0.8740.09
92_A360_L0.8740.09
301_L322_I0.8710.09
133_T136_Y0.8710.09
500_N511_R0.8700.09
100_K601_S0.8700.09
541_G558_P0.8690.09
156_L274_K0.8680.09
89_L348_A0.8660.09
366_L375_Y0.8650.09
61_R406_Q0.8650.09
300_T457_T0.8640.09
97_L133_T0.8630.09
90_A423_I0.8620.09
181_Y184_F0.8620.09
316_L319_F0.8610.09
413_G563_F0.8590.09
435_P504_G0.8590.09
75_L613_L0.8570.09
529_S533_R0.8570.09
495_I541_G0.8550.09
606_A619_N0.8540.09
48_S513_V0.8530.09
56_A61_R0.8530.09
28_I621_S0.8520.09
23_A29_P0.8510.09
435_P564_C0.8500.09
574_D597_Q0.8490.09
57_I603_A0.8490.09
156_L519_N0.8490.09
361_M445_F0.8460.09
101_L423_I0.8450.09
374_L382_V0.8440.09
294_I364_M0.8430.09
135_Y368_R0.8410.09
613_L619_N0.8390.09
400_M562_A0.8380.09
351_L529_S0.8380.09
279_V459_V0.8380.09
50_V440_T0.8380.09
104_M271_F0.8360.09
149_G192_C0.8350.09
494_Y511_R0.8350.09
171_C193_L0.8340.09
205_F341_V0.8330.09
125_I231_K0.8310.09
149_G500_N0.8300.09
60_R235_K0.8290.09
324_S371_L0.8270.09
302_H517_L0.8270.09
230_K494_Y0.8260.09
67_N228_Y0.8220.09
427_F570_S0.8210.09
504_G619_N0.8210.09
94_Y474_I0.8200.09
55_L104_M0.8200.09
272_P506_V0.8190.09
158_W201_P0.8180.09
233_L433_I0.8170.09
153_G558_P0.8160.09
299_P371_L0.8150.09
171_C531_L0.8150.09
198_F531_L0.8120.09
540_P568_L0.8110.09
608_A612_L0.8090.09
606_A615_T0.8080.09
437_L448_I0.8070.09
522_H530_L0.8060.09
287_Y494_Y0.8040.09
53_L331_V0.8040.09
404_S505_V0.8030.09
182_A502_M0.8020.09
617_V635_E0.8020.09
149_G374_L0.8010.09
152_L423_I0.7990.09
169_V429_V0.7990.09
404_S408_A0.7970.09
293_L475_R0.7960.09
269_F405_Y0.7960.09
610_W617_V0.7950.09
356_N542_Y0.7940.09
597_Q643_S0.7900.09
229_V414_M0.7900.09
377_G545_Y0.7870.09
149_G298_L0.7870.09
614_Y619_N0.7870.09
630_Q638_I0.7860.09
535_V552_E0.7850.09
364_M410_L0.7850.09
472_L488_S0.7840.09
423_I449_G0.7820.09
299_P355_V0.7810.09
422_F622_L0.7810.09
91_V436_I0.7800.09
105_V121_E0.7790.09
171_C435_P0.7790.09
77_P619_N0.7790.09
392_S397_V0.7790.09
29_P37_E0.7790.09
123_W454_F0.7770.09
50_V57_I0.7760.09
614_Y620_P0.7740.09
609_H627_K0.7730.09
130_Y160_H0.7710.09
149_G436_I0.7710.09
143_T354_L0.7700.09
417_Q493_S0.7700.09
272_P501_V0.7690.09
298_L324_S0.7670.09
229_V364_M0.7650.09
136_Y610_W0.7640.09
114_T509_I0.7640.09
376_R387_R0.7630.09
190_I428_A0.7630.09
235_K559_V0.7620.09
131_Y614_Y0.7600.09
434_I489_L0.7590.09
105_V382_V0.7580.09
134_L398_C0.7570.09
30_P79_N0.7560.09
328_Q387_R0.7560.09
50_V62_Q0.7530.09
45_A51_V0.7530.09
55_L172_P0.7530.09
376_R597_Q0.7520.09
111_L342_E0.7520.09
111_L432_I0.7520.09
153_G465_Q0.7510.09
291_L614_Y0.7490.08
45_A67_N0.7480.08
40_F467_V0.7480.08
495_I519_N0.7480.08
190_I273_L0.7450.08
180_Y227_D0.7430.08
100_K542_Y0.7420.08
416_I533_R0.7420.08
347_S437_L0.7400.08
158_W200_Y0.7400.08
495_I547_H0.7390.08
396_L606_A0.7390.08
204_L517_L0.7380.08
297_V454_F0.7380.08
299_P398_C0.7370.08
160_H519_N0.7370.08
368_R558_P0.7360.08
133_T517_L0.7360.08
511_R616_L0.7350.08
193_L204_L0.7300.08
162_G596_K0.7300.08
78_V387_R0.7300.08
408_A536_E0.7300.08
383_F495_I0.7290.08
419_L456_L0.7270.08
374_L391_P0.7260.08
435_P497_F0.7260.08
283_F446_H0.7260.08
390_R618_N0.7250.08
99_C166_W0.7240.08
312_I476_K0.7240.08
103_G604_K0.7230.08
382_V415_A0.7210.08
380_L432_I0.7200.08
161_F317_A0.7190.08
39_L42_I0.7180.08
366_L389_I0.7180.08
39_L568_L0.7170.08
165_V627_K0.7170.08
435_P496_L0.7140.08
147_K520_I0.7130.08
153_G406_Q0.7130.08
467_V593_Q0.7100.08
228_Y517_L0.7090.08
67_N289_M0.7070.08
80_F497_F0.7050.08
491_L524_G0.7040.08
162_G236_K0.7030.08
191_A629_F0.7030.08
22_K28_I0.7020.08
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545_Y557_H0.6030.07
78_V418_T0.6030.07
113_F149_G0.6030.07
638_I643_S0.6020.07
507_L564_C0.6010.07
354_L625_S0.6010.07
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71_L75_L0.6000.07
287_Y563_F0.5990.07
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282_A484_N0.5970.07
181_Y201_P0.5960.07
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91_V545_Y0.5960.07
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439_G542_Y0.5950.07
152_L317_A0.5950.07
70_G111_L0.5940.07
370_N402_F0.5930.07
456_L548_Y0.5920.07
330_V437_L0.5920.07
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70_G180_Y0.5900.07
166_W422_F0.5890.07
139_L557_H0.5880.07
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474_I482_D0.5800.07
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361_M413_G0.5760.07
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181_Y217_S0.5740.07
330_V347_S0.5730.07
377_G552_E0.5730.07
178_Y405_Y0.5730.07
136_Y620_P0.5730.07
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142_G335_V0.5720.07
378_D552_E0.5720.07
399_W552_E0.5700.07
43_C275_L0.5700.07
190_I551_I0.5700.07
95_G333_I0.5690.07
376_R628_H0.5690.07
298_L306_R0.5690.07
341_V507_L0.5670.07
230_K396_L0.5670.07
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423_I464_I0.5660.07
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191_A617_V0.5630.07
72_T78_V0.5630.07
428_A505_V0.5620.07
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73_G500_N0.5610.07
196_L500_N0.5610.07
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159_T602_N0.5540.07
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563_F620_P0.5520.07
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459_V470_R0.5490.07
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470_R501_V0.5480.07
284_I499_V0.5470.07
113_F233_L0.5460.07
190_I562_A0.5460.07
129_L218_E0.5440.07
200_Y556_S0.5440.07
404_S558_P0.5430.07
494_Y618_N0.5430.07
280_V286_L0.5420.07
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235_K551_I0.5410.07
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49_L73_G0.5400.07
497_F519_N0.5400.07
475_R485_N0.5400.07
362_R622_L0.5390.07
504_G525_R0.5360.07
368_R473_F0.5360.07
494_Y561_K0.5350.07
305_R312_I0.5350.07
222_S235_K0.5340.07
436_I518_F0.5330.07
42_I64_L0.5330.07
196_L465_Q0.5320.07
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39_L151_V0.5310.07
255_R427_F0.5300.07
606_A612_L0.5300.07
463_L471_F0.5300.07
333_I348_A0.5300.07
35_A40_F0.5290.07
141_C157_S0.5290.07
444_L505_V0.5270.07
234_K329_E0.5260.07
432_I544_C0.5260.07
35_A52_M0.5250.07
320_N541_G0.5250.07
126_L456_L0.5240.07
70_G316_L0.5240.07
286_L487_G0.5240.07
157_S163_I0.5230.07
307_G556_S0.5220.07
153_G200_Y0.5220.07
98_F292_L0.5220.07
272_P284_I0.5220.07
114_T383_F0.5220.07
501_V541_G0.5220.07
140_A172_P0.5210.07
141_C501_V0.5210.07
316_L324_S0.5200.07
331_V563_F0.5200.07
205_F578_A0.5200.07
464_I622_L0.5200.07
233_L262_I0.5190.07
528_I551_I0.5190.07
299_P319_F0.5180.07
285_A290_A0.5170.07
130_Y345_Y0.5150.07
156_L475_R0.5150.07
542_Y566_L0.5140.07
91_V602_N0.5130.07
66_D551_I0.5110.07
269_F329_E0.5110.07
422_F486_R0.5100.07
48_S367_H0.5090.07
30_P35_A0.5090.07
52_M400_M0.5090.07
489_L554_S0.5090.07
560_M604_K0.5080.07
364_M474_I0.5070.07
183_L236_K0.5070.07
484_N509_I0.5070.07
284_I434_I0.5060.07
90_A367_H0.5060.07
418_T487_G0.5050.07
521_V543_R0.5050.07
196_L564_C0.5040.07
247_K250_L0.5040.07
134_L421_F0.5040.07
272_P281_V0.5030.07
74_L570_S0.5030.07
72_T183_L0.5020.07
381_N489_L0.5020.07
188_P513_V0.5020.07
90_A482_D0.5020.07
286_L535_V0.5010.07
96_V317_A0.5010.07
330_V442_L0.5010.07
463_L521_V0.5010.07
612_L618_N0.5000.07
184_F231_K0.5000.07
404_S536_E0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qho_A 1 0.0239 18.9 0.988 Contact Map
4m5d_A 1 0 12.7 0.989 Contact Map
1cqt_I 1 0.0328 8.1 0.99 Contact Map
4s0v_A 1 0.4388 6.6 0.99 Contact Map
1n7l_A 1 0.0791 5.7 0.99 Contact Map
4x8w_A 1 0.0164 5.6 0.99 Contact Map
3pbl_A 1 0.4328 5.5 0.99 Contact Map
3eff_K 1 0.2015 5.4 0.99 Contact Map
3ol0_A 1 0.0612 5.4 0.99 Contact Map
2kj1_A 1 0.0194 5.4 0.99 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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