GREMLIN Database
T0889_1_242 - T0889 1-242
ID: 38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 242 (226)
Sequences: 2953 (1927)
Seq/√Len: 128.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_D67_D3.5871.00
112_N156_S3.5791.00
106_D110_N3.5551.00
116_V160_I3.2461.00
41_E45_K3.1021.00
137_V164_V2.8851.00
87_A137_V2.8641.00
16_A38_D2.8571.00
113_V159_A2.8521.00
10_A27_M2.6891.00
30_A223_T2.6271.00
25_E50_K2.5561.00
158_W162_C2.5171.00
23_S218_V2.3351.00
19_I186_V2.3301.00
26_A216_E2.2541.00
21_L25_E2.1231.00
110_N114_N2.0231.00
15_A36_M2.0081.00
134_D222_L1.9481.00
82_L123_V1.9391.00
41_E59_V1.9361.00
106_D114_N1.9321.00
86_H138_T1.9221.00
9_V33_R1.9191.00
26_A30_A1.9001.00
117_M159_A1.8961.00
164_V180_S1.8741.00
37_V60_V1.8251.00
27_M222_L1.8201.00
120_V135_I1.8111.00
48_C57_P1.7701.00
27_M84_I1.7431.00
98_V128_I1.7351.00
84_I222_L1.7141.00
96_D99_D1.6971.00
62_L115_V1.6831.00
139_S161_N1.6821.00
120_V163_F1.6591.00
10_A84_I1.6401.00
92_Y190_L1.6301.00
35_V75_V1.5991.00
65_P106_D1.5821.00
164_V178_V1.5081.00
124_L171_V1.4871.00
143_A161_N1.4791.00
16_A39_R1.4681.00
179_G221_M1.4641.00
127_M133_G1.4551.00
40_D43_A1.4431.00
181_I218_V1.4311.00
131_R175_G1.4311.00
37_V71_L1.4121.00
12_V24_A1.4061.00
101_D104_A1.4051.00
76_L126_H1.3971.00
109_L113_V1.3941.00
32_A84_I1.3851.00
128_I174_H1.3831.00
81_Q130_R1.3771.00
22_A212_S1.3661.00
87_A164_V1.3641.00
158_W161_N1.3531.00
26_A219_M1.3451.00
187_V210_E1.3421.00
47_L50_K1.3391.00
9_V81_Q1.3311.00
21_L47_L1.3241.00
27_M219_M1.3211.00
127_M130_R1.3101.00
177_R225_P1.3051.00
117_M163_F1.2991.00
74_R78_K1.2991.00
33_R54_T1.2851.00
69_A73_P1.2741.00
30_A219_M1.2721.00
60_V71_L1.2511.00
102_T121_H1.2501.00
67_D70_T1.2451.00
12_V23_S1.2281.00
76_L81_Q1.2210.99
28_L34_V1.1880.99
8_K83_D1.1710.99
21_L46_A1.1660.99
25_E29_A1.1630.99
72_L123_V1.1540.99
43_A189_A1.1440.99
120_V167_V1.1260.99
138_T218_V1.1050.99
97_L121_H1.1050.99
139_S182_S1.0890.99
87_A119_N1.0810.99
11_A82_L1.0780.99
73_P77_E1.0780.99
24_A36_M1.0760.99
142_A150_E1.0710.99
93_V104_A1.0690.99
58_L71_L1.0600.99
113_V155_S1.0500.98
122_D125_P1.0460.98
60_V68_C1.0440.98
186_V209_L1.0410.98
127_M135_I1.0410.98
134_D177_R1.0390.98
139_S143_A1.0330.98
116_V120_V1.0310.98
68_C119_N1.0300.98
151_P166_T1.0300.98
85_L119_N1.0260.98
105_I152_V1.0240.98
45_K48_C1.0160.98
23_S215_A1.0110.98
63_L111_L1.0060.98
134_D179_G1.0050.98
45_K49_N1.0040.98
22_A215_A1.0040.98
25_E51_H1.0020.98
56_I78_K1.0000.98
36_M47_L0.9950.98
126_H130_R0.9900.98
104_A107_R0.9850.98
44_L57_P0.9800.98
40_D193_D0.9770.98
65_P102_T0.9760.98
108_M156_S0.9700.97
220_F224_R0.9590.97
91_T107_R0.9560.97
87_A120_V0.9500.97
146_P165_Q0.9490.97
72_L118_K0.9470.97
41_E57_P0.9460.97
109_L156_S0.9210.96
33_R55_V0.9200.96
140_S157_K0.9190.96
113_V117_M0.9160.96
109_L159_A0.9130.96
26_A29_A0.9120.96
68_C118_K0.9020.96
109_L117_M0.9010.96
36_M48_C0.9000.96
8_K32_A0.8970.96
124_L135_I0.8960.96
17_S189_A0.8940.96
62_L119_N0.8920.96
146_P158_W0.8820.95
37_V58_L0.8810.95
97_L151_P0.8800.95
125_P129_E0.8790.95
58_L74_R0.8780.95
136_I222_L0.8750.95
10_A32_A0.8730.95
5_L32_A0.8710.95
161_N180_S0.8680.95
130_R133_G0.8670.95
46_A49_N0.8640.95
47_L51_H0.8620.95
107_R110_N0.8610.95
211_A215_A0.8500.95
46_A50_K0.8490.94
219_M223_T0.8400.94
28_L36_M0.8380.94
56_I74_R0.8370.94
35_V58_L0.8330.94
154_A166_T0.8290.94
111_L115_V0.8270.94
154_A162_C0.8230.94
116_V137_V0.8150.93
74_R79_A0.7970.92
115_V118_K0.7950.92
144_H182_S0.7950.92
26_A215_A0.7940.92
151_P170_Q0.7930.92
33_R79_A0.7910.92
32_A83_D0.7890.92
186_V214_V0.7870.92
19_I23_S0.7780.91
155_S162_C0.7740.91
139_S160_I0.7740.91
185_P191_L0.7720.91
12_V27_M0.7720.91
22_A211_A0.7710.91
97_L105_I0.7660.91
167_V178_V0.7650.91
51_H55_V0.7630.91
72_L119_N0.7630.91
65_P118_K0.7620.91
13_T88_N0.7610.91
7_G33_R0.7610.91
23_S86_H0.7610.91
136_I218_V0.7600.90
12_V34_V0.7590.90
45_K57_P0.7590.90
19_I183_P0.7570.90
11_A71_L0.7570.90
35_V79_A0.7520.90
70_T74_R0.7430.89
23_S31_G0.7370.89
16_A40_D0.7370.89
210_E213_D0.7360.89
74_R77_E0.7330.89
75_V79_A0.7330.89
143_A158_W0.7300.89
22_A26_A0.7270.88
139_S180_S0.7260.88
124_L176_I0.7260.88
154_A158_W0.7180.88
72_L122_D0.7040.87
120_V164_V0.7030.87
102_T118_K0.7020.87
60_V67_D0.7020.87
7_G32_A0.7020.87
177_R224_R0.7010.87
82_L127_M0.7000.87
35_V71_L0.6990.86
133_G175_G0.6930.86
105_I121_H0.6920.86
28_L51_H0.6910.86
147_T150_E0.6900.86
161_N182_S0.6900.86
189_A192_A0.6870.85
112_N157_K0.6840.85
124_L128_I0.6830.85
136_I181_I0.6820.85
216_E220_F0.6780.85
76_L79_A0.6760.85
15_A47_L0.6750.84
24_A28_L0.6690.84
93_V108_M0.6660.84
116_V119_N0.6650.84
90_G183_P0.6650.84
68_C122_D0.6640.84
85_L127_M0.6640.84
155_S163_F0.6630.83
24_A51_H0.6630.83
92_Y191_L0.6620.83
76_L130_R0.6610.83
26_A212_S0.6610.83
100_A152_V0.6580.83
142_A154_A0.6550.83
63_L107_R0.6510.82
42_A45_K0.6500.82
37_V75_V0.6490.82
88_N116_V0.6480.82
59_V67_D0.6470.82
212_S216_E0.6460.82
140_S153_Y0.6410.81
92_Y194_W0.6410.81
86_H218_V0.6400.81
76_L129_E0.6400.81
152_V156_S0.6400.81
70_T73_P0.6380.81
15_A24_A0.6380.81
22_A25_E0.6380.81
38_D44_L0.6370.81
14_G20_G0.6360.81
5_L8_K0.6350.81
83_D130_R0.6300.80
17_S43_A0.6260.80
52_G55_V0.6260.80
25_E47_L0.6230.79
85_L123_V0.6230.79
37_V68_C0.6180.79
151_P155_S0.6160.79
4_E7_G0.6150.79
14_G18_G0.6120.78
171_V176_I0.6100.78
136_I221_M0.6080.78
66_E69_A0.6030.77
90_G112_N0.6010.77
21_L50_K0.5990.77
44_L59_V0.5990.77
66_E103_M0.5960.76
142_A182_S0.5930.76
91_T108_M0.5920.76
58_L78_K0.5890.76
127_M132_T0.5880.75
146_P154_A0.5790.74
67_D71_L0.5790.74
78_K81_Q0.5760.74
48_C51_H0.5760.74
23_S26_A0.5740.74
128_I171_V0.5710.73
84_I134_D0.5680.73
38_D111_L0.5670.73
116_V164_V0.5670.73
144_H180_S0.5650.73
153_Y157_K0.5640.72
171_V174_H0.5640.72
175_G178_V0.5610.72
69_A126_H0.5610.72
66_E70_T0.5610.72
85_L135_I0.5590.72
97_L120_V0.5580.72
63_L110_N0.5520.71
60_V119_N0.5510.71
162_C166_T0.5500.71
108_M152_V0.5490.70
39_R111_L0.5490.70
30_A216_E0.5490.70
75_V123_V0.5470.70
136_I179_G0.5440.70
69_A125_P0.5410.69
146_P166_T0.5400.69
84_I127_M0.5400.69
17_S47_L0.5400.69
114_N117_M0.5380.69
104_A197_E0.5370.69
71_L123_V0.5350.68
92_Y150_E0.5350.68
75_V82_L0.5330.68
159_A162_C0.5320.68
23_S28_L0.5320.68
33_R53_D0.5310.68
91_T111_L0.5300.68
168_R227_G0.5290.68
72_L126_H0.5270.67
114_N118_K0.5260.67
108_M184_G0.5240.67
29_A216_E0.5240.67
134_D224_R0.5220.67
19_I214_V0.5210.66
13_T89_A0.5200.66
56_I79_A0.5160.66
42_A46_A0.5150.66
158_W165_Q0.5130.65
11_A75_V0.5110.65
32_A53_D0.5110.65
207_S213_D0.5110.65
144_H161_N0.5100.65
215_A222_L0.5100.65
143_A182_S0.5090.65
62_L116_V0.5090.65
34_V47_L0.5090.65
65_P122_D0.5070.64
103_M121_H0.5060.64
221_M229_T0.5050.64
34_V86_H0.5030.64
65_P103_M0.5020.64
29_A52_G0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2et6_A 1 0.9628 100 0.211 Contact Map
1zem_A 1 0.9752 100 0.22 Contact Map
3wtc_A 1 0.9917 100 0.234 Contact Map
4bmn_A 1 0.9463 100 0.235 Contact Map
1nff_A 1 0.9876 100 0.237 Contact Map
1vl8_A 1 0.9917 100 0.238 Contact Map
2c07_A 1 0.9752 100 0.24 Contact Map
4z9x_A 1 1 100 0.241 Contact Map
4weo_A 1 0.9463 100 0.242 Contact Map
4is2_A 1 0.8636 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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