T0889_1_242 - CASP12 - GREMLIN Contacts

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T0889_1_242 - T0889 1-242

ID:	38	Sequences: MARELEGKVAAVTGAASGIGLASAEAMLAAGARVVMVDRDEAALKALCNKHGDTVIPLVVDLLDPEDCATLLPRVLEKACQLDILHANAGTYVGGDLVDADTMAIDRMLNLNVNVVMKNVHDVLPHMIERRTGDIIVTSSLAAHFPTPWEPVYASSKWAINCFVQTVRRQVFKHGIRVGSISPGPVVSALLADWPPEKLKEARDSGSLLEASDVAEVVMFMLTRPRGMTIRDVLMLPTNFDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	242 (226)
Sequences:	2953 (1927)
Seq/√Len:	128.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_D	67_D	3.587	1.00
112_N	156_S	3.579	1.00
106_D	110_N	3.555	1.00
116_V	160_I	3.246	1.00
41_E	45_K	3.102	1.00
137_V	164_V	2.885	1.00
87_A	137_V	2.864	1.00
16_A	38_D	2.857	1.00
113_V	159_A	2.852	1.00
10_A	27_M	2.689	1.00
30_A	223_T	2.627	1.00
25_E	50_K	2.556	1.00
158_W	162_C	2.517	1.00
23_S	218_V	2.335	1.00
19_I	186_V	2.330	1.00
26_A	216_E	2.254	1.00
21_L	25_E	2.123	1.00
110_N	114_N	2.023	1.00
15_A	36_M	2.008	1.00
134_D	222_L	1.948	1.00
82_L	123_V	1.939	1.00
41_E	59_V	1.936	1.00
106_D	114_N	1.932	1.00
86_H	138_T	1.922	1.00
9_V	33_R	1.919	1.00
26_A	30_A	1.900	1.00
117_M	159_A	1.896	1.00
164_V	180_S	1.874	1.00
37_V	60_V	1.825	1.00
27_M	222_L	1.820	1.00
120_V	135_I	1.811	1.00
48_C	57_P	1.770	1.00
27_M	84_I	1.743	1.00
98_V	128_I	1.735	1.00
84_I	222_L	1.714	1.00
96_D	99_D	1.697	1.00
62_L	115_V	1.683	1.00
139_S	161_N	1.682	1.00
120_V	163_F	1.659	1.00
10_A	84_I	1.640	1.00
92_Y	190_L	1.630	1.00
35_V	75_V	1.599	1.00
65_P	106_D	1.582	1.00
164_V	178_V	1.508	1.00
124_L	171_V	1.487	1.00
143_A	161_N	1.479	1.00
16_A	39_R	1.468	1.00
179_G	221_M	1.464	1.00
127_M	133_G	1.455	1.00
40_D	43_A	1.443	1.00
181_I	218_V	1.431	1.00
131_R	175_G	1.431	1.00
37_V	71_L	1.412	1.00
12_V	24_A	1.406	1.00
101_D	104_A	1.405	1.00
76_L	126_H	1.397	1.00
109_L	113_V	1.394	1.00
32_A	84_I	1.385	1.00
128_I	174_H	1.383	1.00
81_Q	130_R	1.377	1.00
22_A	212_S	1.366	1.00
87_A	164_V	1.364	1.00
158_W	161_N	1.353	1.00
26_A	219_M	1.345	1.00
187_V	210_E	1.342	1.00
47_L	50_K	1.339	1.00
9_V	81_Q	1.331	1.00
21_L	47_L	1.324	1.00
27_M	219_M	1.321	1.00
127_M	130_R	1.310	1.00
177_R	225_P	1.305	1.00
117_M	163_F	1.299	1.00
74_R	78_K	1.299	1.00
33_R	54_T	1.285	1.00
69_A	73_P	1.274	1.00
30_A	219_M	1.272	1.00
60_V	71_L	1.251	1.00
102_T	121_H	1.250	1.00
67_D	70_T	1.245	1.00
12_V	23_S	1.228	1.00
76_L	81_Q	1.221	0.99
28_L	34_V	1.188	0.99
8_K	83_D	1.171	0.99
21_L	46_A	1.166	0.99
25_E	29_A	1.163	0.99
72_L	123_V	1.154	0.99
43_A	189_A	1.144	0.99
120_V	167_V	1.126	0.99
138_T	218_V	1.105	0.99
97_L	121_H	1.105	0.99
139_S	182_S	1.089	0.99
87_A	119_N	1.081	0.99
11_A	82_L	1.078	0.99
73_P	77_E	1.078	0.99
24_A	36_M	1.076	0.99
142_A	150_E	1.071	0.99
93_V	104_A	1.069	0.99
58_L	71_L	1.060	0.99
113_V	155_S	1.050	0.98
122_D	125_P	1.046	0.98
60_V	68_C	1.044	0.98
186_V	209_L	1.041	0.98
127_M	135_I	1.041	0.98
134_D	177_R	1.039	0.98
139_S	143_A	1.033	0.98
116_V	120_V	1.031	0.98
68_C	119_N	1.030	0.98
151_P	166_T	1.030	0.98
85_L	119_N	1.026	0.98
105_I	152_V	1.024	0.98
45_K	48_C	1.016	0.98
23_S	215_A	1.011	0.98
63_L	111_L	1.006	0.98
134_D	179_G	1.005	0.98
45_K	49_N	1.004	0.98
22_A	215_A	1.004	0.98
25_E	51_H	1.002	0.98
56_I	78_K	1.000	0.98
36_M	47_L	0.995	0.98
126_H	130_R	0.990	0.98
104_A	107_R	0.985	0.98
44_L	57_P	0.980	0.98
40_D	193_D	0.977	0.98
65_P	102_T	0.976	0.98
108_M	156_S	0.970	0.97
220_F	224_R	0.959	0.97
91_T	107_R	0.956	0.97
87_A	120_V	0.950	0.97
146_P	165_Q	0.949	0.97
72_L	118_K	0.947	0.97
41_E	57_P	0.946	0.97
109_L	156_S	0.921	0.96
33_R	55_V	0.920	0.96
140_S	157_K	0.919	0.96
113_V	117_M	0.916	0.96
109_L	159_A	0.913	0.96
26_A	29_A	0.912	0.96
68_C	118_K	0.902	0.96
109_L	117_M	0.901	0.96
36_M	48_C	0.900	0.96
8_K	32_A	0.897	0.96
124_L	135_I	0.896	0.96
17_S	189_A	0.894	0.96
62_L	119_N	0.892	0.96
146_P	158_W	0.882	0.95
37_V	58_L	0.881	0.95
97_L	151_P	0.880	0.95
125_P	129_E	0.879	0.95
58_L	74_R	0.878	0.95
136_I	222_L	0.875	0.95
10_A	32_A	0.873	0.95
5_L	32_A	0.871	0.95
161_N	180_S	0.868	0.95
130_R	133_G	0.867	0.95
46_A	49_N	0.864	0.95
47_L	51_H	0.862	0.95
107_R	110_N	0.861	0.95
211_A	215_A	0.850	0.95
46_A	50_K	0.849	0.94
219_M	223_T	0.840	0.94
28_L	36_M	0.838	0.94
56_I	74_R	0.837	0.94
35_V	58_L	0.833	0.94
154_A	166_T	0.829	0.94
111_L	115_V	0.827	0.94
154_A	162_C	0.823	0.94
116_V	137_V	0.815	0.93
74_R	79_A	0.797	0.92
115_V	118_K	0.795	0.92
144_H	182_S	0.795	0.92
26_A	215_A	0.794	0.92
151_P	170_Q	0.793	0.92
33_R	79_A	0.791	0.92
32_A	83_D	0.789	0.92
186_V	214_V	0.787	0.92
19_I	23_S	0.778	0.91
155_S	162_C	0.774	0.91
139_S	160_I	0.774	0.91
185_P	191_L	0.772	0.91
12_V	27_M	0.772	0.91
22_A	211_A	0.771	0.91
97_L	105_I	0.766	0.91
167_V	178_V	0.765	0.91
51_H	55_V	0.763	0.91
72_L	119_N	0.763	0.91
65_P	118_K	0.762	0.91
13_T	88_N	0.761	0.91
7_G	33_R	0.761	0.91
23_S	86_H	0.761	0.91
136_I	218_V	0.760	0.90
12_V	34_V	0.759	0.90
45_K	57_P	0.759	0.90
19_I	183_P	0.757	0.90
11_A	71_L	0.757	0.90
35_V	79_A	0.752	0.90
70_T	74_R	0.743	0.89
23_S	31_G	0.737	0.89
16_A	40_D	0.737	0.89
210_E	213_D	0.736	0.89
74_R	77_E	0.733	0.89
75_V	79_A	0.733	0.89
143_A	158_W	0.730	0.89
22_A	26_A	0.727	0.88
139_S	180_S	0.726	0.88
124_L	176_I	0.726	0.88
154_A	158_W	0.718	0.88
72_L	122_D	0.704	0.87
120_V	164_V	0.703	0.87
102_T	118_K	0.702	0.87
60_V	67_D	0.702	0.87
7_G	32_A	0.702	0.87
177_R	224_R	0.701	0.87
82_L	127_M	0.700	0.87
35_V	71_L	0.699	0.86
133_G	175_G	0.693	0.86
105_I	121_H	0.692	0.86
28_L	51_H	0.691	0.86
147_T	150_E	0.690	0.86
161_N	182_S	0.690	0.86
189_A	192_A	0.687	0.85
112_N	157_K	0.684	0.85
124_L	128_I	0.683	0.85
136_I	181_I	0.682	0.85
216_E	220_F	0.678	0.85
76_L	79_A	0.676	0.85
15_A	47_L	0.675	0.84
24_A	28_L	0.669	0.84
93_V	108_M	0.666	0.84
116_V	119_N	0.665	0.84
90_G	183_P	0.665	0.84
68_C	122_D	0.664	0.84
85_L	127_M	0.664	0.84
155_S	163_F	0.663	0.83
24_A	51_H	0.663	0.83
92_Y	191_L	0.662	0.83
76_L	130_R	0.661	0.83
26_A	212_S	0.661	0.83
100_A	152_V	0.658	0.83
142_A	154_A	0.655	0.83
63_L	107_R	0.651	0.82
42_A	45_K	0.650	0.82
37_V	75_V	0.649	0.82
88_N	116_V	0.648	0.82
59_V	67_D	0.647	0.82
212_S	216_E	0.646	0.82
140_S	153_Y	0.641	0.81
92_Y	194_W	0.641	0.81
86_H	218_V	0.640	0.81
76_L	129_E	0.640	0.81
152_V	156_S	0.640	0.81
70_T	73_P	0.638	0.81
15_A	24_A	0.638	0.81
22_A	25_E	0.638	0.81
38_D	44_L	0.637	0.81
14_G	20_G	0.636	0.81
5_L	8_K	0.635	0.81
83_D	130_R	0.630	0.80
17_S	43_A	0.626	0.80
52_G	55_V	0.626	0.80
25_E	47_L	0.623	0.79
85_L	123_V	0.623	0.79
37_V	68_C	0.618	0.79
151_P	155_S	0.616	0.79
4_E	7_G	0.615	0.79
14_G	18_G	0.612	0.78
171_V	176_I	0.610	0.78
136_I	221_M	0.608	0.78
66_E	69_A	0.603	0.77
90_G	112_N	0.601	0.77
21_L	50_K	0.599	0.77
44_L	59_V	0.599	0.77
66_E	103_M	0.596	0.76
142_A	182_S	0.593	0.76
91_T	108_M	0.592	0.76
58_L	78_K	0.589	0.76
127_M	132_T	0.588	0.75
146_P	154_A	0.579	0.74
67_D	71_L	0.579	0.74
78_K	81_Q	0.576	0.74
48_C	51_H	0.576	0.74
23_S	26_A	0.574	0.74
128_I	171_V	0.571	0.73
84_I	134_D	0.568	0.73
38_D	111_L	0.567	0.73
116_V	164_V	0.567	0.73
144_H	180_S	0.565	0.73
153_Y	157_K	0.564	0.72
171_V	174_H	0.564	0.72
175_G	178_V	0.561	0.72
69_A	126_H	0.561	0.72
66_E	70_T	0.561	0.72
85_L	135_I	0.559	0.72
97_L	120_V	0.558	0.72
63_L	110_N	0.552	0.71
60_V	119_N	0.551	0.71
162_C	166_T	0.550	0.71
108_M	152_V	0.549	0.70
39_R	111_L	0.549	0.70
30_A	216_E	0.549	0.70
75_V	123_V	0.547	0.70
136_I	179_G	0.544	0.70
69_A	125_P	0.541	0.69
146_P	166_T	0.540	0.69
84_I	127_M	0.540	0.69
17_S	47_L	0.540	0.69
114_N	117_M	0.538	0.69
104_A	197_E	0.537	0.69
71_L	123_V	0.535	0.68
92_Y	150_E	0.535	0.68
75_V	82_L	0.533	0.68
159_A	162_C	0.532	0.68
23_S	28_L	0.532	0.68
33_R	53_D	0.531	0.68
91_T	111_L	0.530	0.68
168_R	227_G	0.529	0.68
72_L	126_H	0.527	0.67
114_N	118_K	0.526	0.67
108_M	184_G	0.524	0.67
29_A	216_E	0.524	0.67
134_D	224_R	0.522	0.67
19_I	214_V	0.521	0.66
13_T	89_A	0.520	0.66
56_I	79_A	0.516	0.66
42_A	46_A	0.515	0.66
158_W	165_Q	0.513	0.65
11_A	75_V	0.511	0.65
32_A	53_D	0.511	0.65
207_S	213_D	0.511	0.65
144_H	161_N	0.510	0.65
215_A	222_L	0.510	0.65
143_A	182_S	0.509	0.65
62_L	116_V	0.509	0.65
34_V	47_L	0.509	0.65
65_P	122_D	0.507	0.64
103_M	121_H	0.506	0.64
221_M	229_T	0.505	0.64
34_V	86_H	0.503	0.64
65_P	103_M	0.502	0.64
29_A	52_G	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2et6_A	1	0.9628	100	0.211	Contact Map
1zem_A	1	0.9752	100	0.22	Contact Map
3wtc_A	1	0.9917	100	0.234	Contact Map
4bmn_A	1	0.9463	100	0.235	Contact Map
1nff_A	1	0.9876	100	0.237	Contact Map
1vl8_A	1	0.9917	100	0.238	Contact Map
2c07_A	1	0.9752	100	0.24	Contact Map
4z9x_A	1	1	100	0.241	Contact Map
4weo_A	1	0.9463	100	0.242	Contact Map
4is2_A	1	0.8636	100	0.242	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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