GREMLIN Database
T0886_FULL_1_474 - T0886_FULL 1-474
ID: 35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 474 (439)
Sequences: 3421 (2684)
Seq/√Len: 128.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_S233_E4.7611.00
231_N242_S4.6211.00
12_D15_D4.1481.00
101_S230_A4.0811.00
281_K368_D3.4821.00
285_K289_E3.1411.00
233_E240_K3.0731.00
107_K237_D3.0701.00
374_D377_G3.0141.00
98_Q235_T2.9651.00
234_I248_V2.8951.00
362_I367_L2.7531.00
296_K359_T2.7061.00
145_N153_A2.6981.00
282_D286_K2.5561.00
435_Q439_T2.5401.00
363_D366_K2.4921.00
350_L381_Y2.4841.00
104_T230_A2.4741.00
285_K364_E2.4641.00
100_N233_E2.4561.00
145_N149_G2.4431.00
25_G428_A2.4291.00
248_V259_V2.4141.00
243_I250_D2.4031.00
369_K373_A2.3981.00
151_R167_I2.3301.00
233_E242_S2.2361.00
234_I241_R2.2291.00
15_D19_K2.2061.00
56_F294_L2.2051.00
355_T361_E2.2011.00
428_A432_A2.1681.00
231_N244_A2.1451.00
285_K362_I2.1081.00
81_I263_T2.1061.00
235_T240_K2.0761.00
13_Y17_V2.0561.00
355_T359_T2.0391.00
445_L449_Q2.0371.00
14_T439_T2.0111.00
247_S258_D1.9971.00
437_K441_Q1.9701.00
52_A297_F1.9701.00
36_E421_D1.9421.00
94_T272_T1.9391.00
263_T269_I1.9341.00
59_A290_A1.9171.00
32_L420_V1.9071.00
281_K364_E1.9051.00
381_Y388_L1.9031.00
458_S462_N1.9001.00
21_V431_L1.8961.00
154_I178_L1.8951.00
284_V367_L1.8901.00
144_N149_G1.8851.00
82_L97_I1.8541.00
82_L271_L1.8511.00
164_S181_T1.8351.00
21_V434_L1.8291.00
296_K300_E1.7831.00
434_L437_K1.7821.00
125_T137_A1.7651.00
100_N235_T1.7421.00
82_L269_I1.7411.00
367_L371_I1.7101.00
149_G153_A1.7011.00
289_E293_T1.6941.00
29_T33_A1.6891.00
39_T413_L1.6771.00
438_L442_F1.6551.00
170_D175_R1.6501.00
43_L413_L1.6431.00
19_K22_N1.6341.00
345_R349_A1.6331.00
167_I174_S1.6281.00
105_S183_T1.6221.00
6_I9_G1.6221.00
297_F301_Q1.6121.00
53_I396_M1.6091.00
24_E434_L1.6001.00
148_A152_D1.6001.00
432_A436_E1.5931.00
100_N240_K1.5791.00
127_N137_A1.5741.00
18_N22_N1.5711.00
44_T47_G1.5531.00
106_S189_I1.5491.00
434_L438_L1.5491.00
77_S269_I1.5421.00
316_G319_L1.5391.00
25_G431_L1.5261.00
225_Y228_K1.5161.00
78_N261_A1.4821.00
95_Y237_D1.4771.00
284_V362_I1.4721.00
154_I165_A1.4641.00
72_R86_A1.4641.00
288_V362_I1.4611.00
141_D144_N1.4611.00
78_N81_I1.4511.00
346_N349_A1.4501.00
74_A84_A1.4491.00
458_S461_D1.4461.00
248_V257_F1.4451.00
422_T426_D1.4401.00
68_V283_N1.4341.00
84_A271_L1.4321.00
33_A424_K1.4301.00
102_L259_V1.4301.00
321_D409_R1.4291.00
60_L392_L1.4161.00
278_A282_D1.3991.00
73_T274_S1.3901.00
36_E424_K1.3881.00
136_P161_A1.3871.00
178_L191_V1.3821.00
421_D425_A1.3811.00
252_I255_V1.3801.00
52_A293_T1.3731.00
83_K260_K1.3731.00
23_L26_A1.3711.00
436_E440_T1.3571.00
125_T139_T1.3461.00
281_K285_K1.3371.00
45_A301_Q1.3361.00
127_N135_L1.3321.00
98_Q263_T1.3311.00
13_Y446_S1.3191.00
304_V313_P1.3191.00
286_K289_E1.3051.00
302_T324_V1.3051.00
440_T444_L1.3041.00
81_I261_A1.3041.00
278_A368_D1.2981.00
14_T18_N1.2911.00
327_L399_Y1.2581.00
140_V150_M1.2561.00
243_I248_V1.2561.00
97_I236_V1.2511.00
354_T360_L1.2501.00
263_T266_G1.2501.00
427_L431_L1.2451.00
40_T417_L1.2381.00
443_N447_A1.2381.00
397_K401_D1.2331.00
39_T417_L1.2331.00
414_Q418_S1.2311.00
294_L298_I1.2291.00
39_T416_T1.2220.99
463_L466_L1.2190.99
295_T328_V1.2150.99
72_R92_A1.2040.99
33_A36_E1.2030.99
234_I259_V1.2020.99
169_T174_S1.2020.99
353_T363_D1.2000.99
364_E368_D1.1920.99
10_S446_S1.1860.99
35_L423_Q1.1850.99
108_I225_Y1.1820.99
43_L47_G1.1740.99
146_T149_G1.1710.99
129_S190_K1.1660.99
11_T445_L1.1630.99
59_A62_A1.1610.99
290_A293_T1.1550.99
280_V375_F1.1460.99
449_Q453_T1.1430.99
407_D411_T1.1420.99
20_M442_F1.1340.99
453_T457_K1.1320.99
368_D372_S1.1320.99
38_T42_R1.1320.99
17_V21_V1.1290.99
43_L414_Q1.1260.99
403_Q407_D1.1190.99
295_T359_T1.1190.99
234_I240_K1.1160.99
248_V251_V1.1100.99
371_I378_V1.1090.99
54_S57_Q1.1020.99
283_N286_K1.1000.99
62_A286_K1.0970.99
84_A257_F1.0960.99
394_D397_K1.0930.99
98_Q265_A1.0930.99
284_V382_F1.0920.99
108_I189_I1.0920.99
415_K418_S1.0920.99
282_D285_K1.0920.99
304_V308_G1.0870.99
18_N435_Q1.0870.99
401_D407_D1.0860.99
232_G259_V1.0840.99
75_K274_S1.0830.99
21_V435_Q1.0760.99
426_D429_K1.0730.99
298_I324_V1.0670.99
11_T16_L1.0670.99
429_K432_A1.0670.99
230_A233_E1.0650.99
376_E380_S1.0640.99
347_L352_I1.0610.99
7_G10_S1.0540.98
236_V241_R1.0530.98
352_I360_L1.0510.98
32_L427_L1.0510.98
43_L417_L1.0500.98
97_I271_L1.0430.98
82_L257_F1.0410.98
25_G29_T1.0380.98
127_N194_S1.0350.98
419_N423_Q1.0250.98
232_G246_N1.0210.98
280_V283_N1.0200.98
140_V145_N1.0190.98
165_A178_L1.0170.98
13_Y445_L1.0150.98
147_L167_I1.0130.98
62_A283_N1.0130.98
350_L378_V1.0110.98
102_L262_V1.0110.98
460_T464_A1.0080.98
170_D173_G1.0050.98
129_S135_L1.0040.98
429_K433_A0.9930.98
20_M24_E0.9920.98
432_A435_Q0.9920.98
83_K258_D0.9900.98
140_V153_A0.9880.98
431_L435_Q0.9880.98
304_V319_L0.9830.98
129_S132_D0.9820.98
453_T456_Q0.9810.98
152_D156_Q0.9800.98
412_T416_T0.9790.98
372_S375_F0.9780.98
104_T262_V0.9760.98
422_T425_A0.9740.97
49_F301_Q0.9730.97
148_A167_I0.9720.97
234_I243_I0.9700.97
297_F300_E0.9650.97
76_S79_E0.9650.97
73_T276_D0.9640.97
96_Q270_T0.9630.97
36_E417_L0.9630.97
36_E40_T0.9620.97
55_A293_T0.9550.97
277_D372_S0.9550.97
305_T313_P0.9520.97
7_G446_S0.9490.97
236_V251_V0.9490.97
187_K229_A0.9470.97
146_T150_M0.9470.97
276_D279_G0.9470.97
100_N234_I0.9460.97
288_V367_L0.9440.97
187_K244_A0.9390.97
195_D198_S0.9380.97
281_K362_I0.9350.97
17_V435_Q0.9340.97
39_T43_L0.9300.97
334_E395_K0.9290.97
32_L424_K0.9290.97
425_A428_A0.9280.97
457_K460_T0.9260.97
36_E420_V0.9240.97
57_Q393_G0.9230.97
101_S262_V0.9220.96
279_G282_D0.9200.96
305_T308_G0.9180.96
418_S422_T0.9180.96
55_A290_A0.9140.96
423_Q426_D0.9120.96
411_T415_K0.9100.96
370_A378_V0.9100.96
5_S9_G0.9010.96
80_D261_A0.9000.96
53_I294_L0.8970.96
59_A286_K0.8950.96
37_K41_T0.8890.96
280_V371_I0.8830.96
241_R251_V0.8820.95
335_L360_L0.8800.95
193_V196_D0.8790.95
369_K372_S0.8750.95
145_N150_M0.8740.95
344_V350_L0.8680.95
141_D149_G0.8660.95
109_A226_V0.8590.95
348_A353_T0.8580.95
74_A86_A0.8540.95
69_F382_F0.8510.95
141_D145_N0.8510.95
58_T61_T0.8490.94
151_R165_A0.8490.94
293_T297_F0.8480.94
76_S81_I0.8460.94
128_I138_I0.8420.94
298_I301_Q0.8420.94
61_T393_G0.8400.94
186_G244_A0.8390.94
5_S8_V0.8370.94
47_G50_K0.8370.94
425_A429_K0.8340.94
16_L442_F0.8330.94
445_L448_M0.8310.94
49_F327_L0.8300.94
182_K187_K0.8300.94
50_K54_S0.8290.94
330_T395_K0.8280.94
295_T299_N0.8260.94
27_A430_R0.8250.94
9_G446_S0.8240.94
85_S256_S0.8230.93
334_E391_R0.8190.93
279_G283_N0.8180.93
288_V352_I0.8160.93
95_Y273_V0.8150.93
395_K399_Y0.8140.93
73_T278_A0.8130.93
17_V443_N0.8120.93
25_G28_K0.8090.93
410_T414_Q0.8090.93
21_V25_G0.8080.93
28_K427_L0.8070.93
26_A30_N0.8050.93
365_K369_K0.8050.93
49_F324_V0.8010.93
278_A281_K0.8000.93
58_T62_A0.7990.92
19_K23_L0.7980.92
23_L27_A0.7950.92
98_Q264_E0.7900.92
52_A55_A0.7890.92
43_L410_T0.7850.92
106_S225_Y0.7820.92
185_D188_D0.7800.92
417_L421_D0.7790.91
418_S421_D0.7770.91
28_K428_A0.7730.91
129_S192_E0.7730.91
366_K369_K0.7720.91
151_R176_L0.7710.91
377_G380_S0.7700.91
19_K24_E0.7660.91
21_V427_L0.7660.91
232_G248_V0.7660.91
104_T227_T0.7650.91
298_I328_V0.7610.91
327_L395_K0.7610.91
47_G51_S0.7590.90
108_I223_A0.7590.90
29_T424_K0.7580.90
328_V332_R0.7540.90
140_V144_N0.7520.90
21_V24_E0.7510.90
433_A436_E0.7490.90
190_K210_D0.7480.90
337_A391_R0.7470.90
436_E439_T0.7430.89
448_M451_E0.7420.89
52_A294_L0.7410.89
448_M452_M0.7390.89
399_Y405_I0.7390.89
26_A29_T0.7380.89
185_D244_A0.7370.89
110_L223_A0.7370.89
90_A255_V0.7370.89
291_Y295_T0.7360.89
42_R416_T0.7360.89
171_N174_S0.7340.89
22_N26_A0.7320.89
167_I176_L0.7320.89
255_V273_V0.7280.89
243_I249_S0.7280.89
186_G231_N0.7270.88
288_V292_N0.7250.88
149_G152_D0.7250.88
136_P159_K0.7230.88
123_S145_N0.7220.88
79_E83_K0.7220.88
106_S229_A0.7220.88
49_F298_I0.7190.88
446_S449_Q0.7120.87
455_R458_S0.7110.87
64_N393_G0.7100.87
106_S188_D0.7100.87
243_I259_V0.7090.87
97_I250_D0.7090.87
34_T37_K0.7080.87
232_G243_I0.7070.87
128_I161_A0.7050.87
72_R275_R0.7050.87
431_L434_L0.7050.87
353_T361_E0.7030.87
185_D231_N0.7030.87
288_V360_L0.7030.87
28_K424_K0.7020.87
393_G397_K0.7010.87
259_V262_V0.6990.86
438_L441_Q0.6970.86
257_F271_L0.6950.86
45_A317_A0.6940.86
344_V370_A0.6940.86
76_S269_I0.6930.86
20_M23_L0.6920.86
101_S104_T0.6910.86
331_M360_L0.6910.86
282_D289_E0.6870.85
357_D361_E0.6840.85
234_I257_F0.6840.85
262_V266_G0.6840.85
325_R329_N0.6830.85
188_D229_A0.6820.85
449_Q456_Q0.6820.85
128_I136_P0.6810.85
300_E303_V0.6790.85
447_A451_E0.6780.85
24_E27_A0.6780.85
71_A279_G0.6760.85
14_T435_Q0.6760.85
182_K245_S0.6730.84
445_L452_M0.6730.84
455_R462_N0.6730.84
85_S258_D0.6730.84
416_T419_N0.6720.84
277_D368_D0.6720.84
48_Q297_F0.6710.84
442_F452_M0.6700.84
123_S144_N0.6670.84
339_N388_L0.6660.84
462_N466_L0.6660.84
57_Q61_T0.6650.84
95_Y257_F0.6640.83
53_I406_L0.6620.83
19_K25_G0.6610.83
94_T270_T0.6610.83
17_V439_T0.6600.83
444_L448_M0.6600.83
376_E379_A0.6600.83
56_F290_A0.6590.83
452_M456_Q0.6590.83
32_L36_E0.6580.83
150_M207_L0.6580.83
415_K419_N0.6580.83
299_N328_V0.6570.83
366_K370_A0.6560.83
419_N422_T0.6560.83
68_V71_A0.6560.83
41_T317_A0.6550.83
71_A283_N0.6540.83
46_L324_V0.6510.82
21_V28_K0.6500.82
83_K86_A0.6500.82
123_S142_S0.6480.82
81_I269_I0.6480.82
439_T443_N0.6460.82
65_S68_V0.6450.82
60_L396_M0.6430.82
50_K410_T0.6420.81
54_S58_T0.6410.81
76_S82_L0.6410.81
150_M154_I0.6410.81
180_S229_A0.6390.81
162_G181_T0.6340.81
61_T397_K0.6340.81
298_I327_L0.6340.81
144_N153_A0.6340.81
34_T38_T0.6320.80
13_Y439_T0.6320.80
305_T314_V0.6310.80
123_S149_G0.6310.80
128_I163_V0.6300.80
50_K400_T0.6280.80
387_G391_R0.6270.80
130_V133_T0.6260.80
56_F388_L0.6260.80
324_V328_V0.6250.80
128_I191_V0.6250.80
111_Q224_G0.6240.80
10_S453_T0.6230.79
33_A37_K0.6230.79
459_I463_L0.6230.79
106_S180_S0.6220.79
27_A427_L0.6220.79
333_S337_A0.6220.79
394_D398_P0.6200.79
16_L20_M0.6200.79
80_D260_K0.6200.79
452_M455_R0.6200.79
420_V424_K0.6190.79
97_I234_I0.6170.79
142_S145_N0.6170.79
74_A255_V0.6150.79
106_S228_K0.6150.79
25_G435_Q0.6150.79
30_N34_T0.6140.78
57_Q397_K0.6140.78
21_V26_A0.6140.78
462_N465_S0.6130.78
53_I327_L0.6120.78
86_A90_A0.6110.78
46_L321_D0.6100.78
410_T413_L0.6090.78
110_L224_G0.6090.78
155_N178_L0.6090.78
110_L113_I0.6080.78
109_A175_R0.6080.78
344_V381_Y0.6070.78
382_F387_G0.6070.78
123_S141_D0.6050.77
386_T394_D0.6050.77
84_A255_V0.6040.77
426_D430_R0.6040.77
365_K368_D0.6030.77
17_V431_L0.6030.77
76_S271_L0.6020.77
424_K428_A0.6020.77
14_T17_V0.6020.77
49_F318_L0.6000.77
29_T431_L0.5990.77
74_A271_L0.5980.77
396_M399_Y0.5960.76
243_I251_V0.5960.76
333_S336_I0.5960.76
284_V352_I0.5930.76
43_L46_L0.5930.76
421_D424_K0.5920.76
163_V178_L0.5890.76
384_G390_K0.5890.76
90_A273_V0.5880.75
50_K407_D0.5860.75
23_L434_L0.5850.75
291_Y360_L0.5850.75
39_T420_V0.5820.75
250_D253_D0.5800.74
185_D242_S0.5790.74
61_T64_N0.5780.74
155_N165_A0.5780.74
339_N391_R0.5780.74
27_A435_Q0.5760.74
177_V237_D0.5760.74
379_A383_T0.5760.74
325_R328_V0.5760.74
124_G131_G0.5750.74
173_G243_I0.5740.74
331_M392_L0.5740.74
349_A370_A0.5730.74
361_E365_K0.5720.73
251_V257_F0.5720.73
299_N359_T0.5720.73
55_A58_T0.5710.73
352_I362_I0.5710.73
48_Q52_A0.5700.73
239_L291_Y0.5680.73
302_T320_G0.5660.73
37_K40_T0.5650.73
397_K400_T0.5650.73
248_V258_D0.5640.72
21_V27_A0.5640.72
285_K368_D0.5620.72
121_F124_G0.5610.72
370_A373_A0.5570.71
338_S346_N0.5570.71
424_K446_S0.5560.71
19_K442_F0.5560.71
424_K427_L0.5550.71
348_A354_T0.5550.71
49_F297_F0.5540.71
459_I462_N0.5540.71
304_V315_T0.5520.71
100_N262_V0.5490.70
35_L38_T0.5490.70
396_M400_T0.5480.70
54_S400_T0.5480.70
82_L263_T0.5460.70
333_S352_I0.5430.70
107_K179_S0.5430.70
463_L467_P0.5420.69
170_D239_L0.5420.69
380_S384_G0.5420.69
184_G231_N0.5400.69
29_T34_T0.5390.69
27_A32_L0.5390.69
28_K431_L0.5390.69
302_T319_L0.5390.69
40_T43_L0.5390.69
96_Q104_T0.5380.69
232_G245_S0.5370.69
79_E260_K0.5360.69
398_P401_D0.5350.68
35_L39_T0.5340.68
304_V314_V0.5340.68
13_Y18_N0.5340.68
330_T334_E0.5330.68
438_L452_M0.5330.68
13_Y332_R0.5330.68
81_I260_K0.5320.68
22_N25_G0.5320.68
21_V438_L0.5320.68
95_Y239_L0.5310.68
355_T360_L0.5310.68
433_A437_K0.5310.68
447_A450_D0.5310.68
193_V197_G0.5300.68
46_L318_L0.5300.68
97_I392_L0.5300.68
295_T332_R0.5270.67
82_L234_I0.5270.67
62_A65_S0.5260.67
183_T244_A0.5260.67
77_S82_L0.5250.67
193_V208_A0.5230.67
308_G314_V0.5230.67
105_S180_S0.5230.67
101_S242_S0.5230.67
108_I209_F0.5220.67
423_Q427_L0.5200.66
60_L389_A0.5200.66
107_K177_V0.5200.66
287_F335_L0.5180.66
456_Q460_T0.5170.66
72_R273_V0.5160.66
353_T366_K0.5150.66
168_I177_V0.5140.65
138_I161_A0.5140.65
234_I251_V0.5120.65
60_L68_V0.5120.65
430_R434_L0.5110.65
442_F449_Q0.5100.65
446_S450_D0.5090.65
308_G315_T0.5090.65
434_L439_T0.5090.65
338_S391_R0.5090.65
183_T231_N0.5080.64
115_D146_T0.5080.64
69_F383_T0.5070.64
19_K54_S0.5060.64
169_T243_I0.5060.64
349_A366_K0.5050.64
72_R89_S0.5040.64
172_S242_S0.5030.64
57_Q400_T0.5030.64
350_L354_T0.5030.64
56_F60_L0.5020.64
287_F360_L0.5020.64
386_T391_R0.5020.64
366_K418_S0.5020.64
301_Q317_A0.5010.63
17_V438_L0.5010.63
439_T445_L0.5010.63
116_P148_A0.5010.63
16_L19_K0.5000.63
97_I257_F0.5000.63
252_I257_F0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bu8_A 1 0.0274 86.5 0.954 Contact Map
3c9i_A 1 0.3017 75.9 0.959 Contact Map
2yy0_A 1 0.0802 52.5 0.965 Contact Map
2z5i_A 1 0.1034 42.6 0.967 Contact Map
4lin_A 1 0.3249 42.5 0.967 Contact Map
4cgk_A 1 0.1941 39.5 0.967 Contact Map
3ghg_C 1 0.2321 34.4 0.968 Contact Map
1lwu_C 1 0.1329 32.5 0.969 Contact Map
3ci9_A 1 0.0928 24.4 0.971 Contact Map
3q8t_A 1 0.1814 23.8 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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