T0886_1_346 - CASP12 - GREMLIN Contacts

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T0886_1_346 - T0886 1-346

ID:	34	Sequences: MGHHHHHHGGSENLYFQGNEDILKASATQSAVAGTYQIQVNSLATSSKIALQAIADPANAKFNSGTLNISVGDTKLPAITVDSSNNTLAGMRDAINQAGKEAGVSATIITDNSGSRLVLSSTKTGDGKDIKVEVSDDGSGGNTSLSQLAFDPATAPKLSDGAAAGYVTKAANGEITVDGLKRSIASNSVSDVIDGVSFDVKAVTEAGKPITLTVSRDDAGVKDNVKKFVEAYNTLTKFINEQTVVTKVGEDKNPVTGALLGDASVRALVNTMRSELIASNENGSVRNLAALGITTTKDGTLEIDEKKLDKAISADFEGVASYFTGDTGLAKRLGDKMKPYTDAQGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	346 (308)
Sequences:	2908 (2246)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_N	183_S	4.529	1.00
42_S	174_E	4.217	1.00
42_S	171_A	3.710	1.00
48_K	178_D	3.644	1.00
222_K	309_D	3.527	1.00
226_K	230_E	3.324	1.00
174_E	181_K	3.072	1.00
315_D	318_G	2.936	1.00
303_I	308_L	2.933	1.00
237_K	300_T	2.881	1.00
226_K	305_E	2.771	1.00
296_T	302_E	2.740	1.00
175_I	189_V	2.725	1.00
257_G	260_L	2.686	1.00
184_I	191_D	2.606	1.00
189_V	200_V	2.552	1.00
175_I	182_R	2.540	1.00
95_I	119_L	2.536	1.00
45_T	171_A	2.494	1.00
86_N	94_A	2.491	1.00
291_L	322_Y	2.459	1.00
296_T	300_T	2.443	1.00
39_Q	176_T	2.438	1.00
41_N	174_E	2.431	1.00
23_L	38_I	2.419	1.00
223_D	227_K	2.394	1.00
304_D	307_K	2.377	1.00
226_K	303_I	2.376	1.00
85_N	90_G	2.374	1.00
22_I	204_T	2.295	1.00
238_F	242_Q	2.275	1.00
166_Y	169_K	2.193	1.00
86_N	90_G	2.160	1.00
322_Y	329_L	2.151	1.00
92_R	108_I	2.100	1.00
35_T	213_T	2.079	1.00
176_T	181_K	2.075	1.00
174_E	183_S	2.074	1.00
23_L	212_L	2.073	1.00
204_T	210_I	2.041	1.00
188_S	199_D	2.038	1.00
23_L	210_I	2.002	1.00
222_K	305_E	1.999	1.00
172_N	185_A	1.946	1.00
111_D	116_R	1.937	1.00
310_K	314_A	1.895	1.00
47_S	130_I	1.891	1.00
230_E	234_T	1.876	1.00
308_L	312_I	1.820	1.00
105_S	122_T	1.811	1.00
41_N	176_T	1.800	1.00
286_R	290_A	1.718	1.00
66_T	78_A	1.714	1.00
245_V	254_P	1.708	1.00
43_L	200_V	1.672	1.00
243_T	265_V	1.650	1.00
225_V	308_L	1.639	1.00
77_P	102_A	1.600	1.00
189_V	198_F	1.596	1.00
287_N	290_A	1.585	1.00
18_G	210_I	1.571	1.00
19_N	22_I	1.542	1.00
90_G	94_A	1.542	1.00
39_Q	204_T	1.540	1.00
108_I	115_S	1.538	1.00
68_N	78_A	1.481	1.00
70_S	131_K	1.472	1.00
237_K	241_E	1.443	1.00
313_S	316_F	1.443	1.00
235_L	239_I	1.439	1.00
66_T	80_T	1.437	1.00
41_N	181_K	1.436	1.00
36_Y	178_D	1.425	1.00
19_N	202_A	1.424	1.00
204_T	207_G	1.414	1.00
46_S	124_T	1.411	1.00
38_I	177_V	1.405	1.00
222_K	226_K	1.402	1.00
219_A	223_D	1.399	1.00
49_I	130_I	1.388	1.00
145_L	148_L	1.383	1.00
225_V	303_I	1.383	1.00
295_T	301_L	1.369	1.00
221_V	224_N	1.364	1.00
119_L	132_V	1.356	1.00
177_V	192_V	1.347	1.00
89_A	93_D	1.339	1.00
87_T	90_G	1.338	1.00
22_I	202_A	1.292	1.00
236_T	240_N	1.290	1.00
193_I	196_V	1.288	1.00
236_T	269_V	1.281	1.00
42_S	203_V	1.268	1.00
24_K	201_K	1.266	1.00
309_D	313_S	1.258	1.00
175_I	181_K	1.254	1.00
338_K	342_D	1.253	1.00
229_V	303_I	1.252	1.00
70_S	133_E	1.245	1.00
175_I	200_V	1.244	1.00
24_K	199_D	1.241	1.00
305_E	309_D	1.240	1.00
236_T	300_T	1.235	1.00
25_A	212_L	1.234	1.00
224_N	227_K	1.232	1.00
145_L	150_F	1.227	1.00
221_V	316_F	1.212	0.99
225_V	323_F	1.200	0.99
293_I	301_L	1.197	0.99
271_T	336_K	1.197	0.99
246_T	249_G	1.187	0.99
39_Q	206_A	1.185	0.99
184_I	189_V	1.182	0.99
81_V	86_N	1.169	0.99
189_V	192_V	1.166	0.99
68_N	135_S	1.149	0.99
70_S	76_L	1.139	0.99
245_V	260_L	1.129	0.99
88_L	108_I	1.112	0.99
128_K	185_A	1.108	0.99
110_T	115_S	1.107	0.99
246_T	254_P	1.104	0.99
219_A	309_D	1.098	0.99
227_K	230_E	1.097	0.99
312_I	319_V	1.089	0.99
91_M	148_L	1.086	0.99
177_V	182_R	1.081	0.99
50_A	167_V	1.071	0.99
49_I	166_Y	1.069	0.99
123_K	128_K	1.069	0.99
268_L	340_Y	1.066	0.99
38_I	212_L	1.062	0.99
241_E	244_V	1.058	0.99
56_D	60_A	1.054	0.98
173_G	200_V	1.048	0.98
95_I	106_A	1.047	0.98
47_S	170_A	1.037	0.98
67_L	134_V	1.037	0.98
182_R	192_V	1.027	0.98
294_T	304_D	1.026	0.98
25_A	198_F	1.024	0.98
68_N	76_L	1.022	0.98
69_I	79_I	1.012	0.98
81_V	94_A	1.008	0.98
238_F	241_E	1.000	0.98
231_A	234_T	0.999	0.98
218_D	313_S	0.996	0.98
126_D	183_S	0.988	0.98
83_S	86_N	0.981	0.98
48_K	118_V	0.969	0.97
49_I	164_A	0.962	0.97
51_L	54_I	0.955	0.97
288_L	293_I	0.953	0.97
129_D	170_A	0.953	0.97
47_S	166_Y	0.946	0.97
43_L	203_V	0.945	0.97
50_A	118_V	0.940	0.97
93_D	97_Q	0.938	0.97
239_I	269_V	0.932	0.97
126_D	172_N	0.931	0.97
235_L	272_M	0.927	0.97
23_L	198_F	0.926	0.97
291_L	319_V	0.924	0.97
64_S	86_N	0.919	0.96
39_Q	205_E	0.917	0.96
84_S	90_G	0.915	0.96
269_V	273_R	0.913	0.96
229_V	308_L	0.913	0.96
311_A	319_V	0.910	0.96
89_A	108_I	0.902	0.96
21_D	202_A	0.902	0.96
112_N	115_S	0.896	0.96
69_I	102_A	0.893	0.96
223_D	226_K	0.892	0.96
175_I	184_I	0.892	0.96
219_A	222_K	0.888	0.96
96_N	106_A	0.886	0.96
81_V	91_M	0.886	0.96
38_I	198_F	0.886	0.96
149_A	152_P	0.885	0.96
47_S	129_D	0.882	0.95
134_V	149_A	0.878	0.95
130_I	166_Y	0.877	0.95
184_I	190_S	0.876	0.95
217_D	220_G	0.873	0.95
234_T	238_F	0.871	0.95
239_I	265_V	0.871	0.95
173_G	187_N	0.868	0.95
45_T	168_T	0.868	0.95
69_I	95_I	0.866	0.95
306_K	310_K	0.866	0.95
136_D	139_S	0.864	0.95
128_K	170_A	0.864	0.95
126_D	185_A	0.862	0.95
35_T	211_T	0.858	0.95
328_G	332_R	0.855	0.95
110_T	184_I	0.854	0.95
221_V	312_I	0.848	0.94
337_M	341_T	0.840	0.94
307_K	310_K	0.839	0.94
31_A	214_V	0.834	0.94
274_S	277_I	0.833	0.94
21_D	201_K	0.833	0.94
189_V	197_S	0.832	0.94
222_K	303_I	0.827	0.94
335_D	338_K	0.824	0.94
111_D	114_G	0.823	0.93
92_R	117_L	0.822	0.93
334_G	338_K	0.821	0.93
275_E	332_R	0.819	0.93
41_N	175_I	0.818	0.93
317_E	321_S	0.816	0.93
171_A	174_E	0.815	0.93
229_V	293_I	0.812	0.93
184_I	192_V	0.806	0.93
38_I	175_I	0.801	0.93
52_Q	165_G	0.796	0.92
310_K	313_S	0.795	0.92
193_I	198_F	0.792	0.92
285_V	311_A	0.789	0.92
127_G	185_A	0.787	0.92
134_V	137_D	0.783	0.92
175_I	192_V	0.783	0.92
50_A	116_R	0.782	0.92
276_L	301_L	0.772	0.91
80_T	84_S	0.771	0.91
69_I	132_V	0.771	0.91
106_A	119_L	0.770	0.91
220_G	223_D	0.763	0.91
245_V	249_G	0.760	0.90
294_T	302_E	0.759	0.90
37_Q	211_T	0.759	0.90
146_S	150_F	0.755	0.90
126_D	129_D	0.752	0.90
86_N	91_M	0.747	0.90
69_I	104_V	0.745	0.90
45_T	203_V	0.739	0.89
289_A	294_T	0.739	0.89
239_I	242_Q	0.739	0.89
246_T	260_L	0.739	0.89
246_T	255_V	0.736	0.89
103_G	122_T	0.735	0.89
146_S	149_A	0.734	0.89
38_I	191_D	0.733	0.89
191_D	194_D	0.731	0.89
90_G	93_D	0.730	0.89
125_G	172_N	0.729	0.89
318_G	321_S	0.729	0.89
64_S	90_G	0.727	0.88
271_T	275_E	0.725	0.88
249_G	256_T	0.723	0.88
128_K	172_N	0.722	0.88
265_V	269_V	0.720	0.88
131_K	151_D	0.718	0.88
231_A	236_T	0.716	0.88
334_G	337_M	0.714	0.88
23_L	204_T	0.713	0.87
41_N	203_V	0.711	0.87
24_K	27_A	0.709	0.87
175_I	198_F	0.709	0.87
232_Y	301_L	0.707	0.87
198_F	201_K	0.707	0.87
27_A	31_A	0.703	0.87
173_G	186_S	0.701	0.87
203_V	207_G	0.698	0.86
71_V	130_I	0.697	0.86
127_G	172_N	0.697	0.86
317_E	320_A	0.693	0.86
107_T	118_V	0.693	0.86
260_L	266_R	0.692	0.86
216_R	221_V	0.692	0.86
223_D	230_E	0.689	0.86
17_Q	20_E	0.684	0.85
218_D	309_D	0.680	0.85
243_T	260_L	0.679	0.85
263_A	266_R	0.677	0.85
275_E	336_K	0.677	0.85
118_V	178_D	0.676	0.85
198_F	212_L	0.676	0.85
107_T	111_D	0.675	0.84
64_S	85_N	0.672	0.84
279_S	287_N	0.670	0.84
65_G	72_G	0.665	0.84
25_A	32_V	0.665	0.84
61_K	87_T	0.664	0.83
335_D	339_P	0.663	0.83
249_G	260_L	0.661	0.83
144_S	149_A	0.659	0.83
123_K	186_S	0.656	0.83
57_P	89_A	0.653	0.82
31_A	36_Y	0.652	0.82
256_T	260_L	0.646	0.82
249_G	254_P	0.646	0.82
196_V	212_L	0.646	0.82
245_V	256_T	0.646	0.82
48_K	170_A	0.645	0.82
228_F	293_I	0.643	0.81
69_I	77_P	0.642	0.81
87_T	91_M	0.642	0.81
17_Q	210_I	0.642	0.81
329_L	332_R	0.641	0.81
225_V	293_I	0.640	0.81
36_Y	214_V	0.639	0.81
33_A	216_R	0.638	0.81
245_V	261_G	0.638	0.81
266_R	270_N	0.637	0.81
285_V	291_L	0.637	0.81
45_T	126_D	0.636	0.81
294_T	307_K	0.634	0.81
249_G	255_V	0.633	0.80
139_S	144_S	0.631	0.80
240_N	300_T	0.631	0.80
100_K	103_G	0.631	0.80
235_L	269_V	0.630	0.80
131_K	152_P	0.630	0.80
63_N	114_G	0.629	0.80
71_V	74_T	0.629	0.80
285_V	290_A	0.625	0.80
146_S	151_D	0.625	0.80
75_K	135_S	0.624	0.80
39_Q	207_G	0.624	0.80
323_F	328_G	0.622	0.79
53_A	114_G	0.622	0.79
327_T	335_D	0.621	0.79
229_V	233_N	0.619	0.79
79_I	102_A	0.618	0.79
92_R	106_A	0.618	0.79
104_V	224_N	0.618	0.79
64_S	80_T	0.616	0.79
22_I	39_Q	0.615	0.79
337_M	340_Y	0.614	0.78
77_P	100_K	0.614	0.78
180_L	314_A	0.613	0.78
284_S	318_G	0.612	0.78
34_G	177_V	0.612	0.78
228_F	323_F	0.610	0.78
85_N	94_A	0.609	0.78
31_A	196_V	0.607	0.78
48_K	120_S	0.607	0.78
164_A	167_V	0.605	0.77
109_I	118_V	0.605	0.77
306_K	309_D	0.605	0.77
316_F	320_A	0.604	0.77
285_V	315_D	0.604	0.77
336_K	340_Y	0.604	0.77
22_I	201_K	0.603	0.77
51_L	164_A	0.602	0.77
64_S	84_S	0.602	0.77
280_N	332_R	0.600	0.77
331_K	335_D	0.599	0.77
70_S	73_D	0.596	0.76
268_L	338_K	0.596	0.76
276_L	290_A	0.595	0.76
229_V	301_L	0.595	0.76
46_S	168_T	0.592	0.76
247_K	258_A	0.592	0.76
22_I	40_V	0.590	0.76
232_Y	236_T	0.590	0.76
91_M	95_I	0.590	0.76
144_S	147_Q	0.588	0.75
246_T	256_T	0.587	0.75
243_T	261_G	0.586	0.75
76_L	79_I	0.585	0.75
87_T	94_A	0.581	0.75
190_S	199_D	0.578	0.74
124_T	172_N	0.577	0.74
22_I	210_I	0.576	0.74
196_V	214_V	0.576	0.74
203_V	206_A	0.575	0.74
46_S	121_S	0.575	0.74
69_I	78_A	0.574	0.74
311_A	315_D	0.574	0.74
280_N	329_L	0.573	0.74
23_L	175_I	0.571	0.73
119_L	130_I	0.571	0.73
81_V	85_N	0.570	0.73
40_V	44_A	0.569	0.73
42_S	45_T	0.569	0.73
318_G	322_Y	0.568	0.73
144_S	151_D	0.565	0.73
117_L	121_S	0.565	0.73
33_A	213_T	0.564	0.72
80_T	83_S	0.564	0.72
111_D	121_S	0.563	0.72
20_E	24_K	0.562	0.72
239_I	336_K	0.561	0.72
240_N	269_V	0.560	0.72
108_I	117_L	0.560	0.72
112_N	183_S	0.558	0.72
240_N	313_S	0.558	0.72
44_A	187_N	0.556	0.71
109_I	335_D	0.556	0.71
72_G	81_V	0.555	0.71
220_G	224_N	0.553	0.71
70_S	130_I	0.553	0.71
232_Y	273_R	0.553	0.71
244_V	260_L	0.552	0.71
134_V	148_L	0.550	0.71
336_K	339_P	0.550	0.71
126_D	170_A	0.549	0.70
307_K	311_A	0.549	0.70
23_L	232_Y	0.549	0.70
240_N	244_V	0.546	0.70
184_I	200_V	0.545	0.70
103_G	123_K	0.545	0.70
52_Q	164_A	0.545	0.70
268_L	336_K	0.544	0.70
47_S	128_K	0.544	0.70
230_E	305_E	0.544	0.70
177_V	193_I	0.543	0.70
73_D	76_L	0.543	0.70
313_S	317_E	0.542	0.69
335_D	342_D	0.541	0.69
248_V	255_V	0.540	0.69
65_G	69_I	0.540	0.69
260_L	268_L	0.536	0.69
37_Q	45_T	0.536	0.69
247_K	255_V	0.536	0.69
215_S	223_D	0.535	0.68
291_L	330_A	0.534	0.68
145_L	151_D	0.533	0.68
92_R	194_D	0.533	0.68
248_V	253_N	0.532	0.68
227_K	235_L	0.532	0.68
57_P	60_A	0.530	0.68
227_K	231_A	0.529	0.68
237_K	298_D	0.528	0.67
121_S	125_G	0.526	0.67
150_F	164_A	0.526	0.67
297_K	302_E	0.525	0.67
275_E	278_A	0.525	0.67
109_I	179_G	0.522	0.67
168_T	265_V	0.522	0.67
47_S	169_K	0.520	0.66
59_N	89_A	0.520	0.66
107_T	194_D	0.517	0.66
109_I	180_L	0.517	0.66
38_I	173_G	0.516	0.66
256_T	261_G	0.516	0.66
79_I	100_K	0.514	0.65
303_I	311_A	0.514	0.65
145_L	149_A	0.510	0.65
130_I	295_T	0.510	0.65
298_D	302_E	0.509	0.65
104_V	119_L	0.509	0.65
67_L	117_L	0.508	0.64
242_Q	258_A	0.508	0.64
66_T	133_E	0.508	0.64
193_I	239_I	0.508	0.64
290_A	311_A	0.507	0.64
111_D	180_L	0.506	0.64
247_K	254_P	0.505	0.64
187_N	299_G	0.504	0.64
215_S	310_K	0.504	0.64
51_L	116_R	0.503	0.64
261_G	330_A	0.503	0.64
24_K	198_F	0.503	0.64
227_K	237_K	0.502	0.64
25_A	200_V	0.502	0.64
48_K	184_I	0.502	0.64
274_S	293_I	0.501	0.63
291_L	303_I	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jql_B	1	0.1358	7.8	0.964	Contact Map
1pc2_A	1	0.3439	5.1	0.967	Contact Map
3qml_C	1	0.3208	3.5	0.969	Contact Map
3gfz_A	1	0.2428	2.9	0.971	Contact Map
1yj7_A	1	0.2081	2.6	0.971	Contact Map
2wgo_A	1	0.1185	2.6	0.971	Contact Map
1lyq_A	1	0.1705	2.5	0.972	Contact Map
3f1i_S	1	0.1301	2.3	0.972	Contact Map
3or1_C	1	0.159	2.2	0.973	Contact Map
1uhr_A	1	0.1301	2.2	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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