GREMLIN Database
T0885_1_116 - T0885 1-116
ID: 32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (103)
Sequences: 128 (111)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_L73_L3.0960.95
55_D70_V2.9740.94
65_L69_C2.9080.93
72_H75_R2.8150.92
31_A89_L2.3970.84
63_R93_G2.1210.75
75_R100_S2.0660.73
72_H108_D1.9880.70
20_L70_V1.8300.64
75_R78_H1.8210.63
45_A73_L1.7320.59
63_R105_A1.6910.57
37_Y72_H1.6830.57
71_G104_D1.6350.55
46_F81_D1.6280.54
72_H100_S1.6230.54
34_S45_A1.6020.53
25_P66_A1.5160.49
95_D98_V1.5050.48
26_E90_L1.4820.47
75_R108_D1.4770.47
46_F49_L1.4670.47
33_L69_C1.4600.46
49_L80_L1.4090.44
36_A69_C1.3980.43
36_A98_V1.3820.43
68_T104_D1.3710.42
87_E111_I1.3520.41
66_A71_G1.3470.41
33_L68_T1.3380.40
74_A80_L1.3330.40
31_A106_L1.3300.40
55_D88_F1.2580.37
33_L75_R1.2330.36
40_D93_G1.2120.35
75_R104_D1.1950.34
20_L24_N1.1910.34
19_V45_A1.1700.33
25_P88_F1.1650.33
35_I76_R1.1640.33
73_L102_A1.1420.32
23_G58_R1.1360.32
36_A64_S1.1280.31
57_N105_A1.1130.31
36_A76_R1.1110.31
68_T98_V1.1110.31
31_A77_I1.1050.30
29_A67_V1.0860.30
28_I32_C1.0860.30
65_L92_L1.0810.29
91_S110_R1.0740.29
59_P82_V1.0530.28
28_I54_F1.0520.28
82_V110_R1.0510.28
15_E31_A1.0450.28
18_H94_G1.0360.28
41_D58_R1.0290.27
55_D69_C1.0200.27
54_F82_V0.9930.26
87_E93_G0.9910.26
15_E34_S0.9890.26
104_D108_D0.9860.26
81_D107_D0.9700.25
63_R95_D0.9650.25
88_F92_L0.9570.25
76_R87_E0.9430.24
63_R102_A0.9280.24
9_A113_R0.9280.24
32_C69_C0.9260.24
57_N62_L0.9250.24
42_W80_L0.9250.24
44_W68_T0.9070.23
58_R70_V0.8870.22
11_I57_N0.8810.22
32_C83_A0.8700.22
62_L74_A0.8650.22
63_R99_A0.8620.21
28_I74_A0.8570.21
23_G86_E0.8530.21
66_A79_D0.8510.21
33_L37_Y0.8390.21
35_I40_D0.8380.21
67_V88_F0.8340.21
69_C89_L0.8300.20
74_A107_D0.8270.20
84_M96_Q0.8260.20
102_A106_L0.8250.20
41_D108_D0.7970.19
43_E81_D0.7930.19
32_C54_F0.7900.19
63_R98_V0.7860.19
22_S68_T0.7700.19
66_A73_L0.7670.19
44_W96_Q0.7670.19
85_A109_L0.7650.18
59_P79_D0.7630.18
87_E113_R0.7590.18
37_Y58_R0.7540.18
32_C57_N0.7490.18
83_A107_D0.7430.18
20_L55_D0.7330.18
11_I29_A0.7110.17
78_H108_D0.7080.17
68_T75_R0.7040.17
43_E69_C0.6980.17
70_V101_A0.6940.17
30_D69_C0.6900.16
101_A104_D0.6820.16
71_G105_A0.6810.16
45_A66_A0.6770.16
68_T78_H0.6760.16
72_H81_D0.6600.16
20_L23_G0.6440.15
22_S103_S0.6420.15
33_L80_L0.6400.15
35_I97_A0.6310.15
80_L86_E0.6300.15
64_S101_A0.6250.15
15_E18_H0.6220.15
68_T89_L0.6190.15
55_D77_I0.6030.14
43_E64_S0.6010.14
28_I91_S0.5990.14
47_K63_R0.5940.14
46_F88_F0.5940.14
42_W46_F0.5870.14
16_I102_A0.5790.14
40_D50_K0.5780.14
65_L105_A0.5750.14
29_A86_E0.5740.14
11_I19_V0.5650.13
39_E66_A0.5640.13
60_D104_D0.5610.13
9_A23_G0.5560.13
25_P102_A0.5540.13
18_H56_L0.5520.13
99_A102_A0.5480.13
72_H104_D0.5450.13
39_E96_Q0.5440.13
47_K69_C0.5440.13
37_Y75_R0.5430.13
22_S34_S0.5400.13
100_S104_D0.5370.13
73_L81_D0.5350.13
36_A57_N0.5340.13
13_N44_W0.5290.13
35_I45_A0.5270.13
37_Y100_S0.5180.12
21_A53_A0.5170.12
78_H100_S0.5110.12
103_S107_D0.5080.12
71_G98_V0.5070.12
108_D112_F0.5040.12
17_D73_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2db0_A 1 0.9397 97.3 0.784 Contact Map
4jw2_A 1 0.6121 97.2 0.789 Contact Map
5frp_A 1 0.9741 97.2 0.789 Contact Map
1te4_A 1 0.7328 97.1 0.792 Contact Map
4l7m_A 1 0.8534 97 0.794 Contact Map
2vgl_B 1 0.9828 96.5 0.806 Contact Map
4g3a_A 1 0.9138 96.5 0.807 Contact Map
2vgl_A 1 0.9828 96.4 0.808 Contact Map
3ltj_A 1 0.8448 96.4 0.809 Contact Map
4p6z_G 1 0.9741 96.4 0.809 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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