GREMLIN Database
T0861_1_323 - T0861 1-323
ID: 3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 323 (301)
Sequences: 5358 (2221)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_R265_E4.2001.00
81_A88_L3.7561.00
52_D56_R3.7421.00
54_E86_Y3.6721.00
154_E191_G3.6501.00
51_W84_R3.3731.00
19_R27_R3.0911.00
145_S237_A3.0801.00
154_E187_R3.0421.00
151_E155_K2.9821.00
138_Y141_L2.9601.00
27_R294_N2.9351.00
95_T116_G2.8111.00
254_E283_K2.7771.00
207_D252_N2.6561.00
29_L294_N2.6191.00
187_R240_D2.5431.00
159_P188_Y2.5161.00
87_K110_N2.5141.00
126_K129_E2.4861.00
142_Q145_S2.3871.00
14_H163_E2.3571.00
54_E84_R2.3201.00
65_L81_A2.3081.00
186_S200_S2.2791.00
52_D148_A2.2611.00
47_A51_W2.1091.00
30_A299_L2.0351.00
277_A297_V2.0141.00
17_L296_V2.0121.00
171_V288_E1.9891.00
7_D10_L1.9781.00
258_T279_A1.9731.00
6_E10_L1.9501.00
183_T238_N1.9321.00
199_I246_K1.8831.00
254_E279_A1.8701.00
131_V140_L1.8581.00
69_T74_G1.8451.00
176_V202_A1.8341.00
118_K125_Q1.8301.00
51_W55_K1.7971.00
172_F185_V1.7721.00
20_L278_V1.7661.00
206_T251_T1.7531.00
50_I80_V1.7191.00
209_P218_E1.7131.00
48_N155_K1.7081.00
98_I102_K1.7001.00
251_T254_E1.6991.00
153_H157_T1.6931.00
201_V246_K1.6861.00
6_E19_R1.6721.00
161_I296_V1.6591.00
279_A283_K1.6441.00
262_L278_V1.6421.00
49_M141_L1.6401.00
203_V280_A1.6391.00
158_G188_Y1.6371.00
259_A311_L1.6141.00
246_K287_D1.5931.00
190_K245_D1.5901.00
186_S243_L1.5571.00
115_E118_K1.5561.00
48_N152_I1.5531.00
262_L270_A1.5531.00
101_R111_L1.5471.00
134_N137_K1.5401.00
52_D55_K1.5371.00
270_A274_S1.5331.00
162_W188_Y1.5321.00
277_A300_P1.5181.00
112_V126_K1.5121.00
22_R266_E1.5091.00
129_E133_S1.5011.00
130_I134_N1.4941.00
94_E116_G1.4831.00
248_I283_K1.4761.00
56_R148_A1.4751.00
258_T282_L1.4641.00
171_V201_V1.4621.00
89_T110_N1.4451.00
154_E188_Y1.4271.00
104_L109_A1.4251.00
59_L65_L1.4071.00
274_S299_L1.3961.00
128_E132_A1.3901.00
150_P238_N1.3871.00
4_I29_L1.3831.00
241_L244_V1.3801.00
5_F11_T1.3781.00
161_I169_V1.3711.00
278_V299_L1.3671.00
250_I279_A1.3581.00
66_V130_I1.3411.00
182_L200_S1.3291.00
64_E89_T1.3191.00
18_V268_I1.3181.00
46_G76_A1.2991.00
99_E308_S1.2971.00
48_N52_D1.2911.00
185_V189_I1.2881.00
121_K125_Q1.2871.00
68_P141_L1.2721.00
239_L244_V1.2651.00
38_S79_Y1.2651.00
68_P142_Q1.2501.00
210_V233_G1.2421.00
189_I198_L1.2230.99
23_I282_L1.2150.99
206_T249_G1.2110.99
94_E115_E1.2100.99
193_K197_D1.1990.99
98_I101_R1.1960.99
188_Y192_T1.1960.99
254_E257_S1.1900.99
159_P163_E1.1850.99
65_L141_L1.1780.99
102_K105_K1.1760.99
29_L165_T1.1690.99
162_W192_T1.1670.99
18_V32_V1.1630.99
45_I49_M1.1610.99
32_V299_L1.1490.99
258_T278_V1.1460.99
201_V284_L1.1330.99
283_K286_E1.1200.99
226_K252_N1.1150.99
38_S107_L1.1090.99
171_V284_L1.1070.99
30_A297_V1.0970.99
52_D58_V1.0860.99
170_D293_K1.0840.99
23_I258_T1.0760.99
212_A249_G1.0640.99
170_D294_N1.0590.99
172_F298_I1.0540.98
41_V181_T1.0470.98
158_G185_V1.0400.98
19_R29_L1.0170.98
48_N148_A1.0130.98
169_V296_V1.0100.98
159_P192_T0.9980.98
68_P140_L0.9880.98
258_T261_R0.9870.98
253_E257_S0.9850.98
69_T90_L0.9850.98
281_A297_V0.9820.98
66_V137_K0.9760.98
169_V198_L0.9690.97
188_Y191_G0.9670.97
172_F198_L0.9650.97
152_I156_T0.9640.97
79_Y107_L0.9620.97
240_D243_L0.9610.97
246_K286_E0.9570.97
171_V199_I0.9570.97
76_A80_V0.9560.97
257_S261_R0.9520.97
101_R113_L0.9510.97
187_R191_G0.9490.97
11_T35_R0.9420.97
248_I280_A0.9390.97
165_T294_N0.9350.97
162_W167_G0.9310.97
92_M96_M0.9300.97
89_T134_N0.9230.97
151_E154_E0.9180.96
270_A299_L0.9140.96
106_A269_L0.9090.96
125_Q128_E0.9040.96
26_G293_K0.9020.96
162_W165_T0.8970.96
45_I73_T0.8940.96
172_F189_I0.8920.96
52_D151_E0.8880.96
53_A138_Y0.8870.96
193_K198_L0.8860.96
47_A80_V0.8810.95
30_A274_S0.8790.95
158_G189_I0.8760.95
30_A278_V0.8730.95
77_L88_L0.8680.95
269_L303_G0.8640.95
76_A79_Y0.8630.95
66_V131_V0.8620.95
24_G28_I0.8620.95
9_S83_A0.8620.95
169_V172_F0.8590.95
20_L262_L0.8510.95
78_A104_L0.8500.94
171_V295_I0.8430.94
310_A313_A0.8430.94
203_V276_A0.8380.94
9_S84_R0.8330.94
6_E21_N0.8300.94
73_T178_T0.8300.94
17_L165_T0.8290.94
59_L86_Y0.8270.94
46_G80_V0.8180.93
131_V137_K0.8140.93
58_V148_A0.8130.93
45_I152_I0.8110.93
48_N51_W0.8050.93
8_N79_Y0.8040.93
248_I284_L0.7960.92
90_L104_L0.7950.92
284_L295_I0.7940.92
236_P239_L0.7890.92
182_L243_L0.7880.92
5_F164_D0.7840.92
9_S80_V0.7800.92
34_S302_S0.7790.91
173_I284_L0.7780.91
211_I238_N0.7770.91
92_M113_L0.7740.91
20_L30_A0.7730.91
202_A244_V0.7720.91
124_I233_G0.7720.91
159_P162_W0.7690.91
103_L269_L0.7610.91
261_R282_L0.7580.90
213_Q221_K0.7560.90
275_G279_A0.7560.90
297_V300_P0.7560.90
23_I28_I0.7550.90
162_W193_K0.7540.90
163_E192_T0.7500.90
28_I295_I0.7490.90
168_Q294_N0.7490.90
101_R105_K0.7490.90
8_N11_T0.7470.90
169_V294_N0.7450.90
165_T169_V0.7410.89
147_P150_P0.7400.89
256_I310_A0.7390.89
107_L303_G0.7360.89
58_V138_Y0.7300.89
12_I47_A0.7300.89
145_S238_N0.7260.88
173_I295_I0.7220.88
183_T239_L0.7210.88
260_R313_A0.7200.88
182_L244_V0.7190.88
147_P238_N0.7190.88
252_N256_I0.7180.88
256_I272_I0.7150.88
3_K166_D0.7140.88
175_G230_I0.7130.87
93_P114_T0.7120.87
39_F301_S0.7090.87
105_K110_N0.7040.87
118_K122_G0.7040.87
285_Q295_I0.7010.87
183_T187_R0.7010.87
165_T296_V0.6970.86
66_V140_L0.6960.86
154_E158_G0.6940.86
210_V213_Q0.6940.86
68_P114_T0.6940.86
213_Q222_P0.6900.86
24_G282_L0.6900.86
91_T114_T0.6890.86
50_I65_L0.6880.86
56_R59_L0.6880.86
162_W198_L0.6870.85
3_K164_D0.6860.85
149_N180_G0.6860.85
23_I265_E0.6860.85
23_I261_R0.6840.85
182_L202_A0.6810.85
176_V232_A0.6720.84
91_T127_A0.6700.84
5_F10_L0.6690.84
78_A109_A0.6690.84
41_V300_P0.6680.84
12_I80_V0.6640.83
201_V248_I0.6560.83
170_D292_N0.6540.83
55_K58_V0.6540.83
173_I201_V0.6540.83
20_L266_E0.6520.82
91_T104_L0.6520.82
13_G16_P0.6510.82
89_T112_V0.6490.82
281_A285_Q0.6470.82
68_P93_P0.6460.82
27_R292_N0.6430.81
128_E140_L0.6400.81
59_L138_Y0.6390.81
172_F200_S0.6370.81
72_N76_A0.6340.81
22_R265_E0.6330.80
59_L88_L0.6310.80
263_M269_L0.6280.80
26_G285_Q0.6280.80
255_A276_A0.6270.80
32_V35_R0.6260.80
97_S100_R0.6260.80
304_E307_L0.6250.80
38_S76_A0.6250.80
28_I281_A0.6240.80
21_N24_G0.6230.79
176_V210_V0.6220.79
97_S309_T0.6220.79
227_I255_A0.6210.79
25_N291_T0.6190.79
45_I150_P0.6190.79
171_V293_K0.6160.79
176_V179_G0.6140.78
209_P212_A0.6130.78
278_V297_V0.6130.78
15_T160_E0.6120.78
17_L164_D0.6120.78
230_I276_A0.6120.78
174_A277_A0.6110.78
49_M68_P0.6110.78
28_I285_Q0.6110.78
203_V250_I0.6100.78
190_K200_S0.6100.78
20_L23_I0.6100.78
39_F302_S0.6090.78
248_I279_A0.6090.78
94_E117_A0.6090.78
270_A278_V0.6090.78
82_A264_E0.6090.78
66_V134_N0.6090.78
128_E145_S0.6090.78
9_S51_W0.6080.78
45_I80_V0.6080.78
173_I277_A0.6080.78
178_T267_G0.6060.78
61_P86_Y0.6060.78
15_T44_R0.6050.77
67_E77_L0.6050.77
53_A148_A0.6040.77
23_I266_E0.6030.77
258_T265_E0.6020.77
288_E293_K0.6020.77
183_T240_D0.6000.77
120_M232_A0.6000.77
154_E240_D0.5970.76
204_E225_H0.5970.76
100_R309_T0.5960.76
37_P43_C0.5940.76
53_A59_L0.5940.76
103_L106_A0.5930.76
168_Q193_K0.5930.76
3_K6_E0.5920.76
53_A58_V0.5920.76
70_S100_R0.5910.76
176_V182_L0.5910.76
158_G192_T0.5870.75
106_A260_R0.5860.75
106_A303_G0.5850.75
199_I245_D0.5820.75
309_T312_F0.5810.75
185_V188_Y0.5800.74
21_N27_R0.5770.74
48_N151_E0.5740.74
230_I277_A0.5690.73
262_L268_I0.5660.73
92_M101_R0.5660.73
210_V222_P0.5660.73
302_S305_R0.5650.73
54_E85_G0.5640.72
70_S144_F0.5640.72
202_A212_A0.5630.72
45_I48_N0.5630.72
89_T137_K0.5610.72
3_K163_E0.5610.72
246_K284_L0.5600.72
179_G238_N0.5600.72
162_W169_V0.5590.72
52_D155_K0.5590.72
21_N30_A0.5580.72
82_A267_G0.5580.72
75_I103_L0.5550.71
263_M303_G0.5540.71
121_K222_P0.5540.71
41_V298_I0.5530.71
90_L111_L0.5510.71
21_N266_E0.5510.71
77_L141_L0.5510.71
75_I305_R0.5500.71
49_M138_Y0.5500.71
211_I247_V0.5500.71
312_F315_L0.5460.70
303_G307_L0.5460.70
96_M101_R0.5440.70
8_N268_I0.5440.70
127_A140_L0.5420.69
282_L286_E0.5410.69
128_E142_Q0.5370.69
175_G300_P0.5360.69
26_G292_N0.5320.68
54_E61_P0.5320.68
30_A270_A0.5310.68
7_D84_R0.5290.68
131_V134_N0.5290.68
92_M100_R0.5290.68
277_A298_I0.5290.68
126_K130_I0.5290.68
23_I278_V0.5280.67
251_T279_A0.5270.67
274_S301_S0.5260.67
277_A299_L0.5260.67
21_N265_E0.5260.67
59_L81_A0.5250.67
227_I273_S0.5250.67
186_S190_K0.5250.67
14_H164_D0.5240.67
119_G122_G0.5230.67
83_A267_G0.5230.67
188_Y296_V0.5220.67
8_N18_V0.5220.67
78_A90_L0.5210.66
30_A282_L0.5200.66
181_T298_I0.5200.66
208_S231_G0.5190.66
259_A310_A0.5180.66
251_T283_K0.5170.66
91_T112_V0.5170.66
44_R160_E0.5170.66
131_V141_L0.5160.66
50_I59_L0.5160.66
181_T300_P0.5160.66
274_S300_P0.5150.66
207_D251_T0.5140.65
60_K136_E0.5140.65
30_A34_S0.5140.65
49_M148_A0.5120.65
8_N35_R0.5120.65
103_L304_E0.5110.65
182_L186_S0.5100.65
158_G187_R0.5090.65
179_G239_L0.5090.65
179_G183_T0.5080.64
87_K133_S0.5080.64
212_A233_G0.5060.64
309_T313_A0.5050.64
46_G79_Y0.5050.64
38_S301_S0.5050.64
24_G285_Q0.5040.64
91_T94_E0.5040.64
38_S106_A0.5040.64
104_L111_L0.5030.64
271_G275_G0.5030.64
171_V294_N0.5030.64
96_M144_F0.5020.64
150_P269_L0.5010.63
80_V84_R0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pc3_A 1 0.9845 100 0.38 Contact Map
4aec_A 1 0.9598 100 0.388 Contact Map
4coo_A 1 0.9845 100 0.39 Contact Map
4ofx_A 1 0.8824 100 0.395 Contact Map
1z7w_A 1 0.969 100 0.396 Contact Map
5i7w_A 1 0.9752 100 0.396 Contact Map
3vc3_A 1 0.9721 100 0.397 Contact Map
1y7l_A 1 0.9505 100 0.397 Contact Map
5d84_A 1 0.9598 100 0.397 Contact Map
4ql4_A 1 0.8359 100 0.399 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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