GREMLIN Database
T0883_1_237 - T0883 1-237
ID: 29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 237 (204)
Sequences: 2659 (1828)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_H80_D5.0321.00
96_D100_R3.7231.00
208_L212_A3.6221.00
59_S84_N3.0921.00
202_F212_A2.6481.00
206_A224_N2.6021.00
43_S61_G2.5121.00
36_F82_I2.4421.00
103_S123_K2.4351.00
43_S58_L2.3911.00
165_L169_A2.3711.00
204_T222_E2.3231.00
191_K209_E2.2921.00
100_R148_V2.2841.00
91_T95_N2.1931.00
197_L216_N2.1311.00
85_Q89_D2.0301.00
124_S128_L2.0271.00
159_P185_G2.0001.00
198_E216_N1.9991.00
90_I215_R1.9941.00
160_G187_T1.9901.00
32_S89_D1.9241.00
137_F149_I1.8931.00
139_A145_A1.8881.00
157_T188_T1.8711.00
90_I213_L1.8381.00
193_T211_R1.8071.00
98_A177_Q1.7991.00
67_F70_G1.7991.00
142_D145_A1.7871.00
42_S218_A1.7331.00
117_L135_V1.7191.00
159_P186_T1.7051.00
84_N88_L1.6211.00
138_D166_S1.6161.00
200_I212_A1.5931.00
134_D164_L1.5881.00
113_G132_S1.5821.00
37_A52_I1.5661.00
36_F57_G1.5611.00
85_Q88_L1.5491.00
36_F77_H1.5311.00
97_A195_I1.5271.00
127_S154_T1.5261.00
134_D162_K1.5251.00
58_L61_G1.5171.00
44_V56_L1.4981.00
123_K150_Q1.4901.00
72_L76_L1.4901.00
186_T204_T1.4781.00
79_N84_N1.4401.00
64_I78_I1.4281.00
28_I97_A1.4191.00
58_L78_I1.4041.00
202_F208_L1.3991.00
53_T73_N1.3911.00
92_T95_N1.3801.00
182_A196_A1.3571.00
184_F194_V1.3241.00
187_T205_G1.3231.00
203_D222_E1.3201.00
94_Y177_Q1.3031.00
184_F188_T1.3031.00
47_T222_E1.2961.00
186_T203_D1.2851.00
132_S158_T1.2771.00
197_L215_R1.2741.00
90_I195_I1.2731.00
140_L145_A1.2621.00
56_L72_L1.2561.00
128_L151_I1.2531.00
204_T223_G1.2271.00
43_S218_A1.2261.00
43_S65_G1.2230.99
157_T161_R1.2170.99
49_A223_G1.2100.99
190_F194_V1.2060.99
129_A156_T1.2050.99
118_T140_L1.2030.99
138_D142_D1.2020.99
199_S217_G1.1970.99
58_L62_T1.1770.99
126_S152_A1.1710.99
147_F169_A1.1610.99
91_T215_R1.1610.99
106_V125_T1.1570.99
162_K189_S1.1490.99
25_Q100_R1.1400.99
108_I112_I1.1390.99
58_L79_N1.1340.99
26_T100_R1.1270.99
138_D145_A1.0690.99
37_A54_G1.0560.99
101_V121_L1.0470.98
118_T147_F1.0270.98
41_G87_K1.0100.98
202_F224_N1.0060.98
37_A73_N0.9990.98
125_T152_A0.9910.98
181_S199_S0.9890.98
90_I97_A0.9700.97
46_N50_T0.9640.97
137_F174_I0.9620.97
139_A169_A0.9600.97
108_I115_L0.9560.97
108_I124_S0.9520.97
29_T96_D0.9510.97
131_S161_R0.9430.97
108_I128_L0.9350.97
201_T222_E0.9210.96
48_G71_I0.9200.96
221_M224_N0.9150.96
103_S150_Q0.9120.96
134_D161_R0.9070.96
139_A165_L0.9040.96
159_P203_D0.9040.96
161_R188_T0.9040.96
131_S158_T0.8960.96
62_T79_N0.8940.96
150_Q177_Q0.8940.96
46_N70_G0.8890.96
33_A195_I0.8850.96
59_S87_K0.8810.95
136_T164_L0.8770.95
180_S197_L0.8750.95
33_A93_A0.8700.95
55_D77_H0.8640.95
95_N98_A0.8550.95
141_G145_A0.8530.95
111_N132_S0.8510.95
155_L190_F0.8490.94
39_I57_G0.8420.94
212_A226_F0.8340.94
64_I70_G0.8340.94
46_N223_G0.8330.94
139_A166_S0.8330.94
88_L92_T0.8320.94
40_A58_L0.8300.94
129_A132_S0.8290.94
154_T183_S0.8260.94
38_V219_V0.8240.94
95_N99_A0.8210.93
163_V176_W0.8190.93
153_S180_S0.8180.93
64_I67_F0.8140.93
56_L76_L0.8120.93
141_G167_G0.8100.93
113_G158_T0.8080.93
107_T124_S0.8070.93
77_H83_A0.8070.93
58_L63_S0.8050.93
43_S63_S0.8030.93
63_S78_I0.7980.92
110_G125_T0.7960.92
88_L91_T0.7910.92
43_S62_T0.7910.92
64_I76_L0.7900.92
116_T138_D0.7900.92
30_L33_A0.7900.92
109_S124_S0.7890.92
100_R146_I0.7870.92
37_A53_T0.7850.92
27_P173_N0.7840.92
59_S79_N0.7820.92
58_L83_A0.7750.91
93_A195_I0.7730.91
191_K207_T0.7690.91
171_A209_E0.7660.91
37_A226_F0.7570.90
165_L171_A0.7530.90
135_V163_V0.7520.90
56_L64_I0.7460.90
129_A158_T0.7440.90
42_S198_E0.7410.89
96_D99_A0.7400.89
139_A142_D0.7380.89
28_I146_I0.7380.89
138_D167_G0.7300.89
124_S151_I0.7280.88
119_P140_L0.7240.88
151_I178_V0.7200.88
32_S85_Q0.7150.88
87_K215_R0.7150.88
201_T218_A0.7140.88
81_A85_Q0.7090.87
140_L167_G0.7090.87
185_G203_D0.7070.87
156_T178_V0.7030.87
30_L93_A0.7020.87
51_N73_N0.7000.86
204_T224_N0.6980.86
94_Y98_A0.6930.86
35_N55_D0.6870.85
202_F206_A0.6860.85
101_V105_M0.6860.85
184_F202_F0.6790.85
42_S61_G0.6780.85
119_P145_A0.6730.84
194_V212_A0.6720.84
139_A167_G0.6720.84
41_G91_T0.6660.84
48_G223_G0.6640.83
87_K91_T0.6590.83
33_A39_I0.6580.83
76_L83_A0.6580.83
154_T181_S0.6550.83
187_T204_T0.6530.82
195_I215_R0.6490.82
67_F71_I0.6480.82
107_T110_G0.6480.82
82_I85_Q0.6460.82
101_V104_D0.6460.82
132_S161_R0.6450.82
97_A146_I0.6390.81
171_A211_R0.6350.81
127_S151_I0.6340.81
200_I213_L0.6340.81
96_D148_V0.6320.80
79_N83_A0.6280.80
158_T161_R0.6250.80
40_A87_K0.6250.80
155_L178_V0.6220.79
144_S170_L0.6180.79
115_L119_P0.6180.79
170_L173_N0.6170.79
38_V44_V0.6140.78
109_S123_K0.6140.78
184_F208_L0.6100.78
43_S78_I0.6070.78
157_T185_G0.6060.78
175_Y205_G0.6060.78
149_I176_W0.6060.78
154_T203_D0.6030.77
27_P175_Y0.6030.77
181_S198_E0.6000.77
104_D108_I0.5990.77
52_I56_L0.5960.76
27_P100_R0.5950.76
172_S209_E0.5940.76
91_T197_L0.5920.76
142_D170_L0.5900.76
41_G198_E0.5870.75
77_H82_I0.5860.75
157_T184_F0.5850.75
44_V64_I0.5840.75
159_P187_T0.5840.75
189_S207_T0.5830.75
157_T190_F0.5810.75
145_A167_G0.5790.74
41_G213_L0.5780.74
106_V123_K0.5770.74
41_G216_N0.5760.74
146_I175_Y0.5740.74
128_L152_A0.5740.74
51_N70_G0.5740.74
173_N193_T0.5730.74
104_D121_L0.5710.73
41_G215_R0.5710.73
111_N129_A0.5690.73
146_I173_N0.5670.73
176_W211_R0.5650.73
104_D107_T0.5620.72
68_P71_I0.5610.72
111_N158_T0.5600.72
31_G92_T0.5600.72
106_V109_S0.5590.72
113_G131_S0.5570.71
87_K90_I0.5560.71
112_I151_I0.5480.70
28_I96_D0.5460.70
202_F226_F0.5430.70
111_N115_L0.5410.69
154_T180_S0.5400.69
104_D118_T0.5370.69
173_N211_R0.5340.68
182_A194_V0.5330.68
124_S129_A0.5330.68
45_T220_T0.5320.68
31_G89_D0.5310.68
50_T224_N0.5300.68
42_S87_K0.5250.67
23_T26_T0.5240.67
187_T203_D0.5230.67
171_A193_T0.5220.67
27_P97_A0.5190.66
125_T129_A0.5190.66
207_T225_T0.5180.66
59_S88_L0.5170.66
94_Y179_S0.5160.66
105_M123_K0.5150.66
107_T128_L0.5110.65
154_T178_V0.5110.65
135_V147_F0.5110.65
110_G115_L0.5110.65
127_S153_S0.5100.65
92_T96_D0.5060.64
98_A150_Q0.5050.64
198_E217_G0.5050.64
46_N67_F0.5030.64
154_T218_A0.5020.64
154_T196_A0.5020.64
123_K151_I0.5010.63
147_F173_N0.5010.63
124_S152_A0.5010.63
184_F206_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uyu_A 1 0.8903 100 0.184 Contact Map
3vn3_A 1 0.8523 100 0.187 Contact Map
4nu3_A 1 0.8692 100 0.188 Contact Map
4nuh_A 1 0.8523 100 0.204 Contact Map
3wp9_A 1 0.8861 100 0.205 Contact Map
4om9_A 1 0.8608 35.1 0.951 Contact Map
2lq1_A 1 0.097 19.4 0.957 Contact Map
1wxr_A 1 0.8776 9.1 0.963 Contact Map
4peu_A 1 0.5992 4.2 0.968 Contact Map
3zsc_A 1 0.6203 3.9 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.