GREMLIN Database
T0882_1_89 - T0882 1-89
ID: 28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (86)
Sequences: 116 (59)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_T44_P2.5800.69
34_T48_A2.5280.67
28_H76_A2.3070.60
7_K10_I2.1710.55
66_V69_V2.0370.50
69_V76_A2.0120.49
8_L36_K1.9920.48
29_N42_D1.9630.47
17_G26_E1.9570.47
29_N41_G1.9210.46
27_T40_D1.9010.45
59_A78_E1.8250.42
23_C35_F1.8170.42
29_N32_M1.7730.40
56_F61_E1.6950.38
64_S67_D1.6770.37
12_N82_E1.6520.36
74_E78_E1.6400.36
32_M41_G1.5940.34
9_R21_V1.5830.34
2_M7_K1.5290.32
23_C37_F1.5100.31
13_V49_T1.4800.30
33_V48_A1.4260.29
80_L83_D1.3780.27
41_G56_F1.3310.26
27_T42_D1.2900.25
14_S19_R1.2630.24
74_E85_S1.2430.24
46_E69_V1.2020.23
4_S84_V1.1990.23
42_D47_I1.1910.22
57_I77_D1.1750.22
7_K21_V1.1660.22
31_K38_D1.1600.22
58_L61_E1.1320.21
3_T6_P1.1130.20
74_E82_E1.0980.20
75_K84_V1.0980.20
2_M11_L1.0860.20
26_E67_D1.0530.19
29_N39_L1.0480.19
35_F44_P1.0390.19
4_S85_S1.0250.18
4_S10_I1.0050.18
47_I51_M0.9840.17
56_F77_D0.9800.17
27_T35_F0.9690.17
71_E78_E0.9680.17
38_D41_G0.9620.17
26_E59_A0.9570.17
70_R78_E0.9390.17
53_N67_D0.9260.16
39_L73_I0.9190.16
12_N64_S0.9160.16
76_A80_L0.9060.16
13_V21_V0.8950.16
2_M6_P0.8950.16
26_E75_K0.8940.16
53_N78_E0.8920.16
81_S87_E0.8880.16
79_M82_E0.8810.15
63_E66_V0.8600.15
21_V72_I0.8570.15
61_E80_L0.8440.15
23_C44_P0.8390.15
33_V47_I0.8330.15
27_T33_V0.8320.14
39_L66_V0.8300.14
68_Q81_S0.8260.14
45_E51_M0.8210.14
51_M58_L0.8110.14
3_T7_K0.8020.14
2_M5_R0.7950.14
11_L53_N0.7850.14
21_V58_L0.7790.14
18_D22_E0.7680.13
30_R62_R0.7550.13
23_C47_I0.7430.13
27_T58_L0.7420.13
35_F47_I0.7380.13
4_S36_K0.7280.13
36_K65_F0.7270.13
27_T51_M0.7200.13
44_P48_A0.7170.13
54_N86_V0.7140.12
3_T84_V0.7140.12
37_F44_P0.7080.12
25_L33_V0.7000.12
37_F47_I0.6860.12
23_C33_V0.6610.12
30_R70_R0.6600.12
10_I75_K0.6530.12
24_Q45_E0.6510.12
21_V24_Q0.6490.11
7_K20_V0.6450.11
28_H51_M0.6440.11
11_L52_V0.6320.11
6_P26_E0.6270.11
33_V44_P0.6220.11
36_K72_I0.6160.11
57_I71_E0.6120.11
32_M80_L0.6100.11
43_N46_E0.6090.11
65_F72_I0.6040.11
46_E83_D0.6040.11
56_F65_F0.5950.11
53_N76_A0.5910.11
43_N51_M0.5880.11
3_T87_E0.5790.10
3_T85_S0.5760.10
52_V73_I0.5680.10
25_L47_I0.5640.10
16_K49_T0.5640.10
50_I67_D0.5600.10
32_M61_E0.5600.10
33_V63_E0.5570.10
59_A77_D0.5490.10
75_K80_L0.5470.10
27_T44_P0.5420.10
9_R19_R0.5350.10
74_E84_V0.5310.10
7_K67_D0.5280.10
56_F80_L0.5240.10
17_G67_D0.5210.10
4_S11_L0.5100.10
26_E78_E0.5040.09
27_T45_E0.5040.09
24_Q51_M0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lru_A 1 0.8539 93.1 0.825 Contact Map
2v3s_A 1 0.8427 75.1 0.866 Contact Map
1upk_A 1 0.9438 11.6 0.917 Contact Map
4hkf_A 1 0.4944 9.5 0.92 Contact Map
2dq3_A 1 0.6292 9.3 0.92 Contact Map
2k89_A 1 0.7416 7.6 0.923 Contact Map
2a2p_A 1 0.7528 5.8 0.928 Contact Map
4l8h_A 1 0.7079 5.7 0.928 Contact Map
4b5o_A 1 0.6292 4.7 0.93 Contact Map
3h0d_A 1 0.8989 4.4 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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