GREMLIN Database
HgcA_HgcB_1_433 - HgcA_HgcB 1-433
ID: 278 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 433 (419)
Sequences: 2460 (1805)
Seq/√Len: 88.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_L159_F5.5211.00
113_R116_Q4.5271.00
77_I161_R4.5111.00
28_L32_L4.1121.00
363_S366_D3.8461.00
359_V400_V3.7631.00
181_A242_L3.7041.00
17_T48_V3.5711.00
7_T10_G3.5011.00
109_V142_C3.2721.00
103_S141_I3.2311.00
240_V294_A3.1641.00
174_T179_E3.1481.00
58_L79_A3.0861.00
84_V105_V3.0781.00
370_H389_M2.8321.00
426_R429_D2.7861.00
353_L382_I2.7161.00
125_L129_A2.7051.00
247_L258_L2.6881.00
425_G428_I2.6391.00
109_V123_L2.6101.00
30_A65_L2.6051.00
231_V263_A2.5461.00
137_E141_I2.5381.00
349_S385_F2.5321.00
60_T66_T2.5131.00
137_E140_R2.4901.00
343_R384_D2.4281.00
59_V123_L2.4011.00
105_V109_V2.3541.00
136_R148_W2.3541.00
106_A142_C2.2631.00
177_L242_L2.2571.00
375_V380_T2.2461.00
160_L164_N2.2201.00
184_I238_V2.1771.00
365_V380_T2.1701.00
291_S320_Q2.1701.00
54_T119_E2.1271.00
181_A184_I2.1031.00
110_N115_H2.0751.00
70_L81_L2.0711.00
365_V375_V2.0491.00
359_V399_P2.0431.00
135_A148_W2.0341.00
362_G365_V2.0151.00
186_V190_Q2.0021.00
252_F301_T1.9761.00
306_P415_L1.9751.00
148_W396_R1.9271.00
168_E371_R1.9071.00
425_G429_D1.9031.00
106_A141_I1.8871.00
65_L69_T1.8441.00
77_I160_L1.8361.00
45_L117_V1.8001.00
285_W327_A1.7961.00
52_D78_D1.7941.00
158_A162_N1.7771.00
343_R387_A1.7681.00
288_A323_A1.7641.00
172_G371_R1.7601.00
73_R153_A1.7551.00
60_T70_L1.7531.00
152_R173_V1.7301.00
203_F218_L1.7241.00
94_A129_A1.6981.00
103_S106_A1.6981.00
346_D386_D1.6861.00
384_D387_A1.6801.00
360_G380_T1.6751.00
148_W363_S1.6651.00
317_M419_W1.6621.00
303_Y389_M1.6591.00
295_M320_Q1.6591.00
418_V425_G1.6581.00
173_V179_E1.6571.00
362_G375_V1.6381.00
53_R119_E1.6371.00
283_T287_T1.6361.00
105_V129_A1.6311.00
106_A138_V1.6231.00
311_K348_V1.6191.00
77_I156_L1.6041.00
58_L70_L1.6031.00
58_L73_R1.5991.00
166_A171_R1.5961.00
295_M313_M1.5861.00
69_T73_R1.5811.00
122_E145_K1.5791.00
353_L373_L1.5531.00
418_V423_L1.5481.00
15_V67_F1.5411.00
195_L229_T1.5351.00
26_G39_F1.5201.00
77_I157_P1.5141.00
125_L133_V1.5061.00
235_A259_V1.4961.00
50_E78_D1.4901.00
60_T125_L1.4901.00
348_V386_D1.4891.00
66_T70_L1.4861.00
422_R425_G1.4831.00
105_V131_T1.4760.99
136_R363_S1.4650.99
325_L329_G1.4650.99
376_R381_T1.4640.99
56_P164_N1.4540.99
347_G386_D1.4190.99
352_A404_T1.4070.99
105_V125_L1.4020.99
19_L72_E1.3810.99
353_L380_T1.3670.99
249_W254_P1.3660.99
25_V28_L1.3650.99
35_N38_D1.3580.99
101_T105_V1.3540.99
159_F366_D1.3540.99
122_E147_L1.3450.99
306_P310_E1.3330.99
421_H424_T1.3280.99
424_T427_K1.3200.99
110_N141_I1.3180.99
257_A323_A1.3170.99
39_F64_K1.3140.99
183_L297_F1.3090.99
32_L35_N1.3080.99
421_H428_I1.2660.98
104_E108_S1.2650.98
421_H425_G1.2530.98
24_R28_L1.2510.98
101_T129_A1.2430.98
105_V133_V1.2290.98
206_S225_A1.2190.98
417_S421_H1.2180.98
131_T396_R1.2130.98
158_A167_D1.2090.98
19_L23_D1.2070.98
259_V290_A1.2020.98
251_Q316_G1.1950.98
235_A263_A1.1950.98
418_V428_I1.1940.98
240_V259_V1.1890.98
139_E363_S1.1880.98
360_G375_V1.1870.98
343_R346_D1.1820.98
64_K68_D1.1770.97
138_V146_V1.1600.97
292_W417_S1.1560.97
10_G13_P1.1530.97
30_A35_N1.1510.97
184_I242_L1.1510.97
210_P213_F1.1490.97
122_E164_N1.1420.97
423_L428_I1.1420.97
151_I173_V1.1390.97
191_L233_A1.1340.97
135_A363_S1.1330.97
127_Q150_P1.1290.97
360_G379_K1.1270.97
107_F111_A1.1270.97
29_R35_N1.1260.97
306_P406_T1.1260.97
423_L427_K1.1150.96
168_E172_G1.1130.96
421_H426_R1.1090.96
264_G287_T1.0960.96
110_N142_C1.0960.96
134_A148_W1.0920.96
373_L403_I1.0890.96
31_R36_R1.0880.96
176_T179_E1.0860.96
424_T428_I1.0850.96
27_D65_L1.0720.96
240_V247_L1.0700.96
424_T429_D1.0600.95
396_R407_P1.0600.95
169_A174_T1.0580.95
32_L65_L1.0530.95
69_T72_E1.0530.95
309_V313_M1.0480.95
203_F222_G1.0450.95
66_T83_V1.0330.95
407_P419_W1.0310.95
360_G376_R1.0300.94
249_W258_L1.0250.94
374_A381_T1.0110.94
417_S426_R1.0060.94
58_L160_L1.0050.94
128_L151_I1.0030.94
7_T12_V0.9960.93
322_L326_A0.9950.93
190_Q300_S0.9950.93
56_P122_E0.9930.93
414_Y418_V0.9910.93
84_V129_A0.9900.93
121_R144_F0.9880.93
210_P214_S0.9870.93
159_F166_A0.9840.93
21_R25_V0.9840.93
27_D30_A0.9820.93
264_G286_A0.9770.93
374_A383_L0.9760.93
418_V421_H0.9710.93
349_S389_M0.9710.93
375_V379_K0.9710.93
102_A129_A0.9690.92
235_A239_L0.9680.92
228_A233_A0.9650.92
10_G14_R0.9610.92
239_L263_A0.9550.92
32_L189_Y0.9530.92
422_R428_I0.9510.92
58_L156_L0.9500.92
281_A327_A0.9450.92
33_G186_V0.9380.91
127_Q149_G0.9330.91
240_V290_A0.9290.91
237_S293_Q0.9280.91
303_Y370_H0.9280.91
179_E182_A0.9270.91
136_R396_R0.9220.90
139_E145_K0.9210.90
313_M348_V0.9200.90
134_A396_R0.9130.90
37_H40_K0.9110.90
73_R154_R0.9100.90
354_D357_K0.9100.90
309_V318_P0.9060.90
414_Y421_H0.9050.90
112_V123_L0.9020.90
353_L375_V0.9000.89
137_E396_R0.8960.89
32_L188_L0.8930.89
129_A148_W0.8900.89
311_K345_I0.8890.89
15_V81_L0.8890.89
60_T84_V0.8870.89
148_W399_P0.8860.89
52_D55_S0.8840.89
288_A324_A0.8780.88
181_A238_V0.8770.88
253_W291_S0.8770.88
85_D127_Q0.8730.88
158_A161_R0.8730.88
235_A290_A0.8720.88
313_M316_G0.8720.88
70_L153_A0.8670.88
252_F303_Y0.8670.88
233_A237_S0.8630.87
172_G370_H0.8600.87
341_D387_A0.8590.87
188_L234_L0.8580.87
310_E415_L0.8530.87
26_G64_K0.8500.87
14_R50_E0.8490.86
282_L286_A0.8470.86
352_A385_F0.8460.86
23_D26_G0.8450.86
418_V424_T0.8440.86
416_V420_L0.8430.86
287_T291_S0.8420.86
89_I389_M0.8410.86
420_L423_L0.8400.86
413_A417_S0.8370.86
253_W316_G0.8370.86
27_D39_F0.8370.86
29_R32_L0.8340.85
66_T81_L0.8340.85
30_A34_T0.8320.85
285_W324_A0.8310.85
380_T403_I0.8290.85
305_S313_M0.8290.85
85_D150_P0.8280.85
195_L233_A0.8280.85
139_E142_C0.8210.85
292_W300_S0.8210.85
28_L65_L0.8160.84
370_H373_L0.8160.84
309_V348_V0.8150.84
422_R427_K0.8150.84
163_G362_G0.8100.84
66_T153_A0.8090.84
278_D334_G0.8080.84
123_L142_C0.8070.84
59_V125_L0.8070.84
124_I164_N0.8070.84
14_R47_C0.8050.83
168_E374_A0.8040.83
207_A214_S0.8030.83
153_A156_L0.8030.83
68_D71_R0.8020.83
357_K400_V0.7980.83
58_L66_T0.7960.83
102_A106_A0.7920.82
39_F65_L0.7900.82
406_T416_V0.7870.82
60_T65_L0.7860.82
254_P258_L0.7820.82
47_C51_P0.7810.82
382_I386_D0.7790.81
389_M409_T0.7780.81
303_Y342_F0.7780.81
277_A333_A0.7770.81
295_M301_T0.7770.81
423_L426_R0.7750.81
130_A373_L0.7750.81
383_L387_A0.7730.81
7_T14_R0.7700.81
211_D214_S0.7670.80
134_A137_E0.7670.80
99_L129_A0.7660.80
106_A134_A0.7650.80
61_A66_T0.7650.80
247_L294_A0.7640.80
162_N167_D0.7630.80
55_S133_V0.7610.80
365_V371_R0.7610.80
82_L105_V0.7600.80
13_P19_L0.7600.80
313_M317_M0.7590.80
313_M320_Q0.7590.80
373_L404_T0.7550.79
57_V114_L0.7540.79
225_A282_L0.7540.79
197_A200_P0.7530.79
26_G30_A0.7530.79
58_L77_I0.7500.79
268_A283_T0.7500.79
418_V422_R0.7480.79
18_Y75_T0.7480.79
58_L89_I0.7470.79
416_V419_W0.7460.78
317_M321_A0.7450.78
373_L380_T0.7450.78
30_A89_I0.7450.78
257_A287_T0.7440.78
422_R426_R0.7400.78
306_P317_M0.7380.78
292_W320_Q0.7340.77
45_L49_G0.7320.77
292_W313_M0.7270.77
89_I94_A0.7240.76
247_L254_P0.7220.76
310_E315_R0.7200.76
320_Q331_W0.7200.76
25_V29_R0.7190.76
41_V89_I0.7180.76
108_S111_A0.7180.76
188_L238_V0.7160.76
84_V104_E0.7150.76
257_A286_A0.7140.75
194_P292_W0.7130.75
281_A331_W0.7110.75
191_L293_Q0.7110.75
131_T144_F0.7110.75
66_T79_A0.7110.75
191_L414_Y0.7080.75
362_G400_V0.7060.75
109_V114_L0.7050.74
282_L331_W0.7040.74
421_H427_K0.6970.74
295_M306_P0.6950.73
184_I237_S0.6920.73
10_G41_V0.6920.73
363_S373_L0.6850.72
284_L323_A0.6850.72
292_W317_M0.6830.72
310_E419_W0.6810.72
179_E342_F0.6790.72
27_D32_L0.6780.72
14_R60_T0.6780.72
306_P419_W0.6780.72
127_Q414_Y0.6740.71
235_A310_E0.6730.71
24_R27_D0.6730.71
349_S352_A0.6720.71
101_T146_V0.6710.71
125_L131_T0.6710.71
19_L142_C0.6700.71
25_V34_T0.6700.71
329_G333_A0.6690.71
65_L186_V0.6690.71
326_A329_G0.6680.70
19_L69_T0.6670.70
222_G228_A0.6670.70
19_L27_D0.6670.70
232_G290_A0.6670.70
48_V73_R0.6660.70
15_V41_V0.6640.70
350_S409_T0.6640.70
187_E293_Q0.6630.70
102_A148_W0.6620.70
183_L287_T0.6620.70
198_A229_T0.6610.70
359_V371_R0.6580.69
7_T15_V0.6580.69
371_R383_L0.6570.69
24_R72_E0.6570.69
311_K318_P0.6560.69
259_V294_A0.6560.69
232_G287_T0.6550.69
414_Y425_G0.6530.69
173_V214_S0.6520.69
26_G63_Y0.6490.68
77_I162_N0.6490.68
253_W295_M0.6490.68
45_L168_E0.6470.68
292_W416_V0.6450.68
131_T414_Y0.6450.68
357_K401_E0.6440.68
187_E300_S0.6410.67
395_A403_I0.6400.67
232_G236_G0.6400.67
187_E301_T0.6390.67
307_S348_V0.6390.67
418_V427_K0.6350.67
48_V153_A0.6350.67
306_P421_H0.6340.66
33_G36_R0.6320.66
35_N327_A0.6290.66
166_A309_V0.6270.66
106_A144_F0.6270.66
197_A201_L0.6250.65
176_T181_A0.6250.65
359_V401_E0.6240.65
184_I188_L0.6230.65
102_A105_V0.6230.65
19_L65_L0.6220.65
310_E406_T0.6200.65
201_L239_L0.6200.65
263_A267_A0.6200.65
70_L129_A0.6190.65
16_R48_V0.6180.65
258_L294_A0.6180.65
21_R24_R0.6160.64
195_L199_I0.6140.64
66_T156_L0.6130.64
156_L349_S0.6130.64
239_L356_D0.6120.64
396_R401_E0.6120.64
19_L24_R0.6110.64
67_F70_L0.6100.64
280_L330_L0.6090.63
147_L366_D0.6080.63
116_Q200_P0.6080.63
276_W280_L0.6070.63
186_V300_S0.6050.63
190_Q193_K0.6030.63
82_L112_V0.6030.63
278_D331_W0.6020.62
237_S300_S0.6020.62
10_G15_V0.6020.62
294_A303_Y0.6020.62
389_M407_P0.6000.62
307_S350_S0.5990.62
131_T310_E0.5990.62
353_L359_V0.5970.62
131_T415_L0.5960.62
152_R155_D0.5950.62
292_W413_A0.5950.62
251_Q295_M0.5950.62
60_T162_N0.5930.61
239_L259_V0.5920.61
30_A33_G0.5920.61
118_V144_F0.5910.61
133_V148_W0.5900.61
173_V370_H0.5890.61
363_S396_R0.5880.61
317_M322_L0.5860.60
55_S78_D0.5860.60
315_R319_L0.5850.60
320_Q327_A0.5840.60
85_D149_G0.5830.60
284_L326_A0.5820.60
65_L142_C0.5820.60
84_V108_S0.5820.60
282_L310_E0.5800.60
79_A123_L0.5790.60
194_P197_A0.5780.59
194_P233_A0.5770.59
207_A320_Q0.5770.59
229_T253_W0.5770.59
227_T263_A0.5750.59
16_R20_R0.5750.59
304_T308_G0.5750.59
67_F127_Q0.5750.59
311_K386_D0.5750.59
277_A330_L0.5740.59
313_M318_P0.5730.59
187_E296_N0.5730.59
247_L259_V0.5720.59
319_L322_L0.5700.58
292_W296_N0.5690.58
127_Q418_V0.5690.58
287_T294_A0.5690.58
284_L288_A0.5690.58
112_V142_C0.5690.58
413_A416_V0.5680.58
30_A186_V0.5680.58
15_V48_V0.5680.58
157_P162_N0.5670.58
131_T375_V0.5670.58
174_T302_P0.5670.58
262_A265_T0.5670.58
61_A67_F0.5670.58
66_T69_T0.5660.58
148_W407_P0.5660.58
294_A413_A0.5650.58
121_R134_A0.5650.58
247_L267_A0.5640.58
58_L74_L0.5630.57
207_A212_L0.5620.57
395_A401_E0.5620.57
127_Q173_V0.5610.57
60_T129_A0.5610.57
291_S316_G0.5590.57
63_Y303_Y0.5560.56
384_D403_I0.5560.56
209_G214_S0.5540.56
157_P161_R0.5540.56
74_L77_I0.5520.56
417_S423_L0.5520.56
150_P173_V0.5510.56
201_L403_I0.5500.56
28_L34_T0.5500.56
27_D69_T0.5500.56
131_T389_M0.5490.56
414_Y417_S0.5490.56
123_L165_K0.5490.56
85_D151_I0.5490.56
73_R295_M0.5480.55
177_L184_I0.5480.55
212_L310_E0.5470.55
150_P414_Y0.5460.55
206_S331_W0.5460.55
79_A350_S0.5450.55
37_H66_T0.5450.55
422_R429_D0.5450.55
262_A266_L0.5440.55
265_T283_T0.5430.55
66_T160_L0.5400.54
349_S386_D0.5400.54
70_L131_T0.5400.54
199_I202_L0.5400.54
360_G378_R0.5390.54
102_A146_V0.5390.54
355_T403_I0.5370.54
117_V174_T0.5370.54
274_H285_W0.5360.54
262_A289_V0.5360.54
279_P283_T0.5350.54
167_D170_M0.5350.54
7_T47_C0.5340.53
59_V62_N0.5340.53
200_P204_L0.5340.53
407_P414_Y0.5340.53
254_P319_L0.5340.53
282_L315_R0.5330.53
94_A158_A0.5320.53
29_R125_L0.5310.53
26_G29_R0.5290.53
48_V74_L0.5270.53
58_L65_L0.5260.52
133_V201_L0.5250.52
204_L227_T0.5250.52
301_T310_E0.5250.52
67_F150_P0.5240.52
301_T306_P0.5240.52
363_S399_P0.5240.52
306_P413_A0.5230.52
154_R178_R0.5220.52
355_T381_T0.5220.52
35_N186_V0.5220.52
209_G213_F0.5210.52
20_R25_V0.5210.52
204_L278_D0.5210.52
166_A313_M0.5200.52
236_G313_M0.5200.52
306_P315_R0.5180.51
70_L303_Y0.5180.51
209_G212_L0.5170.51
129_A370_H0.5170.51
420_L428_I0.5160.51
46_Y49_G0.5160.51
54_T106_A0.5160.51
236_G240_V0.5160.51
257_A316_G0.5160.51
301_T346_D0.5160.51
187_E190_Q0.5150.51
414_Y419_W0.5150.51
152_R174_T0.5150.51
122_E359_V0.5150.51
84_V146_V0.5140.51
182_A185_P0.5140.51
409_T413_A0.5140.51
47_C125_L0.5140.51
305_S309_V0.5120.51
52_D119_E0.5120.51
319_L323_A0.5120.51
295_M317_M0.5120.51
112_V115_H0.5120.51
106_A146_V0.5100.50
253_W396_R0.5100.50
161_R352_A0.5090.50
124_I415_L0.5090.50
291_S373_L0.5090.50
94_A102_A0.5080.50
182_A343_R0.5070.50
232_G327_A0.5070.50
234_L237_S0.5060.50
380_T383_L0.5060.50
382_I385_F0.5060.50
258_L300_S0.5050.50
134_A277_A0.5050.50
414_Y427_K0.5050.50
230_L325_L0.5040.49
282_L334_G0.5040.49
191_L212_L0.5030.49
148_W287_T0.5030.49
10_G47_C0.5030.49
48_V75_T0.5010.49
213_F217_A0.5010.49
76_S373_L0.5000.49
214_S222_G0.5000.49
118_V121_R0.5000.49
66_T289_V0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4djd_C 1 0.3672 100 0.773 Contact Map
2h9a_A 1 0.3672 100 0.782 Contact Map
1hfe_L 1 0.2194 99.5 0.922 Contact Map
3gyx_B 1 0.194 99.4 0.925 Contact Map
1dwl_A 1 0.1293 99.3 0.927 Contact Map
1f2g_A 1 0.127 99.3 0.927 Contact Map
1jnr_B 1 0.194 99.3 0.927 Contact Map
1xer_A 1 0.0716 99.3 0.927 Contact Map
4id8_A 1 0.1363 99.3 0.928 Contact Map
1iqz_A 1 0.1617 99.3 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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