T0862_C_1_101 - CASP12 - GREMLIN Contacts

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T0862_C_1_101 - T0862_C 1-101

ID:	27	Sequences: KTVDKLNQKQESAIKKIDNTIKNALKDHDIIGTLKDMDGKPVPKENGGYWDAMQEMQNTLRGLRNHADTLKNVNNPEAQAAYGRATDAINKIESALKGYGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	101 (86)
Sequences:	85 (75)
Seq/√Len:	8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_K	56_M	6.387	1.00
54_Q	58_N	2.827	0.84
15_K	61_R	2.760	0.83
35_K	42_V	2.319	0.70
24_A	36_D	2.154	0.64
26_K	29_D	2.137	0.63
21_I	51_D	1.966	0.57
19_N	32_G	1.883	0.53
16_K	31_I	1.655	0.44
52_A	63_L	1.622	0.43
20_T	62_G	1.604	0.42
18_D	27_D	1.601	0.42
64_R	68_D	1.521	0.39
64_R	93_E	1.493	0.38
42_V	58_N	1.467	0.37
74_N	77_E	1.463	0.36
9_K	12_S	1.423	0.35
23_N	54_Q	1.366	0.33
34_L	55_E	1.365	0.33
30_I	37_M	1.356	0.32
48_G	63_L	1.352	0.32
19_N	89_I	1.343	0.32
59_T	62_G	1.310	0.31
85_A	89_I	1.280	0.30
8_Q	12_S	1.236	0.28
36_D	41_P	1.199	0.27
82_Y	86_T	1.196	0.27
48_G	94_S	1.178	0.26
26_K	37_M	1.174	0.26
18_D	77_E	1.168	0.26
57_Q	89_I	1.155	0.26
68_D	83_G	1.119	0.24
11_E	57_Q	1.110	0.24
21_I	32_G	1.106	0.24
58_N	97_K	1.105	0.24
41_P	67_A	1.096	0.24
15_K	97_K	1.089	0.24
29_D	63_L	1.086	0.23
58_N	94_S	1.076	0.23
43_P	49_Y	1.070	0.23
8_Q	13_A	1.034	0.22
35_K	84_R	1.030	0.22
26_K	91_K	1.014	0.21
84_R	88_A	1.011	0.21
19_N	50_W	0.998	0.21
12_S	16_K	0.998	0.21
19_N	23_N	0.974	0.20
74_N	83_G	0.972	0.20
30_I	38_D	0.959	0.20
81_A	85_A	0.956	0.20
11_E	65_N	0.953	0.20
21_I	64_R	0.947	0.20
24_A	91_K	0.946	0.20
14_I	61_R	0.935	0.19
66_H	84_R	0.924	0.19
31_I	47_G	0.919	0.19
34_L	41_P	0.899	0.18
17_I	66_H	0.895	0.18
20_T	53_M	0.894	0.18
64_R	89_I	0.883	0.18
39_G	50_W	0.883	0.18
67_A	82_Y	0.880	0.18
61_R	90_N	0.868	0.18
26_K	83_G	0.843	0.17
51_D	89_I	0.832	0.17
44_K	50_W	0.831	0.17
83_G	86_T	0.815	0.16
53_M	60_L	0.810	0.16
42_V	47_G	0.808	0.16
14_I	66_H	0.808	0.16
61_R	68_D	0.797	0.16
63_L	85_A	0.793	0.16
34_L	56_M	0.786	0.16
39_G	67_A	0.784	0.16
46_N	76_P	0.769	0.15
44_K	62_G	0.762	0.15
24_A	63_L	0.757	0.15
10_Q	34_L	0.753	0.15
39_G	47_G	0.747	0.15
34_L	92_I	0.742	0.15
25_L	34_L	0.737	0.15
18_D	22_K	0.737	0.15
51_D	64_R	0.735	0.15
80_A	83_G	0.724	0.14
14_I	91_K	0.721	0.14
13_A	80_A	0.717	0.14
78_A	92_I	0.706	0.14
25_L	55_E	0.689	0.14
60_L	89_I	0.687	0.14
23_N	50_W	0.685	0.14
37_M	95_A	0.678	0.14
37_M	86_T	0.678	0.14
49_Y	67_A	0.674	0.13
36_D	55_E	0.659	0.13
17_I	52_A	0.655	0.13
53_M	57_Q	0.649	0.13
31_I	38_D	0.630	0.13
10_Q	27_D	0.626	0.13
67_A	86_T	0.625	0.13
78_A	86_T	0.623	0.13
14_I	55_E	0.623	0.13
28_H	35_K	0.620	0.12
14_I	23_N	0.608	0.12
29_D	94_S	0.606	0.12
93_E	97_K	0.605	0.12
33_T	45_E	0.604	0.12
42_V	65_N	0.598	0.12
59_T	89_I	0.597	0.12
20_T	50_W	0.592	0.12
48_G	84_R	0.586	0.12
15_K	65_N	0.582	0.12
38_D	82_Y	0.574	0.12
95_A	98_G	0.571	0.12
33_T	88_A	0.571	0.12
55_E	92_I	0.569	0.12
53_M	59_T	0.562	0.11
55_E	81_A	0.549	0.11
60_L	64_R	0.548	0.11
49_Y	97_K	0.548	0.11
37_M	59_T	0.540	0.11
16_K	65_N	0.535	0.11
21_I	30_I	0.534	0.11
27_D	61_R	0.534	0.11
81_A	84_R	0.530	0.11
64_R	80_A	0.526	0.11
78_A	82_Y	0.513	0.11
23_N	66_H	0.508	0.11
17_I	88_A	0.507	0.11
39_G	55_E	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5bu8_A	1	0.0693	20.3	0.91	Contact Map
2ov9_A	1	0.6337	9.9	0.922	Contact Map
3prh_A	1	0.8911	7.1	0.927	Contact Map
3tzl_A	1	0.8911	6.7	0.928	Contact Map
2btq_B	1	0.7822	6.7	0.928	Contact Map
3rio_A	1	0.2772	5.6	0.931	Contact Map
3n9i_A	1	0.9109	5.5	0.931	Contact Map
2g36_A	1	0.9109	5.4	0.931	Contact Map
4r1d_B	1	0.2871	5.4	0.931	Contact Map
3sz3_A	1	0.9208	5.3	0.931	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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