GREMLIN Database
T0862_C_1_101 - T0862_C 1-101
ID: 27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (86)
Sequences: 85 (75)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_K56_M6.3871.00
54_Q58_N2.8270.84
15_K61_R2.7600.83
35_K42_V2.3190.70
24_A36_D2.1540.64
26_K29_D2.1370.63
21_I51_D1.9660.57
19_N32_G1.8830.53
16_K31_I1.6550.44
52_A63_L1.6220.43
20_T62_G1.6040.42
18_D27_D1.6010.42
64_R68_D1.5210.39
64_R93_E1.4930.38
42_V58_N1.4670.37
74_N77_E1.4630.36
9_K12_S1.4230.35
23_N54_Q1.3660.33
34_L55_E1.3650.33
30_I37_M1.3560.32
48_G63_L1.3520.32
19_N89_I1.3430.32
59_T62_G1.3100.31
85_A89_I1.2800.30
8_Q12_S1.2360.28
36_D41_P1.1990.27
82_Y86_T1.1960.27
48_G94_S1.1780.26
26_K37_M1.1740.26
18_D77_E1.1680.26
57_Q89_I1.1550.26
68_D83_G1.1190.24
11_E57_Q1.1100.24
21_I32_G1.1060.24
58_N97_K1.1050.24
41_P67_A1.0960.24
15_K97_K1.0890.24
29_D63_L1.0860.23
58_N94_S1.0760.23
43_P49_Y1.0700.23
8_Q13_A1.0340.22
35_K84_R1.0300.22
26_K91_K1.0140.21
84_R88_A1.0110.21
19_N50_W0.9980.21
12_S16_K0.9980.21
19_N23_N0.9740.20
74_N83_G0.9720.20
30_I38_D0.9590.20
81_A85_A0.9560.20
11_E65_N0.9530.20
21_I64_R0.9470.20
24_A91_K0.9460.20
14_I61_R0.9350.19
66_H84_R0.9240.19
31_I47_G0.9190.19
34_L41_P0.8990.18
17_I66_H0.8950.18
20_T53_M0.8940.18
64_R89_I0.8830.18
39_G50_W0.8830.18
67_A82_Y0.8800.18
61_R90_N0.8680.18
26_K83_G0.8430.17
51_D89_I0.8320.17
44_K50_W0.8310.17
83_G86_T0.8150.16
53_M60_L0.8100.16
42_V47_G0.8080.16
14_I66_H0.8080.16
61_R68_D0.7970.16
63_L85_A0.7930.16
34_L56_M0.7860.16
39_G67_A0.7840.16
46_N76_P0.7690.15
44_K62_G0.7620.15
24_A63_L0.7570.15
10_Q34_L0.7530.15
39_G47_G0.7470.15
34_L92_I0.7420.15
25_L34_L0.7370.15
18_D22_K0.7370.15
51_D64_R0.7350.15
80_A83_G0.7240.14
14_I91_K0.7210.14
13_A80_A0.7170.14
78_A92_I0.7060.14
25_L55_E0.6890.14
60_L89_I0.6870.14
23_N50_W0.6850.14
37_M95_A0.6780.14
37_M86_T0.6780.14
49_Y67_A0.6740.13
36_D55_E0.6590.13
17_I52_A0.6550.13
53_M57_Q0.6490.13
31_I38_D0.6300.13
10_Q27_D0.6260.13
67_A86_T0.6250.13
78_A86_T0.6230.13
14_I55_E0.6230.13
28_H35_K0.6200.12
14_I23_N0.6080.12
29_D94_S0.6060.12
93_E97_K0.6050.12
33_T45_E0.6040.12
42_V65_N0.5980.12
59_T89_I0.5970.12
20_T50_W0.5920.12
48_G84_R0.5860.12
15_K65_N0.5820.12
38_D82_Y0.5740.12
95_A98_G0.5710.12
33_T88_A0.5710.12
55_E92_I0.5690.12
53_M59_T0.5620.11
55_E81_A0.5490.11
60_L64_R0.5480.11
49_Y97_K0.5480.11
37_M59_T0.5400.11
16_K65_N0.5350.11
21_I30_I0.5340.11
27_D61_R0.5340.11
81_A84_R0.5300.11
64_R80_A0.5260.11
78_A82_Y0.5130.11
23_N66_H0.5080.11
17_I88_A0.5070.11
39_G55_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bu8_A 1 0.0693 20.3 0.91 Contact Map
2ov9_A 1 0.6337 9.9 0.922 Contact Map
3prh_A 1 0.8911 7.1 0.927 Contact Map
3tzl_A 1 0.8911 6.7 0.928 Contact Map
2btq_B 1 0.7822 6.7 0.928 Contact Map
3rio_A 1 0.2772 5.6 0.931 Contact Map
3n9i_A 1 0.9109 5.5 0.931 Contact Map
2g36_A 1 0.9109 5.4 0.931 Contact Map
4r1d_B 1 0.2871 5.4 0.931 Contact Map
3sz3_A 1 0.9208 5.3 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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