GREMLIN Database
T0879_1_223 - T0879 1-223
ID: 25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 223 (192)
Sequences: 2263 (1774)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E66_R4.6461.00
41_Y198_Q4.5371.00
36_D62_E4.1671.00
39_D66_R4.1251.00
49_V60_I2.9621.00
41_Y201_Q2.7351.00
43_V197_I2.7301.00
194_E198_Q2.6131.00
49_V63_E2.5961.00
101_K107_D2.4571.00
69_T211_T2.3731.00
76_S92_D2.3431.00
34_L193_V2.3371.00
97_N142_L2.3171.00
91_D95_Q2.1451.00
162_E195_Q2.1411.00
75_A95_Q2.0811.00
169_I199_W2.0751.00
40_K194_E2.0531.00
151_S182_Q2.0231.00
165_V195_Q1.9521.00
152_G155_N1.9411.00
19_I200_G1.8441.00
197_I201_Q1.8421.00
37_V190_V1.7391.00
51_N75_A1.7141.00
44_K68_H1.7091.00
16_N206_T1.7021.00
41_Y197_I1.6871.00
99_I103_Q1.6331.00
41_Y194_E1.6031.00
116_G147_W1.5721.00
32_Q62_E1.5611.00
54_P57_Q1.5431.00
33_G191_N1.5271.00
43_V207_F1.5261.00
34_L190_V1.5201.00
165_V169_I1.5171.00
168_V196_I1.4521.00
17_K205_Y1.4471.00
79_Y115_G1.4471.00
61_A65_K1.4461.00
199_W202_A1.4261.00
25_D184_D1.4061.00
37_V197_I1.4031.00
32_Q59_M1.4021.00
199_W203_N1.3841.00
50_T74_S1.3731.00
54_P103_Q1.3601.00
39_D62_E1.3561.00
98_S102_A1.3551.00
20_Y208_L1.3521.00
198_Q202_A1.3501.00
37_V41_Y1.3501.00
145_C210_L1.3471.00
36_D66_R1.3321.00
18_I206_T1.2841.00
94_E97_N1.2811.00
37_V193_V1.2761.00
149_V178_S1.2621.00
48_F110_I1.2591.00
54_P99_I1.2521.00
193_V197_I1.2351.00
54_P60_I1.2351.00
43_V201_Q1.2291.00
148_N178_S1.2251.00
94_E98_S1.2150.99
135_N139_A1.2110.99
55_D99_I1.1960.99
113_F146_D1.1940.99
60_I63_E1.1900.99
172_V200_G1.1880.99
31_T184_D1.1820.99
78_K92_D1.1780.99
198_Q201_Q1.1610.99
18_I208_L1.1430.99
20_Y210_L1.1370.99
85_S88_A1.1270.99
27_P184_D1.1230.99
63_E70_V1.1150.99
30_Y190_V1.1100.99
187_E191_N1.1080.99
99_I102_A1.1070.99
58_N61_A1.0920.99
150_S155_N1.0880.99
37_V194_E1.0620.99
75_A96_M1.0560.99
19_I180_V1.0550.99
94_E140_R1.0540.98
72_I97_N1.0500.98
165_V192_A1.0420.98
188_F191_N1.0390.98
74_S80_N1.0260.98
42_N201_Q1.0220.98
64_A104_T1.0190.98
79_Y82_I1.0120.98
83_Y88_A1.0040.98
197_I207_F0.9950.98
75_A99_I0.9910.98
64_A106_N0.9860.98
35_L62_E0.9640.97
204_G207_F0.9610.97
42_N65_K0.9600.97
35_L63_E0.9560.97
168_V180_V0.9440.97
90_F136_D0.9440.97
20_Y209_P0.9430.97
166_Q170_S0.9310.97
87_Q91_D0.9300.97
136_D139_A0.9190.96
164_V192_A0.9100.96
60_I100_I0.8960.96
60_I70_V0.8960.96
35_L68_H0.8900.96
151_S164_V0.8820.95
145_C179_V0.8790.95
150_S154_A0.8780.95
36_D40_K0.8770.95
149_V180_V0.8750.95
60_I103_Q0.8720.95
44_K209_P0.8720.95
209_P213_S0.8710.95
96_M100_I0.8630.95
90_F94_E0.8630.95
182_Q196_I0.8580.95
86_E121_V0.8560.95
72_I96_M0.8560.95
19_I174_S0.8530.95
210_L214_S0.8480.94
17_K176_N0.8480.94
38_L45_A0.8460.94
73_H77_H0.8380.94
165_V196_I0.8370.94
93_L111_I0.8370.94
48_F145_C0.8330.94
59_M63_E0.8330.94
168_V200_G0.8250.94
52_T76_S0.8210.93
115_G154_A0.8180.93
39_D68_H0.8100.93
95_Q98_S0.8090.93
26_G184_D0.8060.93
69_T110_I0.8000.92
164_V168_V0.7970.92
164_V188_F0.7970.92
136_D140_R0.7950.92
46_T210_L0.7930.92
90_F139_A0.7930.92
163_Q167_N0.7810.92
72_I93_L0.7810.92
27_P53_H0.7790.91
69_T209_P0.7780.91
113_F144_Y0.7710.91
98_S101_K0.7650.91
192_A196_I0.7650.91
93_L137_V0.7640.91
100_I104_T0.7640.91
29_K184_D0.7640.91
20_Y213_S0.7570.90
165_V199_W0.7560.90
46_T69_T0.7510.90
151_S168_V0.7480.90
79_Y117_S0.7370.89
137_V144_Y0.7370.89
149_V174_S0.7360.89
30_Y33_G0.7320.89
166_Q169_I0.7280.88
72_I111_I0.7250.88
21_L182_Q0.7220.88
80_N111_I0.7200.88
169_I203_N0.7200.88
175_H178_S0.7170.88
23_F193_V0.7150.88
88_A91_D0.7130.87
179_V210_L0.7110.87
89_F136_D0.7090.87
37_V40_K0.7060.87
161_T165_V0.7040.87
110_I211_T0.7030.87
189_S193_V0.6980.86
119_N133_L0.6960.86
147_W181_L0.6930.86
41_Y193_V0.6930.86
150_S181_L0.6900.86
81_Q117_S0.6810.85
195_Q199_W0.6800.85
31_T35_L0.6790.85
27_P31_T0.6780.85
96_M99_I0.6760.85
17_K203_N0.6750.84
74_S78_K0.6730.84
18_I207_F0.6720.84
48_F71_A0.6580.83
149_V168_V0.6560.83
201_Q207_F0.6550.83
69_T210_L0.6550.83
86_E136_D0.6510.82
70_V104_T0.6480.82
43_V209_P0.6450.82
28_G32_Q0.6430.81
61_A64_A0.6400.81
163_Q166_Q0.6390.81
161_T195_Q0.6350.81
34_L189_S0.6350.81
32_Q36_D0.6340.81
50_T184_D0.6340.81
86_E90_F0.6310.80
35_L66_R0.6290.80
62_E65_K0.6280.80
133_L136_D0.6280.80
51_N99_I0.6270.80
186_K193_V0.6260.80
90_F140_R0.6140.78
28_G53_H0.6120.78
100_I103_Q0.6090.78
49_V54_P0.6080.78
72_I142_L0.6080.78
46_T209_P0.6070.78
30_Y34_L0.6000.77
89_F133_L0.5980.77
34_L37_V0.5970.76
97_N107_D0.5960.76
23_F182_Q0.5910.76
21_L43_V0.5860.75
200_G203_N0.5860.75
80_N83_Y0.5830.75
160_S188_F0.5820.75
70_V100_I0.5780.74
115_G151_S0.5770.74
98_S107_D0.5710.73
32_Q35_L0.5690.73
168_V192_A0.5680.73
25_D53_H0.5680.73
174_S200_G0.5650.73
157_K160_S0.5630.72
186_K189_S0.5590.72
168_V182_Q0.5560.71
93_L142_L0.5560.71
111_I137_V0.5550.71
78_K83_Y0.5540.71
153_D189_S0.5540.71
76_S95_Q0.5500.71
33_G37_V0.5480.70
49_V184_D0.5460.70
24_D112_R0.5430.70
92_D96_M0.5410.69
20_Y46_T0.5400.69
19_I199_W0.5380.69
19_I207_F0.5380.69
28_G184_D0.5370.69
39_D42_N0.5370.69
174_S178_S0.5360.69
88_A92_D0.5350.68
54_P96_M0.5350.68
18_I212_T0.5330.68
30_Y71_A0.5310.68
54_P100_I0.5310.68
205_Y208_L0.5300.68
23_F26_G0.5290.68
59_M184_D0.5290.68
150_S164_V0.5280.67
24_D27_P0.5280.67
149_V164_V0.5230.67
57_Q102_A0.5220.67
149_V172_V0.5210.66
83_Y89_F0.5200.66
116_G181_L0.5190.66
55_D75_A0.5190.66
81_Q88_A0.5170.66
191_N195_Q0.5170.66
80_N89_F0.5140.65
110_I210_L0.5120.65
25_D31_T0.5120.65
24_D114_P0.5120.65
115_G180_V0.5070.64
35_L45_A0.5070.64
162_E170_S0.5060.64
208_L212_T0.5060.64
56_Y59_M0.5050.64
196_I200_G0.5050.64
20_Y142_L0.5040.64
164_V171_G0.5030.64
64_A70_V0.5030.64
23_F34_L0.5020.64
162_E166_Q0.5020.64
40_K202_A0.5010.63
117_S133_L0.5000.63
28_G34_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cc0_A 1 0.8565 100 0.264 Contact Map
4m1b_A 1 0.8744 100 0.274 Contact Map
1ny1_A 1 0.9193 100 0.279 Contact Map
2c1i_A 1 0.9148 100 0.281 Contact Map
2w3z_A 1 0.8789 100 0.282 Contact Map
2y8u_A 1 0.9193 100 0.284 Contact Map
2j13_A 1 0.8341 100 0.294 Contact Map
2c71_A 1 0.843 100 0.301 Contact Map
2iw0_A 1 0.9148 100 0.303 Contact Map
2vyo_A 1 0.8744 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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