GREMLIN Database
T0878_316_358 - T0878 316-358
ID: 23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 43 (40)
Sequences: 11 (8)
Seq/√Len: 1.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_P28_D2.3610.17
13_A21_I2.1600.15
16_E34_M2.1130.15
35_I39_H1.9370.13
7_D21_I1.8840.13
27_T30_Q1.8550.13
17_T37_K1.8310.13
29_A32_R1.6820.12
18_D37_K1.6740.12
20_I26_K1.4550.10
7_D13_A1.3960.10
9_K12_K1.3800.10
37_K40_E1.3400.09
26_K33_A1.2450.09
26_K34_M1.1680.09
27_T36_R1.1180.08
9_K40_E1.1080.08
4_A23_P1.0500.08
4_A25_G1.0500.08
10_L23_P1.0500.08
10_L25_G1.0500.08
4_A10_L1.0500.08
29_A33_A1.0370.08
2_T11_W1.0160.08
2_T6_Q1.0160.08
6_Q11_W1.0160.08
2_T5_F0.9670.08
5_F11_W0.9670.08
5_F38_T0.9190.07
28_D32_R0.9040.07
18_D36_R0.9000.07
11_W14_L0.8140.07
2_T14_L0.8140.07
6_Q14_L0.8140.07
36_R40_E0.8110.07
33_A37_K0.7660.07
17_T36_R0.6880.06
6_Q38_T0.6870.06
2_T38_T0.6870.06
11_W38_T0.6870.06
28_D33_A0.6850.06
21_I32_R0.6840.06
12_K26_K0.6560.06
16_E26_K0.6180.06
12_K33_A0.6030.06
8_P37_K0.6010.06
13_A18_D0.6010.06
8_P13_A0.5940.06
19_L25_G0.5750.06
4_A19_L0.5750.06
10_L19_L0.5750.06
19_L23_P0.5750.06
16_E36_R0.5700.06
18_D40_E0.5440.06
26_K32_R0.5350.06
20_I28_D0.5300.06
3_I35_I0.5090.06
30_Q36_R0.5030.06
12_K40_E0.5020.06
12_K36_R0.5000.06
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cq3_A 1 0.8372 19.2 0.85 Contact Map
1odh_A 1 0.6744 9.1 0.87 Contact Map
2nw8_A 1 0.3953 8.2 0.873 Contact Map
3vk5_A 1 0.3488 5.6 0.882 Contact Map
1x6v_B 1 0.9535 5 0.885 Contact Map
2vga_A 1 0.8372 4.9 0.886 Contact Map
1vky_A 1 0.9302 4.7 0.886 Contact Map
4njc_A 1 1 4.4 0.888 Contact Map
3pt1_A 1 0.9302 4 0.89 Contact Map
3ddd_A 1 0.5116 3.7 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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