GREMLIN Database
T0878_20_315 - T0878 20-315
ID: 22 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 296 (270)
Sequences: 524 (398)
Seq/√Len: 24.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_L191_T5.2941.00
110_W130_F4.0881.00
135_L143_L4.0561.00
7_A51_L3.8271.00
74_E112_K3.5801.00
71_Y105_W3.3741.00
223_M272_G3.3081.00
268_H286_N3.1021.00
146_Q199_V3.0611.00
89_H286_N2.7760.99
89_H268_H2.6470.99
89_H128_Q2.6430.99
90_T151_Q2.6420.99
270_K286_N2.4760.99
89_H270_K2.4530.98
111_P114_A2.4390.98
58_V95_A2.4260.98
29_Y91_K2.3900.98
221_A274_T2.3840.98
210_F285_I2.3090.98
93_V106_L2.2230.97
128_Q268_H2.1860.97
108_H111_P2.1770.97
103_A114_A2.1200.96
1_S4_L2.1020.96
5_W51_L2.0530.95
229_I265_T2.0160.95
219_L223_M1.9890.94
90_T133_L1.9440.94
67_G161_G1.9430.93
73_D270_K1.8980.93
37_V71_Y1.8800.92
128_Q286_N1.8420.92
210_F215_V1.8290.91
108_H114_A1.8210.91
8_Y88_G1.7800.90
7_A130_F1.7790.90
229_I264_E1.7460.89
128_Q270_K1.7370.89
73_D89_H1.7280.89
73_D286_N1.7100.88
54_T57_S1.6870.87
139_T142_K1.6660.87
56_D60_G1.6490.86
191_T197_F1.6480.86
8_Y37_V1.6320.86
103_A106_L1.6300.85
105_W108_H1.6140.85
222_D275_T1.5880.84
231_G288_M1.5850.84
69_I155_V1.5810.84
236_V288_M1.5760.83
109_S114_A1.5690.83
155_V272_G1.5460.82
76_P271_W1.5440.82
248_I271_W1.5240.81
68_W157_L1.5190.81
132_C281_C1.5190.81
108_H113_Y1.5030.80
67_G96_F1.4930.80
126_Y226_E1.4880.80
141_G168_P1.4880.80
9_K54_T1.4810.79
50_A57_S1.4790.79
184_S214_L1.4470.78
281_C287_R1.4340.77
106_L114_A1.4110.76
111_P270_K1.4070.76
73_D111_P1.4060.76
49_G53_Y1.3920.75
239_S242_V1.3840.74
37_V241_G1.3760.74
151_Q284_D1.3640.73
109_S113_Y1.3630.73
146_Q185_D1.3600.73
212_N216_G1.3580.73
109_S128_Q1.3530.73
268_H283_G1.3510.73
283_G286_N1.3440.72
134_S159_R1.3420.72
239_S247_D1.3310.71
73_D109_S1.3250.71
71_Y107_L1.3180.71
220_K243_H1.3070.70
54_T215_V1.3060.70
69_I90_T1.3010.70
140_A169_L1.2970.69
94_I147_M1.2830.69
188_D195_V1.2820.69
145_A168_P1.2750.68
202_K228_W1.2680.68
8_Y11_P1.2530.67
269_A281_C1.2510.67
158_P173_T1.2300.65
72_N210_F1.2270.65
96_F288_M1.2220.65
200_I210_F1.2190.65
108_H287_R1.2180.64
216_G245_T1.2040.64
151_Q210_F1.1970.63
191_T194_G1.1870.62
267_D281_C1.1750.62
55_L94_I1.1740.62
37_V44_M1.1440.60
104_L278_N1.1350.59
111_P122_P1.1330.59
76_P156_Y1.1290.58
138_A220_K1.1260.58
230_R265_T1.1190.58
230_R288_M1.1160.58
151_Q172_L1.1050.57
71_Y88_G1.1050.57
270_K284_D1.1020.57
74_E86_T1.1010.57
97_D283_G1.0890.56
124_P147_M1.0860.55
102_S134_S1.0810.55
283_G287_R1.0800.55
216_G223_M1.0710.54
73_D91_K1.0690.54
52_F114_A1.0630.54
104_L113_Y1.0560.53
93_V113_Y1.0550.53
73_D268_H1.0300.52
151_Q215_V1.0280.51
111_P268_H1.0240.51
131_L197_F1.0210.51
123_T216_G1.0160.51
105_W271_W1.0160.51
114_A284_D1.0120.50
103_A109_S1.0070.50
65_T220_K1.0060.50
144_A172_L1.0050.50
251_I262_W1.0030.50
1_S175_P1.0000.49
55_L155_V0.9940.49
3_D9_K0.9900.49
91_K209_D0.9760.48
44_M230_R0.9690.47
153_P233_I0.9650.47
97_D102_S0.9560.46
106_L111_P0.9490.46
178_A255_K0.9460.46
6_F280_V0.9450.45
89_H126_Y0.9320.45
188_D198_K0.9120.43
15_K212_N0.9090.43
153_P223_M0.9020.42
44_M107_L0.9010.42
155_V181_P0.9000.42
89_H109_S0.8990.42
106_L109_S0.8990.42
227_T274_T0.8950.42
258_A263_P0.8940.42
171_A176_L0.8900.42
73_D88_G0.8880.41
89_H111_P0.8800.41
65_T192_R0.8790.41
217_P226_E0.8760.41
109_S270_K0.8760.41
2_V54_T0.8740.41
243_H247_D0.8680.40
111_P284_D0.8660.40
104_L117_S0.8650.40
153_P219_L0.8650.40
111_P286_N0.8630.40
8_Y12_K0.8620.40
29_Y50_A0.8610.40
121_V262_W0.8520.39
6_F135_L0.8510.39
173_T199_V0.8470.39
51_L131_L0.8450.39
88_G258_A0.8440.38
163_L260_W0.8430.38
135_L189_F0.8380.38
54_T94_I0.8360.38
56_D138_A0.8290.37
74_E89_H0.8290.37
182_G203_N0.8260.37
235_P282_V0.8230.37
221_A269_A0.8230.37
8_Y71_Y0.8170.37
110_W114_A0.8090.36
210_F284_D0.8050.36
74_E203_N0.7950.35
61_D165_H0.7950.35
30_Y69_I0.7940.35
50_A54_T0.7930.35
129_T172_L0.7920.35
66_T147_M0.7880.35
75_M95_A0.7850.35
88_G268_H0.7830.34
145_A191_T0.7800.34
108_H281_C0.7770.34
131_L199_V0.7760.34
52_F211_W0.7720.34
11_P127_G0.7660.33
270_K283_G0.7650.33
170_Y174_Q0.7590.33
134_S224_Y0.7590.33
108_H122_P0.7510.32
148_A271_W0.7500.32
134_S148_A0.7500.32
71_Y271_W0.7490.32
134_S169_L0.7470.32
109_S286_N0.7450.32
156_Y202_K0.7450.32
44_M71_Y0.7450.32
10_V247_D0.7390.32
212_N226_E0.7380.32
209_D287_R0.7360.31
72_N75_M0.7360.31
109_S268_H0.7350.31
145_A185_D0.7350.31
143_L212_N0.7340.31
60_G145_A0.7340.31
134_S241_G0.7310.31
196_P220_K0.7310.31
61_D65_T0.7290.31
68_W102_S0.7290.31
144_A227_T0.7200.30
9_K71_Y0.7190.30
147_M285_I0.7190.30
88_G270_K0.7160.30
152_Q265_T0.7160.30
2_V5_W0.7160.30
121_V166_T0.7130.30
91_K251_I0.7120.30
216_G221_A0.7120.30
5_W10_V0.7110.30
221_A275_T0.7110.30
72_N154_Q0.7100.30
38_Q192_R0.7080.30
86_T171_A0.7070.30
121_V283_G0.7050.30
55_L113_Y0.7020.29
256_L259_P0.6960.29
8_Y181_P0.6960.29
88_G122_P0.6950.29
39_K198_K0.6950.29
227_T231_G0.6940.29
209_D212_N0.6940.29
6_F51_L0.6930.29
103_A283_G0.6920.29
140_A158_P0.6910.29
126_Y266_Q0.6910.29
136_D192_R0.6900.29
168_P222_D0.6890.29
146_Q201_A0.6870.29
49_G148_A0.6860.28
68_W134_S0.6850.28
267_D271_W0.6850.28
142_K187_L0.6840.28
157_L213_D0.6830.28
238_D247_D0.6800.28
88_G149_L0.6800.28
141_G167_S0.6740.28
221_A278_N0.6730.28
79_A196_P0.6720.28
127_G230_R0.6670.27
37_V105_W0.6670.27
241_G271_W0.6670.27
126_Y228_W0.6650.27
255_K258_A0.6630.27
36_A50_A0.6600.27
74_E226_E0.6590.27
177_N209_D0.6590.27
55_L143_L0.6590.27
69_I195_V0.6580.27
59_F260_W0.6560.27
119_P122_P0.6550.27
44_M220_K0.6550.27
144_A149_L0.6540.27
11_P271_W0.6540.27
109_S284_D0.6540.27
61_D101_S0.6540.27
142_K190_K0.6510.26
42_N274_T0.6510.26
200_I218_T0.6490.26
138_A193_G0.6480.26
147_M273_I0.6460.26
32_R85_A0.6450.26
1_S220_K0.6440.26
89_H228_W0.6410.26
8_Y146_Q0.6400.26
56_D204_R0.6390.26
95_A125_L0.6380.26
105_W133_L0.6360.26
49_G58_V0.6320.25
12_K45_N0.6310.25
201_A206_W0.6270.25
43_L120_G0.6270.25
98_I118_V0.6270.25
72_N217_P0.6230.25
111_P128_Q0.6170.25
65_T101_S0.6160.25
156_Y276_T0.6150.25
164_D182_G0.6150.25
56_D127_G0.6140.24
176_L188_D0.6130.24
88_G286_N0.6130.24
33_Q245_T0.6110.24
66_T152_Q0.6110.24
105_W267_D0.6100.24
19_S29_Y0.6100.24
12_K217_P0.6080.24
158_P276_T0.6070.24
103_A111_P0.6060.24
144_A155_V0.6060.24
203_N212_N0.6040.24
10_V51_L0.6030.24
31_D51_L0.6030.24
127_G156_Y0.6010.24
101_S176_L0.6000.24
74_E182_G0.5990.24
248_I273_I0.5980.24
19_S142_K0.5980.24
68_W271_W0.5970.24
76_P143_L0.5970.24
162_G178_A0.5960.24
73_D227_T0.5950.23
136_D211_W0.5950.23
6_F37_V0.5920.23
149_L182_G0.5850.23
118_V162_G0.5840.23
59_F282_V0.5830.23
48_K220_K0.5820.23
155_V211_W0.5790.23
57_S123_T0.5780.23
107_L283_G0.5770.23
224_Y275_T0.5740.22
226_E251_I0.5720.22
245_T261_A0.5720.22
262_W268_H0.5720.22
88_G128_Q0.5690.22
175_P246_Y0.5670.22
151_Q285_I0.5640.22
30_Y189_F0.5610.22
122_P256_L0.5600.22
133_L218_T0.5590.22
211_W272_G0.5580.22
87_L129_T0.5580.22
213_D227_T0.5570.22
105_W122_P0.5560.22
138_A207_G0.5560.22
44_M47_P0.5560.22
84_N87_L0.5560.22
240_D272_G0.5550.22
127_G213_D0.5550.22
4_L19_S0.5530.21
140_A214_L0.5520.21
105_W111_P0.5520.21
5_W173_T0.5500.21
40_S50_A0.5500.21
74_E268_H0.5490.21
186_S220_K0.5490.21
139_T189_F0.5490.21
161_G176_L0.5480.21
202_K270_K0.5480.21
44_M119_P0.5460.21
51_L58_V0.5430.21
109_S126_Y0.5410.21
38_Q48_K0.5400.21
56_D155_V0.5400.21
184_S194_G0.5400.21
1_S157_L0.5380.21
110_W123_T0.5360.21
5_W215_V0.5360.21
70_L196_P0.5350.21
67_G166_T0.5310.20
6_F165_H0.5310.20
193_G240_D0.5310.20
197_F237_L0.5280.20
69_I124_P0.5280.20
7_A181_P0.5260.20
210_F216_G0.5230.20
162_G258_A0.5230.20
248_I261_A0.5210.20
143_L179_S0.5210.20
134_S203_N0.5180.20
125_L155_V0.5180.20
102_S135_L0.5160.20
73_D128_Q0.5160.20
101_S195_V0.5150.20
153_P175_P0.5140.20
130_F139_T0.5130.20
42_N186_S0.5130.20
90_T264_E0.5130.20
36_A58_V0.5130.20
115_S274_T0.5120.20
36_A101_S0.5120.20
59_F200_I0.5110.19
8_Y129_T0.5100.19
5_W95_A0.5100.19
162_G261_A0.5090.19
247_D287_R0.5080.19
116_P143_L0.5080.19
127_G208_K0.5060.19
142_K196_P0.5050.19
253_L271_W0.5030.19
221_A236_V0.5030.19
95_A104_L0.5020.19
47_P240_D0.5000.19
201_A258_A0.5000.19
67_G168_P0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rkl_A 1 0.1351 7.9 0.971 Contact Map
1by6_A 1 0.1216 5.7 0.973 Contact Map
3w1y_A 1 0.1824 3.9 0.975 Contact Map
4xc5_A 1 0.3649 3.4 0.976 Contact Map
5azf_A 1 0.2061 3.3 0.976 Contact Map
3h9d_A 1 0.2061 3.2 0.976 Contact Map
1whv_A 1 0.3176 2.2 0.978 Contact Map
3ksk_A 1 0.1791 2.2 0.978 Contact Map
4eoy_A 1 0.2027 2.2 0.978 Contact Map
3vtw_A 1 0.2061 2.1 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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