GREMLIN Database
T0878_1_358 - T0878 1-358
ID: 21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 358 (313)
Sequences: 282 (237)
Seq/√Len: 13.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_L210_T4.3941.00
108_H147_Q3.1910.98
108_H305_N3.1280.98
18_N23_L3.0440.97
92_D315_G3.0410.97
310_Q313_R3.0230.97
90_Y124_W3.0210.97
108_H287_H3.0180.97
287_H305_N3.0080.97
147_Q287_H2.9110.96
108_H289_K2.9100.96
242_M291_G2.8290.96
300_C319_A2.6620.94
289_K305_N2.6580.94
305_N310_Q2.5830.93
108_H313_R2.5580.92
93_E131_K2.4550.91
147_Q305_N2.3890.89
310_Q315_G2.3550.89
287_H313_R2.3460.89
305_N313_R2.2540.86
69_A125_L2.2280.86
18_N21_V2.2190.86
70_L73_T2.1670.84
26_A70_L2.1600.84
229_F304_I2.0710.81
151_C300_C2.0520.81
319_A329_L2.0480.81
234_V317_T2.0340.80
92_D289_K2.0010.79
287_H310_Q1.9980.79
48_Y69_A1.9770.78
20_S23_L1.9310.76
147_Q289_K1.9230.76
289_K313_R1.8930.75
112_V125_L1.8820.74
92_D305_N1.8380.73
92_D108_H1.8360.72
127_H306_R1.8240.72
25_F325_L1.8230.72
18_N22_D1.8020.71
15_D19_R1.7980.71
127_H151_C1.7880.70
28_K73_T1.7640.69
127_H300_C1.7500.69
130_P289_K1.7260.68
92_D310_Q1.7020.66
151_C319_A1.6820.66
151_C286_D1.6550.64
90_Y188_L1.6490.64
130_P305_N1.6400.63
107_G305_N1.6200.62
147_Q313_R1.6110.62
320_F325_L1.6080.62
73_T76_S1.5680.60
165_Q218_V1.5660.60
289_K315_G1.5540.59
234_V288_A1.5440.59
27_Y90_Y1.5410.58
30_P74_L1.5250.58
129_W149_F1.5250.58
128_S303_D1.5200.57
108_H310_Q1.5170.57
229_F317_T1.5090.57
300_C306_R1.4790.55
127_H319_A1.4620.54
116_D121_S1.4440.53
108_H130_P1.4400.53
21_V24_W1.4340.53
163_A191_L1.4270.53
230_W317_T1.4240.52
49_Y180_G1.4240.52
48_Y132_Y1.4180.52
287_H302_G1.4130.52
73_T207_D1.3960.51
30_P146_G1.3930.51
260_G290_W1.3830.50
93_E108_H1.3820.50
304_I317_T1.3800.50
110_K303_D1.3790.50
92_D287_H1.3640.49
110_K128_S1.3570.49
27_Y107_G1.3540.49
306_R316_G1.3510.48
174_V197_A1.3440.48
250_G307_M1.3440.48
56_V260_G1.3340.48
228_D306_R1.3230.47
92_D313_R1.3170.47
85_T254_P1.3160.47
46_Y128_S1.3060.46
190_A195_L1.3050.46
240_A293_T1.3050.46
130_P287_H1.3040.46
15_D18_N1.3030.46
307_M320_F1.2950.46
30_P342_T1.2920.45
90_Y107_G1.2830.45
124_W290_W1.2700.44
238_L242_M1.2680.44
210_T216_F1.2620.44
286_D300_C1.2560.43
107_G168_L1.2470.43
288_A300_C1.2370.42
289_K310_Q1.2240.42
19_R23_L1.2240.42
126_L318_I1.2190.42
69_A298_W1.2180.41
92_D130_P1.2170.41
107_G313_R1.2160.41
49_Y91_N1.2100.41
122_A125_L1.2090.41
90_Y126_L1.2020.41
130_P313_R1.1880.40
130_P310_Q1.1860.40
56_V90_Y1.1750.39
151_C306_R1.1730.39
24_W48_Y1.1730.39
146_G249_R1.1720.39
288_A319_A1.1700.39
309_T320_F1.1700.39
191_L200_P1.1630.39
153_S337_P1.1560.38
24_W70_L1.1510.38
74_L162_L1.1430.38
95_P124_W1.1360.37
229_F234_V1.1340.37
230_W291_G1.1280.37
241_D294_T1.1180.36
88_I272_L1.1120.36
306_R319_A1.1010.36
266_D306_R1.0900.35
15_D22_D1.0860.35
127_H286_D1.0810.35
92_D110_K1.0770.34
284_T309_T1.0750.34
146_G242_M1.0650.34
166_M336_I1.0570.34
71_F126_L1.0450.33
133_A186_S1.0440.33
27_Y148_T1.0360.33
122_A287_H1.0300.32
69_A76_S1.0220.32
226_G246_T1.0180.32
108_H128_S1.0170.32
49_Y80_D1.0160.32
93_E147_Q1.0150.32
242_M264_T1.0150.32
110_K130_P1.0100.31
132_Y322_D1.0060.31
237_T242_M1.0010.31
133_A303_D1.0010.31
95_P175_Y0.9970.31
133_A242_M0.9900.30
287_H315_G0.9890.30
326_W330_C0.9740.30
208_F327_K0.9680.29
240_A288_A0.9630.29
48_Y122_A0.9560.29
125_L330_C0.9560.29
46_Y275_L0.9510.29
257_D266_D0.9500.29
78_F134_S0.9500.29
125_L241_D0.9470.29
299_V329_L0.9460.28
170_Q316_G0.9430.28
92_D107_G0.9420.28
80_D217_K0.9410.28
132_Y151_C0.9400.28
153_S167_A0.9400.28
44_Y68_G0.9400.28
28_K221_K0.9390.28
21_V28_K0.9390.28
264_T293_T0.9350.28
72_Y140_V0.9330.28
40_S43_G0.9270.28
181_G201_G0.9260.28
63_M129_W0.9260.28
56_V124_W0.9260.28
136_S149_F0.9240.28
149_F158_T0.9230.27
89_L120_S0.9230.27
147_Q246_T0.9230.27
47_V90_Y0.9210.27
256_L292_I0.9200.27
135_P293_T0.9170.27
88_I174_V0.9170.27
26_A149_F0.9150.27
154_L162_L0.9140.27
210_T320_F0.9070.27
124_W152_L0.9050.27
148_T302_G0.8970.26
48_Y76_S0.8970.26
283_E303_D0.8950.26
107_G287_H0.8950.26
159_A233_L0.8910.26
225_W281_W0.8910.26
100_R244_V0.8900.26
248_I283_E0.8890.26
22_D28_K0.8870.26
110_K305_N0.8800.26
125_L153_S0.8800.26
109_T283_E0.8780.26
113_I174_V0.8770.26
107_G289_K0.8760.26
172_P175_Y0.8690.25
17_Q23_L0.8650.25
327_K331_E0.8650.25
236_P245_E0.8640.25
122_A302_G0.8610.25
69_A107_G0.8600.25
128_S148_T0.8590.25
180_G299_V0.8550.25
241_D293_T0.8540.25
95_P290_W0.8520.25
130_P147_Q0.8520.25
86_G180_G0.8450.24
17_Q20_S0.8450.24
248_I284_T0.8450.24
145_Y247_W0.8450.24
93_E289_K0.8440.24
29_V68_G0.8420.24
97_D149_F0.8420.24
242_M292_I0.8400.24
78_F228_D0.8400.24
70_L272_L0.8360.24
147_Q310_Q0.8350.24
221_K247_W0.8330.24
166_M240_A0.8320.24
207_D214_V0.8320.24
267_I290_W0.8310.24
76_S122_A0.8310.24
45_E79_G0.8300.24
229_F235_G0.8230.23
265_Y285_Q0.8220.23
258_S261_V0.8210.23
56_V242_M0.8210.23
64_N89_L0.8210.23
108_H148_T0.8150.23
107_G277_A0.8110.23
44_Y194_P0.8070.23
174_V267_I0.8070.23
128_S305_N0.8060.23
163_A174_V0.8060.23
56_V129_W0.8040.23
249_R307_M0.8040.23
86_G281_W0.8030.23
178_R181_G0.8020.23
73_T301_V0.8000.23
221_K289_K0.7990.23
128_S147_Q0.7980.23
90_Y109_T0.7960.22
85_T160_G0.7950.22
302_G306_R0.7950.22
57_Q249_R0.7940.22
141_P154_L0.7930.22
123_L162_L0.7900.22
74_L174_V0.7900.22
49_Y88_I0.7880.22
113_I195_L0.7870.22
236_P266_D0.7850.22
247_W290_W0.7820.22
93_E287_H0.7800.22
128_S145_Y0.7790.22
162_L311_E0.7780.22
96_A160_G0.7760.22
210_T213_G0.7710.22
192_T208_F0.7650.21
25_F180_G0.7650.21
62_L91_N0.7650.21
91_N153_S0.7640.21
200_P257_D0.7630.21
91_N110_K0.7620.21
107_G165_Q0.7610.21
203_S213_G0.7600.21
91_N122_A0.7580.21
108_H246_T0.7570.21
44_Y232_D0.7520.21
113_I170_Q0.7510.21
27_Y56_V0.7490.21
110_K289_K0.7490.21
29_V153_S0.7470.21
250_G310_Q0.7440.21
272_L318_I0.7440.21
153_S178_R0.7410.20
331_E336_I0.7400.20
90_Y300_C0.7400.20
92_D299_V0.7400.20
75_D223_R0.7360.20
25_F260_G0.7350.20
91_N272_L0.7320.20
131_K258_S0.7310.20
40_S47_V0.7310.20
29_V74_L0.7310.20
124_W292_I0.7310.20
55_A109_T0.7270.20
85_T139_G0.7260.20
260_G342_T0.7260.20
97_D291_G0.7210.20
125_L133_A0.7140.20
154_L208_F0.7110.19
69_A213_G0.7110.19
124_W260_G0.7100.19
141_P148_T0.7060.19
245_E270_I0.7030.19
208_F291_G0.7030.19
129_W241_D0.6990.19
170_Q191_L0.6990.19
290_W342_T0.6960.19
89_L259_D0.6940.19
156_L233_L0.6920.19
302_G305_N0.6900.19
125_L193_Q0.6890.19
307_M310_Q0.6870.19
90_Y141_P0.6850.19
31_K122_A0.6830.19
60_P65_D0.6810.18
231_N235_G0.6780.18
41_A129_W0.6770.18
18_N317_T0.6740.18
73_T234_V0.6730.18
104_A194_P0.6720.18
124_W300_C0.6710.18
254_P320_F0.6710.18
18_N152_L0.6700.18
157_A161_K0.6680.18
25_F148_T0.6680.18
286_D319_A0.6620.18
153_S243_Y0.6610.18
122_A209_K0.6610.18
76_S297_N0.6550.18
44_Y239_K0.6540.18
233_L237_T0.6540.18
56_V329_L0.6520.18
24_W45_E0.6510.18
208_F301_V0.6470.17
89_L216_F0.6470.17
142_T261_V0.6450.17
69_A149_F0.6450.17
21_V315_G0.6440.17
17_Q70_L0.6430.17
114_A162_L0.6420.17
339_P342_T0.6400.17
281_W304_I0.6390.17
244_V329_L0.6390.17
73_T302_G0.6380.17
34_K37_D0.6380.17
246_T305_N0.6380.17
310_Q314_G0.6360.17
46_Y76_S0.6340.17
15_D91_N0.6330.17
44_Y167_A0.6330.17
242_M281_W0.6330.17
31_K162_L0.6290.17
259_D264_T0.6270.17
27_Y124_W0.6260.17
53_V158_T0.6260.17
228_D299_V0.6250.17
48_Y287_H0.6240.17
28_K74_L0.6230.17
213_G302_G0.6230.17
124_W329_L0.6220.17
93_E175_Y0.6200.17
337_P342_T0.6190.17
52_Q180_G0.6190.17
44_Y266_D0.6170.17
41_A297_N0.6160.16
125_L134_S0.6160.16
219_I229_F0.6160.16
251_K329_L0.6140.16
29_V257_D0.6120.16
28_K130_P0.6110.16
25_F70_L0.6100.16
114_A144_L0.6100.16
200_P327_K0.6080.16
142_T270_I0.6070.16
292_I326_W0.6040.16
91_N94_M0.6030.16
93_E313_R0.6020.16
56_V126_L0.5950.16
188_L267_I0.5950.16
129_W290_W0.5940.16
86_G115_F0.5930.16
20_S220_A0.5930.16
91_N303_D0.5900.16
71_F114_A0.5880.16
219_I281_W0.5870.16
298_W321_Q0.5870.16
314_G325_L0.5860.16
179_T203_S0.5850.16
44_Y145_Y0.5840.16
95_P200_P0.5840.16
250_G305_N0.5830.16
112_V150_L0.5820.16
107_G310_Q0.5800.15
117_I291_G0.5790.15
303_D313_R0.5780.15
170_Q229_F0.5780.15
189_Y193_Q0.5770.15
107_G246_T0.5760.15
166_M292_I0.5750.15
249_R284_T0.5700.15
146_G286_D0.5670.15
157_A212_G0.5670.15
305_N315_G0.5660.15
178_R233_L0.5630.15
49_Y331_E0.5630.15
63_M150_L0.5620.15
330_C335_I0.5590.15
225_W266_D0.5590.15
44_Y86_G0.5580.15
125_L298_W0.5570.15
32_L70_L0.5550.15
16_E59_S0.5550.15
175_Y286_D0.5550.15
260_G329_L0.5520.15
110_K287_H0.5520.15
149_F213_G0.5510.15
246_T250_G0.5510.15
21_V84_T0.5500.15
100_R153_S0.5500.15
163_A168_L0.5490.15
90_Y329_L0.5480.15
214_V322_D0.5480.15
147_Q315_G0.5470.15
241_D248_I0.5460.15
75_D235_G0.5460.15
113_I191_L0.5440.14
141_P318_I0.5430.14
148_T305_N0.5430.14
303_D316_G0.5420.14
166_M290_W0.5400.14
165_Q220_A0.5380.14
42_S166_M0.5370.14
320_F326_W0.5370.14
108_H315_G0.5370.14
222_N244_V0.5360.14
288_A315_G0.5350.14
107_G147_Q0.5350.14
107_G223_R0.5350.14
223_R297_N0.5320.14
48_Y128_S0.5310.14
150_L293_T0.5290.14
209_K239_K0.5280.14
40_S98_A0.5270.14
220_A249_R0.5270.14
41_A49_Y0.5250.14
141_P150_L0.5240.14
27_Y30_P0.5230.14
140_V154_L0.5220.14
114_A198_S0.5210.14
188_L213_G0.5200.14
116_D302_G0.5190.14
312_K335_I0.5190.14
171_Q192_T0.5170.14
131_K142_T0.5170.14
330_C339_P0.5170.14
160_G267_I0.5120.14
55_A149_F0.5120.14
63_M194_P0.5100.14
182_L224_K0.5100.14
74_L132_Y0.5100.14
89_L233_L0.5080.14
293_T312_K0.5080.14
29_V155_D0.5070.14
160_G187_P0.5060.14
24_W191_L0.5040.13
178_R205_S0.5030.13
165_Q292_I0.5020.13
150_L197_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rkl_A 1 0.148 5.1 0.977 Contact Map
4z29_A 1 0 5 0.977 Contact Map
1whv_A 1 0.257 4.5 0.978 Contact Map
5e1l_A 1 0.2235 4.3 0.978 Contact Map
4zdn_A 1 0.1341 3.9 0.978 Contact Map
3d53_A 1 0.1592 3.3 0.979 Contact Map
1ig6_A 1 0.2598 3.3 0.979 Contact Map
4xel_A 1 0.162 3.2 0.979 Contact Map
3gvf_A 1 0.1676 3.2 0.979 Contact Map
3j7y_a 1 0 3 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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