GREMLIN Database
T0824_1_110 - T0824 1-110 (CASP11)
ID: 2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (105)
Sequences: 690 (574)
Seq/√Len: 56.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D78_R5.0721.00
34_C63_W3.3561.00
35_T70_E3.1731.00
59_D86_R3.1451.00
35_T104_R2.5711.00
45_R66_A2.5611.00
49_L60_R2.4831.00
68_C105_I2.3971.00
90_S94_N2.2541.00
67_M96_L2.2511.00
18_T80_V2.2411.00
12_A23_S2.2151.00
12_A19_G2.1981.00
21_H76_S2.1291.00
60_R79_Y2.0191.00
18_T84_D1.8080.99
18_T88_A1.7930.99
17_E81_S1.7540.99
100_A103_T1.6430.99
17_E84_D1.5990.98
52_I79_Y1.5300.98
15_Y87_G1.5170.98
47_E50_K1.4940.98
85_N89_G1.4820.97
22_I65_M1.4500.97
65_M92_V1.4250.97
37_E44_R1.4200.97
25_A63_W1.3970.96
61_D85_N1.3260.95
63_W107_F1.3120.95
20_A24_D1.2820.94
34_C65_M1.2730.94
85_N88_A1.2700.94
36_I99_Y1.2660.94
34_C68_C1.2580.93
59_D85_N1.2570.93
54_T60_R1.2150.92
40_G44_R1.2050.92
72_G75_A1.1730.91
60_R77_V1.1590.90
52_I60_R1.1540.90
38_R101_D1.1370.89
31_A63_W1.0950.88
25_A31_A1.0840.87
48_S75_A1.0830.87
58_F79_Y1.0780.87
43_K47_E1.0440.85
19_G99_Y1.0410.85
54_T79_Y1.0190.83
42_D53_P1.0150.83
17_E80_V1.0080.83
23_S27_K0.9880.81
91_W96_L0.9540.79
18_T65_M0.9330.78
53_P79_Y0.9150.76
25_A29_G0.9110.76
69_E101_D0.9020.75
22_I26_I0.8970.75
68_C92_V0.8970.75
62_E89_G0.8720.73
6_D103_T0.8640.72
9_Y108_I0.8620.72
59_D82_S0.8560.71
51_G56_P0.8450.70
59_D90_S0.8400.70
25_A30_H0.8260.69
59_D88_A0.8180.68
92_V107_F0.8170.68
61_D89_G0.8170.68
19_G79_Y0.8080.67
70_E104_R0.8070.67
15_Y91_W0.7920.65
25_A34_C0.7920.65
104_R107_F0.7840.64
55_K79_Y0.7740.63
87_G90_S0.7680.63
82_S85_N0.7590.62
20_A23_S0.7460.61
48_S71_G0.7460.61
81_S88_A0.7420.60
82_S86_R0.7380.60
61_D66_A0.7310.59
21_H25_A0.7300.59
24_D27_K0.7270.59
37_E40_G0.7210.58
92_V96_L0.7070.57
35_T68_C0.7010.56
59_D83_S0.7000.56
39_S43_K0.6990.56
49_L77_V0.6930.55
33_V104_R0.6930.55
10_F19_G0.6920.55
53_P70_E0.6750.53
70_E74_G0.6690.52
49_L52_I0.6630.52
33_V106_L0.6610.52
62_E66_A0.6530.51
28_A108_I0.6530.51
55_K58_F0.6520.51
6_D99_Y0.6520.51
44_R48_S0.6510.50
20_A69_E0.6470.50
36_I101_D0.6470.50
16_P45_R0.6310.48
21_H79_Y0.6300.48
10_F109_V0.6190.47
92_V95_R0.6180.47
43_K81_S0.6150.47
36_I67_M0.6120.46
96_L99_Y0.6070.46
59_D87_G0.6050.45
32_D43_K0.6010.45
23_S78_R0.5990.45
36_I96_L0.5940.44
20_A78_R0.5930.44
19_G25_A0.5920.44
16_P84_D0.5830.43
21_H85_N0.5800.43
23_S79_Y0.5800.43
65_M68_C0.5790.43
45_R48_S0.5780.43
65_M88_A0.5770.43
22_I25_A0.5740.42
99_Y103_T0.5740.42
41_A51_G0.5690.42
24_D28_A0.5690.42
80_V85_N0.5690.42
62_E67_M0.5670.41
10_F22_I0.5640.41
54_T57_G0.5620.41
90_S97_N0.5620.41
60_R85_N0.5570.40
53_P57_G0.5530.40
13_S50_K0.5510.40
34_C91_W0.5500.40
46_Q108_I0.5480.39
62_E85_N0.5480.39
106_L109_V0.5470.39
63_W109_V0.5440.39
26_I63_W0.5420.39
53_P97_N0.5410.39
6_D77_V0.5330.38
80_V84_D0.5330.38
19_G26_I0.5310.38
19_G52_I0.5260.37
32_D106_L0.5240.37
57_G82_S0.5230.37
19_G23_S0.5230.37
8_L14_R0.5200.37
43_K69_E0.5180.36
11_P23_S0.5150.36
27_K81_S0.5140.36
63_W91_W0.5130.36
20_A94_N0.5130.36
49_L79_Y0.5070.35
58_F83_S0.5060.35
57_G93_G0.5010.35
16_P74_G0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cmy_B 1 0.1909 11.2 0.919 Contact Map
2plx_B 1 0.2364 5.6 0.929 Contact Map
3ja7_A 1 0.9182 4 0.934 Contact Map
3a0r_A 1 0.9091 3.2 0.937 Contact Map
1bkr_A 1 0.3727 2.2 0.942 Contact Map
4xa4_A 1 0.3091 2.2 0.942 Contact Map
2gkw_B 1 0.1545 2 0.944 Contact Map
1rfs_A 1 0.2818 1.9 0.944 Contact Map
2dlw_A 1 0.3364 1.8 0.945 Contact Map
3bdl_A 1 0.2091 1.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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